Combinatorial biosynthesis of novel antibiotics related to daptomycin

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 46, 2006, Pages 17462-17467

  Nguyen, Kien T ^a   Ritz, Daniel ^a,b   Gu, Jian Qiao ^a   Alexander, Dylan ^a   Chu, Min ^a   Miao, Vivian ^a,c   Brian, Paul ^a   Baltz, Richard H ^a  

^a Cubist Pharmaceutical ^*  (United States)

^b ACTELION PHARMACEUTICALS LTD   (Switzerland)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Cubicin; Genetic engineering; Nonribosomal peptide; Streptomyces

Indexed keywords

ANTIBIOTIC AGENT; CYCLOPEPTIDE; DAPTOMYCIN; GLUTAMIC ACID 3 METHYLTRANSFERASE; LIPOPEPTIDE; METHYLTRANSFERASE; NONRIBOSOMAL PEPTIDE SYNTHETASE; PROTEIN DPTBC; SYNTHETASE; UNCLASSIFIED DRUG;

ARTICLE; BACTEREMIA; BACTERIAL ENDOCARDITIS; BACTERIAL STRAIN; COMBINATORIAL CHEMISTRY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INACTIVATION; ENZYME SUBUNIT; ESCHERICHIA COLI; GENETIC ENGINEERING; GRAM POSITIVE BACTERIUM; MEMBRANE PERMEABILITY; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MUTANT; NONHUMAN; NUCLEOTIDE SEQUENCE; OUTER MEMBRANE; PRIORITY JOURNAL; SKIN INFECTION; STAPHYLOCOCCUS AUREUS; STREPTOMYCES; STREPTOMYCES ROSEOSPORUS;

AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; DAPTOMYCIN; GENE DELETION; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; MUTATION; SEQUENCE ALIGNMENT; STAPHYLOCOCCUS AUREUS; STREPTOMYCES;

ESCHERICHIA COLI; POSIBACTERIA; STAPHYLOCOCCUS AUREUS; STREPTOMYCES; STREPTOMYCES FILAMENTOSUS;

EID: 33751218042     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0608589103     Document Type: Article

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