-
1
-
-
67649286622
-
Cell biology: Beyond the prion principle
-
A. Aguzzi Cell biology: Beyond the prion principle Nature 459 2009 924 925
-
(2009)
Nature
, vol.459
, pp. 924-925
-
-
Aguzzi, A.1
-
2
-
-
72149125838
-
The transcellular spread of cytosolic amyloids, prions, and prionoids
-
A. Aguzzi, and L. Rajendran The transcellular spread of cytosolic amyloids, prions, and prionoids Neuron 64 2009 783 790
-
(2009)
Neuron
, vol.64
, pp. 783-790
-
-
Aguzzi, A.1
Rajendran, L.2
-
4
-
-
66249103703
-
RNA granules: Post-transcriptional and epigenetic modulators of gene expression
-
P. Anderson, and N. Kedersha RNA granules: post-transcriptional and epigenetic modulators of gene expression Nat. Rev. Mol. Cell Biol. 10 2009 430 436
-
(2009)
Nat. Rev. Mol. Cell Biol.
, vol.10
, pp. 430-436
-
-
Anderson, P.1
Kedersha, N.2
-
5
-
-
48249083430
-
The multifunctional FUS, EWS and TAF15 proto-oncoproteins show cell type-specific expression patterns and involvement in cell spreading and stress response
-
M.K. Andersson, A. Sthlberg, Y. Arvidsson, A. Olofsson, H. Semb, G. Stenman, O. Nilsson, and P. Aman The multifunctional FUS, EWS and TAF15 proto-oncoproteins show cell type-specific expression patterns and involvement in cell spreading and stress response BMC Cell Biol. 9 2008 37
-
(2008)
BMC Cell Biol.
, vol.9
, pp. 37
-
-
Andersson, M.K.1
Sthlberg, A.2
Arvidsson, Y.3
Olofsson, A.4
Semb, H.5
Stenman, G.6
Nilsson, O.7
Aman, P.8
-
6
-
-
33750716074
-
TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
-
DOI 10.1016/j.bbrc.2006.10.093, PII S0006291X06023187
-
T. Arai, M. Hasegawa, H. Akiyama, K. Ikeda, T. Nonaka, H. Mori, D. Mann, K. Tsuchiya, M. Yoshida, Y. Hashizume, and T. Oda TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis Biochem. Biophys. Res. Commun. 351 2006 602 611 (Pubitemid 44708852)
-
(2006)
Biochemical and Biophysical Research Communications
, vol.351
, Issue.3
, pp. 602-611
-
-
Arai, T.1
Hasegawa, M.2
Akiyama, H.3
Ikeda, K.4
Nonaka, T.5
Mori, H.6
Mann, D.7
Tsuchiya, K.8
Yoshida, M.9
Hashizume, Y.10
Oda, T.11
-
7
-
-
78751616191
-
TDP-43 regulates its mRNA levels through a negative feedback loop
-
Y.M. Ayala, L. De Conti, S.E. Avendaño-Vázquez, A. Dhir, M. Romano, A. D'Ambrogio, J. Tollervey, J. Ule, M. Baralle, E. Buratti, and F.E. Baralle TDP-43 regulates its mRNA levels through a negative feedback loop EMBO J. 30 2011 277 288
-
(2011)
EMBO J.
, vol.30
, pp. 277-288
-
-
Ayala, Y.M.1
De Conti, L.2
Avendaño-Vázquez, S.E.3
Dhir, A.4
Romano, M.5
D'Ambrogio, A.6
Tollervey, J.7
Ule, J.8
Baralle, M.9
Buratti, E.10
Baralle, F.E.11
-
8
-
-
0028376473
-
Induction of beta (A4)-amyloid in primates by injection of Alzheimer's disease brain homogenate. Comparison with transmission of spongiform encephalopathy
-
H.F. Baker, R.M. Ridley, L.W. Duchen, T.J. Crow, and C.J. Bruton Induction of beta (A4)-amyloid in primates by injection of Alzheimer's disease brain homogenate. Comparison with transmission of spongiform encephalopathy Mol. Neurobiol. 8 1994 25 39
-
(1994)
Mol. Neurobiol.
, vol.8
, pp. 25-39
-
-
Baker, H.F.1
Ridley, R.M.2
Duchen, L.W.3
Crow, T.J.4
Bruton, C.J.5
-
9
-
-
33744798774
-
Onset and progression in inherited ALS determined by motor neurons and microglia
-
DOI 10.1126/science.1123511
-
S. Boillée, K. Yamanaka, C.S. Lobsiger, N.G. Copeland, N.A. Jenkins, G. Kassiotis, G. Kollias, and D.W. Cleveland Onset and progression in inherited ALS determined by motor neurons and microglia Science 312 2006 1389 1392 (Pubitemid 43839552)
-
(2006)
Science
, vol.312
, Issue.5778
, pp. 1389-1392
-
-
Boillee, S.1
Yamanaka, K.2
Lobsiger, C.S.3
Copeland, N.G.4
Jenkins, N.A.5
Kassiotis, G.6
Kollias, G.7
Cleveland, D.W.8
-
10
-
-
77958519939
-
Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS
-
D.A. Bosco, G. Morfini, N.M. Karabacak, Y. Song, F. Gros-Louis, P. Pasinelli, H. Goolsby, B.A. Fontaine, N. Lemay, and D. McKenna-Yasek Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS Nat. Neurosci. 13 2010 1396 1403
-
(2010)
Nat. Neurosci.
, vol.13
, pp. 1396-1403
-
-
Bosco, D.A.1
Morfini, G.2
Karabacak, N.M.3
Song, Y.4
Gros-Louis, F.5
Pasinelli, P.6
Goolsby, H.7
Fontaine, B.A.8
Lemay, N.9
McKenna-Yasek, D.10
-
11
-
-
0025863618
-
Neuropathological stageing of Alzheimer-related changes
-
H. Braak, and E. Braak Neuropathological stageing of Alzheimer-related changes Acta Neuropathol. 82 1991 239 259
-
(1991)
Acta Neuropathol.
, vol.82
, pp. 239-259
-
-
Braak, H.1
Braak, E.2
-
12
-
-
0038748401
-
Idiopathic Parkinson's disease: Possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen
-
DOI 10.1007/s00702-002-0808-2
-
H. Braak, U. Rüb, W.P. Gai, and K. Del Tredici Idiopathic Parkinson's disease: possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen J. Neural Transm. 110 2003 517 536 (Pubitemid 36543283)
-
(2003)
Journal of Neural Transmission
, vol.110
, Issue.5
, pp. 517-536
-
-
Braak, H.1
Rub, U.2
Gai, W.P.3
Del Tredici, K.4
-
13
-
-
0032544674
-
Aggregation and motor neuron toxicity of an ALS-linked SOD1 mutant independent from wild-type SOD1
-
DOI 10.1126/science.281.5384.1851
-
L.I. Bruijn, M.K. Houseweart, S. Kato, K.L. Anderson, S.D. Anderson, E. Ohama, A.G. Reaume, R.W. Scott, and D.W. Cleveland Aggregation and motor neuron toxicity of an ALS-linked SOD1 mutant independent from wild-type SOD1 Science 281 1998 1851 1854 (Pubitemid 28450505)
-
(1998)
Science
, vol.281
, Issue.5384
, pp. 1851-1854
-
-
Bruijn, L.I.1
Houseweart, M.K.2
Kato, S.3
Anderson, K.L.4
Anderson, S.D.5
Ohama, E.6
Reaume, A.G.7
Scott, R.W.8
Cleveland, D.W.9
-
14
-
-
17444413067
-
In vitro generation of infectious scrapie prions
-
DOI 10.1016/j.cell.2005.02.011
-
J. Castilla, P. Saá, C. Hetz, and C. Soto In vitro generation of infectious scrapie prions Cell 121 2005 195 206 (Pubitemid 40546388)
-
(2005)
Cell
, vol.121
, Issue.2
, pp. 195-206
-
-
Castilla, J.1
Saa, P.2
Hetz, C.3
Soto, C.4
-
15
-
-
77956270117
-
Superoxide dismutase 1 and tgSOD1 mouse spinal cord seed fibrils, suggesting a propagative cell death mechanism in amyotrophic lateral sclerosis
-
R. Chia, M.H. Tattum, S. Jones, J. Collinge, E.M. Fisher, and G.S. Jackson Superoxide dismutase 1 and tgSOD1 mouse spinal cord seed fibrils, suggesting a propagative cell death mechanism in amyotrophic lateral sclerosis PLoS ONE 5 2010 e10627
-
(2010)
PLoS ONE
, vol.5
, pp. 10627
-
-
Chia, R.1
Tattum, M.H.2
Jones, S.3
Collinge, J.4
Fisher, E.M.5
Jackson, G.S.6
-
16
-
-
3943084181
-
Emerging principles of conformation-based prion inheritance
-
DOI 10.1146/annurev.biochem.72.121801.161837
-
P. Chien, J.S. Weissman, and A.H. DePace Emerging principles of conformation-based prion inheritance Annu. Rev. Biochem. 73 2004 617 656 (Pubitemid 39050382)
-
(2004)
Annual Review of Biochemistry
, vol.73
, pp. 617-656
-
-
Chien, P.1
Weissman, J.S.2
DePace, A.H.3
-
17
-
-
67650077008
-
Transmission and spreading of tauopathy in transgenic mouse brain
-
F. Clavaguera, T. Bolmont, R.A. Crowther, D. Abramowski, S. Frank, A. Probst, G. Fraser, A.K. Stalder, M. Beibel, and M. Staufenbiel Transmission and spreading of tauopathy in transgenic mouse brain Nat. Cell Biol. 11 2009 909 913
-
(2009)
Nat. Cell Biol.
