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Volumn 1, Issue 2, 2016, Pages 69-79

The secondary metabolite bioinformatics portal: Computational tools to facilitate synthetic biology of secondary metabolite production

Author keywords

Antibiotics; Bioinformatics; Biosynthesis; Natural product; NRPS; PKS

Indexed keywords

NATURAL PRODUCT;

EID: 85014230646     PISSN: None     EISSN: 2405805X     Source Type: Journal    
DOI: 10.1016/j.synbio.2015.12.002     Document Type: Review
Times cited : (150)

References (129)
  • 3
    • 84930832473 scopus 로고    scopus 로고
    • London; The Review on Antimicrobial Resistance
    • The Review on Antimicrobial Resistance Antimicrobial resistance: tackling a crisis for the health and wealth of nations 2014, London; The Review on Antimicrobial Resistance. http://amr-review.org/sites/default/files/SECURING%20NEW%20DRUGS%20FOR%20FUTURE%20GENERATIONS%20FINAL%20WEB_0.pdf.
    • (2014) Antimicrobial resistance: tackling a crisis for the health and wealth of nations
  • 5
    • 84876002671 scopus 로고
    • Natural products: a continuing source of novel drug leads
    • Cragg G.M., Newman D.J. Natural products: a continuing source of novel drug leads. Biochim Biophys Acta 1830, 2013:3670-3695.
    • (1830) Biochim Biophys Acta , vol.2013 , pp. 3670-3695
    • Cragg, G.M.1    Newman, D.J.2
  • 6
    • 69549111337 scopus 로고    scopus 로고
    • Antibiotics for emerging pathogens
    • Fischbach M.A., Walsh C.T. Antibiotics for emerging pathogens. Science 2009, 325:1089-1093.
    • (2009) Science , vol.325 , pp. 1089-1093
    • Fischbach, M.A.1    Walsh, C.T.2
  • 7
    • 84858308226 scopus 로고    scopus 로고
    • Natural products as sources of new drugs over the 30 years from 1981 to 2010
    • Newman D.J., Cragg G.M. Natural products as sources of new drugs over the 30 years from 1981 to 2010. J Nat Prod 2012, 75:311-335.
    • (2012) J Nat Prod , vol.75 , pp. 311-335
    • Newman, D.J.1    Cragg, G.M.2
  • 8
    • 0036902202 scopus 로고    scopus 로고
    • Big effects from small changes: possible ways to explore nature's chemical diversity
    • Bode H.B., Bethe B., Hofs R., Zeeck A. Big effects from small changes: possible ways to explore nature's chemical diversity. Chembiochem 2002, 3:619-627.
    • (2002) Chembiochem , vol.3 , pp. 619-627
    • Bode, H.B.1    Bethe, B.2    Hofs, R.3    Zeeck, A.4
  • 10
    • 0038561132 scopus 로고    scopus 로고
    • Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis
    • Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T., et al. Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis. Nat Biotechnol 2003, 21:526-531.
    • (2003) Nat Biotechnol , vol.21 , pp. 526-531
    • Ikeda, H.1    Ishikawa, J.2    Hanamoto, A.3    Shinose, M.4    Kikuchi, H.5    Shiba, T.6
  • 11
    • 0035834039 scopus 로고    scopus 로고
    • Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites
    • Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C., Shinose M., et al. Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites. Proc Natl Acad Sci U S A 2001, 98:12215-12220.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 12215-12220
    • Omura, S.1    Ikeda, H.2    Ishikawa, J.3    Hanamoto, A.4    Takahashi, C.5    Shinose, M.6
  • 12
    • 84918813440 scopus 로고    scopus 로고
    • Metabolic engineering of antibiotic factories: new tools for antibiotic production in actinomycetes
    • Weber T., Charusanti P., Musiol-Kroll E.M., Jiang X., Tong Y., Kim H.U., et al. Metabolic engineering of antibiotic factories: new tools for antibiotic production in actinomycetes. Trends Biotechnol 2015, 33:15-26.
    • (2015) Trends Biotechnol , vol.33 , pp. 15-26
    • Weber, T.1    Charusanti, P.2    Musiol-Kroll, E.M.3    Jiang, X.4    Tong, Y.5    Kim, H.U.6
  • 13
    • 84979859096 scopus 로고    scopus 로고
    • AntiSMASH 3.0 - a comprehensive resource for the genome mining of biosynthetic gene clusters
    • Weber T., Blin K., Duddela S., Krug D., Kim H.U., Bruccoleri R., et al. antiSMASH 3.0 - a comprehensive resource for the genome mining of biosynthetic gene clusters. Nucleic Acids Res 2015, 43:W237-43.
    • (2015) Nucleic Acids Res , vol.43 , pp. W237-W243
    • Weber, T.1    Blin, K.2    Duddela, S.3    Krug, D.4    Kim, H.U.5    Bruccoleri, R.6
  • 14
    • 84883353135 scopus 로고    scopus 로고
    • AntiSMASH 2.0 - a versatile platform for genome mining of secondary metabolite producers
    • Blin K., Medema M.H., Kazempour D., Fischbach M., Breitling R., Takano E., et al. antiSMASH 2.0 - a versatile platform for genome mining of secondary metabolite producers. Nucleic Acids Res 2013, 41:W204-12.
    • (2013) Nucleic Acids Res , vol.41 , pp. W204-W212
    • Blin, K.1    Medema, M.H.2    Kazempour, D.3    Fischbach, M.4    Breitling, R.5    Takano, E.6
  • 15
    • 79959920872 scopus 로고    scopus 로고
    • AntiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences
    • Medema M.H., Blin K., Cimermancic P., de Jager V., Zakrzewski P., Fischbach M.A., et al. antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences. Nucleic Acids Res 2011, 39:W339-46.
    • (2011) Nucleic Acids Res , vol.39 , pp. W339-W346
    • Medema, M.H.1    Blin, K.2    Cimermancic, P.3    de Jager, V.4    Zakrzewski, P.5    Fischbach, M.A.6
  • 16
    • 84859078407 scopus 로고    scopus 로고
    • The natural product domain seeker NaPDoS: a phylogeny based bioinformatic tool to classify secondary metabolite gene diversity
    • Ziemert N., Podell S., Penn K., Badger J.H., Allen E., Jensen P.R. The natural product domain seeker NaPDoS: a phylogeny based bioinformatic tool to classify secondary metabolite gene diversity. PLoS ONE 2012, 7:e34064.
