Age-related behavioral changes in Drosophila

Annals of the New York Academy of Sciences

Volumn 1197, Issue , 2010, Pages 9-18

  Iliadi, Konstantin G ^a   Boulianne, Gabrielle L ^a,b  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Aging; Behavior; Cognition; Drosophila; Life span; Locomotion

Indexed keywords

AGING; ANIMAL BEHAVIOR; BEHAVIOR CHANGE; CHICO GENE; CIRCADIAN RHYTHM; COGNITION; CONDITIONING; CONFERENCE PAPER; DROSOPHILA; ECR GENE; FMR1 GENE; GENE MUTATION; INDY GENE; LEARNING; LIFESPAN; LOCOMOTION; MGAT1 GENE; MTH GENE; MYS GENE; NONHUMAN; PHYSICAL ACTIVITY; REPRODUCTION; SEXUAL BEHAVIOR; SOD2 GENE; TASK PERFORMANCE;

EID: 77953203256     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2009.05372.x     Document Type: Conference Paper

References (75)

1. Medawar, P.B. 1952. An unsolved problem of biology. H.K. Lewis. London, United Kingdom.
2. Williams, G.C. 1957. Pleiotropy, natural selection, and the evolution of senescence. Evolution 11: 398-411.
3. Charlesworth, B. 1994. The effect of background selection against deleterious mutations on weakly selected, linked variants. Genet. Res. 63: 213-227.
4. Boulianne, G.L. 2001. Neuronal regulation of lifespan: clues fromflies and worms. Mech. Ageing Dev. 122: 883-894.
5. Grotewiel, M.S. et al. 2005. Functional senescence in Drosophila melanogaster. Ageing Res. Rev. 4: 372-397.
6. Horiuchi, J. & M. Saitoe. 2005. Can flies shed light on our own age-related impairment? Ageing Res. Rev. 4: 83-101.
7. Martin, I. & M.S. Grotewiel. 2006. Distinct genetic influences on locomotor senescence in Drosophila revealed by a series of metrical analyses. Exp. Gerontol. 41: 877-881.
8. Iliadi, K.G., N.N. Iliadi & G.L. Boulianne. 2009. Regulation ofDrosophila life-span: effect of genetic background, sex, mating and social status. Exp. Gerontol. 44: 546-553.
9. Hirsch, J. 1967. Behavior-Genetic Analysis.McGraw-Hill. New York, NY.
10. Martin, J.R. 2003. Locomotor activity: a complex behavioural trait to unravel. Behav. Processes 64: 145-160.
11. Connolly, K. 1966. Locomotor activity in Drosophila. II. Selection for active and inactive strains. Anim. Behav. 14: 444-449.
12. Hay, D.A. 1972. Genetical and maternal determinants of the activity and preening behaviour of Drosophila melanogaster reared in different environments. Heredity 28: 311-336.
13. Branson, K. et al. 2009. High-throughput ethomics in large groups of Drosophila. Nat. Methods 6: 451-457.
14. Grover,D. et al. 2008. Simultaneous tracking of flymovement and gene expression using GFP. BMC Biotechnol. 8: 93.
15. Le Bourg, E. 1983. Patterns of movement and ageing in Drosophila melanogaster. Arch. Gerontol. Geriatr. 2: 299-306.
16. Carey, J.R. et al. 2006. Age-specific and lifetime behavior patterns in Drosophila melanogaster and the Mediterranean fruit fly, Ceratitis capitata. Exp. Gerontol. 41: 93-97.
17. Le Bourg, E. & F.A. Lints. 1984. A longitudinal study of the effects of age on spontaneous locomotor activity in Drosophila melanogaster. Gerontology 30: 79-86. (Pubitemid 14151364)
18. Le Bourg, E. 1987. The rate of living theory. Spontaneous locomotor activity, aging and longevity in Drosophila melanogaster. Exp. Gerontol. 22: 359-369.
19. Fernandez, J.R. et al. 1999. Differences in locomotor activity across the lifespan ofDrosophila melanogaster. Exp. Gerontol. 34: 621-631.
20. vanDijken, F.R.,M.P. van Sambeek&W. Scharloo. 1979. Divergent selection on locomotor activity in Drosophila melanogaster. III. Genetic analysis. Behav. Genet. 9: 563-570. (Pubitemid 10073639)
21. Cook-Wiens, E. & M.S. Grotewiel. 2002. Dissociation between functional senescence and oxidative stress resistance in Drosophila. Exp. Gerontol. 37: 1347-1357.
22. Goddeeris, M.M. et al. 2003. Delayed behavioural aging and altered mortality in Drosophila beta integrin mutants. Aging Cell 2: 257-264.
23. Tamura, T. et al. 2003. Aging specifically impairs amnesiac- dependentmemory in Drosophila. Neuron 40: 1003-1011.
