Absence of alsin function leads to corticospinal motor neuron vulnerability via novel disease mechanisms

Human Molecular Genetics

Volumn 25, Issue 6, 2015, Pages 1074-1087

  Gautam, Mukesh ^a   Jara, Javier H ^a   Sekerkova, Gabriella ^a   Yasvoina, Marina V ^a   Martina, Marco ^a   Özdinler, P Hande ^a,b  

^a NORTHWESTERN UNIVERSITY   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALSIN 2; PROTEIN; UNCLASSIFIED DRUG; ALS2 PROTEIN, MOUSE; GUANINE NUCLEOTIDE EXCHANGE FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOPHAGY; BRAIN CORTEX; CELL LOSS; CELL ORGANELLE; CONTROLLED STUDY; CORTICOSPINAL MOTOR NEURON; CYTOARCHITECTURE; DENDRITE; ELECTRON MICROSCOPY; FEMALE; GOLGI COMPLEX; IMMUNOCYTOCHEMISTRY; IN VIVO STUDY; MALE; MITOCHONDRIAL MEMBRANE; MOTONEURON; MOTOR CORTEX; MOTOR DYSFUNCTION; MOTOR NEURON DISEASE; MOUSE; NONHUMAN; PONS; PRIORITY JOURNAL; PROTEIN FUNCTION; AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL; AXON; DEFICIENCY; DISEASE MODEL; GENETICS; HEREDITARY MOTOR SENSORY NEUROPATHY; KNOCKOUT MOUSE; METABOLISM; MUTATION; PATHOLOGY; PHYSIOLOGY; PYRAMIDAL TRACT;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; AUTOPHAGY; AXONS; CEREBRAL CORTEX; DENDRITES; DISEASE MODELS, ANIMAL; FEMALE; GUANINE NUCLEOTIDE EXCHANGE FACTORS; MICE; MICE, KNOCKOUT; MOTOR NEURON DISEASE; MOTOR NEURONS; MUTATION; PYRAMIDAL TRACTS; SPASTIC PARAPLEGIA, HEREDITARY;

EID: 84960126944     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddv631     Document Type: Article

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