    • (2012) PLoS ONE , vol.7
    • Ziemert, N.1    Podell, S.2    Penn, K.3    Badger, J.H.4    Allen, E.5    Jensen, P.R.6
  • 20
    • 84904554933 scopus 로고    scopus 로고
    • Insights into secondary metabolism from a global analysis of prokaryotic biosynthetic gene clusters
    • Cimermancic P., Medema M.H., Claesen J., Kurita K., Wieland Brown L.C., Mavrommatis K., et al. Insights into secondary metabolism from a global analysis of prokaryotic biosynthetic gene clusters. Cell 2014, 158:412-421.
    • (2014) Cell , vol.158 , pp. 412-421
    • Cimermancic, P.1    Medema, M.H.2    Claesen, J.3    Kurita, K.4    Wieland Brown, L.C.5    Mavrommatis, K.6
  • 23
    • 84895072793 scopus 로고    scopus 로고
    • Microbial genome mining for accelerated natural products discovery: is a renaissance in the making?
    • Bachmann B.O., Van Lanen S.G., Baltz R.H. Microbial genome mining for accelerated natural products discovery: is a renaissance in the making?. J Ind Microbiol Biotechnol 2014, 41:175-184.
    • (2014) J Ind Microbiol Biotechnol , vol.41 , pp. 175-184
    • Bachmann, B.O.1    Van Lanen, S.G.2    Baltz, R.H.3
  • 24
    • 84899651850 scopus 로고    scopus 로고
    • In silico tools for the analysis of antibiotic biosynthetic pathways
    • Weber T. In silico tools for the analysis of antibiotic biosynthetic pathways. Int J Med Microbiol 2014, 304:230-235.
    • (2014) Int J Med Microbiol , vol.304 , pp. 230-235
    • Weber, T.1
  • 25
    • 84939536885 scopus 로고    scopus 로고
    • Computational approaches to natural product discovery
    • Medema M.H., Fischbach M.A. Computational approaches to natural product discovery. Nat Chem Biol 2015, 11:639-648.
    • (2015) Nat Chem Biol , vol.11 , pp. 639-648
    • Medema, M.H.1    Fischbach, M.A.2
  • 26
    • 84895076285 scopus 로고    scopus 로고
    • Bioinformatics tools for genome mining of polyketide and non-ribosomal peptides
    • Boddy C.N. Bioinformatics tools for genome mining of polyketide and non-ribosomal peptides. J Ind Microbiol Biotechnol 2014, 41:443-450.
    • (2014) J Ind Microbiol Biotechnol , vol.41 , pp. 443-450
    • Boddy, C.N.1
  • 27
    • 64249084052 scopus 로고    scopus 로고
    • Chapter 8. Methods for in silico prediction of microbial polyketide and nonribosomal peptide biosynthetic pathways from DNA sequence data
    • Bachmann B.O., Ravel J. Chapter 8. Methods for in silico prediction of microbial polyketide and nonribosomal peptide biosynthetic pathways from DNA sequence data. Methods Enzymol 2009, 458:181-217.
    • (2009) Methods Enzymol , vol.458 , pp. 181-217
    • Bachmann, B.O.1    Ravel, J.2
  • 28
    • 84883572507 scopus 로고    scopus 로고
    • BAGEL3: automated identification of genes encoding bacteriocins and (non-) bactericidal posttranslationally modified peptides
    • van Heel A.J., de Jong A., Montalban-Lopez M., Kok J., Kuipers O.P. BAGEL3: automated identification of genes encoding bacteriocins and (non-) bactericidal posttranslationally modified peptides. Nucleic Acids Res 2013, 41:W448-53.
    • (2013) Nucleic Acids Res , vol.41 , pp. W448-W453
    • van Heel, A.J.1    de Jong, A.2    Montalban-Lopez, M.3    Kok, J.4    Kuipers, O.P.5
  • 31
    • 61649111711 scopus 로고    scopus 로고
    • CLUSEAN: a computer-based framework for the automated analysis of bacterial secondary metabolite biosynthetic gene clusters
    • Weber T., Rausch C., Lopez P., Hoof I., Gaykova V., Huson D.H., et al. CLUSEAN: a computer-based framework for the automated analysis of bacterial secondary metabolite biosynthetic gene clusters. J Biotechnol 2009, 140:13-17.
    • (2009) J Biotechnol , vol.140 , pp. 13-17
    • Weber, T.1    Rausch, C.2    Lopez, P.3    Hoof, I.4    Gaykova, V.5    Huson, D.H.6
  • 33
    • 84880370987 scopus 로고    scopus 로고
    • Mapping gene clusters within arrayed metagenomic libraries to expand the structural diversity of biomedically relevant natural products
    • Owen J.G., Reddy B.V., Ternei M.A., Charlop-Powers Z., Calle P.Y., Kim J.H., et al. Mapping gene clusters within arrayed metagenomic libraries to expand the structural diversity of biomedically relevant natural products. Proc Natl Acad Sci U S A 2013, 110:11797-11802.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 11797-11802
    • Owen, J.G.1    Reddy, B.V.2    Ternei, M.A.3    Charlop-Powers, Z.4    Calle, P.Y.5    Kim, J.H.6
  • 35
    • 84942761231 scopus 로고    scopus 로고
    • An automated Genomes-to-Natural Products platform (GNP) for the discovery of modular natural products
    • Johnston C.W., Skinnider M.A., Wyatt M.A., Li X., Ranieri M.R., Yang L., et al. An automated Genomes-to-Natural Products platform (GNP) for the discovery of modular natural products. Nat Commun 2015, 6:8421.
    • (2015) Nat Commun , vol.6 , pp. 8421
    • Johnston, C.W.1    Skinnider, M.A.2    Wyatt, M.A.3    Li, X.4    Ranieri, M.R.5    Yang, L.6
  • 36
    • 84894140502 scopus 로고    scopus 로고
    • MIDDAS-M: Motif-Independent De Novo Detection of Secondary Metabolite gene clusters through the integration of genome sequencing and transcriptome data
    • Umemura M., Koike H., Nagano N., Ishii T., Kawano J., Yamane N., et al. MIDDAS-M: Motif-Independent De Novo Detection of Secondary Metabolite gene clusters through the integration of genome sequencing and transcriptome data. PLoS ONE 2013, 8:e84028.
