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Volumn 70, Issue 5, 2015, Pages 380-386

Lifespan extension and increased resistance to environmental stressors by N-Acetyl-L-Cysteine in Caenorhabditis elegans

Author keywords

C. elegans; Fertility; Lifespan; N acetyl L cysteine; Stress response

Indexed keywords

ACETYLCYSTEINE; ANTIOXIDANT; GREEN FLUORESCENT PROTEIN; TRANSCRIPTION FACTOR;

EID: 84930531516     PISSN: 18075932     EISSN: None     Source Type: Journal    
DOI: 10.6061/clinics/2015(05)13     Document Type: Article
Times cited : (70)

References (50)
  • 1
    • 77049308856 scopus 로고
    • Aging: A theory based on free radical and radiation chemistry
    • Herman D. Aging: a theory based on free radical and radiation chemistry. J Gerontol. 1956;11(3):298-300, http://dx.doi.org/10.1093/geronj/11.3.298.
    • (1956) J Gerontol. , vol.11 , Issue.3 , pp. 298-300
    • Herman, D.1
  • 3
    • 0025004091 scopus 로고
    • Increased life-span of age-1 mutants in Caenorhabditis elegans and lower Gompertz rate of aging
    • Johnson TE. Increased life-span of age-1 mutants in Caenorhabditis elegans and lower Gompertz rate of aging. Science. 1990;249(4971):908-12, http://dx.doi.org/10.1126/science.2392681.
    • (1990) Science. , vol.249 , Issue.4971 , pp. 908-912
    • Johnson, T.E.1
  • 4
    • 77956958964 scopus 로고    scopus 로고
    • Expression changes in DNA repair enzymes and mitochondrial DNA damage in aging rat lens
    • Zhang Y, Zhang L, Zhang L, Bai J, Ge H, Liu P. Expression changes in DNA repair enzymes and mitochondrial DNA damage in aging rat lens. Mol Vis. 2010;16:1754-63.
    • (2010) Mol Vis. , vol.16 , pp. 1754-1763
    • Zhang, Y.1    Zhang, L.2    Zhang, L.3    Bai, J.4    Ge, H.5    Liu, P.6
  • 5
    • 15344350180 scopus 로고    scopus 로고
    • Can oxidative damage be treated nutritionally?
    • Berger MM. Can oxidative damage be treated nutritionally? Clin Nutri. 2005;24(2):172-83, http://dx.doi.org/10.1016/j.clnu.2004.10.003.
    • (2005) Clin Nutri. , vol.24 , Issue.2 , pp. 172-183
    • Berger, M.M.1
  • 6
    • 0035906326 scopus 로고    scopus 로고
    • Role of plant polyphenols in genomic stability
    • Ferguson LR. Role of plant polyphenols in genomic stability. Mutat Res. 2001;475(1-2):89-111, http://dx.doi.org/10.1016/S0027-5107(01)00073-2.
    • (2001) Mutat Res. , vol.475 , Issue.1-2 , pp. 89-111
    • Ferguson, L.R.1
  • 7
    • 0031561513 scopus 로고    scopus 로고
    • Cancer chemopreventive activity of resveratrol, a natural product derived from grapes
    • Jang M, Cai L, Udeani GO, Slowing KV, Thomas CF, Beecher CW, et al. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science. 1997;275(5297):218-20, http://dx.doi.org/10.1126/ science.275.5297.218.
    • (1997) Science. , vol.275 , Issue.5297 , pp. 218-220
    • Jang, M.1    Cai, L.2    Udeani, G.O.3    Slowing, K.V.4    Thomas, C.F.5    Beecher, C.W.6
  • 8
    • 0141719702 scopus 로고    scopus 로고
    • Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
    • Howitz KT, Bitterman KJ, Cohen HY, Lamming DW, Lavu S, Wood JG, et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature. 2003;425(6954):191-6, http://dx.doi.org/10.1038/ nature01960.
    • (2003) Nature. , vol.425 , Issue.6954 , pp. 191-196
    • Howitz, K.T.1    Bitterman, K.J.2    Cohen, H.Y.3    Lamming, D.W.4    Lavu, S.5    Wood, J.G.6
  • 9
    • 3943071801 scopus 로고    scopus 로고
    • Sirtuin activators mimic caloric restriction and delay ageing in metazoans
    • Wood JG, Rogina B, Lavu S, Howitz K, Helfand SL, Tatar M, et al. Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature. 2004;430(7000):686-9, http://dx.doi.org/10.1038/nature02789.
