A novel synthetic dibenzocyclooctadiene lignan analog XLYF-104-6 attenuates lipopolysaccharide-induced inflammatory response in RAW264.7 macrophage cells and protects BALB/c mice from sepsis

European Journal of Pharmacology

Volumn 729, Issue 1, 2014, Pages 22-29

  Gu, Chunping ^a   Yu, Fang Lin ^b   Yu, Le ^a   He, Xiao Yang ^b   Zhong, Desheng ^a   He, Longgang ^a   Lv, Longyun ^a   Xie, Lan ^b   Liu, Shuwen ^a  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b BEIJING INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (China)

Author keywords

Anti inflammatory drug; Dibenzocyclooctadiene lignin; iNOS expression and NO production; Lipopolysaccharide; NF B; Sepsis

Indexed keywords

1,2,3,10,11 PENTAMETHOXYDIBENZOCYCLOOCTA 6,7 [C]PYRROLE 1,3 DIONE; ANTIINFLAMMATORY AGENT; ENDOTHELIAL NITRIC OXIDE SYNTHASE; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIGNAN DERIVATIVE; LIPOPOLYSACCHARIDE; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; AUTACOID; CYCLOOCTANE DERIVATIVE; DIBENZOCYCLOOCTADIENE LIGNAN; LIGNAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BAGG ALBINO MOUSE; CELL VIABILITY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DOSE RESPONSE; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; ENDOTOXEMIA; ENZYME REPRESSION; FEMALE; IC 50; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; MACROPHAGE; MALE; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; SEPSIS; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; CHEMICALLY INDUCED; CHEMISTRY; DRUG EFFECTS; METABOLISM; TOXICITY;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL LINE; CYCLOOCTANES; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; INFLAMMATION MEDIATORS; LIGNANS; LIPOPOLYSACCHARIDES; MACROPHAGES; MALE; MICE; MICE, INBRED BALB C; SEPSIS;

EID: 84894539849     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2014.01.019     Document Type: Article

References (29)