    • (2013) PLoS ONE , vol.8
    • Umemura, M.1    Koike, H.2    Nagano, N.3    Ishii, T.4    Kawano, J.5    Yamane, N.6
  • 37
    • 84906983992 scopus 로고    scopus 로고
    • Motif-independent prediction of a secondary metabolism gene cluster using comparative genomics: application to sequenced genomes of Aspergillus and ten other filamentous fungal species
    • Takeda I., Umemura M., Koike H., Asai K., Machida M. Motif-independent prediction of a secondary metabolism gene cluster using comparative genomics: application to sequenced genomes of Aspergillus and ten other filamentous fungal species. DNA Res 2014, 21:447-457.
    • (2014) DNA Res , vol.21 , pp. 447-457
    • Takeda, I.1    Umemura, M.2    Koike, H.3    Asai, K.4    Machida, M.5
  • 38
    • 84931262348 scopus 로고    scopus 로고
    • Motif-independent de novo detection of secondary metabolite gene clusters-toward identification from filamentous fungi
    • Umemura M., Koike H., Machida M. Motif-independent de novo detection of secondary metabolite gene clusters-toward identification from filamentous fungi. Front Microbiol 2015, 6:371.
    • (2015) Front Microbiol , vol.6 , pp. 371
    • Umemura, M.1    Koike, H.2    Machida, M.3
  • 39
    • 57149112966 scopus 로고    scopus 로고
    • ClustScan: an integrated program package for the semi-automatic annotation of modular biosynthetic gene clusters and in silico prediction of novel chemical structures
    • Starcevic A., Zucko J., Simunkovic J., Long P.F., Cullum J., Hranueli D. ClustScan: an integrated program package for the semi-automatic annotation of modular biosynthetic gene clusters and in silico prediction of novel chemical structures. Nucleic Acids Res 2008, 36:6882-6892.
    • (2008) Nucleic Acids Res , vol.36 , pp. 6882-6892
    • Starcevic, A.1    Zucko, J.2    Simunkovic, J.3    Long, P.F.4    Cullum, J.5    Hranueli, D.6
  • 41
    • 3442896886 scopus 로고    scopus 로고
    • NRPS-PKS: a knowledge-based resource for analysis of NRPS/PKS megasynthases
    • Ansari M.Z., Yadav G., Gokhale R.S., Mohanty D. NRPS-PKS: a knowledge-based resource for analysis of NRPS/PKS megasynthases. Nucleic Acids Res 2004, 32:W405-13.
    • (2004) Nucleic Acids Res , vol.32 , pp. W405-W413
    • Ansari, M.Z.1    Yadav, G.2    Gokhale, R.S.3    Mohanty, D.4
  • 42
    • 0041620248 scopus 로고    scopus 로고
    • SEARCHPKS: a program for detection and analysis of polyketide synthase domains
    • Yadav G., Gokhale R.S., Mohanty D. SEARCHPKS: a program for detection and analysis of polyketide synthase domains. Nucleic Acids Res 2003, 31:3654-3658.
    • (2003) Nucleic Acids Res , vol.31 , pp. 3654-3658
    • Yadav, G.1    Gokhale, R.S.2    Mohanty, D.3
  • 43
    • 84893481062 scopus 로고    scopus 로고
    • Predicting substrate specificity of adenylation domains of nonribosomal peptide synthetases and other protein properties by latent semantic indexing
    • Baranasic D., Zucko J., Diminic J., Gacesa R., Long P.F., Cullum J., et al. Predicting substrate specificity of adenylation domains of nonribosomal peptide synthetases and other protein properties by latent semantic indexing. J Ind Microbiol Biotechnol 2014, 41:461-467.
    • (2014) J Ind Microbiol Biotechnol , vol.41 , pp. 461-467
    • Baranasic, D.1    Zucko, J.2    Diminic, J.3    Gacesa, R.4    Long, P.F.5    Cullum, J.6
  • 44
    • 84876340080 scopus 로고    scopus 로고
    • Classification of the adenylation and acyl-transferase activity of NRPS and PKS systems using ensembles of substrate specific hidden Markov models
    • Khayatt B.I., Overmars L., Siezen R.J., Francke C. Classification of the adenylation and acyl-transferase activity of NRPS and PKS systems using ensembles of substrate specific hidden Markov models. PLoS ONE 2013, 8:e62136.
    • (2013) PLoS ONE , vol.8
    • Khayatt, B.I.1    Overmars, L.2    Siezen, R.J.3    Francke, C.4
  • 46
    • 26944502019 scopus 로고    scopus 로고
    • Specificity prediction of adenylation domains in nonribosomal peptide synthetases (NRPS) using transductive support vector machines (TSVMs)
    • Rausch C., Weber T., Kohlbacher O., Wohlleben W., Huson D.H. Specificity prediction of adenylation domains in nonribosomal peptide synthetases (NRPS) using transductive support vector machines (TSVMs). Nucleic Acids Res 2005, 33:5799-5808.
    • (2005) Nucleic Acids Res , vol.33 , pp. 5799-5808
    • Rausch, C.1    Weber, T.2    Kohlbacher, O.3    Wohlleben, W.4    Huson, D.H.5
  • 48
    • 23144453475 scopus 로고    scopus 로고
    • SEARCHGTr: a program for analysis of glycosyltransferases involved in glycosylation of secondary metabolites
    • Kamra P., Gokhale R.S., Mohanty D. SEARCHGTr: a program for analysis of glycosyltransferases involved in glycosylation of secondary metabolites. Nucleic Acids Res 2005, 33:W220-5.
    • (2005) Nucleic Acids Res , vol.33 , pp. W220-W225
    • Kamra, P.1    Gokhale, R.S.2    Mohanty, D.3
  • 50
    • 38349095584 scopus 로고    scopus 로고
    • BACTIBASE: a new web-accessible database for bacteriocin characterization
    • Hammami R., Zouhir A., Ben Hamida J., Fliss I. BACTIBASE: a new web-accessible database for bacteriocin characterization. BMC Microbiol 2007, 7:89.
    • (2007) BMC Microbiol , vol.7 , pp. 89
    • Hammami, R.1    Zouhir, A.2    Ben Hamida, J.3    Fliss, I.4
  • 51
    • 77249117208 scopus 로고    scopus 로고
    • BACTIBASE second release: a database and tool platform for bacteriocin characterization
    • Hammami R., Zouhir A., Le Lay C., Ben Hamida J., Fliss I. BACTIBASE second release: a database and tool platform for bacteriocin characterization. BMC Microbiol 2010, 10:22.
