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Volumn 5, Issue , 2016, Pages

Geroscience approaches to increase healthspan and slow aging.

Author keywords

[No Author keywords available]

Indexed keywords

AGING; CARDIOVASCULAR SYSTEM; GOLD STANDARD; HUMAN; LIFESPAN; MODEL; PRECLINICAL STUDY; SCIENTIST;

EID: 85010910630     PISSN: None     EISSN: 20461402     Source Type: Journal    
DOI: 10.12688/F1000RESEARCH.7583.1     Document Type: Review
Times cited : (17)

References (112)
  • 1
    • 0025004091 scopus 로고
    • Increased life-span of age-1 mutants in Caenorhabditis elegans and lower Gompertz rate of aging
    • Johnson TE: Increased life-span of age-1 mutants in Caenorhabditis elegans and lower Gompertz rate of aging. Science. 1990; 249(4971): 908-12.
    • (1990) Science , vol.249 , Issue.4971 , pp. 908-912
    • Johnson, T.E.1
  • 2
    • 0023678537 scopus 로고
    • Three mutants that extend both mean and maximum life span of the nematode, Caenorhabditis elegans, define the age-1 gene
    • Friedman DB, Johnson TE: Three mutants that extend both mean and maximum life span of the nematode, Caenorhabditis elegans, define the age-1 gene. J Gerontol. 1988; 43(4): B102-9.
    • (1988) J Gerontol , vol.43 , Issue.4 , pp. B102-B109
    • Friedman, D.B.1    Johnson, T.E.2
  • 3
    • 1842398374 scopus 로고
    • Genetic analysis of life-span in Caenorhabditis elegans
    • Johnson TE, Wood WB: Genetic analysis of life-span in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 1982; 79(21): 6603-7.
    • (1982) Proc Natl Acad Sci U S A , vol.79 , Issue.21 , pp. 6603-6607
    • Johnson, T.E.1    Wood, W.B.2
  • 4
    • 0029768753 scopus 로고    scopus 로고
    • A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans
    • Morris JZ, Tissenbaum HA, Ruvkun G: A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans. Nature. 1996; 382(6591): 536-9.
    • (1996) Nature , vol.382 , Issue.6591 , pp. 536-539
    • Morris, J.Z.1    Tissenbaum, H.A.2    Ruvkun, G.3
  • 5
    • 0027771804 scopus 로고
    • A C. elegans mutant that lives twice as long as wild type
    • Kenyon C, Chang J, Gensch E, et al.: A C. elegans mutant that lives twice as long as wild type. Nature. 1993; 366(6454): 461-4.
    • (1993) Nature , vol.366 , Issue.6454 , pp. 461-464
    • Kenyon, C.1    Chang, J.2    Gensch, E.3
  • 6
    • 77950200010 scopus 로고    scopus 로고
    • The genetics of ageing
    • Kenyon CJ: The genetics of ageing. Nature. 2010; 464(7288): 504-12.
    • (2010) Nature , vol.464 , Issue.7288 , pp. 504-512
    • Kenyon, C.J.1
  • 7
    • 0035815414 scopus 로고    scopus 로고
    • Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein
    • Clancy DJ, Gems D, Harshman LG, et al.: Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein. Science. 2001; 292(5514): 104-6.
    • (2001) Science , vol.292 , Issue.5514 , pp. 104-106
    • Clancy, D.J.1    Gems, D.2    Harshman, L.G.3
  • 8
    • 0035989388 scopus 로고    scopus 로고
    • Induced overexpression of mitochondrial Mn-superoxide dismutase extends the life span of adult Drosophila melanogaster
    • Sun J, Folk D, Bradley TJ, et al.: Induced overexpression of mitochondrial Mn-superoxide dismutase extends the life span of adult Drosophila melanogaster. Genetics. 2002; 161(2): 661-72.
    • (2002) Genetics , vol.161 , Issue.2 , pp. 661-672
    • Sun, J.1    Folk, D.2    Bradley, T.J.3
  • 9
    • 2342548187 scopus 로고    scopus 로고
    • Effects of simultaneous over-expression of Cu/ZnSOD and MnSOD on Drosophila melanogaster life span
    • Sun J, Molitor J, Tower J: Effects of simultaneous over-expression of Cu/ZnSOD and MnSOD on Drosophila melanogaster life span. Mech Ageing Dev. 2004; 125(5): 341-9.
    • (2004) Mech Ageing Dev , vol.125 , Issue.5 , pp. 341-349
    • Sun, J.1    Molitor, J.2    Tower, J.3
  • 10
    • 0032582489 scopus 로고    scopus 로고
    • Extended life-span and stress resistance in the Drosophila mutant methuselah
    • Lin YJ, Seroude L, Benzer S: Extended life-span and stress resistance in the Drosophila mutant methuselah. Science. 1998; 282(5390): 943-6.
    • (1998) Science , vol.282 , Issue.5390 , pp. 943-946
    • Lin, Y.J.1    Seroude, L.2    Benzer, S.3
  • 11
    • 72649091698 scopus 로고    scopus 로고
    • Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster
    • Bjedov I, Toivonen JM, Kerr F, et al.: Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster. Cell Metab. 2010; 11(1): 35-46.
    • (2010) Cell Metab , vol.11 , Issue.1 , pp. 35-46
    • Bjedov, I.1    Toivonen, J.M.2    Kerr, F.3
  • 12
    • 79954628932 scopus 로고    scopus 로고
    • Ageing in Drosophila: the role of the insulin/Igf and TOR signalling network
    • Partridge L, Alic N, Bjedov I, et al.: Ageing in Drosophila: the role of the insulin/Igf and TOR signalling network. Exp Gerontol. 2011; 46(5): 376-81.
    • (2011) Exp Gerontol , vol.46 , Issue.5 , pp. 376-381
    • Partridge, L.1    Alic, N.2    Bjedov, I.3
  • 13
    • 84901836433 scopus 로고    scopus 로고
    • Studying aging in Drosophila
    • He Y, Jasper H: Studying aging in Drosophila. Methods. 2014; 68(1): 129-33.
    • (2014) Methods , vol.68 , Issue.1 , pp. 129-133
    • He, Y.1    Jasper, H.2
  • 14
    • 84971632052 scopus 로고    scopus 로고
    • Genetic manipulation of cardiac ageing
    • Cannon L, Bodmer R: Genetic manipulation of cardiac ageing. J Physiol. 2016; 594(8): 2075-83.
