Dipeptidyl Vinyl Sulfone as a Novel Chemical Tool to Inhibit HMGB1/NLRP3-Inflammasome and Inflamma-miRs in Aβ-Mediated Microglial Inflammation

ACS Chemical Neuroscience

Volumn 8, Issue 1, 2017, Pages 89-99

  Falcão, Ana S ^a   Carvalho, Luís A R ^a   Lidónio, Gonçalo ^a   Vaz, Ana R ^a   Lucas, Susana D ^a   Moreira, Rui ^a   Brites, Dora ^a  

^a RESEARCH INSTITUTE FOR MEDICINES IMED ULISBOA   (Portugal)

Author keywords

amyloid peptide; HMGB1; inflammasome; Microglia; microRNAs; vinyl sulfones

Indexed keywords

AMYLOID BETA PROTEIN; CATHEPSIN L; CATHEPSIN S; CRYOPYRIN; DIPEPTIDYL VINYL SULFONE; GELATINASE A; GELATINASE B; HIGH MOBILITY GROUP B1 PROTEIN; INFLAMMASOME; INTERLEUKIN 1BETA; LACTATE DEHYDROGENASE; MICRORNA 146A; MICRORNA 155; SULFONE DERIVATIVE; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; UNCLASSIFIED DRUG; AMYLOID BETA-PROTEIN (1-42); ANTIINFLAMMATORY AGENT; DIVINYL SULFONE; LIPOPOLYSACCHARIDE; MATRIX METALLOPROTEINASE; MICRORNA; MIRN146 MICRORNA, MOUSE; MIRN155 MICRORNA, MOUSE; PEPTIDE FRAGMENT; SULFONE;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; ASTROCYTE; CARBON NUCLEAR MAGNETIC RESONANCE; CYCLOADDITION; EMBRYO; EXOSOME; GENE EXPRESSION; MACROPHAGE; MASS SPECTROMETRY; MICROGLIA; MOUSE; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTON NUCLEAR MAGNETIC RESONANCE; REAL TIME POLYMERASE CHAIN REACTION; SPATIAL MEMORY; UPREGULATION; ANIMAL; BRAIN CORTEX; CELL CULTURE; CELL SURVIVAL; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PHAGOCYTE; SYNTHESIS;

AMYLOID BETA-PEPTIDES; ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL SURVIVAL; CELLS, CULTURED; CEREBRAL CORTEX; GENE EXPRESSION REGULATION; HMGB1 PROTEIN; INTERLEUKIN-1BETA; LIPOPOLYSACCHARIDES; MATRIX METALLOPROTEINASES; MICE; MICROGLIA; MICRORNAS; NLR FAMILY, PYRIN DOMAIN-CONTAINING 3 PROTEIN; PEPTIDE FRAGMENTS; PHAGOCYTES; SULFONES;

EID: 85013640037     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/acschemneuro.6b00250     Document Type: Article

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