    • (2010) BMC Microbiol , vol.10 , pp. 22
    • Hammami, R.1    Zouhir, A.2    Le Lay, C.3    Ben Hamida, J.4    Fliss, I.5
  • 52
    • 84876566794 scopus 로고    scopus 로고
    • ClusterMine360: a database of microbial PKS/NRPS biosynthesis
    • Conway K.R., Boddy C.N. ClusterMine360: a database of microbial PKS/NRPS biosynthesis. Nucleic Acids Res 2013, 41:D402-7.
    • (2013) Nucleic Acids Res , vol.41 , pp. D402-D407
    • Conway, K.R.1    Boddy, C.N.2
  • 53
    • 84878234603 scopus 로고    scopus 로고
    • Databases of the thiotemplate modular systems (CSDB) and their in silico recombinants (r-CSDB)
    • Diminic J., Zucko J., Ruzic I.T., Gacesa R., Hranueli D., Long P.F., et al. Databases of the thiotemplate modular systems (CSDB) and their in silico recombinants (r-CSDB). J Ind Microbiol Biotechnol 2013, 40:653-659.
    • (2013) J Ind Microbiol Biotechnol , vol.40 , pp. 653-659
    • Diminic, J.1    Zucko, J.2    Ruzic, I.T.3    Gacesa, R.4    Hranueli, D.5    Long, P.F.6
  • 55
    • 84939493603 scopus 로고    scopus 로고
    • IMG-ABC: a knowledge base to fuel discovery of biosynthetic gene clusters and novel secondary metabolites
    • Hadjithomas M., Chen I.M., Chu K., Ratner A., Palaniappan K., Szeto E., et al. IMG-ABC: a knowledge base to fuel discovery of biosynthetic gene clusters and novel secondary metabolites. MBio 2015, 6:e00932.
    • (2015) MBio , vol.6
    • Hadjithomas, M.1    Chen, I.M.2    Chu, K.3    Ratner, A.4    Palaniappan, K.5    Szeto, E.6
  • 58
    • 84976888261 scopus 로고    scopus 로고
    • ChEBI in 2016: improved services and an expanding collection of metabolites
    • Hastings J., Owen G., Dekker A., Ennis M., Kale N., Muthukrishnan V., et al. ChEBI in 2016: improved services and an expanding collection of metabolites. Nucleic Acids Res 2015, 44(D1):D1214-9.
    • (2015) Nucleic Acids Res , vol.44 , Issue.D1 , pp. D1214-D1219
    • Hastings, J.1    Owen, G.2    Dekker, A.3    Ennis, M.4    Kale, N.5    Muthukrishnan, V.6
  • 60
    • 84937680248 scopus 로고    scopus 로고
    • Editorial: ChemSpider - a tool for natural products research
    • Kelly R., Kidd R. Editorial: ChemSpider - a tool for natural products research. Nat Prod Rep 2015, 32:1163-1164.
    • (2015) Nat Prod Rep , vol.32 , pp. 1163-1164
    • Kelly, R.1    Kidd, R.2
  • 61
    • 84892767391 scopus 로고    scopus 로고
    • KNApSAcK Metabolite Activity Database for retrieving the relationships between metabolites and biological activities
    • Nakamura Y., Afendi F.M., Parvin A.K., Ono N., Tanaka K., Hirai Morita A., et al. KNApSAcK Metabolite Activity Database for retrieving the relationships between metabolites and biological activities. Plant Cell Physiol 2014, 55:e7.
    • (2014) Plant Cell Physiol , vol.55
    • Nakamura, Y.1    Afendi, F.M.2    Parvin, A.K.3    Ono, N.4    Tanaka, K.5    Hirai Morita, A.6
  • 62
  • 64
    • 84979258428 scopus 로고    scopus 로고
    • Norine, the knowledgebase dedicated to non-ribosomal peptides, is now open to crowdsourcing
    • Flissi A., Dufresne Y., Michalik J., Tonon L., Janot S., Noe L., et al. Norine, the knowledgebase dedicated to non-ribosomal peptides, is now open to crowdsourcing. Nucleic Acids Res 2015, 44(D1):D1113-8.
    • (2015) Nucleic Acids Res , vol.44 , Issue.D1 , pp. D1113-D1118
    • Flissi, A.1    Dufresne, Y.2    Michalik, J.3    Tonon, L.4    Janot, S.5    Noe, L.6
  • 65
    • 54949108677 scopus 로고    scopus 로고
    • PubChem: integrated platform of small molecules and biological activities
    • American Chemical Society, Washington, DC, editors
    • Bolton E., Wang Y., Thiessen P.A., Bryant S.H. PubChem: integrated platform of small molecules and biological activities. Annual reports in computational chemistry 2008, Vol. 4:217-241. American Chemical Society, Washington, DC, editors.
    • (2008) Annual reports in computational chemistry , vol.4 , pp. 217-241
    • Bolton, E.1    Wang, Y.2    Thiessen, P.A.3    Bryant, S.H.4
  • 66
    • 84876543738 scopus 로고    scopus 로고
    • StreptomeDB: a resource for natural compounds isolated from Streptomyces species
    • Lucas X., Senger C., Erxleben A., Gruning B.A., Doring K., Mosch J., et al. StreptomeDB: a resource for natural compounds isolated from Streptomyces species. Nucleic Acids Res 2013, 41:D1130-6.
    • (2013) Nucleic Acids Res , vol.41 , pp. D1130-D1136
    • Lucas, X.1    Senger, C.2    Erxleben, A.3    Gruning, B.A.4    Doring, K.5    Mosch, J.6
  • 67
    • 84976875272 scopus 로고    scopus 로고
    • StreptomeDB 2.0 - an extended resource of natural products produced by streptomycetes
    • Klementz D., Doring K., Lucas X., Telukunta K.K., Erxleben A., Deubel D., et al. StreptomeDB 2.0 - an extended resource of natural products produced by streptomycetes. Nucleic Acids Res 2016, 44(D1):D509-14.
