Metabolic impact assessment for heterologous protein production in Streptomyces lividans based on genome-scale metabolic network modeling

Mathematical Biosciences

Volumn 246, Issue 1, 2013, Pages 113-121

  Lule, Ivan ^a   D'Huys, Pieter Jan ^a   Van Mellaert, Lieve ^a   Anné, Jozef ^a   Bernaerts, Kristel ^a   Van Impe, Jan ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

(geometric) Flux balance analysis; Genome scale metabolic network; Heterologous proteins; Mouse tumor necrosis factor (mTNF ); Streptomyces lividans

Indexed keywords

FLUX BALANCE ANALYSIS; GENOME-SCALE METABOLIC NETWORK; HETEROLOGOUS PROTEINS; MOUSE TUMORS; STREPTOMYCES LIVIDANS;

AMINO ACIDS; GENES; GLYCOPROTEINS; MACROPHAGES; MAMMALS; METABOLISM; SUBSTRATES;

PROTEINS;

HISTIDINE; LYSINE; TUMOR NECROSIS FACTOR; VALINE;

GENOME; METABOLISM; METABOLITE; MICROORGANISM; MODELING; PROTEIN; TUMOR;

ARTICLE; BACTERIAL GENOME; BIOMASS PRODUCTION; CELL METABOLISM; CONTROLLED STUDY; INTRACELLULAR TRANSPORT; MATHEMATICAL MODEL; METABOLOMICS; NONHUMAN; PROTEIN ENGINEERING; PROTEIN SYNTHESIS; RECOMBINANT DNA TECHNOLOGY; STREPTOMYCES LIVIDANS;

STREPTOMYCES LIVIDANS;

(GEOMETRIC) FLUX BALANCE ANALYSIS; ACTIVE METABOLIC NETWORK; AMN; CBM; CONSTRAINT-BASED MODELING; FBA; FCP; FIRST GROWTH PHASE; FLUX BALANCE ANALYSIS; FLUX VARIABILITY ANALYSIS; FRAGMENTED CELL PELLETS; FVA; GENOME-SCALE METABOLIC NETWORK; GEOMETRIC FLUX BALANCE ANALYSIS; GFBA; GP1; GP2; GSMN; HETEROLOGOUS PROTEINS; MINIMAL LIQUID MEDIUM; MOUSE TUMOR NECROSIS FACTOR (MTNF-Α); NMMP; REC; RECOMBINANT (S. LIVIDANS); SECOND GROWTH PHASE; STREPTOMYCES LIVIDANS; UCP; UNFRAGMENTED CELL PELLETS; WILD-TYPE (S. LIVIDANS); WT;

ANIMALS; GENOME; METABOLIC NETWORKS AND PATHWAYS; MICE; MODELS, BIOLOGICAL; STREPTOMYCES LIVIDANS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84887019367     PISSN: 00255564     EISSN: 18793134     Source Type: Journal    
DOI: 10.1016/j.mbs.2013.08.006     Document Type: Article

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