Defective relocalization of ALS2/alsin missense mutants to Rac1-induced macropinosomes accounts for loss of their cellular function and leads to disturbed amphisome formation

FEBS Letters

Volumn 585, Issue 5, 2011, Pages 730-736

  Otomo, Asako ^a   Kunita, Ryota ^a   Suzuki Utsunomiya, Kyoko ^a   Ikeda, Joh E ^a,b   Hadano, Shinji ^a,c  

^a TOKAI UNIVERSITY   (Japan)

^b CHILDREN S HOSPITAL OF EASTERN ONTARIO   (Canada)

^c TOKAI UNIVERSITY   (Japan)

Author keywords

ALS2; Amphisome; Autophagosome; Endosome; Macropinosome; Rac1

Indexed keywords

ALSIN; CELL PROTEIN; PHOSPHATIDYLINOSITOL 3 PHOSPHATE; PHOSPHATIDYLINOSITOL 3,5 PHOSPHATE; PHOSPHATIDYLINOSITOL 4 PHOSPHATE; PHOSPHATIDYLINOSITOL 5 PHOSPHATE; POLYPHOSPHOINOSITIDE; RAB PROTEIN; RAB5 PROTEIN; RAC1 PROTEIN; UNCLASSIFIED DRUG;

AMPHISOME; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; BINDING AFFINITY; CELL FUNCTION; CELL ORGANELLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENDOSOME; MACROPINOSOME; MISSENSE MUTATION; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION;

ENDOSOMES; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HELA CELLS; HUMANS; MUTANT PROTEINS; MUTATION, MISSENSE; PHAGOSOMES; PHOSPHATIDYLINOSITOL PHOSPHATES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; RAB5 GTP-BINDING PROTEINS; RAC1 GTP-BINDING PROTEIN;

EID: 79952317005     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2011.01.045     Document Type: Article

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