24. Simon, A.F., D.T. Liang & D.E. Krantz. 2006. Differential decline in behavioral performance of Drosophila melanogaster with age. Mech. Ageing Dev. 127: 647-651.
25. Kondratov, R.V. 2007. A role of the circadian system and circadian proteins in aging. Ageing Res. Rev. 6: 12-27.
26. Aschoff, J., S.Daan&G.A.Groos. 1982. Vertebrate Circadian Systems: Structure and Physiology. Springer-Verlag. Berlin, Germany.
27. Wang, G.K. & A. Sehgal. 2002. Signaling components that drive circadian rhythms. Curr. Opin. Neurobiol. 12: 331-338.
28. Cirelli, C. 2003. Searching for sleep mutants of Drosophila melanogaster. Bioessays 25: 940-949.
29. Pittendrigh, C.S. & D.H. Minis. 1972. Circadian systems: longevity as a function of circadian resonance in Drosophila melanogaster. Proc. Natl. Acad. Sci. USA 69: 1537-1539.
30. Li, J.C. & F. Xu. 1997. Influences of light-dark shifting on the immune system, tumor growth and life span of rats, mice and fruit flies as well as on the counteraction of melatonin. Biol. Signals 6: 77-89.
31. Kumar, S., A. Mohan & V.K. Sharma. 2005. Circadian dysfunction reduces lifespan inDrosophila melanogaster. Chronobiol. Int. 22: 641-653.
32. Hendricks, J.C. et al. 2003. Gender dimorphism in the role of cycle (BMAL1) in rest, rest regulation, and longevity in Drosophila melanogaster. J. Biol. Rhythms 18: 12-25.
33. Klarsfeld, A. & F. Rouyer. 1998. Effects of circadian mutations and LD periodicity on the life span of Drosophila melanogaster. J. Biol. Rhythms 13: 471-478.
34. Koh, K. et al. 2006.ADrosophila model for age-associated changes in sleep:wake cycles. Proc. Natl. Acad. Sci. USA 103: 13843-13847.
35. Shaw,P.J. et al. 2002. Stress response genesprotect against lethal effects of sleep deprivation in Drosophila. Nature 417: 287-291.
36. Cirelli, C. et al. 2005. Reduced sleep in Drosophila Shaker mutants. Nature 434: 1087-1092.
37. Economos, A.C. et al. 1979. Quantitative analysis of mating behavior in aging male Drosophila melanogaster. Mech. Ageing Dev. 10: 233-240.
38. Partridge, L.&M. Farquhar. 1981. Sexual activity reduces lifespan of male fruitflies. Nature 294: 580-582.
39. David, J., Y. Cohet & P. Foluillet. 1975. The variability between individuals as a measure of senescence: a study of the number of eggs laid and the percentage of hatched eggs in the case of Drosophila melanogaster. Exp. Gerontol. 10: 17-25.
40. Partridge, L., A. Green & K. Fowler. 1987. Effects of egg production and of exposure to males on female survival inDrosophila melanogaster. J. Insect Physiol. 33: 745-749.
41. Fowler, K. & L. Partridge. 1989. A cost of mating in female fruitflies. Nature 338: 760-761.
42. Chapman, T. et al. 1995. Cost of mating in Drosophila melanogaster females is mediated by male accessory gland products. Nature 373: 241-244.
43. Partridge, L., S.D. Pletcher &W. Mair. 2005. Dietary restriction, mortality trajectories, risk and damage. Mech. Ageing Dev. 126: 35-41.
44. Rogina,B. et al. 2007. Distinct biological epochs in the reproductive life of female Drosophila melanogaster. Mech. Ageing Dev. 128: 477-485.
45. Barnes, A.I. et al. 2006. No extension of lifespan by ablation of germ line in Drosophila. Proc. Biol. Sci. 273: 939-947.
46. Flatt, T. et al. 2008. Drosophila germ-line modulation of insulin signaling and lifespan. Proc. Natl. Acad. Sci. USA 105: 6368-6373.
47. Hsu, H.J., L. LaFever & D. Drummond-Barbosa. 2008. Diet controls normal and tumorous germline stem cells via insulin-dependent and -independent mechanisms in Drosophila. Dev. Biol. 313: 700-712.
48. Skoulakis, E.M. & S. Grammenoudi. 2006. Dunces and da Vincis: the genetics of learning and memory in Drosophila. Cell. Mol. Life Sci. 63: 975-988.
49. Le Bourg, E. 1983. Aging and habituation of the tarsal response in Drosophila melanogaster. Gerontology 29: 388-393.
50. Fois, C., J. Medioni & E. Le Bourg. 1991. Habituation of the proboscis extension response as a function of age in Drosophila melanogaster. Gerontology 37: 187-192.
