p62 plays a protective role in the autophagic degradation of polyglutamine protein oligomers in polyglutamine disease model flies

Journal of Biological Chemistry

Volumn 290, Issue 3, 2015, Pages 1442-1453

  Saitoh, Yuji ^a,b,c   Fujikake, Nobuhiro ^a   Okamoto, Yuma ^a   Akiko Popiel, H ^a   Hatanaka, Yusuke ^a   Ueyama, Morio ^a   Suzuki, Mari ^a   Gaumer, Sébastien ^d   Murata, Miho ^b,c   Wada, Keiji ^a   Nagai, Yoshitaka ^a,e  

^a NATIONAL INSTITUTE OF NEUROSCIENCE   (Japan)

^b NATIONAL INSTITUTE OF MENTAL HEALTH   (Japan)

^c CHIBA UNIVERSITY   (Japan)

^d LABORATOIRE DES SCIENCES DU CLIMAT ET DE L ENVIRONNEMENT   (France)

^e JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AGGREGATES; BIODEGRADATION; OLIGOMERS; PROTEINS;

AUTOPHAGIC DEGRADATION; IMMUNOHISTOCHEMICAL ANALYSIS; PATHOGENIC CONDITIONS; POLYGLUTAMINE (POLYQ); POLYGLUTAMINE DISEASE; POLYGLUTAMINE PROTEINS; THERAPEUTIC POTENTIALS; UBIQUITINATED PROTEINS;

NEURODEGENERATIVE DISEASES;

NEUROPEPTIDE; OLIGOMER; POLYGLUTAMINE PROTEIN; PROTEIN P62; UNCLASSIFIED DRUG; DROSOPHILA PROTEIN; PEPTIDE; POLYGLUTAMINE; TAF6 PROTEIN, DROSOPHILA; TATA BINDING PROTEIN ASSOCIATED FACTOR; TRANSCRIPTION FACTOR IID; UBIQUITINATED PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOPHAGY; BIOACCUMULATION; CONTROLLED STUDY; DEGENERATIVE DISEASE; DISEASE EXACERBATION; DROSOPHILA; GENE; GENE SILENCING; IMMUNOHISTOCHEMISTRY; LOSS OF FUNCTION MUTATION; NONHUMAN; P62 GENE; POLYGLUTAMINE DISEASE; PROTEIN AGGREGATION; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; ANIMAL; CHEMISTRY; CYTOPLASM; METABOLISM; PHOSPHORYLATION; PHOTORECEPTOR CELL; PROTEIN DENATURATION; PROTEIN FOLDING; SCANNING ELECTRON MICROSCOPY; TRANSGENE; ULTRASTRUCTURE;

ANIMALS; AUTOPHAGY; CYTOPLASM; DROSOPHILA; DROSOPHILA PROTEINS; IMMUNOHISTOCHEMISTRY; MICROSCOPY, ELECTRON, SCANNING; NEURODEGENERATIVE DISEASES; PEPTIDES; PHOSPHORYLATION; PHOTORECEPTOR CELLS, INVERTEBRATE; PROTEIN DENATURATION; PROTEIN FOLDING; TATA-BINDING PROTEIN ASSOCIATED FACTORS; TRANSCRIPTION FACTOR TFIID; TRANSGENES; UBIQUITINATED PROTEINS;

EID: 84961290118     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.590281     Document Type: Article

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