-
1
-
-
38349093613
-
Remarkable longevity and stress resistance of nematode PI3K-null mutants
-
Ayyadevara, S., Alla, R., Thaden, J. J., and Shmookler Reis, R. J. (2008). Remarkable longevity and stress resistance of nematode PI3K-null mutants. Aging Cell 7, 13-22. doi: 10.1111/j.1474-9726.2007.00348.x.
-
(2008)
Aging Cell
, vol.7
, pp. 13-22
-
-
Ayyadevara, S.1
Alla, R.2
Thaden, J.J.3
Shmookler Reis, R.J.4
-
2
-
-
84878473064
-
Somatotropic signaling: trade-offs between growth, reproductive development, and longevity
-
Bartke, A., Sun, L. Y., and Longo, V. (2013). Somatotropic signaling: trade-offs between growth, reproductive development, and longevity. Physiol. Rev. 93, 571-598. doi: 10.1152/physrev.00006.2012.
-
(2013)
Physiol. Rev
, vol.93
, pp. 571-598
-
-
Bartke, A.1
Sun, L.Y.2
Longo, V.3
-
3
-
-
84940112971
-
-
The Scientist, 1st January 2014
-
Barzilai, N. (2014). Elder pharmacology. The Scientist, 1st January 2014. Available at: http://www.the-scientist.com/?articles.view/articleNo/38688/title/Elder-Pharmacology/.
-
(2014)
Elder pharmacology
-
-
Barzilai, N.1
-
4
-
-
33750029285
-
Aging and immortality: quasi-programmed senescence and its pharmacologic inhibition
-
Blagosklonny, M. V. (2006). Aging and immortality: quasi-programmed senescence and its pharmacologic inhibition. Cell Cycle 5, 2087-2102. doi: 10.4161/cc.5.18.3288.
-
(2006)
Cell Cycle
, vol.5
, pp. 2087-2102
-
-
Blagosklonny, M.V.1
-
5
-
-
55849152355
-
Aging: ROS or TOR
-
Blagosklonny, M. V. (2008). Aging: ROS or TOR. Cell Cycle 7, 3344-3354. doi: 10.4161/cc.7.21.6965.
-
(2008)
Cell Cycle
, vol.7
, pp. 3344-3354
-
-
Blagosklonny, M.V.1
-
6
-
-
77955722198
-
Revisiting the antagonistic pleiotropy theory of aging: TOR-driven program and quasi-program
-
Blagosklonny, M. V. (2010). Revisiting the antagonistic pleiotropy theory of aging: TOR-driven program and quasi-program. Cell Cycle 9, 3151-3156. doi: 10.4161/cc.9.16.13120.
-
(2010)
Cell Cycle
, vol.9
, pp. 3151-3156
-
-
Blagosklonny, M.V.1
-
7
-
-
84868027889
-
How to save medicare: the anti-aging remedy
-
Blagosklonny, M. V. (2012). How to save medicare: the anti-aging remedy. Aging 4, 547-552.
-
(2012)
Aging
, vol.4
, pp. 547-552
-
-
Blagosklonny, M.V.1
-
8
-
-
47849117411
-
New model of health promotion and disease prevention for the 21st century
-
Butler, R. N., Miller, R. A., Perry, D., Carnes, B. A., Williams, T. F., Cassel, C., et al. (2008). New model of health promotion and disease prevention for the 21st century. BMJ 337, a399. doi: 10.1136/bmj.a399.
-
(2008)
BMJ
, vol.337
-
-
Butler, R.N.1
Miller, R.A.2
Perry, D.3
Carnes, B.A.4
Williams, T.F.5
Cassel, C.6
-
9
-
-
0028512679
-
Aging and the goals of medicine
-
Callahan, D. (1994). Aging and the goals of medicine. Hastings Cent. Rep. 24, 39-41. doi: 10.2307/3563499.
-
(1994)
Hastings Cent. Rep
, vol.24
, pp. 39-41
-
-
Callahan, D.1
-
10
-
-
84873638532
-
Aging, cellular senescence, and cancer
-
Campisi, J. (2013). Aging, cellular senescence, and cancer. Ann. Rev. Physiol. 75, 685-705. doi: 10.1146/annurev-physiol-030212-183653.