    • (2004) Nature. , vol.430 , Issue.7000 , pp. 686-689
    • Wood, J.G.1    Rogina, B.2    Lavu, S.3    Howitz, K.4    Helfand, S.L.5    Tatar, M.6
  • 10
    • 31944450272 scopus 로고    scopus 로고
    • Resveratrol prolongs lifespan and retards the onset of age-related markers in a short-lived vertebrate
    • Valenzano DR, Terzibasi E, Genade T, Cattaneo A, Domenici L, Cellerino A. Resveratrol prolongs lifespan and retards the onset of age-related markers in a short-lived vertebrate. Curr Biol. 2006;16(3):296-300, http:// dx.doi.org/10.1016/j.cub.2005.12.038.
    • (2006) Curr Biol. , vol.16 , Issue.3 , pp. 296-300
    • Valenzano, D.R.1    Terzibasi, E.2    Genade, T.3    Cattaneo, A.4    Domenici, L.5    Cellerino, A.6
  • 11
    • 27144436412 scopus 로고    scopus 로고
    • Vitamin E at high doses improves survival, neurological performance, and brain mitochondrial function in aging male mice
    • Navarro A, Gomez C, Sanchez-Pino MJ, Gonzalez H, Bandez MJ, Boveris AD, et al. Vitamin E at high doses improves survival, neurological performance, and brain mitochondrial function in aging male mice. Am J Physiol Regul Integr Comp Physiol. 2005;289(5):R1392-9, http://dx.doi. org/10.1152/ajpregu.00834.2004.
    • (2005) Am J Physiol Regul Integr Comp Physiol. , vol.289 , Issue.5 , pp. R1392-R1399
    • Navarro, A.1    Gomez, C.2    Sanchez-Pino, M.J.3    Gonzalez, H.4    Bandez, M.J.5    Boveris, A.D.6
  • 12
    • 44449099204 scopus 로고    scopus 로고
    • alpha- and gamma-Tocopherol prevent age-related transcriptional alterations in the heart and brain of mice
    • Park SK, Page GP, Kim K, Allison DB, Meydani M, Weindruch R, et al. alpha- and gamma-Tocopherol prevent age-related transcriptional alterations in the heart and brain of mice. J Nutr. 2008;138(6):1010-8.
    • (2008) J Nutr. , vol.138 , Issue.6 , pp. 1010-1018
    • Park, S.K.1    Page, G.P.2    Kim, K.3    Allison, D.B.4    Meydani, M.5    Weindruch, R.6
  • 13
    • 3242707646 scopus 로고    scopus 로고
    • Interventions in aging and age-associated pathologies by means of nutritional approaches
    • Kitani K, Yokozawa T, Osawa T. Interventions in aging and age-associated pathologies by means of nutritional approaches. Ann N Y Acad Sci. 2004;1019(1):424-6, http://dx.doi.org/10.1196/annals.1297.075.
    • (2004) Ann N Y Acad Sci. , vol.1019 , Issue.1 , pp. 424-426
    • Kitani, K.1    Yokozawa, T.2    Osawa, T.3
  • 14
    • 84879822072 scopus 로고    scopus 로고
    • Effect of Acanthopanax sessiliflorus Extracts on Stress Response and Aging in Caenorhabditis elegans
    • Kim CK, Park SK. Effect of Acanthopanax sessiliflorus Extracts on Stress Response and Aging in Caenorhabditis elegans. Food Sci Technol Res. 2013;19(3):439-44, http://dx.doi.org/10.3136/fstr.19.439.
    • (2013) Food Sci Technol Res. , vol.19 , Issue.3 , pp. 439-444
    • Kim, C.K.1    Park, S.K.2
  • 15
    • 67651183792 scopus 로고    scopus 로고
    • Gene expression profiling of aging in multiple mouse strains: Identification of aging biomarkers and impact of dietary antioxidants
    • Park SK, Kim K, Page GP, Allison DB, Weindruch R, Prolla TA. Gene expression profiling of aging in multiple mouse strains: identification of aging biomarkers and impact of dietary antioxidants. Aging Cell. 2009;8 (4):484-95, http://dx.doi.org/10.1111/ace.2009.8.issue-4.
