IL-1β production is dependent on the activation of purinergic receptors and NLRP3 pathway in human macrophages

FASEB Journal

Volumn 29, Issue 10, 2015, Pages 4162-4173

  Gicquel, Thomas ^a,b   Robert, Sacha ^a   Loyer, Pascal ^a   Victoni, Tatiana ^a   Bodin, Aude ^a   Ribault, Catherine ^a   Gleonnec, Florence ^a   Couillin, Isabelle ^c   Boichot, Elisabeth ^a   Lagente, Vincent ^a  

^a INSERM   (France)

^b RENNES UNIVERSITY HOSPITAL   (France)

^c UNIVERSITÉ D'ORLÉANS   (France)

Author keywords

Cytokines; Nlrp3 inflammasome; P2x7 receptor; Uric acid

Indexed keywords

CATHEPSIN B; CRYOPYRIN; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; IVERMECTIN; MESSENGER RNA; PURINERGIC P2 RECEPTOR; PURINERGIC P2X1 RECEPTOR; PURINERGIC P2X4 RECEPTOR; PURINERGIC P2X7 RECEPTOR; PURINERGIC P2Y2 RECEPTOR; PURINERGIC P2Y6 RECEPTOR; PURINERGIC RECEPTOR BLOCKING AGENT; (N-(1-(((CYANOIMINO)(5-QUINOLINYLAMINO) METHYL) AMINO)-2,2-DIMETHYLPROPYL)-2-(3,4-DIMETHOXYPHENYL)ACETAMIDE); ACETAMIDE DERIVATIVE; BENZYLOXYCARBONYLTYROSYL-VALYL-ALANYL-ASPARTIC ACID FLUOROMETHYL KETONE; CA 074 METHYL ESTER; CARRIER PROTEIN; DIPEPTIDE; LIPOPOLYSACCHARIDE; NLRP3 PROTEIN, HUMAN; PEPTIDE CHLOROMETHYL KETONE; QUINOLINE DERIVATIVE; URIC ACID;

ACUTE MONOCYTIC LEUKEMIA; ANIMAL EXPERIMENT; ARTICLE; CELL DIFFERENTIATION; CELL STIMULATION; CELL SURFACE; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; CYTOMETRY; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MACROPHAGE; MOUSE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; CELL CULTURE; DOSE RESPONSE; DRUG EFFECTS; FLOW CYTOMETRY; GENETICS; METABOLISM; TUMOR CELL LINE;

ACETAMIDES; AMINO ACID CHLOROMETHYL KETONES; CARRIER PROTEINS; CELL LINE, TUMOR; CELLS, CULTURED; DIPEPTIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; FLOW CYTOMETRY; GENE EXPRESSION; HUMANS; IMMUNOBLOTTING; INTERLEUKIN-1ALPHA; INTERLEUKIN-1BETA; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MACROPHAGES; QUINOLINES; RECEPTORS, PURINERGIC P2X7; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; URIC ACID;

EID: 84946945259     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.14-267393     Document Type: Article

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