    • (2016) Nucleic Acids Res , vol.44 , Issue.D1 , pp. D509-D514
    • Klementz, D.1    Doring, K.2    Lucas, X.3    Telukunta, K.K.4    Erxleben, A.5    Deubel, D.6
  • 68
    • 80053896196 scopus 로고    scopus 로고
    • Cycloquest: identification of cyclopeptides via database search of their mass spectra against genome databases
    • Mohimani H., Liu W.T., Mylne J.S., Poth A.G., Colgrave M.L., Tran D., et al. Cycloquest: identification of cyclopeptides via database search of their mass spectra against genome databases. J Proteome Res 2011, 10:4505-4512.
    • (2011) J Proteome Res , vol.10 , pp. 4505-4512
    • Mohimani, H.1    Liu, W.T.2    Mylne, J.S.3    Poth, A.G.4    Colgrave, M.L.5    Tran, D.6
  • 69
    • 84869792678 scopus 로고    scopus 로고
    • Dereplicating nonribosomal peptides using an informatic search algorithm for natural products (iSNAP) discovery
    • Ibrahim A., Yang L., Johnston C., Liu X., Ma B., Magarvey N.A. Dereplicating nonribosomal peptides using an informatic search algorithm for natural products (iSNAP) discovery. Proc Natl Acad Sci U S A 2012, 109:19196-19201.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 19196-19201
    • Ibrahim, A.1    Yang, L.2    Johnston, C.3    Liu, X.4    Ma, B.5    Magarvey, N.A.6
  • 70
    • 84941944299 scopus 로고    scopus 로고
    • Exploration of nonribosomal peptide families with an automated informatic search algorithm
    • Yang L., Ibrahim A., Johnston C.W., Skinnider M.A., Ma B., Magarvey N.A. Exploration of nonribosomal peptide families with an automated informatic search algorithm. Chem Biol 2015, 22:1259-1269.
    • (2015) Chem Biol , vol.22 , pp. 1259-1269
    • Yang, L.1    Ibrahim, A.2    Johnston, C.W.3    Skinnider, M.A.4    Ma, B.5    Magarvey, N.A.6
  • 72
    • 84906678559 scopus 로고    scopus 로고
    • NRPquest: coupling mass spectrometry and genome mining for nonribosomal peptide discovery
    • Mohimani H., Liu W.T., Kersten R.D., Moore B.S., Dorrestein P.C., Pevzner P.A. NRPquest: coupling mass spectrometry and genome mining for nonribosomal peptide discovery. J Nat Prod 2014, 77:1902-1909.
    • (2014) J Nat Prod , vol.77 , pp. 1902-1909
    • Mohimani, H.1    Liu, W.T.2    Kersten, R.D.3    Moore, B.S.4    Dorrestein, P.C.5    Pevzner, P.A.6
  • 76
    • 80055082271 scopus 로고    scopus 로고
    • Accelerated profile HMM searches
    • Eddy S.R. Accelerated profile HMM searches. PLoS Comput Biol 2011, 7:e1002195.
    • (2011) PLoS Comput Biol , vol.7
    • Eddy, S.R.1
  • 77
    • 84876587454 scopus 로고    scopus 로고
    • Detecting sequence homology at the gene cluster level with MultiGeneBlast
    • Medema M.H., Takano E., Breitling R. Detecting sequence homology at the gene cluster level with MultiGeneBlast. Mol Biol Evol 2013, 10.1093/molbev/mst025.
    • (2013) Mol Biol Evol
    • Medema, M.H.1    Takano, E.2    Breitling, R.3
  • 78
    • 84920866686 scopus 로고    scopus 로고
    • Automated identification of depsipeptide natural products by an informatic search algorithm
    • Skinnider M.A., Johnston C.W., Zvanych R., Magarvey N.A. Automated identification of depsipeptide natural products by an informatic search algorithm. Chembiochem 2015, 16:223-227.
    • (2015) Chembiochem , vol.16 , pp. 223-227
    • Skinnider, M.A.1    Johnston, C.W.2    Zvanych, R.3    Magarvey, N.A.4
  • 79
    • 84895873870 scopus 로고    scopus 로고
    • Improved lanthipeptide detection and prediction for antiSMASH
    • Blin K., Kazempour D., Wohlleben W., Weber T. Improved lanthipeptide detection and prediction for antiSMASH. PLoS ONE 2014, 9:e89420.
    • (2014) PLoS ONE , vol.9
    • Blin, K.1    Kazempour, D.2    Wohlleben, W.3    Weber, T.4
  • 80
    • 0033179468 scopus 로고    scopus 로고
    • The specificity-conferring code of adenylation domains in nonribosomal peptide synthetases
    • Stachelhaus T., Mootz H.D., Marahiel M.A. The specificity-conferring code of adenylation domains in nonribosomal peptide synthetases. Chem Biol 1999, 6:493-505.
    • (1999) Chem Biol , vol.6 , pp. 493-505
    • Stachelhaus, T.1    Mootz, H.D.2    Marahiel, M.A.3
  • 81
    • 0034013269 scopus 로고    scopus 로고
    • Predictive, structure-based model of amino acid recognition by nonribosomal peptide synthetase adenylation domains
    • Challis G.L., Ravel J., Townsend C.A. Predictive, structure-based model of amino acid recognition by nonribosomal peptide synthetase adenylation domains. Chem Biol 2000, 7:211-224.
    • (2000) Chem Biol , vol.7 , pp. 211-224
    • Challis, G.L.1    Ravel, J.2    Townsend, C.A.3
  • 82
    • 34247279292 scopus 로고    scopus 로고
    • Comprehensive analysis of distinctive polyketide and nonribosomal peptide structural motifs encoded in microbial genomes
    • Minowa Y., Araki M., Kanehisa M. Comprehensive analysis of distinctive polyketide and nonribosomal peptide structural motifs encoded in microbial genomes. J Mol Biol 2007, 368:1500-1517.
    • (2007) J Mol Biol , vol.368 , pp. 1500-1517
    • Minowa, Y.1    Araki, M.2    Kanehisa, M.3
  • 83
    • 84944461014 scopus 로고    scopus 로고
    • Prediction of the substrate for nonribosomal peptide synthetase (NRPS) adenylation domains by virtual screening
    • Lee T.V., Johnson R.D., Arcus V.L., Lott J.S. Prediction of the substrate for nonribosomal peptide synthetase (NRPS) adenylation domains by virtual screening. Proteins 2015, 83(11):2052-2066.
