-
2
-
-
84942787538
-
A summary of the new GINA strategy: a roadmap to asthma control
-
Reddel HK, Bateman ED, Becker A et al. A summary of the new GINA strategy: a roadmap to asthma control. Eur Respir J 2015; 46:622–39.
-
(2015)
Eur Respir J
, vol.46
, pp. 622-639
-
-
Reddel, H.K.1
Bateman, E.D.2
Becker, A.3
-
3
-
-
33747756534
-
Asthma: defining of the persistent adult phenotypes
-
Wenzel SE. Asthma: defining of the persistent adult phenotypes. Lancet 2006; 368:804–13.
-
(2006)
Lancet
, vol.368
, pp. 804-813
-
-
Wenzel, S.E.1
-
4
-
-
84886418931
-
Asthma phenotypes and endotypes: an evolving paradigm for classification
-
Corren J. Asthma phenotypes and endotypes: an evolving paradigm for classification. Discov Med 2013; 15:243–9.
-
(2013)
Discov Med
, vol.15
, pp. 243-249
-
-
Corren, J.1
-
5
-
-
79551505136
-
Asthma endotypes: a new approach to classification of disease entities within the asthma syndrome
-
Lotvall J, Akdis CA, Bacharier LB et al. Asthma endotypes: a new approach to classification of disease entities within the asthma syndrome. J Allergy Clin Immunol 2011; 127:355–60.
-
(2011)
J Allergy Clin Immunol
, vol.127
, pp. 355-360
-
-
Lotvall, J.1
Akdis, C.A.2
Bacharier, L.B.3
-
6
-
-
84856845581
-
Severe asthma: from characteristics to phenotypes to endotypes
-
Wenzel S. Severe asthma: from characteristics to phenotypes to endotypes. Clin Exp Allergy 2012; 42:650–8.
-
(2012)
Clin Exp Allergy
, vol.42
, pp. 650-658
-
-
Wenzel, S.1
-
7
-
-
84864022205
-
Stability of inflammatory phenotypes in asthma
-
Green RH, Pavord I. Stability of inflammatory phenotypes in asthma. Thorax 2012; 67:665–7.
-
(2012)
Thorax
, vol.67
, pp. 665-667
-
-
Green, R.H.1
Pavord, I.2
-
8
-
-
84891371611
-
Asthma heterogeneity and severity-why is comprehensive phenotyping important?
-
Moore WC, Bleecker ER. Asthma heterogeneity and severity-why is comprehensive phenotyping important? Lancet Respir Med 2014; 2:10–1.
-
(2014)
Lancet Respir Med
, vol.2
, pp. 10-11
-
-
Moore, W.C.1
Bleecker, E.R.2
-
9
-
-
84893513577
-
International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma
-
Chung KF, Wenzel SE, Brozek JL et al. International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. Eur Respir J 2014; 43:343–73.
-
(2014)
Eur Respir J
, vol.43
, pp. 343-373
-
-
Chung, K.F.1
Wenzel, S.E.2
Brozek, J.L.3
-
10
-
-
2342591290
-
Revised nomenclature for allergy for global use: Report of the Nomenclature Review Committee of the World Allergy Organization, October 2003
-
Johansson SG, Bieber T, Dahl R et al. Revised nomenclature for allergy for global use: Report of the Nomenclature Review Committee of the World Allergy Organization, October 2003. J Allergy Clin Immunol 2004; 113:832–6.
-
(2004)
J Allergy Clin Immunol
, vol.113
, pp. 832-836
-
-
Johansson, S.G.1
Bieber, T.2
Dahl, R.3
-
11
-
-
0034907372
-
Omalizumab, anti-IgE recombinant humanized monoclonal antibody, for the treatment of severe allergic asthma
-
Busse W, Corren J, Lanier BQ et al. Omalizumab, anti-IgE recombinant humanized monoclonal antibody, for the treatment of severe allergic asthma. J Allergy Clin Immunol 2001; 108:184–90.
-
(2001)
J Allergy Clin Immunol
, vol.108
, pp. 184-190
-
-
Busse, W.1
Corren, J.2
Lanier, B.Q.3
-
12
-
-
67650418178
-
Intrinsic asthma: not so different from allergic asthma but driven by superantigens?
-
Barnes PJ. Intrinsic asthma: not so different from allergic asthma but driven by superantigens? Clin Exp Allergy 2009; 39:1145–51.
-
(2009)
Clin Exp Allergy
, vol.39
, pp. 1145-1151
-
-
Barnes, P.J.1
-
13
-
-
10544256182
-
IL-4 and IL-5 mRNA and protein in bronchial biopsies from patients with atopic and nonatopic asthma: evidence against “intrinsic” asthma being a distinct immunopathologic entity
-
Humbert M, Durham SR, Ying S et al. IL-4 and IL-5 mRNA and protein in bronchial biopsies from patients with atopic and nonatopic asthma: evidence against “intrinsic” asthma being a distinct immunopathologic entity. Am J Respir Crit Care Med 1996; 154:1497–504.
-
(1996)
Am J Respir Crit Care Med
, vol.154
, pp. 1497-1504
-
-
Humbert, M.1
Durham, S.R.2
Ying, S.3
-
14
-
-
0032725001
-
The immunopathology of extrinsic (atopic) and intrinsic (non-atopic) asthma: more similarities than differences
-
Humbert M, Menz G, Ying S et al. The immunopathology of extrinsic (atopic) and intrinsic (non-atopic) asthma: more similarities than differences. Immunol Today 1999; 20:528–33.
