Identification by machine vision of the rate of motor activity decline as a lifespan predictor in C. elegans

Neurobiology of Aging

Volumn 30, Issue 9, 2009, Pages 1498-1503

  Hsu, Ao Lin ^a   Feng, Zhaoyang ^a,b,c   Hsieh, Meng Yin ^a   Xu, X Z Shawn ^a,b  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Aging; Biomarker; C. elegans; Lifespan predictor; Locomotion; Motor activity; Motor deficits

Indexed keywords

BIOLOGICAL MARKER; INSULIN; SOMATOMEDIN C;

AGING; ANIMAL BEHAVIOR; ARTICLE; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; FOOD INTAKE; LIFESPAN; LOCOMOTION; MOTOR ACTIVITY; MOTOR DYSFUNCTION; NONHUMAN; PREDICTION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SIGNAL TRANSDUCTION; STRAIN DIFFERENCE;

AGING; ALGORITHMS; ANIMALS; ARTIFICIAL INTELLIGENCE; BIOLOGICAL MARKERS; CAENORHABDITIS ELEGANS; CALORIC RESTRICTION; EATING; ENERGY METABOLISM; FEEDING BEHAVIOR; INSULIN; INSULIN-LIKE GROWTH FACTOR I; LONGEVITY; MODELS, ANIMAL; MOTOR ACTIVITY; MUTATION; OXIDATIVE STRESS; PATTERN RECOGNITION, AUTOMATED; PREDICTIVE VALUE OF TESTS;

EID: 67650483333     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2007.12.007     Document Type: Article

References (33)