    • (2015) Proteins , vol.83 , Issue.11 , pp. 2052-2066
    • Lee, T.V.1    Johnson, R.D.2    Arcus, V.L.3    Lott, J.S.4
  • 84
    • 84859051266 scopus 로고    scopus 로고
    • PKSIIIexplorer: TSVM approach for predicting Type III polyketide synthase proteins
    • Vijayan M., Chandrika S.K., Vasudevan S.E. PKSIIIexplorer: TSVM approach for predicting Type III polyketide synthase proteins. Bioinformation 2011, 6:125-127.
    • (2011) Bioinformation , vol.6 , pp. 125-127
    • Vijayan, M.1    Chandrika, S.K.2    Vasudevan, S.E.3
  • 88
    • 84876560358 scopus 로고    scopus 로고
    • The ChEBI reference database and ontology for biologically relevant chemistry: enhancements for 2013
    • Hastings J., de Matos P., Dekker A., Ennis M., Harsha B., Kale N., et al. The ChEBI reference database and ontology for biologically relevant chemistry: enhancements for 2013. Nucleic Acids Res 2013, 41:D456-63.
    • (2013) Nucleic Acids Res , vol.41 , pp. D456-D463
    • Hastings, J.1    de Matos, P.2    Dekker, A.3    Ennis, M.4    Harsha, B.5    Kale, N.6
  • 90
    • 84958121975 scopus 로고    scopus 로고
    • Metabolic profiling as a tool for prioritizing antimicrobial compounds
    • Wu C., Choi Y.H., van Wezel G.P. Metabolic profiling as a tool for prioritizing antimicrobial compounds. J Ind Microbiol Biotechnol 2015, 10.1007/s10295-015-1666-x.
    • (2015) J Ind Microbiol Biotechnol
    • Wu, C.1    Choi, Y.H.2    van Wezel, G.P.3
  • 91
    • 84937525959 scopus 로고    scopus 로고
    • Metabolomics in the natural products field - a gateway to novel antibiotics
    • Wu C., Kim H.K., van Wezel G.P., Choi Y.H. Metabolomics in the natural products field - a gateway to novel antibiotics. Drug Discov Today Technol 2015, 13:11-17.
    • (2015) Drug Discov Today Technol , vol.13 , pp. 11-17
    • Wu, C.1    Kim, H.K.2    van Wezel, G.P.3    Choi, Y.H.4
  • 92
    • 38349151554 scopus 로고    scopus 로고
    • Metabolic flux analysis and metabolic engineering of microorganisms
    • Kim H.U., Kim T.Y., Lee S.Y. Metabolic flux analysis and metabolic engineering of microorganisms. Mol Biosyst 2008, 4:113-120.
    • (2008) Mol Biosyst , vol.4 , pp. 113-120
    • Kim, H.U.1    Kim, T.Y.2    Lee, S.Y.3
  • 93
    • 84887019367 scopus 로고    scopus 로고
    • Metabolic impact assessment for heterologous protein production in Streptomyces lividans based on genome-scale metabolic network modeling
    • Lule I., Huys P.J.D., Van Mellaert L., Anne J., Bernaerts K., Van Impe J. Metabolic impact assessment for heterologous protein production in Streptomyces lividans based on genome-scale metabolic network modeling. Math Biosci 2013, 246:113-121.
    • (2013) Math Biosci , vol.246 , pp. 113-121
    • Lule, I.1    Huys, P.J.D.2    Van Mellaert, L.3    Anne, J.4    Bernaerts, K.5    Van Impe, J.6
  • 94
    • 84863440730 scopus 로고    scopus 로고
    • Genome-scale metabolic flux analysis of Streptomyces lividans growing on a complex medium
    • Huys P.J.D., Lule I., Vercammen D., Anne J., Van Impe J.F., Bernaerts K. Genome-scale metabolic flux analysis of Streptomyces lividans growing on a complex medium. J Biotechnol 2012, 161:1-13.
    • (2012) J Biotechnol , vol.161 , pp. 1-13
    • Huys, P.J.D.1    Lule, I.2    Vercammen, D.3    Anne, J.4    Van Impe, J.F.5    Bernaerts, K.6
  • 95
    • 84906949001 scopus 로고    scopus 로고
    • Reconstruction of a high-quality metabolic model enables the identification of gene overexpression targets for enhanced antibiotic production in Streptomyces coelicolor A3(2)
    • Kim M., Sang Yi J., Kim J., Kim J.N., Kim M.W., Kim B.G. Reconstruction of a high-quality metabolic model enables the identification of gene overexpression targets for enhanced antibiotic production in Streptomyces coelicolor A3(2). Biotechnol J 2014, 9:1185-1194.
    • (2014) Biotechnol J , vol.9 , pp. 1185-1194
    • Kim, M.1    Sang Yi, J.2    Kim, J.3    Kim, J.N.4    Kim, M.W.5    Kim, B.G.6
  • 96
    • 84878003979 scopus 로고    scopus 로고
    • Genome-scale metabolic network guided engineering of Streptomyces tsukubaensis for FK506 production improvement
    • Huang D., Li S., Xia M., Wen J., Jia X. Genome-scale metabolic network guided engineering of Streptomyces tsukubaensis for FK506 production improvement. Microb Cell Fact 2013, 12:52.
    • (2013) Microb Cell Fact , vol.12 , pp. 52
    • Huang, D.1    Li, S.2    Xia, M.3    Wen, J.4    Jia, X.5
  • 97
    • 75149129569 scopus 로고    scopus 로고
    • A protocol for generating a high-quality genome-scale metabolic reconstruction
    • Thiele I., Palsson B.O. A protocol for generating a high-quality genome-scale metabolic reconstruction. Nat Protoc 2010, 5:93-121.
    • (2010) Nat Protoc , vol.5 , pp. 93-121
    • Thiele, I.1    Palsson, B.O.2
  • 98
    • 79960356281 scopus 로고    scopus 로고
    • Comparative genome-scale metabolic modeling of actinomycetes: the topology of essential core metabolism
    • Alam M.T., Medema M.H., Takano E., Breitling R. Comparative genome-scale metabolic modeling of actinomycetes: the topology of essential core metabolism. FEBS Lett 2011, 585:2389-2394.
    • (2011) FEBS Lett , vol.585 , pp. 2389-2394
    • Alam, M.T.1    Medema, M.H.2    Takano, E.3    Breitling, R.4
  • 101
    • 84856038703 scopus 로고    scopus 로고
    • The SuBliMinaL Toolbox: automating steps in the reconstruction of metabolic networks
    • Swainston N., Smallbone K., Mendes P., Kell D., Paton N. The SuBliMinaL Toolbox: automating steps in the reconstruction of metabolic networks. J Integr Bioinform 2011, 8:186.