-
(1999)
Immunol Today
, vol.20
, pp. 528-533
-
-
Humbert, M.1
Menz, G.2
Ying, S.3
-
15
-
-
34247485053
-
Noneosinophilic asthma: a distinct clinical and pathologic phenotype
-
Haldar P, Pavord ID. Noneosinophilic asthma: a distinct clinical and pathologic phenotype. J Allergy Clin Immunol 2007; 119:1043–52.
-
(2007)
J Allergy Clin Immunol
, vol.119
, pp. 1043-1052
-
-
Haldar, P.1
Pavord, I.D.2
-
16
-
-
33645101537
-
Inflammatory subtypes in asthma: assessment and identification using induced sputum
-
Simpson JL, Scott R, Boyle MJ, Gibson PG. Inflammatory subtypes in asthma: assessment and identification using induced sputum. Respirology 2006; 11:54–61.
-
(2006)
Respirology
, vol.11
, pp. 54-61
-
-
Simpson, J.L.1
Scott, R.2
Boyle, M.J.3
Gibson, P.G.4
-
17
-
-
0036165793
-
Eosinophilic bronchitis: clinical manifestations and implications for treatment
-
Gibson PG, Fujimura M, Niimi A. Eosinophilic bronchitis: clinical manifestations and implications for treatment. Thorax 2002; 57:178–82.
-
(2002)
Thorax
, vol.57
, pp. 178-182
-
-
Gibson, P.G.1
Fujimura, M.2
Niimi, A.3
-
18
-
-
84882238835
-
Eosinophils in the spotlight: eosinophilic airway inflammation in nonallergic asthma
-
Brusselle GG, Maes T, Bracke KR. Eosinophils in the spotlight: eosinophilic airway inflammation in nonallergic asthma. Nat Med 2013; 19:977–9.
-
(2013)
Nat Med
, vol.19
, pp. 977-979
-
-
Brusselle, G.G.1
Maes, T.2
Bracke, K.R.3
-
19
-
-
84858273561
-
A large subgroup of mild-to-moderate asthma is persistently noneosinophilic
-
McGrath KW, Icitovic N, Boushey HA et al. A large subgroup of mild-to-moderate asthma is persistently noneosinophilic. Am J Respir Crit Care Med 2012; 185:612–9.
-
(2012)
Am J Respir Crit Care Med
, vol.185
, pp. 612-619
-
-
McGrath, K.W.1
Icitovic, N.2
Boushey, H.A.3
-
20
-
-
0036795111
-
Analysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids
-
Green RH, Brightling CE, Woltmann G et al. Analysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids. Thorax 2002; 57:875–9.
-
(2002)
Thorax
, vol.57
, pp. 875-879
-
-
Green, R.H.1
Brightling, C.E.2
Woltmann, G.3
-
21
-
-
84903553827
-
Potentially pathogenic airway bacteria and neutrophilic inflammation in treatment resistant severe asthma
-
Green BJ, Wiriyachaiporn S, Grainge C et al. Potentially pathogenic airway bacteria and neutrophilic inflammation in treatment resistant severe asthma. PLoS One 2014; 9:e100645.
-
(2014)
PLoS One
, vol.9
-
-
Green, B.J.1
Wiriyachaiporn, S.2
Grainge, C.3
-
23
-
-
84927711820
-
Anti-inflammatory deficiencies in neutrophilic asthma: reduced galectin-3 and IL-1RA/IL-1beta
-
Gao P, Gibson PG, Baines KJ et al. Anti-inflammatory deficiencies in neutrophilic asthma: reduced galectin-3 and IL-1RA/IL-1beta. Respir Res 2015; 16:5.
-
(2015)
Respir Res
, vol.16
, pp. 5
-
-
Gao, P.1
Gibson, P.G.2
Baines, K.J.3
-
24
-
-
84959928646
-
Airway dysbiosis: Haemophilus influenzae and Tropheryma in poorly controlled asthma
-
Simpson JL, Daly J, Baines KJ et al. Airway dysbiosis: Haemophilus influenzae and Tropheryma in poorly controlled asthma. Eur Respir J 2016; 47:792–800.
-
(2016)
Eur Respir J
, vol.47
, pp. 792-800
-
-
Simpson, J.L.1
Daly, J.2
Baines, K.J.3
-
25
-
-
84862519263
-
Safety and efficacy of a CXCR2 antagonist in patients with severe asthma and sputum neutrophils: a randomized, placebo-controlled clinical trial
-
Nair P, Gaga M, Zervas E et al. Safety and efficacy of a CXCR2 antagonist in patients with severe asthma and sputum neutrophils: a randomized, placebo-controlled clinical trial. Clin Exp Allergy 2012; 42:1097–103.
-
(2012)
Clin Exp Allergy
, vol.42
, pp. 1097-1103
-
-
Nair, P.1
Gaga, M.2
Zervas, E.3
-
26
-
-
84989916843
-
Efficacy and safety of a CXCR2 antagonist, AZD5069, in patients with uncontrolled persistent asthma: a randomised, double-blind, placebo-controlled trial
-
O'Byrne PM, Metev H, Puu M et al. Efficacy and safety of a CXCR2 antagonist, AZD5069, in patients with uncontrolled persistent asthma: a randomised, double-blind, placebo-controlled trial. Lancet Respir Med 2016; 4:797–806.
