메뉴 건너뛰기




Volumn 6, Issue JUN, 2015, Pages

The aging-disease false dichotomy: Understanding senescence as pathology

Author keywords

Aging; Disease; Evolution; Pathology; Senescence

Indexed keywords

INSULIN; REACTIVE OXYGEN METABOLITE; SOMATOMEDIN C RECEPTOR; TARGET OF RAPAMYCIN KINASE;

EID: 84940101423     PISSN: None     EISSN: 16648021     Source Type: Journal    
DOI: 10.3389/fgene.2015.00212     Document Type: Review
Times cited : (68)

References (44)
  • 1
    • 38349093613 scopus 로고    scopus 로고
    • Remarkable longevity and stress resistance of nematode PI3K-null mutants
    • Ayyadevara, S., Alla, R., Thaden, J. J., and Shmookler Reis, R. J. (2008). Remarkable longevity and stress resistance of nematode PI3K-null mutants. Aging Cell 7, 13-22. doi: 10.1111/j.1474-9726.2007.00348.x.
    • (2008) Aging Cell , vol.7 , pp. 13-22
    • Ayyadevara, S.1    Alla, R.2    Thaden, J.J.3    Shmookler Reis, R.J.4
  • 2
    • 84878473064 scopus 로고    scopus 로고
    • Somatotropic signaling: trade-offs between growth, reproductive development, and longevity
    • Bartke, A., Sun, L. Y., and Longo, V. (2013). Somatotropic signaling: trade-offs between growth, reproductive development, and longevity. Physiol. Rev. 93, 571-598. doi: 10.1152/physrev.00006.2012.
    • (2013) Physiol. Rev , vol.93 , pp. 571-598
    • Bartke, A.1    Sun, L.Y.2    Longo, V.3
  • 3
    • 84940112971 scopus 로고    scopus 로고
    • The Scientist, 1st January 2014
    • Barzilai, N. (2014). Elder pharmacology. The Scientist, 1st January 2014. Available at: http://www.the-scientist.com/?articles.view/articleNo/38688/title/Elder-Pharmacology/.
    • (2014) Elder pharmacology
    • Barzilai, N.1
  • 4
    • 33750029285 scopus 로고    scopus 로고
    • Aging and immortality: quasi-programmed senescence and its pharmacologic inhibition
    • Blagosklonny, M. V. (2006). Aging and immortality: quasi-programmed senescence and its pharmacologic inhibition. Cell Cycle 5, 2087-2102. doi: 10.4161/cc.5.18.3288.
    • (2006) Cell Cycle , vol.5 , pp. 2087-2102
    • Blagosklonny, M.V.1
  • 5
    • 55849152355 scopus 로고    scopus 로고
    • Aging: ROS or TOR
    • Blagosklonny, M. V. (2008). Aging: ROS or TOR. Cell Cycle 7, 3344-3354. doi: 10.4161/cc.7.21.6965.
    • (2008) Cell Cycle , vol.7 , pp. 3344-3354
    • Blagosklonny, M.V.1
  • 6
    • 77955722198 scopus 로고    scopus 로고
    • Revisiting the antagonistic pleiotropy theory of aging: TOR-driven program and quasi-program
    • Blagosklonny, M. V. (2010). Revisiting the antagonistic pleiotropy theory of aging: TOR-driven program and quasi-program. Cell Cycle 9, 3151-3156. doi: 10.4161/cc.9.16.13120.
    • (2010) Cell Cycle , vol.9 , pp. 3151-3156
    • Blagosklonny, M.V.1
  • 7
    • 84868027889 scopus 로고    scopus 로고
    • How to save medicare: the anti-aging remedy
    • Blagosklonny, M. V. (2012). How to save medicare: the anti-aging remedy. Aging 4, 547-552.
    • (2012) Aging , vol.4 , pp. 547-552
    • Blagosklonny, M.V.1
  • 8
    • 47849117411 scopus 로고    scopus 로고
    • New model of health promotion and disease prevention for the 21st century
    • Butler, R. N., Miller, R. A., Perry, D., Carnes, B. A., Williams, T. F., Cassel, C., et al. (2008). New model of health promotion and disease prevention for the 21st century. BMJ 337, a399. doi: 10.1136/bmj.a399.
    • (2008) BMJ , vol.337
    • Butler, R.N.1    Miller, R.A.2    Perry, D.3    Carnes, B.A.4    Williams, T.F.5    Cassel, C.6
  • 9
    • 0028512679 scopus 로고