51. Brigui, N., E. Le Bourg & J. Medioni. 1990. Conditioned suppression of the proboscis-extension response in young, middle-aged, and old Drosophila melanogaster flies: acquisition and extinction. J. Comp. Psychol. 104: 289-296.
52. Fresquet, N. & J. Medioni. 1993. Effects of ageing on visual discrimination learning in Drosophila melanogaster. Q. J. Exp. Psychol. B 46: 399-412.
53. Fresquet, N. 1997. Effect of aging on inhibitory learning and short-termmemory inDrosophila melanogaster. Int. J. Comp. Psychol. 10: 90-109.
54. Fresquet, N. 1999. Effects of aging on the acquisition and extinction of excitatory conditioning in Drosophila melanogaster. Physiol. Behav. 67: 205-211.
55. Tully, T. & W.G. Quinn. 1985. Classical conditioning and retention in normal and mutant Drosophila melanogaster. J. Comp. Physiol. A 157: 263-277.
56. Dubnau, J. & T. Tully. 1998. Gene discovery in Drosophila: new insights for learning andmemory.Annu. Rev. Neurosci. 21: 407-444.
57. Feany, M.B. & W.G. Quinn. 1995. A neuropeptide gene defined by the Drosophila memory mutant amnesiac. Science 268: 869-873.
58. Davis, R.L. 2001. Mushroom bodies, Ca2+ oscillations, and the memory gene amnesiac. Neuron 30: 653-656.
59. Saitoe,M. et al. 2005. Drosophila as a novel animal model for studying the genetics of age-related memory impairment. Rev. Neurosci. 16: 137-149.
60. Yamazaki, D. et al. 2007. The Drosophila DCO mutation suppresses age-related memory impairment without affecting lifespan. Nat. Neurosci. 10: 478-484.
61. Mery, F. 2007. Aging and its differential effects on consolidated memory forms in Drosophila. Exp. Gerontol. 42: 99-101.
62. Siegel, R.W. & J.C. Hall. 1979. Conditioned responses in courtship behavior of normal and mutant Drosophila. Proc. Natl. Acad. Sci. USA 76: 3430-3434.
63. Kamyshev, N.G., K.G. Iliadi & J.V. Bragina. 1999. Drosophila conditioned courtship: two ways of testing memory. Learn. Mem. 6: 1-20.
64. Zawistowski, S. 1988. A replication demonstrating reduced courtship of Drosophila melanogaster by associative learning. J. Comp. Psychol. 102: 174-176.
65. Savvateeva, E.V. et al. 1999. Age-dependent changes in memory and mushroom bodies in the Drosophila mutant vermilion deficient in the kynurenine pathway of tryptophan metabolism. Ross. Fiziol. Zh. Im. I. M. Sechenova 85: 167-183.
66. Le Bourg, E. 2004. Effects of agingonlearned suppression of photopositive tendencies in Drosophila melanogaster. Neurobiol. Aging 25: 1241-1252.
67. Pletcher, S.D. et al. 2002. Genome-wide transcript profiles in aging and calorically restricted Drosophila melanogaster. Curr. Biol. 12: 712-723.
68. Pletcher, S.D., S. Libert & D. Skorupa. 2005. Flies and their golden apples: the effect of dietary restriction on Drosophila aging and age-dependent gene expression. Ageing Res. Rev. 4: 451-480.
69. Lamb,M.G. 1978. Ageing. In The Genetics and Biology of Drosophila, vol.2c.Ashbumer, M. & T.R.F.Wright, Eds.: 43-104. Academic Press. London, United Kingdom.
70. Martinez, V.G. et al. 2007. Age-related changes in climbing behavior and neural circuit physiology in Drosophila. Dev. Neurobiol. 67: 778-791.
71. Piazza, N. et al. 2009.Multiple measures of functionality exhibit progressive decline in a parallel, stochastic fashion in Drosophila Sod2 null mutants. Biogerontology 10: 637-648.
72. Bhandari, P. et al. 2007. Dietary restriction alters demographic but not behavioral aging in Drosophila. Aging Cell 6: 631-637.
73. Sarkar, M. et al. 2006. Null mutations in Drosophila Nacetylglucosaminyltransferase I produce defects in locomotion and a reduced lifespan. J. Biol. Chem. 281: 12776-12785.
74. Mery, F. & T.J. Kawecki. 2003. A fitness cost of learning ability in Drosophila melanogaster. Proc. Biol. Sci. 270: 2465-2469.
75. Burger, J.M. et al. 2008. Learning ability and longevity: a symmetrical evolutionary trade-off in Drosophila. Evolution 62: 1294-1304.