-
(2016)
Lancet Respir Med
, vol.4
, pp. 797-806
-
-
O'Byrne, P.M.1
Metev, H.2
Puu, M.3
-
28
-
-
0022640843
-
Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins
-
Mosmann TR, Cherwinski H, Bond MW et al. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 1986; 136:2348–57.
-
(1986)
J Immunol
, vol.136
, pp. 2348-2357
-
-
Mosmann, T.R.1
Cherwinski, H.2
Bond, M.W.3
-
29
-
-
84925546187
-
Type 2 inflammation in asthma–present in most, absent in many
-
Fahy JV. Type 2 inflammation in asthma–present in most, absent in many. Nat Rev Immunol 2015; 15:57–65.
-
(2015)
Nat Rev Immunol
, vol.15
, pp. 57-65
-
-
Fahy, J.V.1
-
30
-
-
0035134439
-
Type 1/Type 2 immunity in infectious diseases
-
Spellberg B, Edwards JE Jr. Type 1/Type 2 immunity in infectious diseases. Clin Infect Dis 2001; 32:76–102.
-
(2001)
Clin Infect Dis
, vol.32
, pp. 76-102
-
-
Spellberg, B.1
Edwards, J.E.2
-
31
-
-
0026610142
-
Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma
-
Robinson DS, Hamid Q, Ying S et al. Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma. N Engl J Med 1992; 326:298–304.
-
(1992)
N Engl J Med
, vol.326
, pp. 298-304
-
-
Robinson, D.S.1
Hamid, Q.2
Ying, S.3
-
32
-
-
69249150516
-
T-helper type 2-driven inflammation defines major subphenotypes of asthma
-
Woodruff PG, Modrek B, Choy DF et al. T-helper type 2-driven inflammation defines major subphenotypes of asthma. Am J Respir Crit Care Med 2009; 180:388–95.
-
(2009)
Am J Respir Crit Care Med
, vol.180
, pp. 388-395
-
-
Woodruff, P.G.1
Modrek, B.2
Choy, D.F.3
-
33
-
-
78650864775
-
Transcriptional phenotypes of asthma defined by gene expression profiling of induced sputum samples
-
Baines KJ, Simpson JL, Wood LG et al. Transcriptional phenotypes of asthma defined by gene expression profiling of induced sputum samples. J Allergy Clin Immunol 2011; 127:153–60.
-
(2011)
J Allergy Clin Immunol
, vol.127
, pp. 153-160
-
-
Baines, K.J.1
Simpson, J.L.2
Wood, L.G.3
-
34
-
-
79954992071
-
The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4 + T cells
-
Motomura Y, Kitamura H, Hijikata A et al. The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4 + T cells. Nat Immunol 2011; 12:450–9.
-
(2011)
Nat Immunol
, vol.12
, pp. 450-459
-
-
Motomura, Y.1
Kitamura, H.2
Hijikata, A.3
-
36
-
-
84937022817
-
Persistence of asthma requires multiple feedback circuits involving type 2 innate lymphoid cells and IL-33
-
Christianson CA, Goplen NP, Zafar I et al. Persistence of asthma requires multiple feedback circuits involving type 2 innate lymphoid cells and IL-33. J Allergy Clin Immunol 2015; 136:59–68.
-
(2015)
J Allergy Clin Immunol
, vol.136
, pp. 59-68
-
-
Christianson, C.A.1
Goplen, N.P.2
Zafar, I.3
-
37
-
-
84874055169
-
TSLP elicits IL-33-independent innate lymphoid cell responses to promote skin inflammation
-
Kim BS, Siracusa MC, Saenz SA et al. TSLP elicits IL-33-independent innate lymphoid cell responses to promote skin inflammation. Sci Transl Med 2013; 5:170ra16.
-
(2013)
Sci Transl Med
, vol.5
, pp. 170ra16
-
-
Kim, B.S.1
Siracusa, M.C.2
Saenz, S.A.3
-
38
-
-
84963963441
-
IL-25 and CD4(+) TH2 cells enhance type 2 innate lymphoid cell-derived IL-13 production, which promotes IgE-mediated experimental food allergy
-
Lee JB, Chen CY, Liu B et al. IL-25 and CD4(+) TH2 cells enhance type 2 innate lymphoid cell-derived IL-13 production, which promotes IgE-mediated experimental food allergy. J Allergy Clin Immunol 2016; 137:1216–25.
-
(2016)
J Allergy Clin Immunol
, vol.137
, pp. 1216-1225
-
-
Lee, J.B.1
Chen, C.Y.2
Liu, B.3
-
39
-
-
0037592950
-
Stimulation of airway mucin gene expression by interleukin (IL)-17 through IL-6 paracrine/autocrine loop
-
Chen Y, Thai P, Zhao YH et al. Stimulation of airway mucin gene expression by interleukin (IL)-17 through IL-6 paracrine/autocrine loop. J Biol Chem 2003; 278:17036–43.