1. Alcedo J., and Kenyon C. Regulation of C. elegans longevity by specific gustatory and olfactory neurons. Neuron 41 1 (2004) 45-55
2. Altun M., Bergman E., Edstrom E., Johnson H., and Ulfhake B. Behavioral impairments of the aging rat. Physiol. Behav. (2007)
3. Apfeld J., and Kenyon C. Cell nonautonomy of C. elegans daf-2 function in the regulation of diapause and life span. Cell 95 2 (1998) 199-210
4. de Bono M., and Maricq A.V. Neuronal substrates of complex behaviors in C. elegans. Annu. Rev. Neurosci. 28 (2005) 451-501
5. Dillin A., Hsu A.L., Arantes-Oliveira N., Lehrer-Graiwer J., Hsin H., Fraser A.G., Kamath R.S., Ahringer J., and Kenyon C. Rates of behavior and aging specified by mitochondrial function during development. Science 298 5602 (2002) 2398-2401
6. Feng Z., Li W., Ward A., Piggott B.J., Larkspur E., Sternberg P.W., and Xu X.Z.S. A C. elegans model of nicotine-dependent behavior: regulation by TRP family channels. Cell 127 3 (2006) 621-633
7. Finch C.E., and Ruvkun G. The genetics of aging. Annu. Rev. Genomics Hum. Genet. 2 (2001) 435-462
8. Garsin D.A., Villanueva J.M., Begun J., Kim D.H., Sifri C.D., Calderwood S.B., Ruvkun G., and Ausubel F.M. Long-lived C. elegans daf-2 mutants are resistant to bacterial pathogens. Science 300 5627 (2003) 1921
9. Glenn C.F., Chow D.K., David L., Cooke C.A., Gami M.S., Iser W.B., Hanselman K.B., Goldberg I.G., and Wolkow C.A. Behavioral deficits during early stages of aging in Caenorhabditis elegans result from locomotory deficits possibly linked to muscle frailty. J. Gerontol. 59 12 (2004) 1251-1260
10. Guarente L., and Kenyon C. Genetic pathways that regulate ageing in model organisms. Nature 408 6809 (2000) 255-262
11. Hansen M., Hsu A.L., Dillin A., and Kenyon C. New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen. PLoS Genet. 1 1 (2005) 119-128
12. Herndon L.A., Schmeissner P.J., Dudaronek J.M., Brown P.A., Listner K.M., Sakano Y., Paupard M.C., Hall D.H., and Driscoll M. Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans. Nature 419 6909 (2002) 808-814
13. Hosono R., Sato Y., Aizawa S.I., and Mitsui Y. Age-dependent changes in mobility and separation of the nematode Caenorhabditis elegans. Exp. Gerontol. 15 4 (1980) 285-289
14. Huang C., Xiong C., and Kornfeld K. Measurements of age-related changes of physiological processes that predict lifespan of Caenorhabditis elegans. Proc. Natl. Acad. Sci. U.S.A. 101 21 (2004) 8084-8089
15. Ingram D.K., Chefer S., Matochik J., Moscrip T.D., Weed J., Roth G.S., London E.D., and Lane M.A. Aging and caloric restriction in nonhuman primates: behavioral and in vivo brain imaging studies. Ann. NY Acad. Sci. 928 (2001) 316-326
16. Johnson T.E. Aging can be genetically dissected into component processes using long-lived lines of Caenorhabditis elegans. Proc. Natl. Acad. Sci. U.S.A. 84 11 (1987) 3777-3781
17. Johnson T.E. Recent results: biomarkers of aging. Exp. Gerontol. 41 12 (2006) 1243-1246
18. Johnson T.E., Conley W.L., and Keller M.L. Long-lived lines of Caenorhabditis elegans can be used to establish predictive biomarkers of aging. Exp. Gerontol. 23 4-5 (1988) 281-295
19. Kenyon C. The plasticity of aging: insights from long-lived mutants. Cell 120 4 (2005) 449-460
20. Kenyon C., Chang J., Gensch E., Rudner A., and Tabtiang R. A C. elegans mutant that lives twice as long as wild type. Nature 366 6454 (1993) 461-464
21. Kimura K.D., Tissenbaum H.A., Liu Y., and Ruvkun G. daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science 277 5328 (1997) 942-946
22. Lakowski B., and Hekimi S. The genetics of caloric restriction in Caenorhabditis elegans. Proc. Natl. Acad. Sci. U.S.A. 95 22 (1998) 13091-13096
23. Lee G.D., Wilson M.A., Zhu M., Wolkow C.A., de Cabo R., Ingram D.K., and Zou S. Dietary deprivation extends lifespan in Caenorhabditis elegans. Aging cell 5 6 (2006) 515-524
24. Li W., Feng Z., Sternberg P.W., and Xu X.Z.S. A C. elegans stretch receptor neuron revealed by a mechanosensitive TRP channel homologue. Nature 440 7084 (2006) 684-687
25. Libina N., Berman J.R., and Kenyon C. Tissue-specific activities of C. elegans daf-16 in the regulation of lifespan. Cell 115 4 (2003) 489-502
26. Lithgow G.J., White T.M., Hinerfeld D.A., and Johnson T.E. Thermotolerance of a long-lived mutant of Caenorhabditis elegans. J. Gerontol. 49 6 (1994) B270-B276
27. Maruyama I.N., and Brenner S. A phorbol ester/diacylglycerol-binding protein encoded by the unc-13 gene of Caenorhabditis elegans. Proc. Natl. Acad. Sci. U.S.A. 88 13 (1991) 5729-5733
28. Pinkston J.M., Garigan D., Hansen M., and Kenyon C. Mutations that increase the life span of C. elegans inhibit tumor growth. Science 313 5789 (2006) 971-975
29. Rea S.L., Wu D., Cypser J.R., Vaupel J.W., and Johnson T.E. A stress-sensitive reporter predicts longevity in isogenic populations of Caenorhabditis elegans. Nat. Genet. 37 8 (2005) 894-898
30. Ridgel A.L., and Ritzmann R.E. Insights into age-related locomotor declines from studies of insects. Ageing Res. Rev. 4 1 (2005) 23-39
31. Scott B.A., Avidan M.S., and Crowder C.M. Regulation of hypoxic death in C. elegans by the insulin/IGF receptor homolog daf-2. Science 296 5577 (2002) 2388-2391
32. Wolkow C.A. Identifying factors that promote functional aging in Caenorhabditis elegans. Exp. Gerontol. 41 10 (2006) 1001-1006
33. Wolkow C.A., Kimura K.D., Lee M.S., and Ruvkun G. Regulation of C. elegans life-span by insulin like signaling in the nervous system. Science 290 5489 (2000) 147-150