-
(2013)
Ann. Rev. Physiol
, vol.75
, pp. 685-705
-
-
Campisi, J.1
-
11
-
-
10644238666
-
'Is aging a disease?,'
-
ed. A. Caplan (Bloomington: Indiana University Press)
-
Caplan, A. (1992). "Is aging a disease?," in If I were a rich man could I buy a pancreas?, ed. A. Caplan (Bloomington: Indiana University Press), 195-209.
-
(1992)
If I were a rich man could I buy a pancreas?
, pp. 195-209
-
-
Caplan, A.1
-
12
-
-
24744432957
-
Death as an unnatural process. Why is it wrong to seek a cure for aging?
-
Caplan, A. L. (2005). Death as an unnatural process. Why is it wrong to seek a cure for aging? EMBO Rep. 6, S72-S75. doi: 10.1038/sj.embor.7400435.
-
(2005)
EMBO Rep
, vol.6
, pp. S72-S75
-
-
Caplan, A.L.1
-
14
-
-
0036234707
-
Time to talk SENS: critiquing the immutability of human aging
-
de Grey, A. D., Ames, B. N., Andersen, J. K., Bartke, A., Campisi, J., Heward, C. B., et al. (2002). Time to talk SENS: critiquing the immutability of human aging. Ann. N. Y. Acad. Sci. 959, 452-462. doi: 10.1111/j.1749-6632.2002.tb02115.x.
-
(2002)
Ann. N. Y. Acad. Sci
, vol.959
, pp. 452-462
-
-
de Grey, A.D.1
Ames, B.N.2
Andersen, J.K.3
Bartke, A.4
Campisi, J.5
Heward, C.B.6
-
15
-
-
84870348799
-
Programmatic features of aging originating in development: aging mechanisms beyond molecular damage?
-
de Magalhães, J. P. (2012). Programmatic features of aging originating in development: aging mechanisms beyond molecular damage? FASEB J. 26, 4821-4826. doi: 10.1096/fj.12-210872.
-
(2012)
FASEB J
, vol.26
, pp. 4821-4826
-
-
de Magalhães, J.P.1
-
16
-
-
84857054009
-
Compression of morbidity 1980-2011: a focused review of paradigms and progress
-
Fries, J. F., Bruce, B., and Chakravarty, E. (2011). Compression of morbidity 1980-2011: a focused review of paradigms and progress. J. Aging Res. 2011, 261702. doi: 10.4061/2011/261702.
-
(2011)
J. Aging Res
, vol.2011
-
-
Fries, J.F.1
Bruce, B.2
Chakravarty, E.3
-
18
-
-
0036021375
-
Genetic analysis of tissue aging in Caenorhabditis elegans: a role for heat-shock factor and bacterial proliferation
-
Garigan, D., Hsu, A., Fraser, A., Kamath, R., Ahringer, J., and Kenyon, C. (2002). Genetic analysis of tissue aging in Caenorhabditis elegans: a role for heat-shock factor and bacterial proliferation. Genetics 161, 1101-1112.
-
(2002)
Genetics
, vol.161
, pp. 1101-1112
-
-
Garigan, D.1
Hsu, A.2
Fraser, A.3
Kamath, R.4
Ahringer, J.5
Kenyon, C.6
-
19
-
-
84897871341
-
What is an anti-aging treatment?
-
Gems, D. (2014). What is an anti-aging treatment? Exp. Gerontol. 58, 14-18. doi: 10.1016/j.exger.2014.07.003.
-
(2014)
Exp. Gerontol
, vol.58
, pp. 14-18
-
-
Gems, D.1
-
20
-
-
84882603593
-
The origin of aging: imperfectness-driven non-random damage defines the aging process and control of lifespan
-
Gladyshev, V. N. (2013). The origin of aging: imperfectness-driven non-random damage defines the aging process and control of lifespan. Trends Genet. 29, 506-512. doi: 10.1016/j.tig.2013.05.004.
-
(2013)
Trends Genet
, vol.29
, pp. 506-512
-
-
Gladyshev, V.N.1
-
21
-
-
3042751047
-
Life extension and history: the continual search for the fountain of youth
-
Haber, C. (2004). Life extension and history: the continual search for the fountain of youth. J. Gerontol. 59, B515-B522. doi: 10.1093/gerona/59.6.B515.
-
(2004)
J. Gerontol
, vol.59
, pp. B515-B522
-
-
Haber, C.1
-
23
-
-
77049308856
-
Aging: a theory based on free radical and radiation chemistry
-
Harman, D. (1956). Aging: a theory based on free radical and radiation chemistry. J. Gerontol. 11, 298-300. doi: 10.1093/geronj/11.3.298.