-
(2003)
J Biol Chem
, vol.278
, pp. 17036-17043
-
-
Chen, Y.1
Thai, P.2
Zhao, Y.H.3
-
40
-
-
79959937269
-
Th17 cells: new players in asthma pathogenesis
-
Cosmi L, Liotta F, Maggi E et al. Th17 cells: new players in asthma pathogenesis. Allergy 2011; 66:989–98.
-
(2011)
Allergy
, vol.66
, pp. 989-998
-
-
Cosmi, L.1
Liotta, F.2
Maggi, E.3
-
41
-
-
4344688669
-
IL-17 markedly up-regulates beta-defensin-2 expression in human airway epithelium via JAK and NF-kappaB signaling pathways
-
Kao CY, Chen Y, Thai P et al. IL-17 markedly up-regulates beta-defensin-2 expression in human airway epithelium via JAK and NF-kappaB signaling pathways. J Immunol 2004; 173:3482–91.
-
(2004)
J Immunol
, vol.173
, pp. 3482-3491
-
-
Kao, C.Y.1
Chen, Y.2
Thai, P.3
-
42
-
-
85010848184
-
Crosstalk between innate and adaptive cells on allergic process
-
Leite-de-Moraes M, Hammad H, Dy M. Crosstalk between innate and adaptive cells on allergic process. J Allergy (Cairo) 2012; 2012:720568.
-
(2012)
J Allergy (Cairo)
, vol.2012
, pp. 720568
-
-
Leite-de-Moraes, M.1
Hammad, H.2
Dy, M.3
-
43
-
-
80355142109
-
Insights into the initiation of type 2 immune responses
-
Oliphant CJ, Barlow JL, McKenzie AN. Insights into the initiation of type 2 immune responses. Immunology 2011; 134:378–85.
-
(2011)
Immunology
, vol.134
, pp. 378-385
-
-
Oliphant, C.J.1
Barlow, J.L.2
McKenzie, A.N.3
-
44
-
-
0036114371
-
IL-4 secreted from individual naive CD4 + T cells acts in an autocrine manner to induce Th2 differentiation
-
Noben-Trauth N, Hu-Li J, Paul WE. IL-4 secreted from individual naive CD4 + T cells acts in an autocrine manner to induce Th2 differentiation. Eur J Immunol 2002; 32:1428–33.
-
(2002)
Eur J Immunol
, vol.32
, pp. 1428-1433
-
-
Noben-Trauth, N.1
Hu-Li, J.2
Paul, W.E.3
-
45
-
-
50449101434
-
In vivo studies fail to reveal a role for IL-4 or STAT6 signaling in Th2 lymphocyte differentiation
-
van Panhuys N, Tang SC, Prout M et al. In vivo studies fail to reveal a role for IL-4 or STAT6 signaling in Th2 lymphocyte differentiation. Proc Natl Acad Sci USA 2008; 105:12423–8.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 12423-12428
-
-
van Panhuys, N.1
Tang, S.C.2
Prout, M.3
-
46
-
-
79954501837
-
Interleukin-13 signaling and its role in asthma
-
Rael EL, Lockey RF. Interleukin-13 signaling and its role in asthma. World Allergy Organ J 2011; 4:54–64.
-
(2011)
World Allergy Organ J
, vol.4
, pp. 54-64
-
-
Rael, E.L.1
Lockey, R.F.2
-
47
-
-
33745394558
-
Periostin: a novel component of subepithelial fibrosis of bronchial asthma downstream of IL-4 and IL-13 signals
-
Takayama G, Arima K, Kanaji T et al. Periostin: a novel component of subepithelial fibrosis of bronchial asthma downstream of IL-4 and IL-13 signals. J Allergy Clin Immunol 2006; 118:98–104.
-
(2006)
J Allergy Clin Immunol
, vol.118
, pp. 98-104
-
-
Takayama, G.1
Arima, K.2
Kanaji, T.3
-
48
-
-
84960368610
-
Type 2 innate lymphoid cells: at the cross-roads in allergic asthma
-
van Rijt L, von Richthofen H, Van Ree R. Type 2 innate lymphoid cells: at the cross-roads in allergic asthma. Semin Immunopathol 2016; 38:483–96.
-
(2016)
Semin Immunopathol
, vol.38
, pp. 483-496
-
-
van Rijt, L.1
von Richthofen, H.2
Van Ree, R.3
-
49
-
-
84860343753
-
Pulmonary innate lymphoid cells are major producers of IL-5 and IL-13 in murine models of allergic asthma
-
Klein Wolterink RG, Kleinjan A, van Nimwegen M et al. Pulmonary innate lymphoid cells are major producers of IL-5 and IL-13 in murine models of allergic asthma. Eur J Immunol 2012; 42:1106–16.
-
(2012)
Eur J Immunol
, vol.42
, pp. 1106-1116
-
-
Klein Wolterink, R.G.1
Kleinjan, A.2
van Nimwegen, M.3
-
50
-
-
33847273161
-
Unique maturation program of the IgE response in vivo
-
Erazo A, Kutchukhidze N, Leung M et al. Unique maturation program of the IgE response in vivo. Immunity 2007; 26:191–203.
-
(2007)
Immunity
, vol.26
, pp. 191-203
-
-
Erazo, A.1
Kutchukhidze, N.2
Leung, M.3
-
51
-
-
84866372922
-
Targeting interleukins to treat severe asthma
-
Gibeon D, Menzies-Gow AN. Targeting interleukins to treat severe asthma. Expert Rev Respir Med 2012; 6:423–39.