    • (2009) Aging Cell. , vol.8 , Issue.4 , pp. 484-495
    • Park, S.K.1    Kim, K.2    Page, G.P.3    Allison, D.B.4    Weindruch, R.5    Prolla, T.A.6
  • 16
    • 84904647648 scopus 로고    scopus 로고
    • Tempol intake improves inflammatory status in aged mice
    • Yamato M, Ishimatsu A, Yamanaka Y, Mine T, Yamada K. Tempol intake improves inflammatory status in aged mice. J Clin Biochem Nutr. 2014;55 (1):11-4, http://dx.doi.org/10.3164/jcbn.14-4.
    • (2014) J Clin Biochem Nutr. , vol.55 , Issue.1 , pp. 11-14
    • Yamato, M.1    Ishimatsu, A.2    Yamanaka, Y.3    Mine, T.4    Yamada, K.5
  • 17
    • 1642588198 scopus 로고    scopus 로고
    • The impact of alpha-lipoic acid, coenzyme Q10 and caloric restriction on life span and gene expression patterns in mice
    • Lee CK, Pugh TD, Klopp RG, Edwards J, Allison DB, Weindruch R, et al. The impact of alpha-lipoic acid, coenzyme Q10 and caloric restriction on life span and gene expression patterns in mice. Free Radic Biol Med. 2004;36 (8):1043-57, http://dx.doi.org/10.1016/j.freeradbiomed.2004.01.015.
    • (2004) Free Radic Biol Med. , vol.36 , Issue.8 , pp. 1043-1057
    • Lee, C.K.1    Pugh, T.D.2    Klopp, R.G.3    Edwards, J.4    Allison, D.B.5    Weindruch, R.6
  • 18
    • 34347370225 scopus 로고    scopus 로고
    • N-acetyl-l-cysteine affords protection against lead-induced cytotoxicity and oxidative stress in human liver carcinoma (HepG2) cells
    • Yedjou CG, Tchounwou PB. N-acetyl-l-cysteine affords protection against lead-induced cytotoxicity and oxidative stress in human liver carcinoma (HepG2) cells. Int J Environ Res Public Health. 2007;4(2):132-7, http://dx. doi.org/10.3390/ijerph2007040007.
    • (2007) Int J Environ Res Public Health. , vol.4 , Issue.2 , pp. 132-137
    • Yedjou, C.G.1    Tchounwou, P.B.2
  • 19
    • 84862732893 scopus 로고    scopus 로고
    • Uranyl acetate induces oxidative stress and mitochondrial membrane potential collapse in the human dermal fibroblast primary cells
    • Daraie B, Pourahmad J, Hamidi-Pour N, Hosseini MJ, Shaki F, Soleimani M. Uranyl acetate induces oxidative stress and mitochondrial membrane potential collapse in the human dermal fibroblast primary cells. Iran J Pharm Res. 2012;11(2):495-501.
    • (2012) Iran J Pharm Res. , vol.11 , Issue.2 , pp. 495-501
    • Daraie, B.1    Pourahmad, J.2    Hamidi-Pour, N.3    Hosseini, M.J.4    Shaki, F.5    Soleimani, M.6
  • 20
    • 0036184893 scopus 로고    scopus 로고
    • Cellular toxicity of cadmium ions and their detoxification by heavy metalspecific plant peptides, phytochelatins, expressed in Mammalian cells
    • Takagi M, Satofuka H, Amano S, Mizuno H, Eguchi Y, Hirata K, et al. Cellular toxicity of cadmium ions and their detoxification by heavy metalspecific plant peptides, phytochelatins, expressed in Mammalian cells. J Biochem. 2002;131(2):233-9, http://dx.doi.org/10.1093/oxfordjournals. jbchem.a003093.
