Measures of healthspan as indices of aging in Mice-A recommendation

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 71, Issue 4, 2016, Pages 427-430

  Richardson, Arlan ^a,b   Fischer, Kathleen E ^c   Speakman, John R ^d,e   De Cabo, Rafael ^f   Mitchell, Sarah J ^f   Peterson, Charlotte A ^g   Rabinovitch, Peter ^h   Chiao, Ying A ^h   Taffet, George ⁱ   Miller, Richard A ^j   Rentería, René C ^k,l,m   Bower, James ⁿ   Ingram, Donald K ^h   Ladiges, Warren C ^o   Ikeno, Yuji ^f   Sierra, Felipe ^a   Austad, Steven N ^c  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^d UNIVERSITY OF ABERDEEN   (United Kingdom)

^e INSTITUTE OF GENETICS AND DEVELOPMENTAL BIOLOGY   (China)

^f NATIONAL INSTITUTE ON AGING   (United States)

^g UNIVERSITY OF KENTUCKY   (United States)

^h UNIVERSITY OF WASHINGTON   (United States)

ⁱ BAYLOR COLLEGE OF MEDICINE   (United States)

^j UNIVERSITY OF MICHIGAN   (United States)

^k Department of Ophthalmology ^*  (United States)

^l Care Systems Management and Center for Biomedical Neuroscience   (United States)

^m University of California Santa Cruz   (United States)

ⁿ PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

^o Mays Cancer Center at UT Health San Antonio   (United States)

more..

Author keywords

Age; Healthspan; Lifespan; Physiological function

Indexed keywords

AGING; ANIMAL; ANIMAL MODEL; FEMALE; HUMAN; LONGEVITY; MALE; MOUSE; PHYSIOLOGY; QUALITY OF LIFE; SEX DIFFERENCE; TRANSLATIONAL RESEARCH;

AGING; ANIMALS; FEMALE; HUMANS; LONGEVITY; MALE; MICE; MODELS, ANIMAL; QUALITY OF LIFE; SEX FACTORS; TRANSLATIONAL MEDICAL RESEARCH;

EID: 84964890856     PISSN: 10795006     EISSN: 1758535X     Source Type: Journal    
DOI: 10.1093/gerona/glv080     Document Type: Review

References (20)

1. Austad SN. Sex difference in longevity and aging. In: Masoro EJ, Austad SN, eds. The Handbook of the Biology of Aging. 7th ed. Amsterdam: Elsevier; 2011:479-495.
2. Christopher JL, Murray AJ, Mohammed K, et al. The state of US health, 1990-2010 burden of diseases, injuries, and risk factors JAMA. 2013;310:591-608doi:10.1001/jama.2013.13805.
3. Martin GM. The Werner mutation: does it lead to a "public" or "private" mechanism of aging? Mol Med. 1997;3:356-358.
4. Omodei D, Fontana L. Calorie restriction and prevention of age- Associated chronic disease. FEBS Lett. 2011;585:1537-1542. doi:10.1016/j.febslet.2011.03.015.
5. Speakman JR, Mitchell SE. Caloric restriction. Mol Aspects Med. 2011;32:159-221. doi:10.1016/j.mam.2011.07.001.
6. Clinthorne JF, Beli E, Duriancik DM, Gardner EM. NK cell maturation and function in C57BL/6 mice are altered by caloric restriction. J Immunol. 2013;190:712-722. doi:10.4049/jimmunol.1201837.
7. Gardner EM. Caloric restriction decreases survival of aged mice in response to primary influenza infection. J Gerontol A Biol Sci Med Sci. 2005;60:688-694. doi:10.1093/gerona/60.6.688.
8. Reed MJ, Penn PE, Li Y, et al. Enhanced cell proliferation and biosynthesis mediate improved wound repair in refed, caloric-restricted mice. Mech Ageing Dev. 1996;89:21-43. doi:10.1016/0047-6374(96)01737-X.
9. Parks RJ, Fares E, Macdonald JK, et al. A procedure for creating a frailty index based on deficit accumulation in aging mice. J Gerontol A Biol Sci Med Sci. 2012;67:217-227. doi:10.1093/gerona/glr193.
10. Liu, H, Graber, TG, Ferguson-Stegall, L, Thompson, LV. Clinically relevant frailty index for mice. J Gerontol A Biol Sci Med Sci. 2013;68:1326-1336. doi:10.1093/gerona/glt188.
11. Whitehead JC, Hildebrand BA, Sun M, et al. A clinical frailty index in aging mice: comparisons with frailty index data in humans. J Gerontol A Biol Sci Med Sci. 2014;69:621-632. doi:10.1093/gerona/glt136.
12. Graber TG, Ferguson-Stegall L, Kim JH, Thompson LV. C57BL/6 neuromuscular healthspan scoring system. J Gerontol A Biol Sci Med Sci. 2013;68:1326-1336. doi:10.1093/gerona/glt032.
13. Kane AE, Hilmer SN, Boyer D, et al. A validated mouse frailty index to assess longevity interventions: impact of species, calorie restriction and resveratrol. J Gerontol A Biol Sci Med Sci. In press. doi:10.1093/gerona/glu315.
14. Zhang Y, Bokov A, Gelfond J, et al. Rapamycin extends life and health in C57BL/6 mice. J Gerontol A Biol Sci Med Sci. 2014;69:119-130. doi:10.1093/gerona/glt056.
15. Neff F, Flores-Dominguez D, Ryan DP, et al. Rapamycin extends murine lifespan but has limited effects on aging. J Clin Invest. 2013;123: 3272-3291. doi:10.1172/JCI67674.
16. Miller RA, Harrison DE, Astle CM, et al. Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction. Aging Cell. 2014;13:468-477. doi:10.1111/acel.12194.
17. Fok WC, Chen Y, Bokov A, et al. Mice fed rapamycin have an increase in lifespan associated with major changes in the liver transcriptome. PLoS One. 2014;9:e83988. doi:10.1371/journal.pone.0083988.
18. Wilkinson JE, Burmeister L, Brooks SV, et al. Rapamycin slows aging in mice. Aging Cell. 2012;11:675-682. doi:10.1111/j.1474-9726.2012.00832.x.
19. Richardson A. Rapamycin, anti- Aging, and avoiding the fate of Tithonus. J Clin Invest. 2013;123:3204-3206. doi:10.1172/JCI70800.
20. Johnson SC, Martin GM, Rabinovitch PS, Kaeberlein M. Preserving youth: does rapamycin deliver? Sci Transl Med. 2013;5:211-40. doi:10.1126/scitranslmed.3007316.