-
(2012)
Expert Rev Respir Med
, vol.6
, pp. 423-439
-
-
Gibeon, D.1
Menzies-Gow, A.N.2
-
52
-
-
0035295532
-
Study on mutations of beta chain of high-affinity IgE receptor gene in people of Han nationality of southern China
-
Tang Y, Zeng Y, Li Y. [Study on mutations of beta chain of high-affinity IgE receptor gene in people of Han nationality of southern China]. Zhonghua Jie He He Hu Xi Za Zhi 2001; 24:142–4.
-
(2001)
Zhonghua Jie He He Hu Xi Za Zhi
, vol.24
, pp. 142-144
-
-
Tang, Y.1
Zeng, Y.2
Li, Y.3
-
53
-
-
79958219647
-
Biology of the interleukin-9 pathway and its therapeutic potential for the treatment of asthma
-
Oh CK, Raible D, Geba GP, Molfino NA. Biology of the interleukin-9 pathway and its therapeutic potential for the treatment of asthma. Inflamm Allergy Drug Targets 2011; 10:180–6.
-
(2011)
Inflamm Allergy Drug Targets
, vol.10
, pp. 180-186
-
-
Oh, C.K.1
Raible, D.2
Geba, G.P.3
Molfino, N.A.4
-
54
-
-
79952049626
-
Safety profile and clinical activity of multiple subcutaneous doses of MEDI-528, a humanized anti-interleukin-9 monoclonal antibody, in two randomized phase 2a studies in subjects with asthma
-
Parker JM, Oh CK, LaForce C et al. Safety profile and clinical activity of multiple subcutaneous doses of MEDI-528, a humanized anti-interleukin-9 monoclonal antibody, in two randomized phase 2a studies in subjects with asthma. BMC Pulm Med 2011; 11:14.
-
(2011)
BMC Pulm Med
, vol.11
, pp. 14
-
-
Parker, J.M.1
Oh, C.K.2
LaForce, C.3
-
55
-
-
37349073223
-
Unique functions of the type II interleukin 4 receptor identified in mice lacking the interleukin 13 receptor alpha1 chain
-
Ramalingam TR, Pesce JT, Sheikh F et al. Unique functions of the type II interleukin 4 receptor identified in mice lacking the interleukin 13 receptor alpha1 chain. Nat Immunol 2008; 9:25–33.
-
(2008)
Nat Immunol
, vol.9
, pp. 25-33
-
-
Ramalingam, T.R.1
Pesce, J.T.2
Sheikh, F.3
-
56
-
-
2542486456
-
Asthma: mechanisms of disease persistence and progression
-
Cohn L, Elias JA, Chupp GL. Asthma: mechanisms of disease persistence and progression. Annu Rev Immunol 2004; 22:789–815.
-
(2004)
Annu Rev Immunol
, vol.22
, pp. 789-815
-
-
Cohn, L.1
Elias, J.A.2
Chupp, G.L.3
-
57
-
-
0037393323
-
IL-13 receptors and signaling pathways: an evolving web
-
Hershey GK. IL-13 receptors and signaling pathways: an evolving web. J Allergy Clin Immunol 2003; 111:677–90.
-
(2003)
J Allergy Clin Immunol
, vol.111
, pp. 677-690
-
-
Hershey, G.K.1
-
58
-
-
5144224760
-
Is interleukin-13 critical in maintaining airway hyperresponsiveness in allergen-challenged mice?
-
Leigh R, Ellis R, Wattie J et al. Is interleukin-13 critical in maintaining airway hyperresponsiveness in allergen-challenged mice? Am J Respir Crit Care Med 2004; 170:851–6.
-
(2004)
Am J Respir Crit Care Med
, vol.170
, pp. 851-856
-
-
Leigh, R.1
Ellis, R.2
Wattie, J.3
-
59
-
-
30044449492
-
IL-13 signaling through the IL-13alpha2 receptor is involved in induction of TGF-beta1 production and fibrosis
-
Fichtner-Feigl S, Strober W, Kawakami K et al. IL-13 signaling through the IL-13alpha2 receptor is involved in induction of TGF-beta1 production and fibrosis. Nat Med 2006; 12:99–106.
-
(2006)
Nat Med
, vol.12
, pp. 99-106
-
-
Fichtner-Feigl, S.1
Strober, W.2
Kawakami, K.3
-
60
-
-
0037349125
-
Role of Th2 responses in the development of allergen-induced airway remodelling in a murine model of allergic asthma
-
Komai M, Tanaka H, Masuda T et al. Role of Th2 responses in the development of allergen-induced airway remodelling in a murine model of allergic asthma. Br J Pharmacol 2003; 138:912–20.
-
(2003)
Br J Pharmacol
, vol.138
, pp. 912-920
-
-
Komai, M.1
Tanaka, H.2
Masuda, T.3
-
61
-
-
0032545433
-
Requirement for IL-13 independently of IL-4 in experimental asthma
-
Grunig G, Warnock M, Wakil AE et al. Requirement for IL-13 independently of IL-4 in experimental asthma. Science 1998; 282:2261–3.