    • (2016) J Physiol , vol.594 , Issue.8 , pp. 2075-2083
    • Cannon, L.1    Bodmer, R.2
  • 15
    • 0028220114 scopus 로고
    • Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster
    • Orr WC, Sohal RS: Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster. Science. 1994; 263(5150): 1128-30.
    • (1994) Science , vol.263 , Issue.5150 , pp. 1128-1130
    • Orr, W.C.1    Sohal, R.S.2
  • 16
    • 79251483158 scopus 로고    scopus 로고
    • Mammalian models of extended healthy lifespan
    • Selman C, Withers DJ: Mammalian models of extended healthy lifespan. Philos Trans R Soc Lond B Biol Sci. 2011; 366(1561): 99-107.
    • (2011) Philos Trans R Soc Lond B Biol Sci , vol.366 , Issue.1561 , pp. 99-107
    • Selman, C.1    Withers, D.J.2
  • 17
    • 67651163661 scopus 로고    scopus 로고
    • Lifespan extension in genetically modified mice
    • Ladiges W, Van Remmen H, Strong R, et al.: Lifespan extension in genetically modified mice. Aging Cell. 2009; 8(4): 346-52.
    • (2009) Aging Cell , vol.8 , Issue.4 , pp. 346-352
    • Ladiges, W.1    Van Remmen, H.2    Strong, R.3
  • 18
    • 84910029849 scopus 로고    scopus 로고
    • Geroscience: linking aging to chronic disease
    • Kennedy BK, Berger SL, Brunet A, et al.: Geroscience: linking aging to chronic disease. Cell. 2014; 159(4): 709-13.
    • (2014) Cell , vol.159 , Issue.4 , pp. 709-713
    • Kennedy, B.K.1    Berger, S.L.2    Brunet, A.3
  • 19
    • 84954361691 scopus 로고    scopus 로고
    • Chronic mTOR inhibition in mice with rapamycin alters T, B, myeloid, and innate lymphoid cells and gut flora and prolongs life of immune-deficient mice
    • Hurez V, Dao V, Liu A, et al.: Chronic mTOR inhibition in mice with rapamycin alters T, B, myeloid, and innate lymphoid cells and gut flora and prolongs life of immune-deficient mice. Aging Cell. 2015; 14(6): 945-56.
    • (2015) Aging Cell , vol.14 , Issue.6 , pp. 945-956
    • Hurez, V.1    Dao, V.2    Liu, A.3
  • 20
    • 84875738351 scopus 로고    scopus 로고
    • Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism
    • Cabreiro F, Au C, Leung KY, et al.: Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell. 2013; 153(1): 228-39.
    • (2013) Cell , vol.153 , Issue.1 , pp. 228-239
    • Cabreiro, F.1    Au, C.2    Leung, K.Y.3
  • 21
    • 84930531516 scopus 로고    scopus 로고
    • Lifespan extension and increased resistance to environmental stressors by N-acetyl-L-cysteine in Caenorhabditis elegans
    • Oh SI, Park JK, Park SK: Lifespan extension and increased resistance to environmental stressors by N-acetyl-L-cysteine in Caenorhabditis elegans. Clinics (Sao Paulo). 2015; 70(5): 380-6.
    • (2015) Clinics (Sao Paulo) , vol.70 , Issue.5 , pp. 380-386
    • Oh, S.I.1    Park, J.K.2    Park, S.K.3
  • 22
    • 84954374511 scopus 로고    scopus 로고
    • Atypical antidepressants extend lifespan of Caenorhabditis elegans by activation of a non-cell-autonomous stress response
    • Rangaraju S, Solis GM, Andersson SI, et al.: Atypical antidepressants extend lifespan of Caenorhabditis elegans by activation of a non-cell-autonomous stress response. Aging Cell. 2015; 14(6): 971-81.
    • (2015) Aging Cell , vol.14 , Issue.6 , pp. 971-981
    • Rangaraju, S.1    Solis, G.M.2    Andersson, S.I.3
  • 23
    • 84923570725 scopus 로고    scopus 로고
    • Pharmacological classes that extend lifespan of Caenorhabditis elegans
    • Carretero M, Gomez-Amaro RL, Petrascheck M: Pharmacological classes that extend lifespan of Caenorhabditis elegans. Front Genet. 2015; 6: 77.
    • (2015) Front Genet , vol.6 , pp. 77
    • Carretero, M.1    Gomez-Amaro, R.L.2    Petrascheck, M.3
  • 24
    • 84875910045 scopus 로고    scopus 로고
    • Pharmacological lifespan extension of invertebrates
    • Lucanic M, Lithgow GJ, Alavez S: Pharmacological lifespan extension of invertebrates. Ageing Res Rev. 2013; 12(1): 445-58.
    • (2013) Ageing Res Rev , vol.12 , Issue.1 , pp. 445-458
    • Lucanic, M.1    Lithgow, G.J.2    Alavez, S.3
  • 25
    • 84881247539 scopus 로고    scopus 로고
    • Rapamycin extends murine lifespan but has limited effects on aging
    • Neff F, Flores-Dominguez D, Ryan DP, et al.: Rapamycin extends murine lifespan but has limited effects on aging. J Clin Invest. 2013; 123(8): 3272-91.
    • (2013) J Clin Invest , vol.123 , Issue.8 , pp. 3272-3291
    • Neff, F.1    Flores-Dominguez, D.2    Ryan, D.P.3
  • 26
    • 84883785478 scopus 로고    scopus 로고
    • Late-life rapamycin treatment reverses age-related heart dysfunction
    • Flynn JM, O'Leary MN, Zambataro CA, et al.: Late-life rapamycin treatment reverses age-related heart dysfunction. Aging Cell. 2013; 12(5): 851-62.
    • (2013) Aging Cell , vol.12 , Issue.5 , pp. 851-862
    • Flynn, J.M.1    O'Leary, M.N.2    Zambataro, C.A.3
  • 27
    • 84901431879 scopus 로고    scopus 로고
    • Altered proteome turnover and remodeling by short-term caloric restriction or rapamycin rejuvenate the aging heart
    • Dai DF, Karunadharma PP, Chiao YA, et al.: Altered proteome turnover and remodeling by short-term caloric restriction or rapamycin rejuvenate the aging heart. Aging Cell. 2014; 13(3): 529-39.