    • (2002) J Biochem. , vol.131 , Issue.2 , pp. 233-239
    • Takagi, M.1    Satofuka, H.2    Amano, S.3    Mizuno, H.4    Eguchi, Y.5    Hirata, K.6
  • 21
    • 0028604430 scopus 로고
    • Thiol supplier N-acetylcysteine enhances conjugate formation between natural killer cells and K562 or U937 targets but increases the lytic function only against the latter
    • Malorni W, D'Ambrosio A, Rainaldi G, Rivabene R, Viora M. Thiol supplier N-acetylcysteine enhances conjugate formation between natural killer cells and K562 or U937 targets but increases the lytic function only against the latter. Immunol Lett. 1994;43(3):209-14, http://dx.doi.org/ 10.1016/0165-2478(94)90225-9.
    • (1994) Immunol Lett. , vol.43 , Issue.3 , pp. 209-214
    • Malorni, W.1    D'Ambrosio, A.2    Rainaldi, G.3    Rivabene, R.4    Viora, M.5
  • 23
    • 0000957062 scopus 로고
    • Asymptotically efficient rank invarient test procedures
    • Peto R, Peto J. Asymptotically efficient rank invarient test procedures. J Royal Stac Soc Ser A. 1972;135(2):185-207, http://dx.doi.org/10.2307/ 2344317.
    • (1972) J Royal Stac Soc Ser A. , vol.135 , Issue.2 , pp. 185-207
    • Peto, R.1    Peto, J.2
  • 24
    • 0031685525 scopus 로고    scopus 로고
    • Two pleiotropic classes of daf-2 mutation affect larval arrest, adult behavior, reproduction and longevity in Caenorhabditis elegans
    • Gems D, Sutton AJ, Sundermeyer ML, Albert PS, King KV, Edgley ML, et al. Two pleiotropic classes of daf-2 mutation affect larval arrest, adult behavior, reproduction and longevity in Caenorhabditis elegans. Genetics. 1998;150(1):129-55.
    • (1998) Genetics. , vol.150 , Issue.1 , pp. 129-155
    • Gems, D.1    Sutton, A.J.2    Sundermeyer, M.L.3    Albert, P.S.4    King, K.V.5    Edgley, M.L.6
  • 25
    • 33847251514 scopus 로고    scopus 로고
    • Genetic and pharmacological factors that influence reproductive aging in nematodes
    • Hughes SE, Evason K, Xiong C, Kornfeld K. Genetic and pharmacological factors that influence reproductive aging in nematodes. PLoS Genet. 2007;3(2):e25, http://dx.doi.org/10.1371/journal.pgen.0030025.
    • (2007) PLoS Genet. , vol.3 , Issue.2
    • Hughes, S.E.1    Evason, K.2    Xiong, C.3    Kornfeld, K.4
  • 26
    • 0028930267 scopus 로고
    • Genes that regulate both development and longevity in Caenorhabditis elegans
    • Larsen PL, Albert PS, Riddle DL. Genes that regulate both development and longevity in Caenorhabditis elegans. Genetics. 1995;139(4):1567-83.
    • (1995) Genetics. , vol.139 , Issue.4 , pp. 1567-1583
    • Larsen, P.L.1    Albert, P.S.2    Riddle, D.L.3
  • 27
    • 23044445756 scopus 로고    scopus 로고
    • A stress-sensitive reporter predicts longevity in isogenic populations of Caenorhabditis elegans
    • Rea SL, Wu D, Cypser JR, Vaupel JW, Johnson TE. A stress-sensitive reporter predicts longevity in isogenic populations of Caenorhabditis elegans. Nat Genet. 2005;37(8):894-8, http://dx.doi.org/10.1038/ng1608.
    • (2005) Nat Genet. , vol.37 , Issue.8 , pp. 894-898
    • Rea, S.L.1    Wu, D.2    Cypser, J.R.3    Vaupel, J.W.4    Johnson, T.E.5
  • 28
    • 79955622698 scopus 로고    scopus 로고
    • Variable pathogenicity determines individual lifespan in Caenorhabditis elegans
    • Sanchez-Blanco A, Kim SK. Variable pathogenicity determines individual lifespan in Caenorhabditis elegans. PLoS Genet. 2011;7(4):e1002047, http://dx.doi.org/10.1371/journal.pgen.1002047.
    • (2011) PLoS Genet. , vol.7 , Issue.4
    • Sanchez-Blanco, A.1    Kim, S.K.2
  • 29
    • 0031916984 scopus 로고    scopus 로고
    • The free radical theory of aging matures
    • Beckman KB, Ames BN. The free radical theory of aging matures. Physiol Rev. 1998;78(2):547-81.