-
(1998)
Science
, vol.282
, pp. 2261-2263
-
-
Grunig, G.1
Warnock, M.2
Wakil, A.E.3
-
62
-
-
84866774936
-
Lebrikizumab treatment reduces serum periostin levels in asthma patients with elevated baseline levels of periostin
-
Scheerens H, Arron J, Choy D et al. Lebrikizumab treatment reduces serum periostin levels in asthma patients with elevated baseline levels of periostin. Am J Respir Crit Care Med 2012; 185:A3960.
-
(2012)
Am J Respir Crit Care Med
, vol.185
, pp. A3960
-
-
Scheerens, H.1
Arron, J.2
Choy, D.3
-
63
-
-
84884901150
-
IL-13 receptor alpha2 contributes to development of experimental allergic asthma
-
Chen W, Sivaprasad U, Gibson AM et al. IL-13 receptor alpha2 contributes to development of experimental allergic asthma. J Allergy Clin Immunol 2013; 132:951–8.
-
(2013)
J Allergy Clin Immunol
, vol.132
, pp. 951-958
-
-
Chen, W.1
Sivaprasad, U.2
Gibson, A.M.3
-
65
-
-
0036088040
-
IL-13-dependent autocrine signaling mediates altered responsiveness of IgE-sensitized airway smooth muscle
-
Grunstein MM, Hakonarson H, Leiter J et al. IL-13-dependent autocrine signaling mediates altered responsiveness of IgE-sensitized airway smooth muscle. Am J Physiol Lung Cell Mol Physiol 2002; 282:L520–8.
-
(2002)
Am J Physiol Lung Cell Mol Physiol
, vol.282
, pp. L520-L528
-
-
Grunstein, M.M.1
Hakonarson, H.2
Leiter, J.3
-
66
-
-
79958202765
-
Interleukin-13 inhibits proliferation and enhances contractility of human airway smooth muscle cells without change in contractile phenotype
-
Risse PA, Jo T, Suarez F et al. Interleukin-13 inhibits proliferation and enhances contractility of human airway smooth muscle cells without change in contractile phenotype. Am J Physiol Lung Cell Mol Physiol 2011; 300:L958–66.
-
(2011)
Am J Physiol Lung Cell Mol Physiol
, vol.300
, pp. L958-L966
-
-
Risse, P.A.1
Jo, T.2
Suarez, F.3
-
67
-
-
36849042037
-
Modulation of mucus production by interleukin-13 receptor alpha2 in the human airway epithelium
-
Tanabe T, Fujimoto K, Yasuo M et al. Modulation of mucus production by interleukin-13 receptor alpha2 in the human airway epithelium. Clin Exp Allergy 2008; 38:122–34.
-
(2008)
Clin Exp Allergy
, vol.38
, pp. 122-134
-
-
Tanabe, T.1
Fujimoto, K.2
Yasuo, M.3
-
68
-
-
0033560126
-
Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production
-
Zhu Z, Homer RJ, Wang Z et al. Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. J Clin Invest 1999; 103:779–88.
-
(1999)
J Clin Invest
, vol.103
, pp. 779-788
-
-
Zhu, Z.1
Homer, R.J.2
Wang, Z.3
-
69
-
-
0034769498
-
IL-13 induces eosinophil recruitment into the lung by an IL-5- and eotaxin-dependent mechanism
-
Pope SM, Brandt EB, Mishra A et al. IL-13 induces eosinophil recruitment into the lung by an IL-5- and eotaxin-dependent mechanism. J Allergy Clin Immunol 2001; 108:594–601.
-
(2001)
J Allergy Clin Immunol
, vol.108
, pp. 594-601
-
-
Pope, S.M.1
Brandt, E.B.2
Mishra, A.3
-
70
-
-
0029118576
-
Differential regulation of IL-13 and IL-4 production by human CD8 + and CD4 + Th0, Th1 and Th2 T cell clones and EBV-transformed B cells
-
de Waal MR, Abrams JS, Zurawski SM et al. Differential regulation of IL-13 and IL-4 production by human CD8 + and CD4 + Th0, Th1 and Th2 T cell clones and EBV-transformed B cells. Int Immunol 1995; 7:1405–16.
-
(1995)
Int Immunol
, vol.7
, pp. 1405-1416
-
-
de Waal, M.R.1
Abrams, J.S.2
Zurawski, S.M.3
-
72
-
-
35748932380
-
Invariant NKT cells biased for IL-5 production act as crucial regulators of inflammation
-
Sakuishi K, Oki S, Araki M et al. Invariant NKT cells biased for IL-5 production act as crucial regulators of inflammation. J Immunol 2007; 179:3452–62.
-
(2007)
J Immunol
, vol.179
, pp. 3452-3462
-
-
Sakuishi, K.1
Oki, S.2
Araki, M.3
-
73
-
-
0029067565
-
Production of IL-5 by human NK cells and regulation of IL-5 secretion by IL-4, IL-10, and IL-12
-
Warren HS, Kinnear BF, Phillips JH, Lanier LL. Production of IL-5 by human NK cells and regulation of IL-5 secretion by IL-4, IL-10, and IL-12. J Immunol 1995; 154:5144–52.