, vol.11
, pp. 909-913
-
-
Clavaguera, F.1
Bolmont, T.2
Crowther, R.A.3
Abramowski, D.4
Frank, S.5
Probst, A.6
Fraser, G.7
Stalder, A.K.8
Beibel, M.9
Staufenbiel, M.10
-
18
-
-
70350135049
-
TDP-43 is recruited to stress granules in conditions of oxidative insult
-
C. Colombrita, E. Zennaro, C. Fallini, M. Weber, A. Sommacal, E. Buratti, V. Silani, and A. Ratti TDP-43 is recruited to stress granules in conditions of oxidative insult J. Neurochem. 111 2009 1051 1061
-
(2009)
J. Neurochem.
, vol.111
, pp. 1051-1061
-
-
Colombrita, C.1
Zennaro, E.2
Fallini, C.3
Weber, M.4
Sommacal, A.5
Buratti, E.6
Silani, V.7
Ratti, A.8
-
19
-
-
77951183978
-
Prion-like disorders: Blurring the divide between transmissibility and infectivity
-
M. Cushman, B.S. Johnson, O.D. King, A.D. Gitler, and J. Shorter Prion-like disorders: blurring the divide between transmissibility and infectivity J. Cell Sci. 123 2010 1191 1201
-
(2010)
J. Cell Sci.
, vol.123
, pp. 1191-1201
-
-
Cushman, M.1
Johnson, B.S.2
King, O.D.3
Gitler, A.D.4
Shorter, J.5
-
20
-
-
0142184333
-
RNA molecules stimulate prion protein conversion
-
DOI 10.1038/nature01979
-
N.R. Deleault, R.W. Lucassen, and S. Supattapone RNA molecules stimulate prion protein conversion Nature 425 2003 717 720 (Pubitemid 37314314)
-
(2003)
Nature
, vol.425
, Issue.6959
, pp. 717-720
-
-
Deleault, N.R.1
Lucassen, R.W.2
Supattapone, S.3
-
21
-
-
33646466296
-
Conversion to the amyotrophic lateral sclerosis phenotype is associated with intermolecular linked insoluble aggregates of SOD1 in mitochondria
-
H.X. Deng, Y. Shi, Y. Furukawa, H. Zhai, R. Fu, E. Liu, G.H. Gorrie, M.S. Khan, W.Y. Hung, and E.H. Bigio Conversion to the amyotrophic lateral sclerosis phenotype is associated with intermolecular linked insoluble aggregates of SOD1 in mitochondria Proc. Natl. Acad. Sci. USA 103 2006 7142 7147
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 7142-7147
-
-
Deng, H.X.1
Shi, Y.2
Furukawa, Y.3
Zhai, H.4
Fu, R.5
Liu, E.6
Gorrie, G.H.7
Khan, M.S.8
Hung, W.Y.9
Bigio, E.H.10
-
22
-
-
77952932485
-
FUS-immunoreactive inclusions are a common feature in sporadic and non-SOD1 familial amyotrophic lateral sclerosis
-
H.X. Deng, H. Zhai, E.H. Bigio, J. Yan, F. Fecto, K. Ajroud, M. Mishra, S. Ajroud-Driss, S. Heller, and R. Sufit FUS-immunoreactive inclusions are a common feature in sporadic and non-SOD1 familial amyotrophic lateral sclerosis Ann. Neurol. 67 2010 739 748
-
(2010)
Ann. Neurol.
, vol.67
, pp. 739-748
-
-
Deng, H.X.1
Zhai, H.2
Bigio, E.H.3
Yan, J.4
Fecto, F.5
Ajroud, K.6
Mishra, M.7
Ajroud-Driss, S.8
Heller, S.9
Sufit, R.10
-
23
-
-
2942625910
-
Differential loss of striatal projection systems in Huntington's disease: A quantitative immunohistochemical study
-
DOI 10.1016/j.jchemneu.2004.02.005, PII S0891061804000286
-
Y.P. Deng, R.L. Albin, J.B. Penney, A.B. Young, K.D. Anderson, and A. Reiner Differential loss of striatal projection systems in Huntington's disease: a quantitative immunohistochemical study J. Chem. Neuroanat. 27 2004 143 164 (Pubitemid 38739355)
-
(2004)
Journal of Chemical Neuroanatomy
, vol.27
, Issue.3
, pp. 143-164
-
-
Deng, Y.P.1
Albin, R.L.2
Penney, J.B.3
Young, A.B.4
Anderson, K.D.5
Reiner, A.6
-
24
-
-
69149089854
-
Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein
-
P. Desplats, H.J. Lee, E.J. Bae, C. Patrick, E. Rockenstein, L. Crews, B. Spencer, E. Masliah, and S.J. Lee Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein Proc. Natl. Acad. Sci. USA 106 2009 13010 13015
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 13010-13015
-
-
Desplats, P.1
Lee, H.J.2
Bae, E.J.3
Patrick, C.4
Rockenstein, E.5
Crews, L.6
Spencer, B.7
Masliah, E.8
Lee, S.J.9
-
25
-
-
34247473080
-
Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model
-
DOI 10.1038/nn1885, PII NN1885
-
F.P. Di Giorgio, M.A. Carrasco, M.C. Siao, T. Maniatis, and K. Eggan Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model Nat. Neurosci. 10 2007 608 614 (Pubitemid 46652442)
-
(2007)
Nature Neuroscience
, vol.10
, Issue.5
, pp. 608-614
-
-
Di Giorgio, F.P.1
Carrasco, M.A.2
Siao, M.C.3
Maniatis, T.4
Eggan, K.5
-
26
-
-
56549096129
-
Human embryonic stem cell-derived motor neurons are sensitive to the toxic effect of glial cells carrying an ALS-causing mutation
-
F.P. Di Giorgio, G.L. Boulting, S. Bobrowicz, and K.C. Eggan Human embryonic stem cell-derived motor neurons are sensitive to the toxic effect of glial cells carrying an ALS-causing mutation Cell Stem Cell 3 2008 637 648
-
(2008)
Cell Stem Cell
, vol.3
, pp. 637-648
-
-
Di Giorgio, F.P.1
Boulting, G.L.2
Bobrowicz, S.3
Eggan, K.C.4
-
27
-
-
44449177217
-
RNA-binding protein TLS is a major nuclear aggregate-interacting protein in huntingtin exon 1 with expanded polyglutamine-expressing cells
-
H. Doi, K. Okamura, P.O. Bauer, Y. Furukawa, H. Shimizu, M. Kurosawa, Y. Machida, H. Miyazaki, K. Mitsui, Y. Kuroiwa, and N. Nukina RNA-binding protein TLS is a major nuclear aggregate-interacting protein in huntingtin exon 1 with expanded polyglutamine-expressing cells J. Biol. Chem. 283 2008 6489 6500
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 6489-6500
-
-
Doi, H.1
Okamura, K.2
Bauer, P.O.3
Furukawa, Y.4
Shimizu, H.5
Kurosawa, M.6
MacHida, Y.7
Miyazaki, H.8
Mitsui, K.9
Kuroiwa, Y.10
Nukina, N.11
-
28
-
-
73249135817
-
The RNA-binding protein FUS/TLS is a common aggregate-interacting protein in polyglutamine diseases
-
H. Doi, S. Koyano, Y. Suzuki, N. Nukina, and Y. Kuroiwa The RNA-binding protein FUS/TLS is a common aggregate-interacting protein in polyglutamine diseases Neurosci. Res. 66 2010 131 133
-
(2010)
Neurosci. Res.