    • (2011) J Integr Bioinform , vol.8 , pp. 186
    • Swainston, N.1    Smallbone, K.2    Mendes, P.3    Kell, D.4    Paton, N.5
  • 102
    • 84856247380 scopus 로고    scopus 로고
    • FAME, the Flux Analysis and Modeling Environment
    • Boele J., Olivier B.G., Teusink B. FAME, the Flux Analysis and Modeling Environment. BMC Syst Biol 2012, 6:8.
    • (2012) BMC Syst Biol , vol.6 , pp. 8
    • Boele, J.1    Olivier, B.G.2    Teusink, B.3
  • 103
    • 84864000794 scopus 로고    scopus 로고
    • GEMSiRV: a software platform for GEnome-scale metabolic model simulation, reconstruction and visualization
    • Liao Y.C., Tsai M.H., Chen F.C., Hsiung C.A. GEMSiRV: a software platform for GEnome-scale metabolic model simulation, reconstruction and visualization. Bioinformatics 2012, 28:1752-1758.
    • (2012) Bioinformatics , vol.28 , pp. 1752-1758
    • Liao, Y.C.1    Tsai, M.H.2    Chen, F.C.3    Hsiung, C.A.4
  • 104
    • 84856568013 scopus 로고    scopus 로고
    • Construction and completion of flux balance models from pathway databases
    • Latendresse M., Krummenacker M., Trupp M., Karp P.D. Construction and completion of flux balance models from pathway databases. Bioinformatics 2012, 28:388-396.
    • (2012) Bioinformatics , vol.28 , pp. 388-396
    • Latendresse, M.1    Krummenacker, M.2    Trupp, M.3    Karp, P.D.4
  • 105
    • 84864464109 scopus 로고    scopus 로고
    • MicrobesFlux: a web platform for drafting metabolic models from the KEGG database
    • Feng X., Xu Y., Chen Y., Tang Y.J. MicrobesFlux: a web platform for drafting metabolic models from the KEGG database. BMC Syst Biol 2012, 6:94.
    • (2012) BMC Syst Biol , vol.6 , pp. 94
    • Feng, X.1    Xu, Y.2    Chen, Y.3    Tang, Y.J.4
  • 106
    • 84875973063 scopus 로고    scopus 로고
    • The RAVEN toolbox and its use for generating a genome-scale metabolic model for Penicillium chrysogenum
    • Agren R., Liu L., Shoaie S., Vongsangnak W., Nookaew I., Nielsen J. The RAVEN toolbox and its use for generating a genome-scale metabolic model for Penicillium chrysogenum. PLoS Comput Biol 2013, 9:e1002980.
    • (2013) PLoS Comput Biol , vol.9
    • Agren, R.1    Liu, L.2    Shoaie, S.3    Vongsangnak, W.4    Nookaew, I.5    Nielsen, J.6
  • 107
    • 84895735489 scopus 로고    scopus 로고
    • Comparative genome-scale reconstruction of gapless metabolic networks for present and ancestral species
    • Pitkanen E., Jouhten P., Hou J., Syed M.F., Blomberg P., Kludas J., et al. Comparative genome-scale reconstruction of gapless metabolic networks for present and ancestral species. PLoS Comput Biol 2014, 10:e1003465.
    • (2014) PLoS Comput Biol , vol.10
    • Pitkanen, E.1    Jouhten, P.2    Hou, J.3    Syed, M.F.4    Blomberg, P.5    Kludas, J.6
  • 108
    • 84930225331 scopus 로고    scopus 로고
    • Reconstructing genome-scale metabolic models with merlin
    • Dias O., Rocha M., Ferreira E.C., Rocha I. Reconstructing genome-scale metabolic models with merlin. Nucleic Acids Res 2015, 43:3899-3910.
    • (2015) Nucleic Acids Res , vol.43 , pp. 3899-3910
    • Dias, O.1    Rocha, M.2    Ferreira, E.C.3    Rocha, I.4
  • 109
    • 84891635463 scopus 로고    scopus 로고
    • Software platforms to facilitate reconstructing genome-scale metabolic networks
    • Hamilton J.J., Reed J.L. Software platforms to facilitate reconstructing genome-scale metabolic networks. Environ Microbiol 2014, 16:49-59.
    • (2014) Environ Microbiol , vol.16 , pp. 49-59
    • Hamilton, J.J.1    Reed, J.L.2
  • 110
    • 84903172568 scopus 로고    scopus 로고
    • Natural product proteomining, a quantitative proteomics platform, allows rapid discovery of biosynthetic gene clusters for different classes of natural products
    • Gubbens J., Zhu H., Girard G., Song L., Florea B.I., Aston P., et al. Natural product proteomining, a quantitative proteomics platform, allows rapid discovery of biosynthetic gene clusters for different classes of natural products. Chem Biol 2014, 21:707-718.
    • (2014) Chem Biol , vol.21 , pp. 707-718
    • Gubbens, J.1    Zhu, H.2    Girard, G.3    Song, L.4    Florea, B.I.5    Aston, P.6
  • 112
    • 84887624961 scopus 로고    scopus 로고
    • Design-based re-engineering of biosynthetic gene clusters: plug-and-play in practice
    • Frasch H.J., Medema M.H., Takano E., Breitling R. Design-based re-engineering of biosynthetic gene clusters: plug-and-play in practice. Curr Opin Biotechnol 2013, 24:1144-1150.
    • (2013) Curr Opin Biotechnol , vol.24 , pp. 1144-1150
    • Frasch, H.J.1    Medema, M.H.2    Takano, E.3    Breitling, R.4
  • 113
  • 115
    • 27144509740 scopus 로고    scopus 로고
    • Combinatorial polyketide biosynthesis by de novo design and rearrangement of modular polyketide synthase genes
    • Menzella H.G., Reid R., Carney J.R., Chandran S.S., Reisinger S.J., Patel K.G., et al. Combinatorial polyketide biosynthesis by de novo design and rearrangement of modular polyketide synthase genes. Nat Biotechnol 2005, 23:1171-1176.