-
(1956)
J. Gerontol
, vol.11
, pp. 298-300
-
-
Harman, D.1
-
24
-
-
67650944993
-
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
-
Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., et al. (2009). Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 460, 392-395. doi: 10.1038/nature08221.
-
(2009)
Nature
, vol.460
, pp. 392-395
-
-
Harrison, D.E.1
Strong, R.2
Sharp, Z.D.3
Nelson, J.F.4
Astle, C.M.5
Flurkey, K.6
-
25
-
-
0037167855
-
Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans
-
Herndon, L., Schmeissner, P., Dudaronek, J., Brown, P., Listner, K., Sakano, Y., et al. (2002). Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans. Nature 419, 808-814. doi: 10.1038/nature01135.
-
(2002)
Nature
, vol.419
, pp. 808-814
-
-
Herndon, L.1
Schmeissner, P.2
Dudaronek, J.3
Brown, P.4
Listner, K.5
Sakano, Y.6
-
26
-
-
0030074327
-
The urgency of research on ageing
-
Holliday, R. (1996). The urgency of research on ageing. BioEssays 18, 89-90. doi: 10.1002/bies.950180202.
-
(1996)
BioEssays
, vol.18
, pp. 89-90
-
-
Holliday, R.1
-
27
-
-
0020714958
-
The case for mortality
-
Kass, L. (1983). The case for mortality. Am. Scholar. 52, 173-191.
-
(1983)
Am. Scholar
, vol.52
, pp. 173-191
-
-
Kass, L.1
-
28
-
-
84940112972
-
'Mortality and morality: the virtues of finitude,'
-
ed. L. R. Kass (New York: The Free Press)
-
Kass, L. R. (1988). "Mortality and morality: the virtues of finitude," in Toward a More Natural Science: Biology and Human Affairs, ed. L. R. Kass (New York: The Free Press).
-
(1988)
Toward a More Natural Science: Biology and Human Affairs
-
-
Kass, L.R.1
-
29
-
-
77950200010
-
The genetics of ageing
-
Kenyon, C. (2010). The genetics of ageing. Nature 464, 504-512. doi: 10.1038/nature08980.
-
(2010)
Nature
, vol.464
, pp. 504-512
-
-
Kenyon, C.1
-
30
-
-
0034626774
-
Why do we age?
-
Kirkwood, T., and Austad, S. (2000). Why do we age? Nature 408, 233-238. doi: 10.1038/35041682.
-
(2000)
Nature
, vol.408
, pp. 233-238
-
-
Kirkwood, T.1
Austad, S.2
-
31
-
-
0026314114
-
Evolution of senescence: late survival sacrificed for reproduction
-
Kirkwood, T. B. L., and Rose, M. R. (1991). Evolution of senescence: late survival sacrificed for reproduction. Philos. Trans. R. Soc. Lond. B Biol. Sci. 332, 15-24. doi: 10.1098/rstb.1991.0028.
-
(1991)
Philos. Trans. R. Soc. Lond. B Biol. Sci
, vol.332
, pp. 15-24
-
-
Kirkwood, T.B.L.1
Rose, M.R.2
-
32
-
-
34548801348
-
Accelerated accumulation of health deficits as a characteristic of aging
-
Kulminski, A., Ukraintseva, S. V., Akushevich, I., Arbeev, K. G., Land, K., and Yashin, A. I. (2007). Accelerated accumulation of health deficits as a characteristic of aging. Exp. Gerontol. 42, 963-970. doi: 10.1016/j.exger.2007.05.009.
-
(2007)
Exp. Gerontol
, vol.42
, pp. 963-970
-
-
Kulminski, A.1
Ukraintseva, S.V.2
Akushevich, I.3
Arbeev, K.G.4
Land, K.5
Yashin, A.I.6
-
33
-
-
33644669837
-
Programmed and altruistic ageing
-
Longo, V. D., Mitteldorf, J., and Skulachev, V. P. (2005). Programmed and altruistic ageing. Nat. Rev. Genet. 6, 866-872. doi: 10.1038/nrg1706.