, vol.66
, pp. 131-133
-
-
Doi, H.1
Koyano, S.2
Suzuki, Y.3
Nukina, N.4
Kuroiwa, Y.5
-
29
-
-
77955792022
-
ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import
-
D. Dormann, R. Rodde, D. Edbauer, E. Bentmann, I. Fischer, A. Hruscha, M.E. Than, I.R. Mackenzie, A. Capell, and B. Schmid ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import EMBO J. 29 2010 2841 2857
-
(2010)
EMBO J.
, vol.29
, pp. 2841-2857
-
-
Dormann, D.1
Rodde, R.2
Edbauer, D.3
Bentmann, E.4
Fischer, I.5
Hruscha, A.6
Than, M.E.7
MacKenzie, I.R.8
Capell, A.9
Schmid, B.10
-
30
-
-
69149098707
-
Induction of cerebral beta-amyloidosis: Intracerebral versus systemic Abeta inoculation
-
Y.S. Eisele, T. Bolmont, M. Heikenwalder, F. Langer, L.H. Jacobson, Z.X. Yan, K. Roth, A. Aguzzi, M. Staufenbiel, L.C. Walker, and M. Jucker Induction of cerebral beta-amyloidosis: intracerebral versus systemic Abeta inoculation Proc. Natl. Acad. Sci. USA 106 2009 12926 12931
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 12926-12931
-
-
Eisele, Y.S.1
Bolmont, T.2
Heikenwalder, M.3
Langer, F.4
Jacobson, L.H.5
Yan, Z.X.6
Roth, K.7
Aguzzi, A.8
Staufenbiel, M.9
Walker, L.C.10
Jucker, M.11
-
31
-
-
78149392229
-
Peripherally applied Abeta-containing inoculates induce cerebral beta-amyloidosis
-
Y.S. Eisele, U. Obermüller, G. Heilbronner, F. Baumann, S.A. Kaeser, H. Wolburg, L.C. Walker, M. Staufenbiel, M. Heikenwalder, and M. Jucker Peripherally applied Abeta-containing inoculates induce cerebral beta-amyloidosis Science 330 2010 980 982
-
(2010)
Science
, vol.330
, pp. 980-982
-
-
Eisele, Y.S.1
Obermüller, U.2
Heilbronner, G.3
Baumann, F.4
Kaeser, S.A.5
Wolburg, H.6
Walker, L.C.7
Staufenbiel, M.8
Heikenwalder, M.9
Jucker, M.10
-
32
-
-
77956155218
-
Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS
-
A.C. Elden, H.J. Kim, M.P. Hart, A.S. Chen-Plotkin, B.S. Johnson, X. Fang, M. Armakola, F. Geser, R. Greene, and M.M. Lu Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS Nature 466 2010 1069 1075
-
(2010)
Nature
, vol.466
, pp. 1069-1075
-
-
Elden, A.C.1
Kim, H.J.2
Hart, M.P.3
Chen-Plotkin, A.S.4
Johnson, B.S.5
Fang, X.6
Armakola, M.7
Geser, F.8
Greene, R.9
Lu, M.M.10
-
33
-
-
77955352066
-
Novel antibodies reveal inclusions containing non-native SOD1 in sporadic ALS patients
-
K. Forsberg, P.A. Jonsson, P.M. Andersen, D. Bergemalm, K.S. Graffmo, M. Hultdin, J. Jacobsson, R. Rosquist, S.L. Marklund, and T. Brännström Novel antibodies reveal inclusions containing non-native SOD1 in sporadic ALS patients PLoS ONE 5 2010 e11552
-
(2010)
PLoS ONE
, vol.5
, pp. 11552
-
-
Forsberg, K.1
Jonsson, P.A.2
Andersen, P.M.3
Bergemalm, D.4
Graffmo, K.S.5
Hultdin, M.6
Jacobsson, J.7
Rosquist, R.8
Marklund, S.L.9
Brännström, T.10
-
34
-
-
63649160214
-
Conformational diversity of wild-type Tau fibrils specified by templated conformation change
-
B. Frost, J. Ollesch, H. Wille, and M.I. Diamond Conformational diversity of wild-type Tau fibrils specified by templated conformation change J. Biol. Chem. 284 2009 3546 3551
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 3546-3551
-
-
Frost, B.1
Ollesch, J.2
Wille, H.3
Diamond, M.I.4
-
35
-
-
77956155794
-
Interaction with polyglutamine aggregates reveals a Q/N-rich domain in TDP-43
-
R.A. Fuentealba, M. Udan, S. Bell, I. Wegorzewska, J. Shao, M.I. Diamond, C.C. Weihl, and R.H. Baloh Interaction with polyglutamine aggregates reveals a Q/N-rich domain in TDP-43 J. Biol. Chem. 285 2010 26304 26314
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 26304-26314
-
-
Fuentealba, R.A.1
Udan, M.2
Bell, S.3
Wegorzewska, I.4
Shao, J.5
Diamond, M.I.6
Weihl, C.C.7
Baloh, R.H.8
-
36
-
-
51849117597
-
Immunohistochemical identification of messenger RNA-related proteins in basophilic inclusions of adult-onset atypical motor neuron disease
-
K. Fujita, H. Ito, S. Nakano, Y. Kinoshita, R. Wate, and H. Kusaka Immunohistochemical identification of messenger RNA-related proteins in basophilic inclusions of adult-onset atypical motor neuron disease Acta Neuropathol. 116 2008 439 445
-
(2008)
Acta Neuropathol.
, vol.116
, pp. 439-445
-
-
Fujita, K.1
Ito, H.2
Nakano, S.3
Kinoshita, Y.4
Wate, R.5
Kusaka, H.6
-
37
-
-
65549100291
-
Cross-seeding fibrillation of Q/N-rich proteins offers new pathomechanism of polyglutamine diseases
-
Y. Furukawa, K. Kaneko, G. Matsumoto, M. Kurosawa, and N. Nukina Cross-seeding fibrillation of Q/N-rich proteins offers new pathomechanism of polyglutamine diseases J. Neurosci. 29 2009 5153 5162
-
(2009)