    • (2014) Aging Cell , vol.13 , Issue.3 , pp. 529-539
    • Dai, D.F.1    Karunadharma, P.P.2    Chiao, Y.A.3
  • 29
    • 12244261636 scopus 로고    scopus 로고
    • Anticonvulsant medications extend worm life-span
    • Evason K, Huang C, Yamben I, et al.: Anticonvulsant medications extend worm life-span. Science. 2005; 307(5707): 258-62.
    • (2005) Science , vol.307 , Issue.5707 , pp. 258-262
    • Evason, K.1    Huang, C.2    Yamben, I.3
  • 31
    • 84940101423 scopus 로고    scopus 로고
    • The aging-disease false dichotomy: understanding senescence as pathology
    • Gems D: The aging-disease false dichotomy: understanding senescence as pathology. Front Genet. 2015; 6: 212.
    • (2015) Front Genet , vol.6 , pp. 212
    • Gems, D.1
  • 32
    • 38949145803 scopus 로고    scopus 로고
    • A systematic look at an old problem
    • Kirkwood TB: A systematic look at an old problem. Nature. 2008; 451(7179): 644-7.
    • (2008) Nature , vol.451 , Issue.7179 , pp. 644-647
    • Kirkwood, T.B.1
  • 34
    • 50649085536 scopus 로고    scopus 로고
    • Toward a control theory analysis of aging
    • Murphy MP, Partridge L: Toward a control theory analysis of aging. Annu Rev Biochem. 2008; 77: 777-98.
    • (2008) Annu Rev Biochem , vol.77 , pp. 777-798
    • Murphy, M.P.1    Partridge, L.2
  • 35
    • 21544483766 scopus 로고    scopus 로고
    • Elevated aortic pulse wave velocity, a marker of arterial stiffness, predicts cardiovascular events in wellfunctioning older adults
    • Sutton-Tyrrell K, Najjar SS, Boudreau RM, et al.: Elevated aortic pulse wave velocity, a marker of arterial stiffness, predicts cardiovascular events in wellfunctioning older adults. Circulation. 2005; 111(25): 3384-90.
    • (2005) Circulation , vol.111 , Issue.25 , pp. 3384-3390
    • Sutton-Tyrrell, K.1    Najjar, S.S.2    Boudreau, R.M.3
  • 36
    • 73949113190 scopus 로고    scopus 로고
    • Physical performance and subsequent disability and survival in older adults with malignancy: results from the health, aging and body composition study
    • Klepin HD, Geiger AM, Tooze JA, et al.: Physical performance and subsequent disability and survival in older adults with malignancy: results from the health, aging and body composition study. J Am Geriatr Soc. 2010; 58(1): 76-82.
    • (2010) J Am Geriatr Soc , vol.58 , Issue.1 , pp. 76-82
    • Klepin, H.D.1    Geiger, A.M.2    Tooze, J.A.3
  • 37
    • 78049503674 scopus 로고    scopus 로고
    • Fat infiltration of muscle, diabetes, and clinical fracture risk in older adults
    • Schafer AL, Vittinghoff E, Lang TF, et al.: Fat infiltration of muscle, diabetes, and clinical fracture risk in older adults. J Clin Endocrinol Metab. 2010; 95(11): E368-72.
    • (2010) J Clin Endocrinol Metab , vol.95 , Issue.11 , pp. E368-E372
    • Schafer, A.L.1    Vittinghoff, E.2    Lang, T.F.3
  • 38
    • 84857914911 scopus 로고    scopus 로고
    • Pulse wave velocity is associated with muscle mass decline: Health ABC study
    • Abbatecola AM, Chiodini P, Gallo C, et al.: Pulse wave velocity is associated with muscle mass decline: Health ABC study. Age (Dordr). 2012; 34(2): 469-78.
    • (2012) Age (Dordr) , vol.34 , Issue.2 , pp. 469-478
    • Abbatecola, A.M.1    Chiodini, P.2    Gallo, C.3
  • 39
    • 84863011636 scopus 로고    scopus 로고
    • Muscle strength, mass, and quality in older men and women with knee osteoarthritis
    • Conroy MB, Kwoh CK, Krishnan E, et al.: Muscle strength, mass, and quality in older men and women with knee osteoarthritis. Arthritis Care Res (Hoboken). 2012; 64(1): 15-21.
    • (2012) Arthritis Care Res (Hoboken) , vol.64 , Issue.1 , pp. 15-21
    • Conroy, M.B.1    Kwoh, C.K.2    Krishnan, E.3
  • 40
    • 84907220247 scopus 로고    scopus 로고
    • Association of urinary injury biomarkers with mortality and cardiovascular events
    • Sarnak MJ, Katz R, Newman A, et al.: Association of urinary injury biomarkers with mortality and cardiovascular events. J Am Soc Nephrol. 2014; 25(7): 1545-53.
    • (2014) J Am Soc Nephrol , vol.25 , Issue.7 , pp. 1545-1553
    • Sarnak, M.J.1    Katz, R.2    Newman, A.3
  • 41
    • 84903975477 scopus 로고    scopus 로고
    • Association between cerebellar gray matter volumes, gait speed, and information-processing ability in older adults enrolled in the Health ABC study
    • Nadkarni NK, Nunley KA, Aizenstein H, et al.: Association between cerebellar gray matter volumes, gait speed, and information-processing ability in older adults enrolled in the Health ABC study. J Gerontol A Biol Sci Med Sci. 2014; 69(8): 996-1003.
    • (2014) J Gerontol A Biol Sci Med Sci , vol.69 , Issue.8 , pp. 996-1003
    • Nadkarni, N.K.1    Nunley, K.A.2    Aizenstein, H.3
  • 42
    • 79952740412 scopus 로고    scopus 로고
    • Age trajectories of physiological indices in relation to healthy life course
    • Arbeev KG, Ukraintseva SV, Akushevich I, et al.: Age trajectories of physiological indices in relation to healthy life course. Mech Ageing Dev. 2011; 132(3): 93-102.
    • (2011) Mech Ageing Dev , vol.132 , Issue.3 , pp. 93-102
    • Arbeev, K.G.1    Ukraintseva, S.V.2    Akushevich, I.3
  • 43
    • 84875196441 scopus 로고    scopus 로고
    • Trajectories of gait speed predict mortality in well-functioning older adults: the Health, Aging and Body Composition study
    • White DK, Neogi T, Nevitt MC, et al.: Trajectories of gait speed predict mortality in well-functioning older adults: the Health, Aging and Body Composition study. J Gerontol A Biol Sci Med Sci. 2013; 68(4): 456-64.
