An endoperoxide-based hybrid approach to deliver falcipain inhibitors inside malaria parasites

ChemMedChem

Volumn 8, Issue 9, 2013, Pages 1528-1536

  Oliveira, Rudi ^a   Newton, Ana S ^a   Guedes, Rita C ^a   Miranda, Daniela ^a   Amewu, Richard K ^b   Srivastava, Abhishek ^c   Gut, Jiri ^d   Rosenthal, Philip J ^d   O'Neill, Paul M ^b   Ward, Stephen A ^c   Lopes, Francisca ^a   Moreira, Rui ^a  

^a RESEARCH INSTITUTE FOR MEDICINES IMED ULISBOA   (Portugal)

^b UNIVERSITY OF LIVERPOOL   (United Kingdom)

^c LIVERPOOL SCHOOL OF TROPICAL MEDICINE   (United Kingdom)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Antimalarial agents; Falcipains; Hybrids; Peroxides; Vinyl sulfones

Indexed keywords

ANTIMALARIAL AGENT; CARBON OXYGEN MONOCYCLE; CHLOROQUINE; CYSTEINE PROTEINASE; CYSTEINE PROTEINASE INHIBITOR; ENDOPEROXIDE; FALCIPAIN 2 INHIBITOR; HEMOGLOBIN; IRON; SULFONE DERIVATIVE; TETRAOXANE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIMALARIAL DRUG RESISTANCE; ANTIMALARIAL DRUG SUSCEPTIBILITY; ARTICLE; CONTROLLED STUDY; DIGESTIVE SYSTEM; DRUG BINDING SITE; DRUG DELIVERY SYSTEM; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; ERYTHROCYTE; HUMAN; HUMAN CELL; HYBRID; IC 50; MOLECULAR DOCKING; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL;

ANTIMALARIAL AGENTS; FALCIPAINS; HYBRIDS; PEROXIDES; VINYL SULFONES;

ANTIMALARIALS; ARTEMISININS; BINDING SITES; CHLOROQUINE; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; DRUG RESISTANCE; ERYTHROCYTES; FERROUS COMPOUNDS; HEMOGLOBINS; HUMANS; MALARIA; MOLECULAR DOCKING SIMULATION; PLASMODIUM FALCIPARUM; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONES; TETRAOXANES;

EID: 84883052282     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201300202     Document Type: Article

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