J. Neurosci.
, vol.29
, pp. 5153-5162
-
-
Furukawa, Y.1
Kaneko, K.2
Matsumoto, G.3
Kurosawa, M.4
Nukina, N.5
-
38
-
-
79956311051
-
A seeding reaction recapitulates intracellular formation of Sarkosyl-insoluble transactivation response element (TAR) DNA-binding protein-43 inclusions
-
Y. Furukawa, K. Kaneko, S. Watanabe, K. Yamanaka, and N. Nukina A seeding reaction recapitulates intracellular formation of Sarkosyl-insoluble transactivation response element (TAR) DNA-binding protein-43 inclusions J. Biol. Chem. 286 2011 18664 18672
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 18664-18672
-
-
Furukawa, Y.1
Kaneko, K.2
Watanabe, S.3
Yamanaka, K.4
Nukina, N.5
-
39
-
-
0014021742
-
Experimental transmission of a Kuru-like syndrome to chimpanzees
-
D.C. Gajdusek, C.J. Gibbs, and M. Alpers Experimental transmission of a Kuru-like syndrome to chimpanzees Nature 209 1966 794 796
-
(1966)
Nature
, vol.209
, pp. 794-796
-
-
Gajdusek, D.C.1
Gibbs, C.J.2
Alpers, M.3
-
40
-
-
9444279617
-
Stress granule assembly is mediated by prion-like aggregation of TIA-1
-
DOI 10.1091/mbc.E04-08-0715
-
N. Gilks, N. Kedersha, M. Ayodele, L. Shen, G. Stoecklin, L.M. Dember, and P. Anderson Stress granule assembly is mediated by prion-like aggregation of TIA-1 Mol. Biol. Cell 15 2004 5383 5398 (Pubitemid 39564732)
-
(2004)
Molecular Biology of the Cell
, vol.15
, Issue.12
, pp. 5383-5398
-
-
Gilks, N.1
Kedersha, N.2
Ayodele, M.3
Shen, L.4
Stoecklin, G.5
Dember, L.M.6
Anderson, P.7
-
41
-
-
41949119043
-
TDP-43 A315T mutation in familial motor neuron disease
-
DOI 10.1002/ana.21344
-
M.A. Gitcho, R.H. Baloh, S. Chakraverty, K. Mayo, J.B. Norton, D. Levitch, K.J. Hatanpaa, C.L. White 3rd, E.H. Bigio, and R. Caselli TDP-43 A315T mutation in familial motor neuron disease Ann. Neurol. 63 2008 535 538 (Pubitemid 351614720)
-
(2008)
Annals of Neurology
, vol.63
, Issue.4
, pp. 535-538
-
-
Gitcho, M.A.1
Baloh, R.H.2
Chakraverty, S.3
Mayo, K.4
Norton, J.B.5
Levitch, D.6
Hatanpaa, K.J.7
White III, C.L.8
Bigio, E.H.9
Caselli, R.10
Baker, M.11
Al-Lozi, M.T.12
Morris, J.C.13
Pestronk, A.14
Rademakers, R.15
Goate, A.M.16
Cairns, N.J.17
-
42
-
-
80053652133
-
Intermolecular transmission of superoxide dismutase 1 misfolding in living cells
-
L.I. Grad, W.C. Guest, A. Yanai, E. Pokrishevsky, M.A. O'Neill, E. Gibbs, V. Semenchenko, M. Yousefi, D.S. Wishart, S.S. Plotkin, and N.R. Cashman Intermolecular transmission of superoxide dismutase 1 misfolding in living cells Proc. Natl. Acad. Sci. USA 108 2011 16398 16403
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 16398-16403
-
-
Grad, L.I.1
Guest, W.C.2
Yanai, A.3
Pokrishevsky, E.4
O'Neill, M.A.5
Gibbs, E.6
Semenchenko, V.7
Yousefi, M.8
Wishart, D.S.9
Plotkin, S.S.10
Cashman, N.R.11
-
43
-
-
79955441814
-
Seeding of normal Tau by pathological Tau conformers drives pathogenesis of Alzheimer-like tangles
-
J.L. Guo, and V.M. Lee Seeding of normal Tau by pathological Tau conformers drives pathogenesis of Alzheimer-like tangles J. Biol. Chem. 286 2011 15317 15331
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 15317-15331
-
-
Guo, J.L.1
Lee, V.M.2
-
44
-
-
79960040173
-
An ALS-associated mutation affecting TDP-43 enhances protein aggregation, fibril formation and neurotoxicity
-
W. Guo, Y. Chen, X. Zhou, A. Kar, P. Ray, X. Chen, E.J. Rao, M. Yang, H. Ye, and L. Zhu An ALS-associated mutation affecting TDP-43 enhances protein aggregation, fibril formation and neurotoxicity Nat. Struct. Mol. Biol. 18 2011 822 830
-
(2011)
Nat. Struct. Mol. Biol.
, vol.18
, pp. 822-830
-
-
Guo, W.1
Chen, Y.2
Zhou, X.3
Kar, A.4
Ray, P.5
Chen, X.6
Rao, E.J.7
Yang, M.8
Ye, H.9
Zhu, L.10
-
45
-
-
80052783545
-
Astrocytes from familial and sporadic ALS patients are toxic to motor neurons
-
A.M. Haidet-Phillips, M.E. Hester, C.J. Miranda, K. Meyer, L. Braun, A. Frakes, S. Song, S. Likhite, M.J. Murtha, and K.D. Foust Astrocytes from familial and sporadic ALS patients are toxic to motor neurons Nat. Biotechnol. 29 2011 824 828
-
(2011)
Nat. Biotechnol.
, vol.29
, pp. 824-828
-
-
Haidet-Phillips, A.M.1
Hester, M.E.2
Miranda, C.J.3
Meyer, K.4
Braun, L.5
Frakes, A.6
Song, S.7
Likhite, S.8
Murtha, M.J.9
Foust, K.D.10
-
46
-
-
79551519276
-
α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells
-
C. Hansen, E. Angot, A.L. Bergström, J.A. Steiner, L. Pieri, G. Paul, T.F. Outeiro, R. Melki, P. Kallunki, and K. Fog α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells J. Clin. Invest. 121 2011 715 725
-
(2011)
J. Clin. Invest.
, vol.121
, pp. 715-725
-
-
Hansen, C.1
Angot, E.2
Bergström, A.L.3
Steiner, J.A.4
Pieri, L.5
Paul, G.6
Outeiro, T.F.7
Melki, R.8
Kallunki, P.9
Fog, K.10
-
47
-
-
79961133270
-
MAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune response
-
F. Hou, L. Sun, H. Zheng, B. Skaug, Q.X. Jiang, and Z.J. Chen MAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune response Cell 146 2011 448 461
-
(2011)
Cell
, vol.146
, pp. 448-461
-
-
Hou, F.1
Sun, L.2
Zheng, H.3
Skaug, B.4
Jiang, Q.X.5
Chen, Z.J.6
-
48
-
-
77954643023
-
Sustained expression of TDP-43 and FUS in motor neurons in rodent's lifetime
-
C. Huang, P.Y. Xia, and H. Zhou Sustained expression of TDP-43 and FUS in motor neurons in rodent's lifetime Int. J. Biol. Sci. 6 2010 396 406
-
(2010)
Int. J. Biol. Sci.
, vol.6
, pp. 396-406
-
-
Huang, C.1
Xia, P.Y.2
Zhou, H.3
-
49
-
-
46749138739
-
Enrichment of C-terminal fragments in TAR DNA-binding protein-43 cytoplasmic inclusions in brain but not in spinal cord of frontotemporal lobar degeneration and amyotrophic lateral sclerosis
-
DOI 10.2353/ajpath.2008.080003
-
L.M. Igaz, L.K. Kwong, Y. Xu, A.C. Truax, K. Uryu, M. Neumann, C.M. Clark, L.B. Elman, B.L. Miller, and M. Grossman Enrichment of C-terminal fragments in TAR DNA-binding protein-43 cytoplasmic inclusions in brain but not in spinal cord of frontotemporal lobar degeneration and amyotrophic lateral sclerosis Am. J. Pathol. 173 2008 182 194 (Pubitemid 351947966)
-
(2008)
American Journal of Pathology
, vol.173
, Issue.1
, pp. 182-194
-
-
Igaz, L.M.1
Kwong, L.K.2
Xu, Y.3
Truax, A.C.4
Uryu, K.5
Neumann, M.6
Clark, C.M.7
Elman, L.B.8
Miller, B.L.9
Grossman, M.10
McCluskey, L.F.11
Trojanowski, J.Q.12
Lee, V.M.-Y.13
-
50
-
-
79551523377
-
Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice
-
L.M. Igaz, L.K. Kwong, E.B. Lee, A. Chen-Plotkin, E. Swanson, T. Unger, J. Malunda, Y. Xu, M.J. Winton, J.Q. Trojanowski, and V.M. Lee Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice J. Clin. Invest. 121 2011 726 738
-
(2011)
J. Clin. Invest.
, vol.121
, pp. 726-738
-
-
Igaz, L.M.1
Kwong, L.K.2
Lee, E.B.3
Chen-Plotkin, A.4
Swanson, E.5
Unger, T.6
Malunda, J.7
Xu, Y.8
Winton, M.J.9
Trojanowski, J.Q.10
Lee, V.M.11
-
51
-
-
74049164709
-
Non-cell autonomous toxicity in neurodegenerative disorders: ALS and beyond
-
H. Ilieva, M. Polymenidou, and D.W. Cleveland Non-cell autonomous toxicity in neurodegenerative disorders: ALS and beyond J. Cell Biol. 187 2009 761 772
-
(2009)
J. Cell Biol.
, vol.187
, pp. 761-772
-
-
Ilieva, H.1
Polymenidou, M.2
Cleveland, D.W.3
-
52
-
-
79551472601
-
Nuclear transport impairment of amyotrophic lateral sclerosis-linked mutations in FUS/TLS
-
D. Ito, M. Seki, Y. Tsunoda, H. Uchiyama, and N. Suzuki Nuclear transport impairment of amyotrophic lateral sclerosis-linked mutations in FUS/TLS Ann. Neurol. 69 2011 152 162
-
(2011)
Ann. Neurol.