    • (1998) Physiol Rev. , vol.78 , Issue.2 , pp. 547-581
    • Beckman, K.B.1    Ames, B.N.2
  • 30
    • 79958737943 scopus 로고    scopus 로고
    • The interplay between protein L-isoaspartyl methyltransferase activity and insulin-like signaling to extend lifespan in Caenorhabditis elegans
    • Khare S, Linster CL, Clarke SG. The interplay between protein L-isoaspartyl methyltransferase activity and insulin-like signaling to extend lifespan in Caenorhabditis elegans. PloS One. 2011;6(6):e20850, http://dx. doi.org/10.1371/journal.pone.0020850.
    • (2011) PloS One. , vol.6 , Issue.6
    • Khare, S.1    Linster, C.L.2    Clarke, S.G.3
  • 31
    • 84892949233 scopus 로고    scopus 로고
    • Chicoric acid is an antioxidant molecule that stimulates AMP kinase pathway in L6 myotubes and extends lifespan in Caenorhabditis elegans
    • Schlernitzauer A, Oiry C, Hamad R, Galas S, Cortade F, Chabi B, et al. Chicoric acid is an antioxidant molecule that stimulates AMP kinase pathway in L6 myotubes and extends lifespan in Caenorhabditis elegans. PloS One. 2013;8(11):e78788, http://dx.doi.org/10.1371/journal.pone.0078788.
    • (2013) PloS One. , vol.8 , Issue.11
    • Schlernitzauer, A.1    Oiry, C.2    Hamad, R.3    Galas, S.4    Cortade, F.5    Chabi, B.6
  • 32
    • 77649311383 scopus 로고    scopus 로고
    • Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1
    • Onken B, Driscoll M. Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1. PloS One. 2010;5(1):e8758, http://dx.doi.org/ 10.1371/journal.pone.0008758.
    • (2010) PloS One. , vol.5 , Issue.1
    • Onken, B.1    Driscoll, M.2
  • 33
    • 84875468930 scopus 로고    scopus 로고
    • Significant longevity- extending effects of Alpinia zerumbet leaf extract on the life span of Caenorhabditis elegans
    • Upadhyay A, Chompoo J, Taira N, Fukuta M, Tawata S. Significant longevity- extending effects of Alpinia zerumbet leaf extract on the life span of Caenorhabditis elegans. Biosci Biotechnol Biochem. 2013;77(2):217-23.
    • (2013) Biosci Biotechnol Biochem. , vol.77 , Issue.2 , pp. 217-223
    • Upadhyay, A.1    Chompoo, J.2    Taira, N.3    Fukuta, M.4    Tawata, S.5
  • 34
    • 84885101263 scopus 로고    scopus 로고
    • Extension of lifespan and protection against oxidative stress by an antioxidant herb mixture complex (KPG-7) in Caenorhabditis elegans
    • Moriwaki T, Kato S, Kato Y, Hosoki A, Zhang-Akiyama QM. Extension of lifespan and protection against oxidative stress by an antioxidant herb mixture complex (KPG-7) in Caenorhabditis elegans. J Clin Biochem Nutr. 2013;53(2):81-8, http://dx.doi.org/10.3164/jcbn.13-11.
    • (2013) J Clin Biochem Nutr. , vol.53 , Issue.2 , pp. 81-88
    • Moriwaki, T.1    Kato, S.2    Kato, Y.3    Hosoki, A.4    Zhang-Akiyama, Q.M.5
  • 35
    • 0031450129 scopus 로고    scopus 로고
    • N-acetylcysteine slows down ageing and increases the life span of Drosophila melanogaster
    • Brack C, Bechter-Thuring E, Labuhn, M. N-acetylcysteine slows down ageing and increases the life span of Drosophila melanogaster. Cell Mol Life Sci. 1997;53(11-12):960-6.