    • (2013) J Gerontol A Biol Sci Med Sci , vol.68 , Issue.4 , pp. 456-464
    • White, D.K.1    Neogi, T.2    Nevitt, M.C.3
  • 46
    • 35748937319 scopus 로고    scopus 로고
    • Improvement in usual gait speed predicts better survival in older adults
    • Hardy SE, Perera S, Roumani YF, et al.: Improvement in usual gait speed predicts better survival in older adults. J Am Geriatr Soc. 2007; 55(11): 1727-34.
    • (2007) J Am Geriatr Soc , vol.55 , Issue.11 , pp. 1727-1734
    • Hardy, S.E.1    Perera, S.2    Roumani, Y.F.3
  • 47
    • 84960482307 scopus 로고    scopus 로고
    • Gait Speed Predicts Incident Disability: A Pooled Analysis
    • Perera S, Patel KV, Rosano C, et al.: Gait Speed Predicts Incident Disability: A Pooled Analysis. J Gerontol A Biol Sci Med Sci. 2016; 71(1): 63-71.
    • (2016) J Gerontol A Biol Sci Med Sci , vol.71 , Issue.1 , pp. 63-71
    • Perera, S.1    Patel, K.V.2    Rosano, C.3
  • 48
    • 84947290768 scopus 로고    scopus 로고
    • Longitudinal Study of Changes in Daily Activity Rhythms over the Lifespan in Individual Male and Female C57BL/6J Mice
    • Stowie AC, Glass JD: Longitudinal Study of Changes in Daily Activity Rhythms over the Lifespan in Individual Male and Female C57BL/6J Mice. J Biol Rhythms. 2015; 30(6): 563-8.
    • (2015) J Biol Rhythms , vol.30 , Issue.6 , pp. 563-568
    • Stowie, A.C.1    Glass, J.D.2
  • 49
    • 0017838157 scopus 로고
    • Age dependent changes in the behavior of Caenorhabditis elegans on attraction to Escherichia coli
    • Hosono R: Age dependent changes in the behavior of Caenorhabditis elegans on attraction to Escherichia coli. Exp Gerontol. 1978; 13(1-2): 31-6.
    • (1978) Exp Gerontol , vol.13 , Issue.1-2 , pp. 31-36
    • Hosono, R.1
  • 50
    • 0018855590 scopus 로고
    • Age-dependent changes in mobility and separation of the nematode Caenorhabditis elegans
    • Hosono R, Sato Y, Aizawa SI, et al.: Age-dependent changes in mobility and separation of the nematode Caenorhabditis elegans. Exp Gerontol. 1980; 15(4): 285-9.
    • (1980) Exp Gerontol , vol.15 , Issue.4 , pp. 285-289
    • Hosono, R.1    Sato, Y.2    Aizawa, S.I.3
  • 51
    • 0019949378 scopus 로고
    • Life span of the wild and mutant nematode Caenorhabditis elegans. Effects of sex, sterilization, and temperature
    • Hosono R, Mitsui Y, Sato Y, et al.: Life span of the wild and mutant nematode Caenorhabditis elegans. Effects of sex, sterilization, and temperature. Exp Gerontol. 1982; 17(2): 163-72.
    • (1982) Exp Gerontol , vol.17 , Issue.2 , pp. 163-172
    • Hosono, R.1    Mitsui, Y.2    Sato, Y.3
  • 52
    • 77953203256 scopus 로고    scopus 로고
    • Age-related behavioral changes in Drosophila
    • Iliadi KG, Boulianne GL: Age-related behavioral changes in Drosophila. Ann N Y Acad Sci. 2010; 1197: 9-18.
    • (2010) Ann N Y Acad Sci , vol.1197 , pp. 9-18
    • Iliadi, K.G.1    Boulianne, G.L.2
  • 53
    • 0037167855 scopus 로고    scopus 로고
    • Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans
    • Herndon LA, Schmeissner PJ, Dudaronek JM, et al.: Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans. Nature. 2002; 419(6909): 808-14.
    • (2002) Nature , vol.419 , Issue.6909 , pp. 808-814
    • Herndon, L.A.1    Schmeissner, P.J.2    Dudaronek, J.M.3
  • 54
    • 67650483333 scopus 로고    scopus 로고
    • Identification by machine vision of the rate of motor activity decline as a lifespan predictor in C. elegans
    • Hsu AL, Feng Z, Hsieh MY, et al.: Identification by machine vision of the rate of motor activity decline as a lifespan predictor in C. elegans. Neurobiol Aging. 2009; 30(9): 1498-503.
    • (2009) Neurobiol Aging , vol.30 , Issue.9 , pp. 1498-1503
    • Hsu, A.L.1    Feng, Z.2    Hsieh, M.Y.3
  • 55
    • 84864050465 scopus 로고    scopus 로고
    • Using GFP video to track 3D movement and conditional gene expression in free-moving flies
    • Ardekani R, Huang YM, Sancheti P, et al.: Using GFP video to track 3D movement and conditional gene expression in free-moving flies. PLoS One. 2012; 7(7): e40506.
    • (2012) PLoS One , vol.7 , Issue.7
    • Ardekani, R.1    Huang, Y.M.2    Sancheti, P.3
  • 56
    • 84871317479 scopus 로고    scopus 로고
    • Three-dimensional tracking and behaviour monitoring of multiple fruit flies
    • Ardekani R, Biyani A, Dalton JE, et al.: Three-dimensional tracking and behaviour monitoring of multiple fruit flies. J R Soc Interface. 2013; 10(78): 20120547.
    • (2013) J R Soc Interface , vol.10 , Issue.78
    • Ardekani, R.1    Biyani, A.2    Dalton, J.E.3
  • 57
    • 84878883772 scopus 로고    scopus 로고
    • Assessing senescence in Drosophila using video tracking
    • Ardekani R, Tavaré S, Tower J: Assessing senescence in Drosophila using video tracking. Methods Mol Biol. 2013; 965: 501-16.
    • (2013) Methods Mol Biol , vol.965 , pp. 501-516
    • Ardekani, R.1    Tavaré, S.2    Tower, J.3
  • 58
    • 56849121888 scopus 로고    scopus 로고
    • Age-related behaviors have distinct transcriptional profiles in Caenorhabditis elegans
    • Golden TR, Hubbard A, Dando C, et al.: Age-related behaviors have distinct transcriptional profiles in Caenorhabditis elegans. Aging Cell. 2008; 7(6): 850-65.