-
(1995)
J Immunol
, vol.154
, pp. 5144-5152
-
-
Warren, H.S.1
Kinnear, B.F.2
Phillips, J.H.3
Lanier, L.L.4
-
74
-
-
82355162913
-
Interleukin-5 and IL-5 receptor in health and diseases
-
Takatsu K. Interleukin-5 and IL-5 receptor in health and diseases. Proc Jpn Acad Ser B Phys Biol Sci 2011; 87:463–85.
-
(2011)
Proc Jpn Acad Ser B Phys Biol Sci
, vol.87
, pp. 463-485
-
-
Takatsu, K.1
-
75
-
-
0037393468
-
Anti-IL-5 (mepolizumab) therapy induces bone marrow eosinophil maturational arrest and decreases eosinophil progenitors in the bronchial mucosa of atopic asthmatics
-
Menzies-Gow A, Flood-Page P, Sehmi R et al. Anti-IL-5 (mepolizumab) therapy induces bone marrow eosinophil maturational arrest and decreases eosinophil progenitors in the bronchial mucosa of atopic asthmatics. J Allergy Clin Immunol 2003; 111:714–9.
-
(2003)
J Allergy Clin Immunol
, vol.111
, pp. 714-719
-
-
Menzies-Gow, A.1
Flood-Page, P.2
Sehmi, R.3
-
76
-
-
0025122836
-
The biological role of interleukin 5
-
Sanderson CJ. The biological role of interleukin 5. Int J Cell Cloning 1990; 8(Suppl. 1):147–53.
-
(1990)
Int J Cell Cloning
, vol.8
, pp. 147-153
-
-
Sanderson, C.J.1
-
78
-
-
0035348498
-
Eosinophil trafficking in asthma
-
Wardlaw AJ. Eosinophil trafficking in asthma. Clin Med 2001; 1:214–8.
-
(2001)
Clin Med
, vol.1
, pp. 214-218
-
-
Wardlaw, A.J.1
-
79
-
-
70450175479
-
IL-5- and eosinophil-mediated inflammation: from discovery to therapy
-
Kouro T, Takatsu K. IL-5- and eosinophil-mediated inflammation: from discovery to therapy. Int Immunol 2009; 21:1303–9.
-
(2009)
Int Immunol
, vol.21
, pp. 1303-1309
-
-
Kouro, T.1
Takatsu, K.2
-
80
-
-
0029039388
-
IL-9 induces expression of granzymes and high-affinity IgE receptor in murine T helper clones
-
Louahed J, Kermouni A, Van Snick J, Renauld JC. IL-9 induces expression of granzymes and high-affinity IgE receptor in murine T helper clones. J Immunol 1995; 154:5061–70.
-
(1995)
J Immunol
, vol.154
, pp. 5061-5070
-
-
Louahed, J.1
Kermouni, A.2
Van Snick, J.3
Renauld, J.C.4
-
81
-
-
0035719955
-
Th2 cytokines and asthma. Interleukin-9 as a therapeutic target for asthma
-
Zhou Y, McLane M, Levitt RC. Th2 cytokines and asthma. Interleukin-9 as a therapeutic target for asthma. Respir Res 2001; 2:80–4.
-
(2001)
Respir Res
, vol.2
, pp. 80-84
-
-
Zhou, Y.1
McLane, M.2
Levitt, R.C.3
-
82
-
-
0036683621
-
Anti-interleukin-9 antibody treatment inhibits airway inflammation and hyperreactivity in mouse asthma model
-
Cheng G, Arima M, Honda K et al. Anti-interleukin-9 antibody treatment inhibits airway inflammation and hyperreactivity in mouse asthma model. Am J Respir Crit Care Med 2002; 166:409–16.
-
(2002)
Am J Respir Crit Care Med
, vol.166
, pp. 409-416
-
-
Cheng, G.1
Arima, M.2
Honda, K.3
-
83
-
-
79953327120
-
IL-9 governs allergen-induced mast cell numbers in the lung and chronic remodeling of the airways
-
Kearley J, Erjefalt JS, Andersson C et al. IL-9 governs allergen-induced mast cell numbers in the lung and chronic remodeling of the airways. Am J Respir Crit Care Med 2011; 183:865–75.
-
(2011)
Am J Respir Crit Care Med
, vol.183
, pp. 865-875
-
-
Kearley, J.1
Erjefalt, J.S.2
Andersson, C.3
-
84
-
-
33847362865
-
IL-13 mediates in vivo IL-9 activities on lung epithelial cells but not on hematopoietic cells
-
Steenwinckel V, Louahed J, Orabona C et al. IL-13 mediates in vivo IL-9 activities on lung epithelial cells but not on hematopoietic cells. J Immunol 2007; 178:3244–51.
-
(2007)
J Immunol
, vol.178
, pp. 3244-3251
-
-
Steenwinckel, V.1
Louahed, J.2
Orabona, C.3
-
85
-
-
84901986444
-
Serum periostin: a novel biomarker for asthma management
-
Matsumoto H. Serum periostin: a novel biomarker for asthma management. Allergol Int 2014; 63:153–60.
-
(2014)
Allergol Int
, vol.63
, pp. 153-160
-
-
Matsumoto, H.1
-
87
-
-
80052438246
-
An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FENO) for clinical applications
-
Dweik RA, Boggs PB, Erzurum SC et al. An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FENO) for clinical applications. Am J Respir Crit Care Med 2011; 184:602–15.