    • Aging and the goals of medicine
    • Callahan, D. (1994). Aging and the goals of medicine. Hastings Cent. Rep. 24, 39-41. doi: 10.2307/3563499.
    • (1994) Hastings Cent. Rep , vol.24 , pp. 39-41
    • Callahan, D.1
  • 10
    • 84873638532 scopus 로고    scopus 로고
    • Aging, cellular senescence, and cancer
    • Campisi, J. (2013). Aging, cellular senescence, and cancer. Ann. Rev. Physiol. 75, 685-705. doi: 10.1146/annurev-physiol-030212-183653.
    • (2013) Ann. Rev. Physiol , vol.75 , pp. 685-705
    • Campisi, J.1
  • 11
    • 10644238666 scopus 로고
    • 'Is aging a disease?,'
    • ed. A. Caplan (Bloomington: Indiana University Press)
    • Caplan, A. (1992). "Is aging a disease?," in If I were a rich man could I buy a pancreas?, ed. A. Caplan (Bloomington: Indiana University Press), 195-209.
    • (1992) If I were a rich man could I buy a pancreas? , pp. 195-209
    • Caplan, A.1
  • 12
    • 24744432957 scopus 로고    scopus 로고
    • Death as an unnatural process. Why is it wrong to seek a cure for aging?
    • Caplan, A. L. (2005). Death as an unnatural process. Why is it wrong to seek a cure for aging? EMBO Rep. 6, S72-S75. doi: 10.1038/sj.embor.7400435.
    • (2005) EMBO Rep , vol.6 , pp. S72-S75
    • Caplan, A.L.1
  • 15
    • 84870348799 scopus 로고    scopus 로고
    • Programmatic features of aging originating in development: aging mechanisms beyond molecular damage?
    • de Magalhães, J. P. (2012). Programmatic features of aging originating in development: aging mechanisms beyond molecular damage? FASEB J. 26, 4821-4826. doi: 10.1096/fj.12-210872.
    • (2012) FASEB J , vol.26 , pp. 4821-4826
    • de Magalhães, J.P.1
  • 16
    • 84857054009 scopus 로고    scopus 로고
    • Compression of morbidity 1980-2011: a focused review of paradigms and progress
    • Fries, J. F., Bruce, B., and Chakravarty, E. (2011). Compression of morbidity 1980-2011: a focused review of paradigms and progress. J. Aging Res. 2011, 261702. doi: 10.4061/2011/261702.
    • (2011) J. Aging Res , vol.2011
    • Fries, J.F.1    Bruce, B.2    Chakravarty, E.3
  • 18
    • 0036021375 scopus 로고    scopus 로고
    • Genetic analysis of tissue aging in Caenorhabditis elegans: a role for heat-shock factor and bacterial proliferation
    • Garigan, D., Hsu, A., Fraser, A., Kamath, R., Ahringer, J., and Kenyon, C. (2002). Genetic analysis of tissue aging in Caenorhabditis elegans: a role for heat-shock factor and bacterial proliferation. Genetics 161, 1101-1112.
    • (2002) Genetics , vol.161 , pp. 1101-1112
    • Garigan, D.1    Hsu, A.2    Fraser, A.3    Kamath, R.4    Ahringer, J.5    Kenyon, C.6
  • 19
    • 84897871341 scopus 로고    scopus 로고
    • What is an anti-aging treatment?
    • Gems, D. (2014). What is an anti-aging treatment? Exp. Gerontol. 58, 14-18. doi: 10.1016/j.exger.2014.07.003.
    • (2014) Exp. Gerontol , vol.58 , pp. 14-18
    • Gems, D.1
  • 20
    • 84882603593 scopus 로고    scopus 로고
    • The origin of aging: imperfectness-driven non-random damage defines the aging process and control of lifespan
    • Gladyshev, V. N. (2013). The origin of aging: imperfectness-driven non-random damage defines the aging process and control of lifespan. Trends Genet. 29, 506-512. doi: 10.1016/j.tig.2013.05.004.
    • (2013) Trends Genet , vol.29 , pp. 506-512
    • Gladyshev, V.N.1
  • 21
    • 3042751047 scopus 로고    scopus 로고
    • Life extension and history: the continual search for the fountain of youth