    • (1997) Cell Mol Life Sci. , vol.53 , Issue.11-12 , pp. 960-966
    • Brack, C.1    Bechter-Thuring, E.2    Labuhn, M.3
  • 36
    • 69949094944 scopus 로고    scopus 로고
    • A method for oral administration of hydrophilic substances to Caenorhabditis elegans: Effects of oral supplementation with antioxidants on the nematode lifespan
    • Shibamura A, Ikeda T, Nishikawa Y. A method for oral administration of hydrophilic substances to Caenorhabditis elegans: Effects of oral supplementation with antioxidants on the nematode lifespan. Mech Ageing Dev. 2009;130(9):652-5, http://dx.doi.org/10.1016/j.mad.2009.06.008.
    • (2009) Mech Ageing Dev. , vol.130 , Issue.9 , pp. 652-655
    • Shibamura, A.1    Ikeda, T.2    Nishikawa, Y.3
  • 38
    • 0035082093 scopus 로고    scopus 로고
    • Longevity and heavy metal resistance in daf-2 and age-1 long-lived mutants of Caenorhabditis elegans
    • Barsyte D, Lovejoy DA, Lithgow GJ. Longevity and heavy metal resistance in daf-2 and age-1 long-lived mutants of Caenorhabditis elegans. FASEB J. 2001;15(3):627-34, http://dx.doi.org/10.1096/fj.99-0966com.
    • (2001) FASEB J. , vol.15 , Issue.3 , pp. 627-634
    • Barsyte, D.1    Lovejoy, D.A.2    Lithgow, G.J.3
  • 39
    • 0036460933 scopus 로고    scopus 로고
    • Life span extensions associated with upregulation of gene expression of antioxidant enzymes in Caenorhabditis elegans; studies of mutation in the age-1, PI3 kinase homologue and short-term exposure to hyperoxia
    • Honda Y, Honda S. Life span extensions associated with upregulation of gene expression of antioxidant enzymes in Caenorhabditis elegans; studies of mutation in the age-1, PI3 kinase homologue and short-term exposure to hyperoxia. J Am Aging Assoc. 2002;25(1):21-8.
    • (2002) J Am Aging Assoc. , vol.25 , Issue.1 , pp. 21-28
    • Honda, Y.1    Honda, S.2
  • 40
    • 0027945612 scopus 로고
    • Thermotolerance of a long-lived mutant of Caenorhabditis elegans
    • Lithgow GJ, White TM, Hinerfeld DA, Johnson TE. Thermotolerance of a long-lived mutant of Caenorhabditis elegans. J Gerontol. 1994;49(6):B270- 6, http://dx.doi.org/10.1093/geronj/49.6.B270.
    • (1994) J Gerontol. , vol.49 , Issue.6 , pp. B270-B276
    • Lithgow, G.J.1    White, T.M.2    Hinerfeld, D.A.3    Johnson, T.E.4
  • 41
    • 0030014296 scopus 로고    scopus 로고
    • A genetic pathway conferring life extension and resistance to UV stress in Caenorhabditis elegans
    • Murakami S, Johnson TE. A genetic pathway conferring life extension and resistance to UV stress in Caenorhabditis elegans. Genetics. 1996;143(3): 1207-18.
    • (1996) Genetics. , vol.143 , Issue.3 , pp. 1207-1218
    • Murakami, S.1    Johnson, T.E.2
  • 42
    • 0029123058 scopus 로고
    • Thermotolerance and extended life-span conferred by single-gene mutations and induced by thermal stress
    • Lithgow GJ, White TM, Melov S, Johnson TE. Thermotolerance and extended life-span conferred by single-gene mutations and induced by thermal stress. Proc Natl Acad Sci U S A. 1995;92(16):7540-4, http://dx. doi.org/10.1073/pnas.92.16.7540.
    • (1995) Proc Natl Acad Sci U S A. , vol.92 , Issue.16 , pp. 7540-7544
    • Lithgow, G.J.1    White, T.M.2    Melov, S.3    Johnson, T.E.4
  • 43
    • 0037127026 scopus 로고    scopus 로고
    • Regulation of life-span by germ-line stem cells in Caenorhabditis elegans
    • Arantes-Oliveira N, Apfeld J, Dillin A, Kenyon C. Regulation of life-span by germ-line stem cells in Caenorhabditis elegans. Science. 2002;295 (5554):502-5, http://dx.doi.org/10.1126/science.1065768.