    • (2005) Nat Biotechnol , vol.23 , pp. 1171-1176
    • Menzella, H.G.1    Reid, R.2    Carney, J.R.3    Chandran, S.S.4    Reisinger, S.J.5    Patel, K.G.6
  • 117
    • 49249127703 scopus 로고    scopus 로고
    • Module extension of a non-ribosomal peptide synthetase of the glycopeptide antibiotic balhimycin produced by Amycolatopsis balhimycina
    • Butz D., Schmiederer T., Hadatsch B., Wohlleben W., Weber T., Süßmuth R.D. Module extension of a non-ribosomal peptide synthetase of the glycopeptide antibiotic balhimycin produced by Amycolatopsis balhimycina. Chembiochem 2008, 9:1195-1200.
    • (2008) Chembiochem , vol.9 , pp. 1195-1200
    • Butz, D.1    Schmiederer, T.2    Hadatsch, B.3    Wohlleben, W.4    Weber, T.5    Süßmuth, R.D.6
  • 118
    • 84858184688 scopus 로고    scopus 로고
    • Reprogramming a module of the 6-deoxyerythronolide B synthase for iterative chain elongation
    • Kapur S., Lowry B., Yuzawa S., Kenthirapalan S., Chen A.Y., Cane D.E., et al. Reprogramming a module of the 6-deoxyerythronolide B synthase for iterative chain elongation. Proc Natl Acad Sci U S A 2012, 109:4110-4115.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 4110-4115
    • Kapur, S.1    Lowry, B.2    Yuzawa, S.3    Kenthirapalan, S.4    Chen, A.Y.5    Cane, D.E.6
  • 119
    • 0033515090 scopus 로고    scopus 로고
    • Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel "unnatural" natural products
    • McDaniel R., Thamchaipenet A., Gustafsson C., Fu H., Betlach M., Ashley G. Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel "unnatural" natural products. Proc Natl Acad Sci U S A 1999, 96:1846-1851.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 1846-1851
    • McDaniel, R.1    Thamchaipenet, A.2    Gustafsson, C.3    Fu, H.4    Betlach, M.5    Ashley, G.6
  • 120
    • 48749083335 scopus 로고    scopus 로고
    • Crystal structure of the termination module of a nonribosomal peptide synthetase
    • Tanovic A., Samel S.A., Essen L.O., Marahiel M.A. Crystal structure of the termination module of a nonribosomal peptide synthetase. Science 2008, 321:659-663.
    • (2008) Science , vol.321 , pp. 659-663
    • Tanovic, A.1    Samel, S.A.2    Essen, L.O.3    Marahiel, M.A.4
  • 121
    • 84957080440 scopus 로고    scopus 로고
    • A structural model for multimodular NRPS assembly lines
    • Marahiel M.A. A structural model for multimodular NRPS assembly lines. Nat Prod Rep 2015, 10.1039/C5NP00082C.
    • (2015) Nat Prod Rep
    • Marahiel, M.A.1
  • 122
    • 84903481589 scopus 로고    scopus 로고
    • Structural rearrangements of a polyketide synthase module during its catalytic cycle
    • Whicher J.R., Dutta S., Hansen D.A., Hale W.A., Chemler J.A., Dosey A.M., et al. Structural rearrangements of a polyketide synthase module during its catalytic cycle. Nature 2014, 510:560-564.
    • (2014) Nature , vol.510 , pp. 560-564
    • Whicher, J.R.1    Dutta, S.2    Hansen, D.A.3    Hale, W.A.4    Chemler, J.A.5    Dosey, A.M.6
  • 124
    • 78650660868 scopus 로고    scopus 로고
    • Molecular recognition between ketosynthase and acyl carrier protein domains of the 6-deoxyerythronolide B synthase
    • Kapur S., Chen A.Y., Cane D.E., Khosla C. Molecular recognition between ketosynthase and acyl carrier protein domains of the 6-deoxyerythronolide B synthase. Proc Natl Acad Sci U S A 2010, 107:22066-22071.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 22066-22071
    • Kapur, S.1    Chen, A.Y.2    Cane, D.E.3    Khosla, C.4
  • 125
    • 84901390725 scopus 로고    scopus 로고
    • Reprogramming acyl carrier protein interactions of an acyl-CoA promiscuous trans-acyltransferase
    • Ye Z., Musiol E.M., Weber T., Williams G.J. Reprogramming acyl carrier protein interactions of an acyl-CoA promiscuous trans-acyltransferase. Chem Biol 2014, 21:636-646.
    • (2014) Chem Biol , vol.21 , pp. 636-646
    • Ye, Z.1    Musiol, E.M.2    Weber, T.3    Williams, G.J.4
  • 127
    • 84934947770 scopus 로고    scopus 로고
    • High-efficiency multiplex genome editing of Streptomyces species using an engineered CRISPR/Cas system
    • Cobb R.E., Wang Y., Zhao H. High-efficiency multiplex genome editing of Streptomyces species using an engineered CRISPR/Cas system. ACS Synth Biol 2015, 4:723-728.
    • (2015) ACS Synth Biol , vol.4 , pp. 723-728
    • Cobb, R.E.1    Wang, Y.2    Zhao, H.3
  • 128
    • 84948382257 scopus 로고    scopus 로고
    • Highly efficient editing of the actinorhodin polyketide chain length factor gene in Streptomyces coelicolor M145 using CRISPR/Cas9-CodA(sm) combined system
    • Zeng H., Wen S., Xu W., He Z., Zhai G., Liu Y., et al. Highly efficient editing of the actinorhodin polyketide chain length factor gene in Streptomyces coelicolor M145 using CRISPR/Cas9-CodA(sm) combined system. Appl Microbiol Biotechnol 2015, 99(24):10575-10585.
    • (2015) Appl Microbiol Biotechnol , vol.99 , Issue.24 , pp. 10575-10585
    • Zeng, H.1    Wen, S.2    Xu, W.3    He, Z.4    Zhai, G.5    Liu, Y.6
  • 129
    • 84926466507 scopus 로고    scopus 로고
    • One-step high-efficiency CRISPR/Cas9-mediated genome editing in Streptomyces
    • Huang H., Zheng G., Jiang W., Hu H., Lu Y. One-step high-efficiency CRISPR/Cas9-mediated genome editing in Streptomyces. Acta Biochim Biophys Sin (Shanghai) 2015, 47:231-243.
    • (2015) Acta Biochim Biophys Sin (Shanghai) , vol.47 , pp. 231-243
    • Huang, H.1    Zheng, G.2    Jiang, W.3    Hu, H.4    Lu, Y.5


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