    • (2008) Aging Cell , vol.7 , Issue.6 , pp. 850-865
    • Golden, T.R.1    Hubbard, A.2    Dando, C.3
  • 59
    • 84922385920 scopus 로고    scopus 로고
    • Uncoupling lifespan and healthspan in Caenorhabditis elegans longevity mutants
    • Bansal A, Zhu LJ, Yen K, et al.: Uncoupling lifespan and healthspan in Caenorhabditis elegans longevity mutants. Proc Natl Acad Sci U S A. 2015; 112(3): E277-86.
    • (2015) Proc Natl Acad Sci U S A , vol.112 , Issue.3 , pp. E277-E286
    • Bansal, A.1    Zhu, L.J.2    Yen, K.3
  • 60
    • 84947805936 scopus 로고    scopus 로고
    • C. elegans maximum velocity correlates with healthspan and is maintained in worms with an insulin receptor mutation
    • Hahm JH, Kim S, DiLoreto R, et al.: C. elegans maximum velocity correlates with healthspan and is maintained in worms with an insulin receptor mutation. Nat Commun. 2015; 6: 8919.
    • (2015) Nat Commun , vol.6 , pp. 8919
    • Hahm, J.H.1    Kim, S.2    DiLoreto, R.3
  • 61
    • 84907857762 scopus 로고    scopus 로고
    • Translational geroscience: emphasizing function to achieve optimal longevity
    • Seals DR, Melov S: Translational geroscience: emphasizing function to achieve optimal longevity. Aging (Albany NY). 2014; 6(9): 718-30.
    • (2014) Aging (Albany NY) , vol.6 , Issue.9 , pp. 718-730
    • Seals, D.R.1    Melov, S.2
  • 62
    • 84964890856 scopus 로고    scopus 로고
    • Measures of Healthspan as Indices of Aging in Mice-A Recommendation
    • Richardson A, Fischer KE, Speakman JR, et al.: Measures of Healthspan as Indices of Aging in Mice-A Recommendation. J Gerontol A Biol Sci Med Sci. 2016; 71(4): 427-30.
    • (2016) J Gerontol A Biol Sci Med Sci , vol.71 , Issue.4 , pp. 427-430
    • Richardson, A.1    Fischer, K.E.2    Speakman, J.R.3
  • 63
    • 80053946722 scopus 로고    scopus 로고
    • High-Throughput Microfluidic Sorting of C. elegans for Automated Force Pattern Measurement
    • Johari S, Nock V, Alkaisi MM, et al.: High-Throughput Microfluidic Sorting of C. elegans for Automated Force Pattern Measurement. MSF. 2012; 700: 182-7.
    • (2012) MSF , vol.700 , pp. 182-187
    • Johari, S.1    Nock, V.2    Alkaisi, M.M.3
  • 64
    • 80052099749 scopus 로고    scopus 로고
    • High-throughput age synchronisation of Caenorhabditis elegans
    • Casadevalli Solvas X, Geier FM, Leroi AM, et al.: High-throughput age synchronisation of Caenorhabditis elegans. Chem Commun (Camb). 2011; 47(35): 9801-3.
    • (2011) Chem Commun (Camb) , vol.47 , Issue.35 , pp. 9801-9803
    • Casadevalli Solvas, X.1    Geier, F.M.2    Leroi, A.M.3
  • 65
    • 84935027170 scopus 로고    scopus 로고
    • High-throughput, motility-based sorter for microswimmers such as C. elegans
    • Yuan J, Zhou J, Raizen DM, et al.: High-throughput, motility-based sorter for microswimmers such as C. elegans. Lab Chip. 2015; 15(13): 2790-8.
    • (2015) Lab Chip , vol.15 , Issue.13 , pp. 2790-2798
    • Yuan, J.1    Zhou, J.2    Raizen, D.M.3
  • 66
    • 79954472118 scopus 로고    scopus 로고
    • Recording lifetime behavior and movement in an invertebrate model
    • Zou S, Liedo P, Altamirano-Robles L, et al.: Recording lifetime behavior and movement in an invertebrate model. PLoS One. 2011; 6(4): e18151.
    • (2011) PLoS One , vol.6 , Issue.4
    • Zou, S.1    Liedo, P.2    Altamirano-Robles, L.3
  • 67
    • 84863731234 scopus 로고    scopus 로고
    • Endurance training protocol and longitudinal performance assays for Drosophila melanogaster
    • Tinkerhess MJ, Ginzberg S, Piazza N, et al.: Endurance training protocol and longitudinal performance assays for Drosophila melanogaster. J Vis Exp. 2012; (61): pii: 3786.
    • (2012) J Vis Exp , Issue.61
    • Tinkerhess, M.J.1    Ginzberg, S.2    Piazza, N.3
  • 68
    • 0030913370 scopus 로고    scopus 로고
    • Functional and metabolic consequences of sarcopenia
    • Evans W: Functional and metabolic consequences of sarcopenia. J Nutr. 1997; 127(5 Suppl): 998S-1003S.
    • (1997) J Nutr , vol.127 , Issue.5 , pp. 998S-1003S
    • Evans, W.1
  • 69
    • 84875667419 scopus 로고    scopus 로고
    • The decline in skeletal muscle mass with aging is mainly attributed to a reduction in type II muscle fiber size
    • Nilwik R, Snijders T, Leenders M, et al.: The decline in skeletal muscle mass with aging is mainly attributed to a reduction in type II muscle fiber size. Exp Gerontol. 2013; 48(5): 492-8.
    • (2013) Exp Gerontol , vol.48 , Issue.5 , pp. 492-498
    • Nilwik, R.1    Snijders, T.2    Leenders, M.3
  • 70
    • 84925440420 scopus 로고    scopus 로고
    • Developing consensus criteria for sarcopenia: an update
    • McLean RR, Kiel DP: Developing consensus criteria for sarcopenia: an update. J Bone Miner Res. 2015; 30(4): 588-92.
    • (2015) J Bone Miner Res , vol.30 , Issue.4 , pp. 588-592
    • McLean, R.R.1    Kiel, D.P.2
  • 71
    • 80955178805 scopus 로고    scopus 로고
    • Loss of intestinal nuclei and intestinal integrity in aging C. elegans
    • McGee MD, Weber D, Day N, et al.: Loss of intestinal nuclei and intestinal integrity in aging C. elegans. Aging Cell. 2011; 10(4): 699-710.