    • (2002) Science. , vol.295 , Issue.5554 , pp. 502-505
    • Arantes-Oliveira, N.1    Apfeld, J.2    Dillin, A.3    Kenyon, C.4
  • 44
    • 84882774195 scopus 로고    scopus 로고
    • Electrolyzed-reduced water increases resistance to oxidative stress, fertility, and lifespan via insulin/IGF-1-like signal in C. elegans
    • Park SK, Park SK. Electrolyzed-reduced water increases resistance to oxidative stress, fertility, and lifespan via insulin/IGF-1-like signal in C. elegans. Biol Res. 2013;46(2):147-52, http://dx.doi.org/10.4067/S0716- 97602013000200005.
    • (2013) Biol Res. , vol.46 , Issue.2 , pp. 147-152
    • Park, S.K.1    Park, S.K.2
  • 45
    • 84874053244 scopus 로고    scopus 로고
    • Electrolyzed-reduced water confers increased resistance to environmental stresses
    • Park SK, Kim JJ, Yu AR, Lee MY, Park SK. Electrolyzed-reduced water confers increased resistance to environmental stresses. Mol Cell Toxicol. 2012;8(3):241-7, http://dx.doi.org/10.1007/s13273-012-0029-1.
    • (2012) Mol Cell Toxicol. , vol.8 , Issue.3 , pp. 241-247
    • Park, S.K.1    Kim, J.J.2    Yu, A.R.3    Lee, M.Y.4    Park, S.K.5
  • 46
    • 34249750383 scopus 로고    scopus 로고
    • Evidence for a trade-off between survival and fitness caused by resveratrol treatment of Caenorhabditis elegans
    • Gruber J, Tang SY, Halliwell B. Evidence for a trade-off between survival and fitness caused by resveratrol treatment of Caenorhabditis elegans. Ann N Y Acad Sci. 2007;1100(1):530-42, http://dx.doi.org/10.1196/ annals.1395.059.
    • (2007) Ann N Y Acad Sci. , vol.1100 , Issue.1 , pp. 530-542
    • Gruber, J.1    Tang, S.Y.2    Halliwell, B.3
  • 47
    • 33644808212 scopus 로고    scopus 로고
    • Blueberry polyphenols increase lifespan and thermotolerance in Caenorhabditis elegans
    • Wilson MA, Shukitt-Hale B, Kalt W, Ingram DK, Joseph JA, Wolkow CA. Blueberry polyphenols increase lifespan and thermotolerance in Caenorhabditis elegans. Aging cell. 2006;5(1):59-68, http://dx.doi.org/ 10.1111/ace.2006.5.issue-1.
    • (2006) Aging cell. , vol.5 , Issue.1 , pp. 59-68
    • Wilson, M.A.1    Shukitt-Hale, B.2    Kalt, W.3    Ingram, D.K.4    Joseph, J.A.5    Wolkow, C.A.6
  • 48
    • 0017782437 scopus 로고
    • Evolution of ageing
    • Kirkwood TB. Evolution of ageing. Nature. 1977;270(5635):301-4, http:// dx.doi.org/10.1038/270301a0.
    • (1977) Nature. , vol.270 , Issue.5635 , pp. 301-304
    • Kirkwood, T.B.1
  • 49
    • 0033609291 scopus 로고    scopus 로고
    • Signals from the reproductive system regulate the lifespan of C. elegans
    • Hsin H, Kenyon C. Signals from the reproductive system regulate the lifespan of C. elegans. Nature. 1999;399(6734):362-6, http://dx.doi.org/ 10.1038/20694.
    • (1999) Nature. , vol.399 , Issue.6734 , pp. 362-366
    • Hsin, H.1    Kenyon, C.2
  • 50
    • 84880133200 scopus 로고    scopus 로고
    • Predicting longevity in C. elegans: Fertility, mobility and gene expression
    • Cypser JR, Wu D, Park SK, Ishii T, Tedesco PM, Mendenhall AR, et al. Predicting longevity in C. elegans: fertility, mobility and gene expression. Mech Ageing Dev. 2013;134(7-8):291-7, http://dx.doi.org/10.1016/ j.mad.2013.02.003.
    • (2013) Mech Ageing Dev. , vol.134 , Issue.7-8 , pp. 291-297
    • Cypser, J.R.1    Wu, D.2    Park, S.K.3    Ishii, T.4    Tedesco, P.M.5    Mendenhall, A.R.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.