Reconstruction of a high-quality metabolic model enables the identification of gene overexpression targets for enhanced antibiotic production in streptomyces coelicolor A3(2)

Biotechnology Journal

Volumn 9, Issue 9, 2014, Pages 1185-1194

  Kim, Minsuk ^a   Sang Yi, Jeong ^a   Kim, Joonwon ^a   Kim, Ji Nu ^a   Kim, Min Woo ^a   Kim, Byung Gee ^a  

^a Seoul National University   (South Korea)

Author keywords

Antibiotics; BCDH; Genome scale model; Metabolic engineering; Streptomyces coelicolor

Indexed keywords

ANTIBIOTICS; BIODEGRADATION; GENES; METABOLIC ENGINEERING; METABOLISM; METABOLITES;

ACETYL-COA CARBOXYLASE; ANTIBIOTIC PRODUCTION; BCDH; COMPLEX METABOLIC NETWORKS; GENOME-SCALE MODEL; SECONDARY METABOLITES; STREPTOMYCES COELICOLOR; STREPTOMYCES COELICOLOR A3(2); GENE OVER-EXPRESSION; HIGH QUALITY; METABOLIC MODELING;

BACTERIA; ANTIBIOTICS;

ACTINORHODINE; ANTHRAQUINONE DERIVATIVE; ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; CULTURE MEDIUM;

BIOLOGICAL MODEL; BIOMASS; BIOSYNTHESIS; CULTURE MEDIUM; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; STREPTOMYCES COELICOLOR; SYSTEMS BIOLOGY;

ANTHRAQUINONES; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BIOMASS; CULTURE MEDIA; GENE EXPRESSION REGULATION, BACTERIAL; MODELS, BIOLOGICAL; STREPTOMYCES COELICOLOR; SYSTEMS BIOLOGY;

EID: 84906949001     PISSN: 18606768     EISSN: 18607314     Source Type: Journal    
DOI: 10.1002/biot.201300539     Document Type: Article

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