    • (2011) Aging Cell , vol.10 , Issue.4 , pp. 699-710
    • McGee, M.D.1    Weber, D.2    Day, N.3
  • 72
    • 33947417262 scopus 로고    scopus 로고
    • Dramatic age-related changes in nuclear and genome copy number in the nematode Caenorhabditis elegans
    • Golden TR, Beckman KB, Lee AH, et al.: Dramatic age-related changes in nuclear and genome copy number in the nematode Caenorhabditis elegans. Aging Cell. 2007; 6(2): 179-88.
    • (2007) Aging Cell , vol.6 , Issue.2 , pp. 179-188
    • Golden, T.R.1    Beckman, K.B.2    Lee, A.H.3
  • 73
    • 84863199545 scopus 로고    scopus 로고
    • cep-1/p53-dependent dysplastic pathology of the aging C. elegans gonad
    • McGee MD, Day N, Graham J, et al.: cep-1/p53-dependent dysplastic pathology of the aging C. elegans gonad. Aging (Albany NY). 2012; 4(4): 256-69.
    • (2012) Aging (Albany NY) , vol.4 , Issue.4 , pp. 256-269
    • McGee, M.D.1    Day, N.2    Graham, J.3
  • 74
    • 0036021375 scopus 로고    scopus 로고
    • Genetic analysis of tissue aging in Caenorhabditis elegans: a role for heat-shock factor and bacterial proliferation
    • Garigan D, Hsu AL, Fraser AG, et al.: Genetic analysis of tissue aging in Caenorhabditis elegans: a role for heat-shock factor and bacterial proliferation. Genetics. 2002; 161(3): 1101-12.
    • (2002) Genetics , vol.161 , Issue.3 , pp. 1101-1112
    • Garigan, D.1    Hsu, A.L.2    Fraser, A.G.3
  • 75
    • 84946035099 scopus 로고    scopus 로고
    • Potential Mechanisms for Cancer Resistance in Elephants and Comparative Cellular Response to DNA Damage in Humans
    • Abegglen LM, Caulin AF, Chan A, et al.: Potential Mechanisms for Cancer Resistance in Elephants and Comparative Cellular Response to DNA Damage in Humans. JAMA. 2015; 314(17): 1850-60.
    • (2015) JAMA , vol.314 , Issue.17 , pp. 1850-1860
    • Abegglen, L.M.1    Caulin, A.F.2    Chan, A.3
  • 76
    • 84862900160 scopus 로고    scopus 로고
    • Neurite sprouting and synapse deterioration in the aging Caenorhabditis elegans nervous system
    • Toth ML, Melentijevic I, Shah L, et al.: Neurite sprouting and synapse deterioration in the aging Caenorhabditis elegans nervous system. J Neurosci. 2012; 32(26): 8778-90.
    • (2012) J Neurosci , vol.32 , Issue.26 , pp. 8778-8790
    • Toth, M.L.1    Melentijevic, I.2    Shah, L.3
  • 77
    • 79959654038 scopus 로고    scopus 로고
    • Spontaneous age-related neurite branching in Caenorhabditis elegans
    • Tank EM, Rodgers KE, Kenyon C: Spontaneous age-related neurite branching in Caenorhabditis elegans. J Neurosci. 2011; 31(25): 9279-88.
    • (2011) J Neurosci , vol.31 , Issue.25 , pp. 9279-9288
    • Tank, E.M.1    Rodgers, K.E.2    Kenyon, C.3
  • 78
    • 23844436700 scopus 로고    scopus 로고
    • In vivo spectrofluorimetry reveals endogenous biomarkers that report healthspan and dietary restriction in Caenorhabditis elegans
    • Gerstbrein B, Stamatas G, Kollias N, et al.: In vivo spectrofluorimetry reveals endogenous biomarkers that report healthspan and dietary restriction in Caenorhabditis elegans. Aging Cell. 2005; 4(3): 127-37.
    • (2005) Aging Cell , vol.4 , Issue.3 , pp. 127-137
    • Gerstbrein, B.1    Stamatas, G.2    Kollias, N.3
  • 79
    • 74249099972 scopus 로고    scopus 로고
    • TGF-beta Sma/Mab signaling mutations uncouple reproductive aging from somatic aging
    • Luo S, Shaw WM, Ashraf J, et al.: TGF-beta Sma/Mab signaling mutations uncouple reproductive aging from somatic aging. PLoS Genet. 2009; 5(12): e1000789.
    • (2009) PLoS Genet , vol.5 , Issue.12
    • Luo, S.1    Shaw, W.M.2    Ashraf, J.3
  • 80
    • 84941217644 scopus 로고    scopus 로고
    • Endurance exercise and selective breeding for longevity extend Drosophila healthspan by overlapping mechanisms
    • Sujkowski A, Bazzell B, Carpenter K, et al.: Endurance exercise and selective breeding for longevity extend Drosophila healthspan by overlapping mechanisms. Aging (Albany NY). 2015; 7(8): 535-52.
    • (2015) Aging (Albany NY) , vol.7 , Issue.8 , pp. 535-552
    • Sujkowski, A.1    Bazzell, B.2    Carpenter, K.3
  • 81
    • 79955979408 scopus 로고    scopus 로고
    • Preservation of femoral bone thickness in middle age predicts survival in genetically heterogeneous mice
    • Miller RA, Kreider J, Galecki A, et al.: Preservation of femoral bone thickness in middle age predicts survival in genetically heterogeneous mice. Aging Cell. 2011; 10(3): 383-91.
    • (2011) Aging Cell , vol.10 , Issue.3 , pp. 383-391
    • Miller, R.A.1    Kreider, J.2    Galecki, A.3
  • 82
    • 77951264436 scopus 로고    scopus 로고
    • Cardiac aging in mice and humans: the role of mitochondrial oxidative stress
    • Dai DF, Rabinovitch PS: Cardiac aging in mice and humans: the role of mitochondrial oxidative stress. Trends Cardiovasc Med. 2009; 19(7): 213-20.
    • (2009) Trends Cardiovasc Med , vol.19 , Issue.7 , pp. 213-220
    • Dai, D.F.1    Rabinovitch, P.S.2
  • 83
    • 0032877158 scopus 로고    scopus 로고
    • Exotic mice as models for aging research: polemic and prospectus
    • Miller RA, Austad S, Burke D, et al.: Exotic mice as models for aging research: polemic and prospectus. Neurobiol Aging. 1999; 20(2): 217-31.