    • Haber, C. (2004). Life extension and history: the continual search for the fountain of youth. J. Gerontol. 59, B515-B522. doi: 10.1093/gerona/59.6.B515.
    • (2004) J. Gerontol , vol.59 , pp. B515-B522
    • Haber, C.1
  • 23
    • 77049308856 scopus 로고
    • Aging: a theory based on free radical and radiation chemistry
    • Harman, D. (1956). Aging: a theory based on free radical and radiation chemistry. J. Gerontol. 11, 298-300. doi: 10.1093/geronj/11.3.298.
    • (1956) J. Gerontol , vol.11 , pp. 298-300
    • Harman, D.1
  • 24
    • 67650944993 scopus 로고    scopus 로고
    • Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
    • Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., et al. (2009). Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 460, 392-395. doi: 10.1038/nature08221.
    • (2009) Nature , vol.460 , pp. 392-395
    • Harrison, D.E.1    Strong, R.2    Sharp, Z.D.3    Nelson, J.F.4    Astle, C.M.5    Flurkey, K.6
  • 25
    • 0037167855 scopus 로고    scopus 로고
    • Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans
    • Herndon, L., Schmeissner, P., Dudaronek, J., Brown, P., Listner, K., Sakano, Y., et al. (2002). Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans. Nature 419, 808-814. doi: 10.1038/nature01135.
    • (2002) Nature , vol.419 , pp. 808-814
    • Herndon, L.1    Schmeissner, P.2    Dudaronek, J.3    Brown, P.4    Listner, K.5    Sakano, Y.6
  • 26
    • 0030074327 scopus 로고    scopus 로고
    • The urgency of research on ageing
    • Holliday, R. (1996). The urgency of research on ageing. BioEssays 18, 89-90. doi: 10.1002/bies.950180202.
    • (1996) BioEssays , vol.18 , pp. 89-90
    • Holliday, R.1
  • 27
    • 0020714958 scopus 로고
    • The case for mortality
    • Kass, L. (1983). The case for mortality. Am. Scholar. 52, 173-191.
    • (1983) Am. Scholar , vol.52 , pp. 173-191
    • Kass, L.1
  • 28
    • 84940112972 scopus 로고
    • 'Mortality and morality: the virtues of finitude,'
    • ed. L. R. Kass (New York: The Free Press)
    • Kass, L. R. (1988). "Mortality and morality: the virtues of finitude," in Toward a More Natural Science: Biology and Human Affairs, ed. L. R. Kass (New York: The Free Press).
    • (1988) Toward a More Natural Science: Biology and Human Affairs
    • Kass, L.R.1
  • 29
    • 77950200010 scopus 로고    scopus 로고
    • The genetics of ageing
    • Kenyon, C. (2010). The genetics of ageing. Nature 464, 504-512. doi: 10.1038/nature08980.
    • (2010) Nature , vol.464 , pp. 504-512
    • Kenyon, C.1
  • 30
    • 0034626774 scopus 로고    scopus 로고
    • Why do we age?
    • Kirkwood, T., and Austad, S. (2000). Why do we age? Nature 408, 233-238. doi: 10.1038/35041682.
    • (2000) Nature , vol.408 , pp. 233-238
    • Kirkwood, T.1    Austad, S.2
  • 31
    • 0026314114 scopus 로고
    • Evolution of senescence: late survival sacrificed for reproduction
    • Kirkwood, T. B. L., and Rose, M. R. (1991). Evolution of senescence: late survival sacrificed for reproduction. Philos. Trans. R. Soc. Lond. B Biol. Sci. 332, 15-24. doi: 10.1098/rstb.1991.0028.
    • (1991) Philos. Trans. R. Soc. Lond. B Biol. Sci , vol.332 , pp. 15-24
    • Kirkwood, T.B.L.1    Rose, M.R.2
  • 32
    • 34548801348 scopus 로고    scopus 로고
    • Accelerated accumulation of health deficits as a characteristic of aging
    • Kulminski, A., Ukraintseva, S. V., Akushevich, I., Arbeev, K. G., Land, K., and Yashin, A. I. (2007). Accelerated accumulation of health deficits as a characteristic of aging. Exp. Gerontol. 42, 963-970. doi: 10.1016/j.exger.2007.05.009.
