Amyloid-β protein oligomer at low nanomolar concentrations activates microglia and induces microglial neurotoxicity

Journal of Biological Chemistry

Volumn 286, Issue 5, 2011, Pages 3693-3706

  Maezawa, Izumi ^a,b   Zimin, Pavel I ^b   Wulff, Heike ^b   Jin, Lee Way ^a,b,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE; AMYLOID PLAQUES; DISSOCIATED CULTURE; DOXYCYCLINE; HIPPOCAMPAL SLICE; IN-VITRO; MICROGLIA; MICROMOLAR CONCENTRATION; NANOMOLAR CONCENTRATION; NEUROINFLAMMATION; NEURONAL DAMAGE; NEURONAL DYSFUNCTION; NEUROTOXICITY; NO RELEASE; NUCLEAR FACTORS; P38 MAPK; POTASSIUM CHANNELS; PROINFLAMMATORY; SCAVENGER RECEPTOR; SYNTHASES;

GLYCOPROTEINS; NITRIC OXIDE; OLIGOMERS; POTASSIUM;

CHEMICAL ACTIVATION;

AMYLOID BETA PROTEIN; CALCIUM ACTIVATED POTASSIUM CHANNEL; CD14 ANTIGEN; DOXYCYCLINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; MICROTUBULE ASSOCIATED PROTEIN 2; MITOGEN ACTIVATED PROTEIN KINASE P38; NEUROTOXIN; NITRIC OXIDE; OLIGOMER; SCAVENGER RECEPTOR A; INTERMEDIATE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; KCNN4 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CALCIUM SIGNALING; CELL ACTIVATION; CELL PROLIFERATION; CELL STRUCTURE; CELL VIABILITY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; HIPPOCAMPUS; IMMUNOCYTOCHEMISTRY; IMMUNOREACTIVITY; MICROGLIA; MOUSE; NERVE CELL LESION; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN CONFORMATION; RAT; ALZHEIMER DISEASE; ANIMAL; C57BL MOUSE; CYTOLOGY; DOSE RESPONSE; DRUG EFFECT; HUMAN; METABOLISM; NERVE CELL; PATHOLOGY; TUMOR CELL CULTURE;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; HIPPOCAMPUS; HUMANS; INTERMEDIATE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; MICE; MICE, INBRED C57BL; MICROGLIA; NEURONS; NITRIC OXIDE; TUMOR CELLS, CULTURED;

EID: 79952810857     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.135244     Document Type: Article

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