-
(2005)
Nat. Rev. Genet
, vol.6
, pp. 866-872
-
-
Longo, V.D.1
Mitteldorf, J.2
Skulachev, V.P.3
-
34
-
-
84878864199
-
The hallmarks of aging
-
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., and Kroemer, G. (2013). The hallmarks of aging. Cell 153, 1194-1217. doi: 10.1016/j.cell.2013.05.039.
-
(2013)
Cell
, vol.153
, pp. 1194-1217
-
-
López-Otín, C.1
Blasco, M.A.2
Partridge, L.3
Serrano, M.4
Kroemer, G.5
-
35
-
-
77957797819
-
TGF-beta and insulin signaling regulate reproductive aging via oocyte and germline quality maintenance
-
Luo, S., Kleemann, G. A., Ashraf, J. M., Shaw, W. M., and Murphy, C. T. (2010). TGF-beta and insulin signaling regulate reproductive aging via oocyte and germline quality maintenance. Cell 143, 299-312. doi: 10.1016/j.cell.2010.09.013.
-
(2010)
Cell
, vol.143
, pp. 299-312
-
-
Luo, S.1
Kleemann, G.A.2
Ashraf, J.M.3
Shaw, W.M.4
Murphy, C.T.5
-
37
-
-
0030663771
-
There is no such thing as aging
-
Peto, R., and Doll, R. (1997). There is no such thing as aging. BMJ 315, 1030-1032. doi: 10.1136/bmj.315.7115.1030.
-
(1997)
BMJ
, vol.315
, pp. 1030-1032
-
-
Peto, R.1
Doll, R.2
-
38
-
-
84916601608
-
Aging is not a disease: implications for intervention
-
Rattan, S. I. S. (2014). Aging is not a disease: implications for intervention. Aging Dis. 5, 196-202. doi: 10.14336/AD.2014.0500196.
-
(2014)
Aging Dis
, vol.5
, pp. 196-202
-
-
Rattan, S.I.S.1
-
39
-
-
34548395418
-
Frailty in relation to the accumulation of deficits
-
Rockwood, K., and Mitnitski, A. (2007). Frailty in relation to the accumulation of deficits. J. Gerontol. 62A, 722-727. doi: 10.1093/gerona/62.7.722.
-
(2007)
J. Gerontol
, vol.62A
, pp. 722-727
-
-
Rockwood, K.1
Mitnitski, A.2
-
40
-
-
0030038103
-
Oxidative stress, caloric restriction, and aging
-
Sohal, R. S., and Weindruch, R. (1996). Oxidative stress, caloric restriction, and aging. Science 273, 59-63. doi: 10.1126/science.273.5271.59.
-
(1996)
Science
, vol.273
, pp. 59-63
-
-
Sohal, R.S.1
Weindruch, R.2
-
41
-
-
78149343508
-
Reactive oxygen species and aging in Caenorhabditis elegans: causal or casual relationship?
-
Van Raamsdonk, J. M., and Hekimi, S. (2010). Reactive oxygen species and aging in Caenorhabditis elegans: causal or casual relationship? Antioxid. Redox Signal. 13, 1911-1953. doi: 10.1089/ars.2010.3215.
-
(2010)
Antioxid. Redox Signal
, vol.13
, pp. 1911-1953
-
-
Van Raamsdonk, J.M.1
Hekimi, S.2
-
42
-
-
84873635293
-
Genome instability and aging
-
Vijg, J., and Suh, Y. (2013). Genome instability and aging. Ann. Rev. Physiol. 75, 645-668. doi: 10.1146/annurev-physiol-030212-183715.
-
(2013)
Ann. Rev. Physiol
, vol.75
, pp. 645-668
-
-
Vijg, J.1
Suh, Y.2
-
43
-
-
0038165393
-
A strategy to reduce cardiovascular disease by more than 80%
-
Wald, N. J., and Law, M. R. (2003). A strategy to reduce cardiovascular disease by more than 80%. BMJ 326, 1419. doi: 10.1136/bmj.326.7404.1419.
-
(2003)
BMJ
, vol.326
, pp. 1419
-
-
Wald, N.J.1
Law, M.R.2
-
44
-
-
0000055057
-
Pleiotropy, natural selection and the evolution of senescence
-
Williams, G. C. (1957). Pleiotropy, natural selection and the evolution of senescence. Evolution 11, 398-411. doi: 10.2307/2406060.
-
(1957)
Evolution
, vol.11
, pp. 398-411
-
-
Williams, G.C.1
|