, vol.69
, pp. 152-162
-
-
Ito, D.1
Seki, M.2
Tsunoda, Y.3
Uchiyama, H.4
Suzuki, N.5
-
53
-
-
39849103473
-
Neuron-specific expression of mutant superoxide dismutase is sufficient to induce amyotrophic lateral sclerosis in transgenic mice
-
DOI 10.1523/JNEUROSCI.5258-07.2008
-
D. Jaarsma, E. Teuling, E.D. Haasdijk, C.I. De Zeeuw, and C.C. Hoogenraad Neuron-specific expression of mutant superoxide dismutase is sufficient to induce amyotrophic lateral sclerosis in transgenic mice J. Neurosci. 28 2008 2075 2088 (Pubitemid 351317636)
-
(2008)
Journal of Neuroscience
, vol.28
, Issue.9
, pp. 2075-2088
-
-
Jaarsma, D.1
Teuling, E.2
Haasdijk, E.D.3
De Zeeuw, C.I.4
Hoogenraad, C.C.5
-
54
-
-
44049097065
-
A yeast TDP-43 proteinopathy model: Exploring the molecular determinants of TDP-43 aggregation and cellular toxicity
-
DOI 10.1073/pnas.0802082105
-
B.S. Johnson, J.M. McCaffery, S. Lindquist, and A.D. Gitler A yeast TDP-43 proteinopathy model: Exploring the molecular determinants of TDP-43 aggregation and cellular toxicity Proc. Natl. Acad. Sci. USA 105 2008 6439 6444 (Pubitemid 351758364)
-
(2008)
Proceedings of the National Academy of Sciences of the United States of America
, vol.105
, Issue.17
, pp. 6439-6444
-
-
Johnson, B.S.1
McCaffery, J.M.2
Lindquist, S.3
Gitler, A.D.4
-
55
-
-
67749133873
-
TDP-43 is intrinsically aggregation-prone, and amyotrophic lateral sclerosis-linked mutations accelerate aggregation and increase toxicity
-
B.S. Johnson, D. Snead, J.J. Lee, J.M. McCaffery, J. Shorter, and A.D. Gitler TDP-43 is intrinsically aggregation-prone, and amyotrophic lateral sclerosis-linked mutations accelerate aggregation and increase toxicity J. Biol. Chem. 284 2009 20329 20339
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 20329-20339
-
-
Johnson, B.S.1
Snead, D.2
Lee, J.J.3
McCaffery, J.M.4
Shorter, J.5
Gitler, A.D.6
-
56
-
-
78149320656
-
The benefits and limitations of animal models for translational research in neurodegenerative diseases
-
M. Jucker The benefits and limitations of animal models for translational research in neurodegenerative diseases Nat. Med. 16 2010 1210 1214
-
(2010)
Nat. Med.
, vol.16
, pp. 1210-1214
-
-
Jucker, M.1
-
57
-
-
42649120983
-
TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis
-
DOI 10.1038/ng.132, PII NG132
-
E. Kabashi, P.N. Valdmanis, P. Dion, D. Spiegelman, B.J. McConkey, C. Vande Velde, J.P. Bouchard, L. Lacomblez, K. Pochigaeva, and F. Salachas TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis Nat. Genet. 40 2008 572 574 (Pubitemid 351601218)
-
(2008)
Nature Genetics
, vol.40
, Issue.5
, pp. 572-574
-
-
Kabashi, E.1
Valdmanis, P.N.2
Dion, P.3
Spiegelman, D.4
McConkey, B.J.5
Velde, C.V.6
Bouchard, J.-P.7
Lacomblez, L.8
Pochigaeva, K.9
Salachas, F.10
Pradat, P.-F.11
Camu, W.12
Meininger, V.13
Dupre, N.14
Rouleau, G.A.15
-
58
-
-
0034657130
-
Evidence for seeding of β-amyloid by intracerebral infusion of Alzheimer brain extracts in β-amyloid precursor protein-transgenic mice
-
M.D. Kane, W.J. Lipinski, M.J. Callahan, F. Bian, R.A. Durham, R.D. Schwarz, A.E. Roher, and L.C. Walker Evidence for seeding of beta -amyloid by intracerebral infusion of Alzheimer brain extracts in beta -amyloid precursor protein-transgenic mice J. Neurosci. 20 2000 3606 3611 (Pubitemid 30266223)
-
(2000)
Journal of Neuroscience
, vol.20
, Issue.10
, pp. 3606-3611
-
-
Kane, M.D.1
Lipinski, W.J.2
Callahan, M.J.3
Bian, F.4
Durham, R.A.5
Schwarz, R.D.6
Roher, A.E.7
Walker, L.C.8
-
59
-
-
0034638837
-
Dynamic shuttling of TIA-1 accompanies the recruitment of mRNA to mammalian stress granules
-
N. Kedersha, M.R. Cho, W. Li, P.W. Yacono, S. Chen, N. Gilks, D.E. Golan, and P. Anderson Dynamic shuttling of TIA-1 accompanies the recruitment of mRNA to mammalian stress granules J. Cell Biol. 151 2000 1257 1268
-
(2000)
J. Cell Biol.
, vol.151
, pp. 1257-1268
-
-
Kedersha, N.1
Cho, M.R.2
Li, W.3
Yacono, P.W.4
Chen, S.5
Gilks, N.6
Golan, D.E.7
Anderson, P.8
-
60
-
-
77953028624
-
Amyotrophic lateral sclerosis is a non-amyloid disease in which extensive misfolding of SOD1 is unique to the familial form
-
A. Kerman, H.N. Liu, S. Croul, J. Bilbao, E. Rogaeva, L. Zinman, J. Robertson, and A. Chakrabartty Amyotrophic lateral sclerosis is a non-amyloid disease in which extensive misfolding of SOD1 is unique to the familial form Acta Neuropathol. 119 2010 335 344
-
(2010)
Acta Neuropathol.
, vol.119
, pp. 335-344
-
-
Kerman, A.1
Liu, H.N.2
Croul, S.3
Bilbao, J.4
Rogaeva, E.5
Zinman, L.6
Robertson, J.7
Chakrabartty, A.8
-
61
-
-
0141593548
-
A quantitative, highly sensitive cell-based infectivity assay for mouse scrapie prions
-
DOI 10.1073/pnas.1834432100
-
P.C. Klöhn, L. Stoltze, E. Flechsig, M. Enari, and C. Weissmann A quantitative, highly sensitive cell-based infectivity assay for mouse scrapie prions Proc. Natl. Acad. Sci. USA 100 2003 11666 11671 (Pubitemid 37205992)
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, Issue.20
, pp. 11666-11671
-
-
Klohn, P.-C.1
Stoltze, L.2
Flechsig, E.3
Enari, M.4
Weissmann, C.5
-
62
-
-
43249114934
-
Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease
-
DOI 10.1038/nm1747, PII NM1747
-
J.H. Kordower, Y. Chu, R.A. Hauser, T.B. Freeman, and C.W. Olanow Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease Nat. Med. 14 2008 504 506 (Pubitemid 351655212)
-
(2008)
Nature Medicine
, vol.14
, Issue.5
, pp. 504-506
-
-
Kordower, J.H.1
Chu, Y.2
Hauser, R.A.3
Freeman, T.B.4
Olanow, C.W.5
-
63
-
-
80855143713
-
Pathological staging of frontotemporal lobar degeneration
-
10.1007/s12031-011-9528-0 Published online May 7, 2011
-
J.J. Kril, and G.M. Halliday Pathological staging of frontotemporal lobar degeneration J. Mol. Neurosci. 2011 10.1007/s12031-011-9528-0 Published online May 7, 2011
-
(2011)
J. Mol. Neurosci.
-
-
Kril, J.J.1
Halliday, G.M.2
-
64
-
-
61349156118
-
Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis
-
T.J. Kwiatkowski Jr., D.A. Bosco, A.L. Leclerc, E. Tamrazian, C.R. Vanderburg, C. Russ, A. Davis, J. Gilchrist, E.J. Kasarskis, and T. Munsat Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis Science 323 2009 1205 1208
-
(2009)
Science
, vol.323
, pp. 1205-1208
-
-
Kwiatkowski, Jr.T.J.1
Bosco, D.A.2
Leclerc, A.L.3
Tamrazian, E.4
Vanderburg, C.R.5
Russ, C.6
Davis, A.7
Gilchrist, J.8
Kasarskis, E.J.9
Munsat, T.10
-
65
-
-
77953890823
-
TDP-43 and FUS/TLS: Emerging roles in RNA processing and neurodegeneration
-
C. Lagier-Tourenne, M. Polymenidou, and D.W. Cleveland TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration Hum. Mol. Genet. 19 R1 2010 R46 R64
-
(2010)
Hum. Mol. Genet.