    • (1999) Neurobiol Aging , vol.20 , Issue.2 , pp. 217-231
    • Miller, R.A.1    Austad, S.2    Burke, D.3
  • 84
    • 64949198433 scopus 로고    scopus 로고
    • Comparative biology of aging
    • Austad SN: Comparative biology of aging. J Gerontol A Biol Sci Med Sci. 2009; 64(2): 199-201.
    • (2009) J Gerontol A Biol Sci Med Sci , vol.64 , Issue.2 , pp. 199-201
    • Austad, S.N.1
  • 85
    • 80855165387 scopus 로고    scopus 로고
    • Genome sequencing reveals insights into physiology and longevity of the naked mole rat
    • Kim EB, Fang X, Fushan AA, et al.: Genome sequencing reveals insights into physiology and longevity of the naked mole rat. Nature. 2011; 479(7372): 223-7.
    • (2011) Nature , vol.479 , Issue.7372 , pp. 223-227
    • Kim, E.B.1    Fang, X.2    Fushan, A.A.3
  • 86
    • 84864491396 scopus 로고    scopus 로고
    • Murine ultrasound imaging for circumferential strain analyses in the angiotensin II abdominal aortic aneurysm model
    • Favreau JT, Nguyen BT, Gao I, et al.: Murine ultrasound imaging for circumferential strain analyses in the angiotensin II abdominal aortic aneurysm model. J Vasc Surg. 2012; 56(2): 462-9.
    • (2012) J Vasc Surg , vol.56 , Issue.2 , pp. 462-469
    • Favreau, J.T.1    Nguyen, B.T.2    Gao, I.3
  • 87
    • 53049109747 scopus 로고    scopus 로고
    • Compounds that confer thermal stress resistance and extended lifespan
    • Benedetti MG, Foster AL, Vantipalli MC, et al.: Compounds that confer thermal stress resistance and extended lifespan. Exp Gerontol. 2008; 43(10): 882-91.
    • (2008) Exp Gerontol , vol.43 , Issue.10 , pp. 882-891
    • Benedetti, M.G.1    Foster, A.L.2    Vantipalli, M.C.3
  • 88
    • 36049018936 scopus 로고    scopus 로고
    • A carboxyfullerene SOD mimetic improves cognition and extends the lifespan of mice
    • Quick KL, Ali SS, Arch R, et al.: A carboxyfullerene SOD mimetic improves cognition and extends the lifespan of mice. Neurobiol Aging. 2008; 29(1): 117-28.
    • (2008) Neurobiol Aging , vol.29 , Issue.1 , pp. 117-128
    • Quick, K.L.1    Ali, S.S.2    Arch, R.3
  • 89
    • 33644794739 scopus 로고    scopus 로고
    • Regulatory issues in aging pharmacology
    • Hefti FF, Bales R: Regulatory issues in aging pharmacology. Aging Cell. 2006; 5(1): 3-8.
    • (2006) Aging Cell , vol.5 , Issue.1 , pp. 3-8
    • Hefti, F.F.1    Bales, R.2
  • 90
    • 3943071801 scopus 로고    scopus 로고
    • Sirtuin activators mimic caloric restriction and delay ageing in metazoans
    • Wood JG, Rogina B, Lavu S, et al.: Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature. 2004; 430(7000): 686-9.
    • (2004) Nature , vol.430 , Issue.7000 , pp. 686-689
    • Wood, J.G.1    Rogina, B.2    Lavu, S.3
  • 91
    • 84877687210 scopus 로고    scopus 로고
    • Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy
    • Loffredo FS, Steinhauser ML, Jay SM, et al.: Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy. Cell. 2013; 153(4): 828-39.
    • (2013) Cell , vol.153 , Issue.4 , pp. 828-839
    • Loffredo, F.S.1    Steinhauser, M.L.2    Jay, S.M.3
  • 92
    • 84946492396 scopus 로고    scopus 로고
    • GDF11 does not rescue aging-related pathological hypertrophy
    • Smith SC, Zhang X, Zhang X, et al.: GDF11 does not rescue aging-related pathological hypertrophy. Circ Res. 2015; 117(11): 926-32.
    • (2015) Circ Res , vol.117 , Issue.11 , pp. 926-932
    • Smith, S.C.1    Zhang, X.2    Zhang, X.3
  • 93
    • 84900323323 scopus 로고    scopus 로고
    • Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscle
    • Sinha M, Jang YC, Oh J, et al.: Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscle. Science. 2014; 344(6184): 649-52.
    • (2014) Science , vol.344 , Issue.6184 , pp. 649-652
    • Sinha, M.1    Jang, Y.C.2    Oh, J.3
  • 94
    • 84937516271 scopus 로고    scopus 로고
    • GDF11 Increases with Age and Inhibits Skeletal Muscle Regeneration
    • Egerman MA, Cadena SM, Gilbert JA, et al.: GDF11 Increases with Age and Inhibits Skeletal Muscle Regeneration. Cell Metab. 2015; 22(1): 164-74.
    • (2015) Cell Metab , vol.22 , Issue.1 , pp. 164-174
    • Egerman, M.A.1    Cadena, S.M.2    Gilbert, J.A.3
  • 95
    • 79951794971 scopus 로고    scopus 로고
    • Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice
    • Miller RA, Harrison DE, Astle CM, et al.: Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice. J Gerontol A Biol Sci Med Sci. 2011; 66(2): 191-201.
    • (2011) J Gerontol A Biol Sci Med Sci , vol.66 , Issue.2 , pp. 191-201
    • Miller, R.A.1    Harrison, D.E.2    Astle, C.M.3
  • 96
    • 84900338737 scopus 로고    scopus 로고
    • Vascular and neurogenic rejuvenation of the aging mouse brain by young systemic factors
    • Katsimpardi L, Litterman NK, Schein PA, et al.: Vascular and neurogenic rejuvenation of the aging mouse brain by young systemic factors. Science. 2014; 344(6184): 630-4.
    • (2014) Science , vol.344 , Issue.6184 , pp. 630-634
    • Katsimpardi, L.1    Litterman, N.K.2    Schein, P.A.3
  • 97
    • 56749182467 scopus 로고    scopus 로고
    • Design of aging intervention studies: the NIA interventions testing program
    • Nadon NL, Strong R, Miller RA, et al.: Design of aging intervention studies: the NIA interventions testing program. Age (Dordr). 2008; 30(4): 187-99.