1. F. Balkwill, K.A. Charles, and A. Mantovani Smoldering and polarized inflammation in the initiation and promotion of malignant disease Cancer Cell 7 2005 211 217
2. J.G. Bode, C. Ehlting, and D. Haussinger The macrophage response towards LPS and its control through the p38(MAPK)-STAT3 axis Cell Signal. 24 2012 1185 1194
3. F. Chen, V. Castranova, X. Shi, and L.M. Demers New Insights into the role of nuclear factor-κb, a ubiquitous transcription factor in the initiation of diseases Clin. Chem. 45 1999 7 17
4. Y.N. Demchenko, and W.M. Kuehl A critical role for the NFκB pathway in multiple myeloma NIH Public Access 1 2010 59 68
5. S. Ghosh, and M. Karin Missing pieces in the NFκB puzzle Cell Press 109 2002 81 96
6. C.A. Gunnett, D.J. Berg, F.M. Faraci, and G. Feuerstein Vascular effects of lipopolysaccharide are enhanced in interleukin-10-deficient mice editorial comment Stroke 30 1999 2191 2196
7. M.S. Hayden, and S. Ghosh Shared principles in NF-kappaB signaling Cell 132 2008 344 362
8. K. Hoshino, O. Takeuchi, T. Kawai, H. Sanjo, T. Ogawa, Y. Takeda, K. Takeda, and S. Akira Cutting edge: toll-like receptor 4(TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product J. Immunol. 162 2012 3749 3752
9. S.P. Hussain, L.J. Hofseth, and C.C. Harris Radical causes of cancer Nat. Rev. Cancer 3 2003 276 285
10. S.B. Joseph, A. Castrillo, B.A. Laffitte, D.J. Mangelsdorf, and P. Tontonoz Reciprocal regulation of inflammation and lipid metabolism by liver X receptors Nat. Med. 9 2003 213 219
11. M. Karin Nuclear factor-κB in cancer development and progression Nature 441 2006 431 436
12. E. Karpuzoglu, and S.A. Ahmed Estrogen regulation of nitric oxide and inducible nitric oxide synthase (iNOS) in immune cells: implications for immunity, autoimmune diseases, and apoptosis Nitric Oxide 15 2006 177 186
13. R.G. Knowles, and S. Moncada Nitric oxide synthases in mammals Biochem. J. 298 1994 249 258
14. M. Kubo, and Y. Motomura Transcriptional regulation of the anti-inflammatory cytokine IL-10 in acquired immune cells Front. Immunol. 3 2012 275
15. K.H. Lee Discovery and development of natural product-derived chemotherapeutic agents based on a medicinal chemistry approach J. Nat. Prod. 73 2010 500 516
16. J.W. Lee, C.J. Bae, Y.J. Choi, S.I. Kim, N.H. Kim, H.J. Lee, S.S. Kim, Y.S. Kwon, and W. Chun 3,4,5-Trihydroxycinnamic acid inhibits LPS-induced iNOS expression by suppressing NF-κB activation in BV2 microglial cells Korean J. Physiol. Pharmacol. 16 2012 107 112
17. W.W. Lin, and M. Karin A cytokine-mediated link between innate immunity, inflammation, and cancer J. Clin Invest. 117 2007 1175 1183
18. J.L. Luo, S. Maeda, L.C. Hsu, H. Yagita, and M. Karin Inhibition of NF-κB in cancer cells converts inflammation-induced tumor growth mediated by TNFα to TRAIL-mediated tumor regression Cancer Cell 6 2004 297 305
19. R. Medzhitov Toll-like receptor and innate immunity Nat. Rev. Immunol. 1 2001 135 145
20. L.H. Naylor Reporter gene technology: the future looks bright Biochem. Pharmacol. 58 1999 749 757
21. T. Phillips, L. Jenkinson, C. McCrae, B. Thong, and J. Unitt Development of a high-throughput human rhinovirus infectivity cell-based assay for identifying antiviral compounds J. Virol. Methods 173 2011 182 188
22. Q. Ruan, and Y.H. Chen Nuclear factor-kappaB in immunity and inflammation: the Treg and Th17 connection Adv. Exp. Med. Biol. 946 2012 207 221
23. S. Singh, and A.K. Gupta Nitric oxide: role in tumour biology and iNOS/NO-based anticancer therapies Cancer Chemother. Pharmacol. 67 2011 1211 1224
24. P.P. Tak, and G.S. Firestein NF-kappaB: a key role in inflammatory diseases J. Clin Invest. 107 2001 7 11
25. I.M. Verma, J.K. Stevenson, E.M. Schwarz, D.V. Antwerp, and S. Miyamoto Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation Genes Dev. 9 1995 2723 2735
26. A. Wullaert, M.C. Bonnet, and M. Pasparakis NF-κB in the regulation of epithelial homeostasis and inflammation Cell Res. 21 2010 146 158
27. G. Wu, H.F. Guo, K. Gao, Y.N. Liu, K.F. Bastow, S.L. Morris-Natschke, K.H. Lee, and L. Xie Synthesis of unsymmetrical biphenyls as potent cytotoxic agents Bioorg. Med. Chem. Lett. 18 2008 5272 5276
28. S. Yamaoka, G. Courtois, C. Bessia, S.T. Whiteside, R. Weil, F. Agou, H.E. Kirk, R.J. Kay, and A. Israël Complementation cloning of NEMO, a component of the IκB kinase complex essential for NF-κB activation Cell Press 93 1998 1231 1240
29. P.J. Yu, W. Ci, G.F. Wang, J.Y. Zhang, S.Y. Wu, W. Xu, H. Jin, Z.G. Zhu, J.J. Zhang, J.X. Pang, and S.G. Wu Praeruptorin A inhibits lipopolysaccharide- induced inflammatory response in murine macrophages through inhibition of NF-kappaB pathway activation Phytother. Res. 25 2011 550 556