Different human copper-zinc superoxide dismutase mutants, SOD1 G93A and SOD1 H46R, exert distinct harmful effects on gross phenotype in mice

PLoS ONE

Volumn 7, Issue 3, 2012, Pages

  Pan, Lei ^a,b   Yoshii, Yasuhiro ^c   Otomo, Asako ^a,b   Ogawa, Haruko ^b   Iwasaki, Yasuo ^c   Shang, Hui Fang ^d   Hadano, Shinji ^a,b,e  

^a TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b TOKAI UNIVERSITY   (Japan)

^c TOHO UNIVERSITY OMORI MEDICAL CENTER   (Japan)

^d SICHUAN UNIVERSITY   (China)

^e TOKAI UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

COPPER ZINC SUPEROXIDE DISMUTASE; ALS2 PROTEIN, MOUSE; GUANINE NUCLEOTIDE EXCHANGE FACTOR; MESSENGER RNA; MUTANT PROTEIN; SOD1 G93A PROTEIN; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COMPARATIVE STUDY; CONGENIC STRAIN; CONTROLLED STUDY; DEATH; GENE DOSAGE; GENE EXPRESSION; GENE MUTATION; GENOTOXICITY; GROWTH RATE; LIFESPAN; MOUSE; MUTANT; NONHUMAN; PHENOTYPE; PHENOTYPIC VARIATION; SEX DIFFERENCE; SURVIVAL RATE; TRANSGENE; WEIGHT REDUCTION; AMINO ACID SUBSTITUTION; AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL; C57BL MOUSE; DBA MOUSE; DISEASE MODEL; ENZYMOLOGY; FEMALE; GENETIC ASSOCIATION; GENETICS; HUMAN; MALE; METABOLISM; MISSENSE MUTATION; MOUSE MUTANT; NUCLEOTIDE SEQUENCE; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; TRANSGENIC MOUSE;

MURINAE; MUS; MUS MUSCULUS;

AMINO ACID SUBSTITUTION; AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; BASE SEQUENCE; DISEASE MODELS, ANIMAL; FEMALE; GENE DOSAGE; GENETIC ASSOCIATION STUDIES; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; MALE; MICE; MICE, CONGENIC; MICE, INBRED C57BL; MICE, INBRED DBA; MICE, KNOCKOUT; MICE, TRANSGENIC; MUTANT PROTEINS; MUTATION, MISSENSE; RNA, MESSENGER; SUPEROXIDE DISMUTASE;

EID: 84858380497     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0033409     Document Type: Article

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