    • (2008) Age (Dordr) , vol.30 , Issue.4 , pp. 187-199
    • Nadon, N.L.1    Strong, R.2    Miller, R.A.3
  • 98
    • 84942882207 scopus 로고    scopus 로고
    • A Trial for the ages
    • Hall SS: A Trial for the ages. Science. 2015; 349(6254): 1274-8.
    • (2015) Science , vol.349 , Issue.6254 , pp. 1274-1278
    • Hall, S.S.1
  • 100
    • 77649311383 scopus 로고    scopus 로고
    • Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1
    • Onken B, Driscoll M: Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1. PLoS One. 2010; 5(1): e8758.
    • (2010) PLoS One , vol.5 , Issue.1
    • Onken, B.1    Driscoll, M.2
  • 101
    • 84919756169 scopus 로고    scopus 로고
    • mTOR inhibition improves immune function in the elderly
    • Mannick JB, Del Giudice G, Lattanzi M, et al.: mTOR inhibition improves immune function in the elderly. Sci Transl Med. 2014; 6(268): 268ra179.
    • (2014) Sci Transl Med , vol.6 , Issue.268
    • Mannick, J.B.1    Del Giudice, G.2    Lattanzi, M.3
  • 102
    • 0034284973 scopus 로고    scopus 로고
    • Extension of life-span with superoxide dismutase/catalase mimetics
    • Melov S, Ravenscroft J, Malik S, et al.: Extension of life-span with superoxide dismutase/catalase mimetics. Science. 2000; 289(5484): 1567-9.
    • (2000) Science , vol.289 , Issue.5484 , pp. 1567-1569
    • Melov, S.1    Ravenscroft, J.2    Malik, S.3
  • 103
    • 0037438948 scopus 로고    scopus 로고
    • No increase in lifespan in Caenorhabditis elegans upon treatment with the superoxide dismutase mimetic EUK-8
    • Keaney M, Gems D: No increase in lifespan in Caenorhabditis elegans upon treatment with the superoxide dismutase mimetic EUK-8. Free Radic Biol Med. 2003; 34(2): 277-82.
    • (2003) Free Radic Biol Med , vol.34 , Issue.2 , pp. 277-282
    • Keaney, M.1    Gems, D.2
  • 104
    • 0037154205 scopus 로고    scopus 로고
    • Life extension in Drosophila by feeding a drug
    • Kang HL, Benzer S, Min KT: Life extension in Drosophila by feeding a drug. Proc Natl Acad Sci U S A. 2002; 99(2): 838-43.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , Issue.2 , pp. 838-843
    • Kang, H.L.1    Benzer, S.2    Min, K.T.3
  • 105
    • 33644808212 scopus 로고    scopus 로고
    • Blueberry polyphenols increase lifespan and thermotolerance in Caenorhabditis elegans
    • Wilson MA, Shukitt-Hale B, Kalt W, et al.: Blueberry polyphenols increase lifespan and thermotolerance in Caenorhabditis elegans. Aging Cell. 2006; 5(1): 59-68.
    • (2006) Aging Cell , vol.5 , Issue.1 , pp. 59-68
    • Wilson, M.A.1    Shukitt-Hale, B.2    Kalt, W.3
  • 106
    • 36549006956 scopus 로고    scopus 로고
    • An antidepressant that extends lifespan in adult Caenorhabditis elegans
    • Petrascheck M, Ye X, Buck LB: An antidepressant that extends lifespan in adult Caenorhabditis elegans. Nature. 2007; 450(7169): 553-6.
    • (2007) Nature , vol.450 , Issue.7169 , pp. 553-556
    • Petrascheck, M.1    Ye, X.2    Buck, L.B.3
  • 107
    • 58149178553 scopus 로고    scopus 로고
    • Antidepressants of the serotonin-antagonist type increase body fat and decrease lifespan of adult Caenorhabditis elegans
    • Zarse K, Ristow M: Antidepressants of the serotonin-antagonist type increase body fat and decrease lifespan of adult Caenorhabditis elegans. PLoS One. 2008; 3(12): e4062.
    • (2008) PLoS One , vol.3 , Issue.12
    • Zarse, K.1    Ristow, M.2
  • 108
    • 38049161971 scopus 로고    scopus 로고
    • Pharmacogenetic analysis of lithiuminduced delayed aging in Caenorhabditis elegans
    • McColl G, Killilea DW, Hubbard AE, et al.: Pharmacogenetic analysis of lithiuminduced delayed aging in Caenorhabditis elegans. J Biol Chem. 2008; 283(1): 350-7.
    • (2008) J Biol Chem , vol.283 , Issue.1 , pp. 350-357
    • McColl, G.1    Killilea, D.W.2    Hubbard, A.E.3
  • 109
    • 67650944993 scopus 로고    scopus 로고
    • Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
    • Harrison DE, Strong R, Sharp ZD, et al.: Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature. 2009; 460(7253): 392-5.
    • (2009) Nature , vol.460 , Issue.7253 , pp. 392-395
    • Harrison, D.E.1    Strong, R.2    Sharp, Z.D.3
  • 110
    • 83755165458 scopus 로고    scopus 로고
    • Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice
    • Anisimov VN, Zabezhinski MA, Popovich IG, et al.: Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice. Cell Cycle. 2011; 10(24): 4230-6.
    • (2011) Cell Cycle , vol.10 , Issue.24 , pp. 4230-4236
    • Anisimov, V.N.1    Zabezhinski, M.A.2    Popovich, I.G.3
  • 111
    • 79954571967 scopus 로고    scopus 로고
    • Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan
    • Alavez S, Vantipalli MC, Zucker DJ, et al.: Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan. Nature. 2011; 472(7342): 226-9.
    • (2011) Nature , vol.472 , Issue.7342 , pp. 226-229
    • Alavez, S.1    Vantipalli, M.C.2    Zucker, D.J.3
  • 112
    • 80052102573 scopus 로고    scopus 로고
    • Pharmacological inhibition of NF-κB prolongs lifespan of Drosophila melanogaster
    • Moskalev A, Shaposhnikov M: Pharmacological inhibition of NF-κB prolongs lifespan of Drosophila melanogaster. Aging (Albany NY). 2011; 3(4): 391-4.
    • (2011) Aging (Albany NY) , vol.3 , Issue.4 , pp. 391-394
    • Moskalev, A.1    Shaposhnikov, M.2


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