, vol.19
, Issue.R1
-
-
Lagier-Tourenne, C.1
Polymenidou, M.2
Cleveland, D.W.3
-
66
-
-
43249110200
-
Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation
-
DOI 10.1038/nm1746, PII NM1746
-
J.Y. Li, E. Englund, J.L. Holton, D. Soulet, P. Hagell, A.J. Lees, T. Lashley, N.P. Quinn, S. Rehncrona, and A. Björklund Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation Nat. Med. 14 2008 501 503 (Pubitemid 351655211)
-
(2008)
Nature Medicine
, vol.14
, Issue.5
, pp. 501-503
-
-
Li, J.-Y.1
Englund, E.2
Holton, J.L.3
Soulet, D.4
Hagell, P.5
Lees, A.J.6
Lashley, T.7
Quinn, N.P.8
Rehncrona, S.9
Bjorklund, A.10
Widner, H.11
Revesz, T.12
Lindvall, O.13
Brundin, P.14
-
67
-
-
78149461229
-
Tar DNA binding protein-43 (TDP-43) associates with stress granules: Analysis of cultured cells and pathological brain tissue
-
L. Liu-Yesucevitz, A. Bilgutay, Y.J. Zhang, T. Vanderwyde, A. Citro, T. Mehta, N. Zaarur, A. McKee, R. Bowser, and M. Sherman Tar DNA binding protein-43 (TDP-43) associates with stress granules: analysis of cultured cells and pathological brain tissue PLoS ONE 5 2010 e13250
-
(2010)
PLoS ONE
, vol.5
, pp. 13250
-
-
Liu-Yesucevitz, L.1
Bilgutay, A.2
Zhang, Y.J.3
Vanderwyde, T.4
Citro, A.5
Mehta, T.6
Zaarur, N.7
McKee, A.8
Bowser, R.9
Sherman, M.10
-
68
-
-
38049170555
-
Prion strain discrimination in cell culture: The cell panel assay
-
S.P. Mahal, C.A. Baker, C.A. Demczyk, E.W. Smith, C. Julius, and C. Weissmann Prion strain discrimination in cell culture: the cell panel assay Proc. Natl. Acad. Sci. USA 104 2007 20908 20913
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 20908-20913
-
-
Mahal, S.P.1
Baker, C.A.2
Demczyk, C.A.3
Smith, E.W.4
Julius, C.5
Weissmann, C.6
-
69
-
-
56549115885
-
Non-cell-autonomous effect of human SOD1 G37R astrocytes on motor neurons derived from human embryonic stem cells
-
M.C. Marchetto, A.R. Muotri, Y. Mu, A.M. Smith, G.G. Cezar, and F.H. Gage Non-cell-autonomous effect of human SOD1 G37R astrocytes on motor neurons derived from human embryonic stem cells Cell Stem Cell 3 2008 649 657
-
(2008)
Cell Stem Cell
, vol.3
, pp. 649-657
-
-
Marchetto, M.C.1
Muotri, A.R.2
Mu, Y.3
Smith, A.M.4
Cezar, G.G.5
Gage, F.H.6
-
70
-
-
79952589652
-
TAR DNA-binding protein 43 (TDP-43) regulates stress granule dynamics via differential regulation of G3BP and TIA-1
-
K.K. McDonald, A. Aulas, L. Destroismaisons, S. Pickles, E. Beleac, W. Camu, G.A. Rouleau, and C. Vande Velde TAR DNA-binding protein 43 (TDP-43) regulates stress granule dynamics via differential regulation of G3BP and TIA-1 Hum. Mol. Genet. 20 2011 1400 1410
-
(2011)
Hum. Mol. Genet.
, vol.20
, pp. 1400-1410
-
-
McDonald, K.K.1
Aulas, A.2
Destroismaisons, L.3
Pickles, S.4
Beleac, E.5
Camu, W.6
Rouleau, G.A.7
Vande Velde, C.8
-
71
-
-
33749020837
-
Exogenous induction of cerebral β-amyloidogenesis is governed bf agent and host
-
DOI 10.1126/science.1131864
-
M. Meyer-Luehmann, J. Coomaraswamy, T. Bolmont, S. Kaeser, C. Schaefer, E. Kilger, A. Neuenschwander, D. Abramowski, P. Frey, and A.L. Jaton Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host Science 313 2006 1781 1784 (Pubitemid 44454153)
-
(2006)
Science
, vol.313
, Issue.5794
, pp. 1781-1784
-
-
Meyer-Luehmann, M.1
Coomaraswamy, J.2
Bolmont, T.3
Kaeser, S.4
Schaefer, C.5
Kilger, E.6
Neuenschwander, A.7
Abramowski, D.8
Frey, P.9
Jaton, A.L.10
Vigouret, J.-M.11
Paganetti, P.12
Walsh, D.M.13
Mathews, P.M.14
Ghiso, J.15
Staufenbiel, M.16
Walker, L.C.17
Jucker, M.18
-
72
-
-
58049221032
-
Divergent patterns of cytosolic TDP-43 and neuronal progranulin expression following axotomy: Implications for TDP-43 in the physiological response to neuronal injury
-
K. Moisse, K. Volkening, C. Leystra-Lantz, I. Welch, T. Hill, and M.J. Strong Divergent patterns of cytosolic TDP-43 and neuronal progranulin expression following axotomy: implications for TDP-43 in the physiological response to neuronal injury Brain Res. 1249 2009 202 211
-
(2009)
Brain Res.
, vol.1249
, pp. 202-211
-
-
Moisse, K.1
Volkening, K.2
Leystra-Lantz, C.3
Welch, I.4
Hill, T.5
Strong, M.J.6
-
73
-
-
84863433677
-
Prion-like acceleration of a synucleinopathy in a transgenic mouse model
-
10.1016/j.neurobiolaging.2011.06.022 Published August 1, 2011
-
A.L. Mougenot, S. Nicot, A. Bencsik, E. Morignat, J. Verchre, L. Lakhdar, S. Legastelois, and T. Baron Prion-like acceleration of a synucleinopathy in a transgenic mouse model Neurobiol. Aging. 2011 10.1016/j.neurobiolaging.2011.06. 022 Published August 1, 2011
-
(2011)
Neurobiol. Aging.
-
-
Mougenot, A.L.1
Nicot, S.2
Bencsik, A.3
Morignat, E.4
Verchre, J.5
Lakhdar, L.6
Legastelois, S.7
Baron, T.8
-
74
-
-
79952743365
-
Prion-like propagation of mutant superoxide dismutase-1 misfolding in neuronal cells
-
C. Münch, J. O'Brien, and A. Bertolotti Prion-like propagation of mutant superoxide dismutase-1 misfolding in neuronal cells Proc. Natl. Acad. Sci. USA 108 2011 3548 3553
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 3548-3553
-
-
Münch, C.1
O'Brien, J.2
Bertolotti, A.3
-
75
-
-
34247475338
-
Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons
-
DOI 10.1038/nn1876, PII NN1876
-
M. Nagai, D.B. Re, T. Nagata, A. Chalazonitis, T.M. Jessell, H. Wichterle, and S. Przedborski Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons Nat. Neurosci. 10 2007 615 622 (Pubitemid 46652435)
-
(2007)
Nature Neuroscience
, vol.10
, Issue.5
, pp. 615-622
-
-
Nagai, M.1
Re, D.B.2
Nagata, T.3
Chalazonitis, A.4
Jessell, T.M.5
Wichterle, H.6
Przedborski, S.7
-
76
-
-
33749632259
-
Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
-
DOI 10.1126/science.1134108
-
M. Neumann, D.M. Sampathu, L.K. Kwong, A.C. Truax, M.C. Micsenyi, T.T. Chou, J. Bruce, T. Schuck, M. Grossman, and C.M. Clark Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis Science 314 2006 130 133 (Pubitemid 44547757)
-
(2006)
Science
, vol.314
, Issue.5796
, pp. 130-133
-
-
Neumann, M.1
Sampathu, D.M.2
Kwong, L.K.3
Truax, A.C.4
Micsenyi, M.C.5
Chou, T.T.6
Bruce, J.7
Schuck, T.8
Grossman, M.9
Clark, C.M.10
McCluskey, L.F.11
Miller, B.L.12
Masliah, E.13
Mackenzie, I.R.14
Feldman, H.15
Feiden, W.16
Kretzschmar, H.A.17
Trojanowski, J.Q.18
Lee, V.M.-Y.19
-
77
-
-
78049376559
-
Seeded aggregation and toxicity of alpha-synuclein and tau: Cellular models of neurodegenerative diseases
-
T. Nonaka, S.T. Watanabe, T. Iwatsubo, and M. Hasegawa Seeded aggregation and toxicity of alpha-synuclein and tau: cellular models of neurodegenerative diseases J. Biol. Chem. 285 2010 34885 34898
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 34885-34898
-
-
Nonaka, T.1
Watanabe, S.T.2
Iwatsubo, T.3
Hasegawa, M.4
-
78
-
-
80055074312
-
Astrocytes carrying the superoxide dismutase 1 (SOD1G93A) mutation induce wild-type motor neuron degeneration in vivo
-
10.1073/pnas.1103141108 Published online October 3 2011
-
S.T. Papadeas, S.E. Kraig, C. O'Banion, A.C. Lepore, and N.J. Maragakis Astrocytes carrying the superoxide dismutase 1 (SOD1G93A) mutation induce wild-type motor neuron degeneration in vivo Proc. Natl. Acad. Sci. USA. 2011 10.1073/pnas.1103141108 Published online October 3 2011
-
(2011)
Proc. Natl. Acad. Sci. USA.
