A Rac1/phosphatidylinositol 3-kinase/Akt3 anti-apoptotic pathway, triggered by alsinLF, the product of the ALS2 gene, antagonizes Cu/Zn-superoxide dismutase (SOD1) mutant-induced motoneuronal cell death

Journal of Biological Chemistry

Volumn 280, Issue 6, 2005, Pages 4532-4543

  Kanekura, Kohsuke ^a   Hashimoto, Yuichi ^a   Kita, Yoshiko ^a   Sasabe, Jumpei ^a   Aiso, Sadakazu ^a   Nishimoto, Ikuo ^a   Matsuoka, Masaaki ^a  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOLS; BIOCHEMISTRY; CELL CULTURE; GENES; NEUROLOGY; NITROGEN COMPOUNDS; TOXICITY;

CELL DEATH; NEUROPROTECTION; NEUROTOXICITY; NUCLEOTIDES;

ENZYMES;

COPPER ZINC SUPEROXIDE DISMUTASE; GUANINE NUCLEOTIDE EXCHANGE FACTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RAC1 PROTEIN;

ALS2 GENE; AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ARTICLE; CELL DEATH; CONTROLLED STUDY; ENZYME ACTIVITY; GENE; GENE OVEREXPRESSION; INHIBITION KINETICS; MOLECULAR MECHANICS; MOTONEURON; NEUROPROTECTION; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; UPREGULATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANDROSTADIENES; ANIMALS; APOPTOSIS; CELL DEATH; CELL LINE; CELLS, CULTURED; CHO CELLS; CRICETINAE; DNA; DOWN-REGULATION; ENZYME INHIBITORS; ESCHERICHIA COLI; GLUTATHIONE; GLUTATHIONE TRANSFERASE; GTP PHOSPHOHYDROLASES; GUANINE; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; IMMUNOBLOTTING; MICE; MODELS, BIOLOGICAL; MOTOR NEURONS; MUTATION; NEURONS; PLASMIDS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RAC1 GTP-BINDING PROTEIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; SEPHAROSE; SUPEROXIDE DISMUTASE; TIME FACTORS; TRANSFECTION;

EID: 14244264186     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M410508200     Document Type: Article

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