Sequential amyloid-β degradation by the matrix metalloproteases MMP-2 and MMP-9

Journal of Biological Chemistry

Volumn 290, Issue 24, 2015, Pages 15078-15091

  Hernandez Guillamon, Mar ^a,b   Mawhirt, Stephanie ^a,d   Blais, Steven ^a   Montaner, Joan ^b,c   Neubert, Thomas A ^a   Rostagno, Agueda ^a   Ghiso, Jorge ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Institut de Recerca   (Spain)

^c UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^d WINTHROP UNIVERSITY HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIAL CELLS; GLYCOPROTEINS; MASS SPECTROMETRY; PEPTIDES;

BLOOD-BRAIN BARRIER; IMMUNOPRECIPITATIONS; INTERNAL STANDARDS; METALLOPROTEASES; PATHOLOGICAL PROCESS; PROTEOLYTIC FRAGMENTS; QUANTITATIVE MASS SPECTROMETRIES; SLOW DEGRADATION;

PROTEINS;

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-16]; AMYLOID BETA PROTEIN[1-30]; AMYLOID BETA PROTEIN[1-34]; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; GELATINASE A; GELATINASE B; RECOMBINANT HUMAN MATRIX METALLOPROTEASE 2; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CYTOTOXICITY; ENZYME KINETICS; ENZYME MECHANISM; ENZYME METABOLISM; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN TARGETING; ENZYME LINKED IMMUNOSORBENT ASSAY; METABOLISM; TUMOR CELL LINE; WESTERN BLOTTING;

AMYLOID BETA-PEPTIDES; BLOTTING, WESTERN; CELL LINE, TUMOR; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; PROTEOLYSIS; RECOMBINANT PROTEINS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 84931291962     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.610931     Document Type: Article

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