-
-
Papadeas, S.T.1
Kraig, S.E.2
O'Banion, C.3
Lepore, A.C.4
Maragakis, N.J.5
-
79
-
-
79956304001
-
A "two-hit" hypothesis for inclusion formation by carboxyl-terminal fragments of TDP-43 protein linked to RNA depletion and impaired microtubule-dependent transport
-
G.S. Pesiridis, K. Tripathy, S. Tanik, J.Q. Trojanowski, and V.M. Lee A "two-hit" hypothesis for inclusion formation by carboxyl-terminal fragments of TDP-43 protein linked to RNA depletion and impaired microtubule-dependent transport J. Biol. Chem. 286 2011 18845 18855
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 18845-18855
-
-
Pesiridis, G.S.1
Tripathy, K.2
Tanik, S.3
Trojanowski, J.Q.4
Lee, V.M.5
-
80
-
-
79953185674
-
Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43
-
M. Polymenidou, C. Lagier-Tourenne, K.R. Hutt, S.C. Huelga, J. Moran, T.Y. Liang, S.C. Ling, E. Sun, E. Wancewicz, and C. Mazur Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43 Nat. Neurosci. 14 2011 459 468
-
(2011)
Nat. Neurosci.
, vol.14
, pp. 459-468
-
-
Polymenidou, M.1
Lagier-Tourenne, C.2
Hutt, K.R.3
Huelga, S.C.4
Moran, J.5
Liang, T.Y.6
Ling, S.C.7
Sun, E.8
Wancewicz, E.9
Mazur, C.10
-
81
-
-
68749083546
-
Variation in aggregation propensities among ALS-associated variants of SOD1: Correlation to human disease
-
M. Prudencio, P.J. Hart, D.R. Borchelt, and P.M. Andersen Variation in aggregation propensities among ALS-associated variants of SOD1: correlation to human disease Hum. Mol. Genet. 18 2009 3217 3226
-
(2009)
Hum. Mol. Genet.
, vol.18
, pp. 3217-3226
-
-
Prudencio, M.1
Hart, P.J.2
Borchelt, D.R.3
Andersen, P.M.4
-
82
-
-
0020321767
-
Novel proteinaceous infectious particles cause scrapie
-
S.B. Prusiner Novel proteinaceous infectious particles cause scrapie Science 216 1982 136 144 (Pubitemid 12089840)
-
(1982)
Science
, vol.216
, Issue.4542
, pp. 136-144
-
-
Prusiner, S.B.1
-
83
-
-
34248226362
-
Implications of ALS focality: Rostral-caudal distribution of lower motor neuron loss postmortem
-
DOI 10.1212/01.wnl.0000261045.57095.56, PII 0000611420070508000006
-
J. Ravits, P. Laurie, Y. Fan, and D.H. Moore Implications of ALS focality: rostral-caudal distribution of lower motor neuron loss postmortem Neurology 68 2007 1576 1582 (Pubitemid 46717981)
-
(2007)
Neurology
, vol.68
, Issue.19
, pp. 1576-1582
-
-
Ravits, J.1
Laurie, P.2
Fan, Y.3
Moore, D.H.4
-
84
-
-
34248202138
-
Focality of upper and lower motor neuron degeneration at the clinical onset of ALS
-
DOI 10.1212/01.wnl.0000260965.20021.47, PII 0000611420070508000005
-
J. Ravits, P. Paul, and C. Jorg Focality of upper and lower motor neuron degeneration at the clinical onset of ALS Neurology 68 2007 1571 1575 (Pubitemid 46717980)
-
(2007)
Neurology
, vol.68
, Issue.19
, pp. 1571-1575
-
-
Ravits, J.1
Paul, P.2
Jorg, C.3
-
85
-
-
59649095699
-
Cytoplasmic penetration and persistent infection of mammalian cells by polyglutamine aggregates
-
P.H. Ren, J.E. Lauckner, I. Kachirskaia, J.E. Heuser, R. Melki, and R.R. Kopito Cytoplasmic penetration and persistent infection of mammalian cells by polyglutamine aggregates Nat. Cell Biol. 11 2009 219 225
-
(2009)
Nat. Cell Biol.
, vol.11
, pp. 219-225
-
-
Ren, P.H.1
Lauckner, J.E.2
Kachirskaia, I.3
Heuser, J.E.4
Melki, R.5
Kopito, R.R.6
-
86
-
-
0027401203
-
Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis
-
DOI 10.1038/362059a0
-
D.R. Rosen, T. Siddique, D. Patterson, D.A. Figlewicz, P. Sapp, A. Hentati, D. Donaldson, J. Goto, J.P. O'Regan, and H.X. Deng Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis Nature 362 1993 59 62 (Pubitemid 23087289)
-
(1993)
Nature
, vol.362
, Issue.6415
, pp. 59-62
-
-
Rosen, D.R.1
Siddique, T.2
Patterson, D.3
Figlewicz, D.A.4
Sapp, P.5
Hentati, A.6
Donaldson, D.7
Goto, J.8
O'Regan, J.P.9
Deng, H.-X.10
Rahmani, Z.11
Krizus, A.12
McKenna-Yasek, D.13
Cayabyab, A.14
Gaston, S.M.15
Berger, R.16
Tanzi, R.E.17
Halperin, J.J.18
Herzfeldt, B.19
-
87
-
-
58149398638
-
Colocalization of transactivation-responsive DNA-binding protein 43 and huntingtin in inclusions of Huntington disease
-
C. Schwab, T. Arai, M. Hasegawa, S. Yu, and P.L. McGeer Colocalization of transactivation-responsive DNA-binding protein 43 and huntingtin in inclusions of Huntington disease J. Neuropathol. Exp. Neurol. 67 2008 1159 1165
-
(2008)
J. Neuropathol. Exp. Neurol.
, vol.67
, pp. 1159-1165
-
-
Schwab, C.1
Arai, T.2
Hasegawa, M.3
Yu, S.4
McGeer, P.L.5
-
88
-
-
19544363062
-
Prions as adaptive conduits of memory and inheritance
-
DOI 10.1038/nrg1616
-
J. Shorter, and S. Lindquist Prions as adaptive conduits of memory and inheritance Nat. Rev. Genet. 6 2005 435 450 (Pubitemid 40733889)
-
(2005)
Nature Reviews Genetics
, vol.6
, Issue.6
, pp. 435-450
-
-
Shorter, J.1
Lindquist, S.2
-
89
-
-
0348077417
-
A Neuronal Isoform of the Aplysia CPEB Has Prion-Like Properties
-
DOI 10.1016/S0092-8674(03)01020-1
-
K. Si, S. Lindquist, and E.R. Kandel A neuronal isoform of the aplysia CPEB has prion-like properties Cell 115 2003 879 891 (Pubitemid 38058499)
-
(2003)
Cell
, vol.115
, Issue.7
, pp. 879-891
-
-
Si, K.1
Lindquist, S.2
Kandel, E.R.3
-
90
-
-
75749134925
-
Aplysia CPEB can form prion-like multimers in sensory neurons that contribute to long-term facilitation
-
K. Si, Y.B. Choi, E. White-Grindley, A. Majumdar, and E.R. Kandel Aplysia CPEB can form prion-like multimers in sensory neurons that contribute to long-term facilitation Cell 140 2010 421 435
-
(2010)
Cell
, vol.140
, pp. 421-435
-
-
Si, K.1
Choi, Y.B.2
White-Grindley, E.3
Majumdar, A.4
Kandel, E.R.5
-
91
-
-
41149180753
-
TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis
-
DOI 10.1126/science.1154584
-
J. Sreedharan, I.P. Blair, V.B. Tripathi, X. Hu, C. Vance, B. Rogelj, S. Ackerley, J.C. Durnall, K.L. Williams, and E. Buratti TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis Science 319 2008 1668 1672 (Pubitemid 351432505)
-
(2008)
Science
, vol.319
, Issue.5870
, pp. 1668-1672
-
-
Sreedharan, J.1
Blair, I.P.2
Tripathi, V.B.3
Hu, X.4
Vance, C.5
Rogelj, B.6
Ackerley, S.7
Durnall, J.C.8
Williams, K.L.9
Buratti, E.10
Baralle, F.11
De Belleroche, J.12
Mitchell, J.D.13
Leigh, P.N.14
Al-Chalabi, A.15
Miller, C.C.16
Nicholson, G.17
Shaw, C.E.18
-
92
-
-
79955502687
-
Molecular determinants and genetic modifiers of aggregation and toxicity for the ALS disease protein FUS/TLS
-
Z. Sun, Z. Diaz, X. Fang, M.P. Hart, A. Chesi, J. Shorter, and A.D. Gitler Molecular determinants and genetic modifiers of aggregation and toxicity for the ALS disease protein FUS/TLS PLoS Biol. 9 2011 e1000614
-
(2011)
PLoS Biol.