    • (2007) Exp. Gerontol , vol.42 , pp. 963-970
    • Kulminski, A.1    Ukraintseva, S.V.2    Akushevich, I.3    Arbeev, K.G.4    Land, K.5    Yashin, A.I.6
  • 33
  • 35
    • 77957797819 scopus 로고    scopus 로고
    • TGF-beta and insulin signaling regulate reproductive aging via oocyte and germline quality maintenance
    • Luo, S., Kleemann, G. A., Ashraf, J. M., Shaw, W. M., and Murphy, C. T. (2010). TGF-beta and insulin signaling regulate reproductive aging via oocyte and germline quality maintenance. Cell 143, 299-312. doi: 10.1016/j.cell.2010.09.013.
    • (2010) Cell , vol.143 , pp. 299-312
    • Luo, S.1    Kleemann, G.A.2    Ashraf, J.M.3    Shaw, W.M.4    Murphy, C.T.5
  • 37
    • 0030663771 scopus 로고    scopus 로고
    • There is no such thing as aging
    • Peto, R., and Doll, R. (1997). There is no such thing as aging. BMJ 315, 1030-1032. doi: 10.1136/bmj.315.7115.1030.
    • (1997) BMJ , vol.315 , pp. 1030-1032
    • Peto, R.1    Doll, R.2
  • 38
    • 84916601608 scopus 로고    scopus 로고
    • Aging is not a disease: implications for intervention
    • Rattan, S. I. S. (2014). Aging is not a disease: implications for intervention. Aging Dis. 5, 196-202. doi: 10.14336/AD.2014.0500196.
    • (2014) Aging Dis , vol.5 , pp. 196-202
    • Rattan, S.I.S.1
  • 39
    • 34548395418 scopus 로고    scopus 로고
    • Frailty in relation to the accumulation of deficits
    • Rockwood, K., and Mitnitski, A. (2007). Frailty in relation to the accumulation of deficits. J. Gerontol. 62A, 722-727. doi: 10.1093/gerona/62.7.722.
    • (2007) J. Gerontol , vol.62A , pp. 722-727
    • Rockwood, K.1    Mitnitski, A.2
  • 40
    • 0030038103 scopus 로고    scopus 로고
    • Oxidative stress, caloric restriction, and aging
    • Sohal, R. S., and Weindruch, R. (1996). Oxidative stress, caloric restriction, and aging. Science 273, 59-63. doi: 10.1126/science.273.5271.59.
    • (1996) Science , vol.273 , pp. 59-63
    • Sohal, R.S.1    Weindruch, R.2
  • 41
    • 78149343508 scopus 로고    scopus 로고
    • Reactive oxygen species and aging in Caenorhabditis elegans: causal or casual relationship?
    • Van Raamsdonk, J. M., and Hekimi, S. (2010). Reactive oxygen species and aging in Caenorhabditis elegans: causal or casual relationship? Antioxid. Redox Signal. 13, 1911-1953. doi: 10.1089/ars.2010.3215.
    • (2010) Antioxid. Redox Signal , vol.13 , pp. 1911-1953
    • Van Raamsdonk, J.M.1    Hekimi, S.2
  • 42
    • 84873635293 scopus 로고    scopus 로고
    • Genome instability and aging
    • Vijg, J., and Suh, Y. (2013). Genome instability and aging. Ann. Rev. Physiol. 75, 645-668. doi: 10.1146/annurev-physiol-030212-183715.
    • (2013) Ann. Rev. Physiol , vol.75 , pp. 645-668
    • Vijg, J.1    Suh, Y.2
  • 43
    • 0038165393 scopus 로고    scopus 로고
    • A strategy to reduce cardiovascular disease by more than 80%
    • Wald, N. J., and Law, M. R. (2003). A strategy to reduce cardiovascular disease by more than 80%. BMJ 326, 1419. doi: 10.1136/bmj.326.7404.1419.
    • (2003) BMJ , vol.326 , pp. 1419
    • Wald, N.J.1    Law, M.R.2
  • 44
    • 0000055057 scopus 로고
    • Pleiotropy, natural selection and the evolution of senescence
    • Williams, G. C. (1957). Pleiotropy, natural selection and the evolution of senescence. Evolution 11, 398-411. doi: 10.2307/2406060.
    • (1957) Evolution , vol.11 , pp. 398-411
    • Williams, G.C.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.