, vol.9
, pp. 1000614
-
-
Sun, Z.1
Diaz, Z.2
Fang, X.3
Hart, M.P.4
Chesi, A.5
Shorter, J.6
Gitler, A.D.7
-
94
-
-
0036403732
-
Prions as protein-based genetic elements
-
DOI 10.1146/annurev.micro.56.013002.100603
-
S.M. Uptain, and S. Lindquist Prions as protein-based genetic elements Annu. Rev. Microbiol. 56 2002 703 741 (Pubitemid 35217472)
-
(2002)
Annual Review of Microbiology
, vol.56
, pp. 703-741
-
-
Uptain, S.M.1
Lindquist, S.2
-
95
-
-
29444443348
-
Chromogranin-mediated secretion of mutant superoxide dismutase proteins linked to amyotrophic lateral sclerosis
-
DOI 10.1038/nn1603
-
M. Urushitani, A. Sik, T. Sakurai, N. Nukina, R. Takahashi, and J.P. Julien Chromogranin-mediated secretion of mutant superoxide dismutase proteins linked to amyotrophic lateral sclerosis Nat. Neurosci. 9 2006 108 118 (Pubitemid 43011916)
-
(2006)
Nature Neuroscience
, vol.9
, Issue.1
, pp. 108-118
-
-
Urushitani, M.1
Sik, A.2
Sakurai, T.3
Nukina, N.4
Takahashi, R.5
Julien, J.-P.6
-
96
-
-
41949100148
-
TARDBP mutations in amyotrophic lateral sclerosis with TDP-43 neuropathology: A genetic and histopathological analysis
-
V.M. Van Deerlin, J.B. Leverenz, L.M. Bekris, T.D. Bird, W. Yuan, L.B. Elman, D. Clay, E.M. Wood, A.S. Chen-Plotkin, and M. Martinez-Lage TARDBP mutations in amyotrophic lateral sclerosis with TDP-43 neuropathology: a genetic and histopathological analysis Lancet Neurol. 7 2008 409 416
-
(2008)
Lancet Neurol.
, vol.7
, pp. 409-416
-
-
Van Deerlin, V.M.1
Leverenz, J.B.2
Bekris, L.M.3
Bird, T.D.4
Yuan, W.5
Elman, L.B.6
Clay, D.7
Wood, E.M.8
Chen-Plotkin, A.S.9
Martinez-Lage, M.10
-
97
-
-
61349162349
-
Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6
-
C. Vance, B. Rogelj, T. Hortobágyi, K.J. De Vos, A.L. Nishimura, J. Sreedharan, X. Hu, B. Smith, D.M. Ruddy, and P. Wright Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6 Science 323 2009 1208 1211
-
(2009)
Science
, vol.323
, pp. 1208-1211
-
-
Vance, C.1
Rogelj, B.2
Hortobágyi, T.3
De Vos, K.J.4
Nishimura, A.L.5
Sreedharan, J.6
Hu, X.7
Smith, B.8
Ruddy, D.M.9
Wright, P.10
-
98
-
-
80053613574
-
Exogenous α-synuclein fibrils induce lewy body pathology leading to synaptic dysfunction and neuron death
-
L.A. Volpicelli-Daley, K.C. Luk, T.P. Patel, S.A. Tanik, D.M. Riddle, A. Stieber, D.F. Meaney, J.Q. Trojanowski, and V.M. Lee Exogenous α-synuclein fibrils induce lewy body pathology leading to synaptic dysfunction and neuron death Neuron 72 2011 57 71
-
(2011)
Neuron
, vol.72
, pp. 57-71
-
-
Volpicelli-Daley, L.A.1
Luk, K.C.2
Patel, T.P.3
Tanik, S.A.4
Riddle, D.M.5
Stieber, A.6
Meaney, D.F.7
Trojanowski, J.Q.8
Lee, V.M.9
-
99
-
-
77957918535
-
TDP-43-mediated neuron loss in vivo requires RNA-binding activity
-
A. Voigt, D. Herholz, F.C. Fiesel, K. Kaur, D. Müller, P. Karsten, S.S. Weber, P.J. Kahle, T. Marquardt, and J.B. Schulz TDP-43-mediated neuron loss in vivo requires RNA-binding activity PLoS ONE 5 2010 e12247
-
(2010)
PLoS ONE
, vol.5
, pp. 12247
-
-
Voigt, A.1
Herholz, D.2
Fiesel, F.C.3
Kaur, K.4
Müller, D.5
Karsten, P.6
Weber, S.S.7
Kahle, P.J.8
Marquardt, T.9
Schulz, J.B.10
-
100
-
-
77649213673
-
Generating a prion with bacterially expressed recombinant prion protein
-
F. Wang, X. Wang, C.G. Yuan, and J. Ma Generating a prion with bacterially expressed recombinant prion protein Science 327 2010 1132 1135
-
(2010)
Science
, vol.327
, pp. 1132-1135
-
-
Wang, F.1
Wang, X.2
Yuan, C.G.3
Ma, J.4
-
101
-
-
42449163952
-
TDP-43, the signature protein of FTLD-U, is a neuronal activity-responsive factor
-
I.F. Wang, L.S. Wu, H.Y. Chang, and C.K. Shen TDP-43, the signature protein of FTLD-U, is a neuronal activity-responsive factor J. Neurochem. 105 2008 797 806
-
(2008)
J. Neurochem.
, vol.105
, pp. 797-806
-
-
Wang, I.F.1
Wu, L.S.2
Chang, H.Y.3
Shen, C.K.4
-
102
-
-
77950788517
-
FUS-immunoreactive intranuclear inclusions in neurodegenerative disease
-
J. Woulfe, D.A. Gray, and I.R. Mackenzie FUS-immunoreactive intranuclear inclusions in neurodegenerative disease Brain Pathol. 20 2010 589 597
-
(2010)
Brain Pathol.
, vol.20
, pp. 589-597
-
-
Woulfe, J.1
Gray, D.A.2
MacKenzie, I.R.3
-
103
-
-
39749188753
-
Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis
-
DOI 10.1038/nn2047, PII NN2047
-
K. Yamanaka, S.J. Chun, S. Boillee, N. Fujimori-Tonou, H. Yamashita, D.H. Gutmann, R. Takahashi, H. Misawa, and D.W. Cleveland Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis Nat. Neurosci. 11 2008 251 253 (Pubitemid 351311795)
-
(2008)
Nature Neuroscience
, vol.11
, Issue.3
, pp. 251-253
-
-
Yamanaka, K.1
Chun, S.J.2
Boillee, S.3
Fujimori-Tonou, N.4
Yamashita, H.5
Gutmann, D.H.6
Takahashi, R.7
Misawa, H.8
Cleveland, D.W.9
-
104
-
-
42949094584
-
TDP-43 mutation in familial amyotrophic lateral sclerosis
-
DOI 10.1002/ana.21392
-
A. Yokoseki, A. Shiga, C.F. Tan, A. Tagawa, H. Kaneko, A. Koyama, H. Eguchi, A. Tsujino, T. Ikeuchi, and A. Kakita TDP-43 mutation in familial amyotrophic lateral sclerosis Ann. Neurol. 63 2008 538 542 (Pubitemid 351614721)
-
(2008)
Annals of Neurology
, vol.63
, Issue.4
, pp. 538-542
-
-
Yokoseki, A.1
Shiga, A.2
Tan, C.-F.3
Tagawa, A.4
Kaneko, H.5
Koyama, A.6
Eguchi, H.7
Tsujino, A.8
Ikeuchi, T.9
Kakita, A.10
Okamoto, K.11
Nishizawa, M.12
Takahashi, H.13
Onodera, O.14
|