-
(2011)
Am J Respir Crit Care Med
, vol.184
, pp. 602-615
-
-
Dweik, R.A.1
Boggs, P.B.2
Erzurum, S.C.3
-
88
-
-
84906337641
-
An airway epithelial iNOS-DUOX2-thyroid peroxidase metabolome drives Th1/Th2 nitrative stress in human severe asthma
-
Voraphani N, Gladwin MT, Contreras AU et al. An airway epithelial iNOS-DUOX2-thyroid peroxidase metabolome drives Th1/Th2 nitrative stress in human severe asthma. Mucosal Immunol 2014; 7:1175–85.
-
(2014)
Mucosal Immunol
, vol.7
, pp. 1175-1185
-
-
Voraphani, N.1
Gladwin, M.T.2
Contreras, A.U.3
-
89
-
-
33644773052
-
The use of exhaled nitric oxide concentration to identify eosinophilic airway inflammation: an observational study in adults with asthma
-
Berry MA, Shaw DE, Green RH et al. The use of exhaled nitric oxide concentration to identify eosinophilic airway inflammation: an observational study in adults with asthma. Clin Exp Allergy 2005; 35:1175–9.
-
(2005)
Clin Exp Allergy
, vol.35
, pp. 1175-1179
-
-
Berry, M.A.1
Shaw, D.E.2
Green, R.H.3
-
90
-
-
77949824278
-
Influence of atopy and asthma on exhaled nitric oxide in an unselected birth cohort study
-
Scott M, Raza A, Karmaus W et al. Influence of atopy and asthma on exhaled nitric oxide in an unselected birth cohort study. Thorax 2010; 65:258–62.
-
(2010)
Thorax
, vol.65
, pp. 258-262
-
-
Scott, M.1
Raza, A.2
Karmaus, W.3
-
91
-
-
79954524131
-
Biomarkers of therapy responsiveness in asthma: pitfalls and promises
-
Vijverberg SJ, Koenderman L, Koster ES et al. Biomarkers of therapy responsiveness in asthma: pitfalls and promises. Clin Exp Allergy 2011; 41:615–29.
-
(2011)
Clin Exp Allergy
, vol.41
, pp. 615-629
-
-
Vijverberg, S.J.1
Koenderman, L.2
Koster, E.S.3
-
93
-
-
85011980437
-
-
(Last accessed 13 January 2017)
-
Genentech I. Xolair Prescribing Information. 2016. Available at: http://www.gene.com/gene/products/information/pdf/xolair-prescribing.pdf (Last accessed 13 January 2017).
-
(2016)
Xolair Prescribing Information
-
-
Genentech, I.1
-
95
-
-
84858322573
-
Clinical update on the use of biomarkers of airway inflammation in the management of asthma
-
Wadsworth S, Sin D, Dorscheid D. Clinical update on the use of biomarkers of airway inflammation in the management of asthma. J Asthma Allergy 2011; 4:77–86.
-
(2011)
J Asthma Allergy
, vol.4
, pp. 77-86
-
-
Wadsworth, S.1
Sin, D.2
Dorscheid, D.3
-
96
-
-
84882824783
-
What is an “eosinophilic phenotype” of asthma?
-
Nair P. What is an “eosinophilic phenotype” of asthma? J Allergy Clin Immunol 2013; 132:81–3.
-
(2013)
J Allergy Clin Immunol
, vol.132
, pp. 81-83
-
-
Nair, P.1
-
97
-
-
85010907490
-
-
(Last accessed 13 January 2017)
-
National Institute for Health and Care Excellence. Mepolizumab for treating severe refractory eosinophilic asthma. 2016. Available at: https://www.nice.org.uk/guidance/GID-TAG519/documents/html-content-3 (Last accessed 13 January 2017).
-
(2016)
Mepolizumab for treating severe refractory eosinophilic asthma
-
-
-
98
-
-
84865145614
-
Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial
-
Pavord ID, Korn S, Howarth P et al. Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial. Lancet 2012; 380:651–9.
-
(2012)
Lancet
, vol.380
, pp. 651-659
-
-
Pavord, I.D.1
Korn, S.2
Howarth, P.3
-
99
-
-
84874196355
-
Distribution of sputum cellular phenotype in a large asthma cohort: predicting factors for eosinophilic vs neutrophilic inflammation
-
Schleich FN, Manise M, Sele J et al. Distribution of sputum cellular phenotype in a large asthma cohort: predicting factors for eosinophilic vs neutrophilic inflammation. BMC Pulm Med 2013; 13:11.
-
(2013)
BMC Pulm Med
, vol.13
, pp. 11
-
-
Schleich, F.N.1
Manise, M.2
Sele, J.3
-
100
-
-
0028791194
-
Exacerbations of asthma without sputum eosinophilia
-
Turner MO, Hussack P, Sears MR et al. Exacerbations of asthma without sputum eosinophilia. Thorax 1995; 50:1057–61.
-
(1995)
Thorax
, vol.50
, pp. 1057-1061
-
-
Turner, M.O.1
Hussack, P.2
Sears, M.R.3
-
101
-
-
33344476409
-
Determining asthma treatment by monitoring sputum cell counts: effect on exacerbations
-
Jayaram L, Pizzichini MM, Cook RJ et al. Determining asthma treatment by monitoring sputum cell counts: effect on exacerbations. Eur Respir J 2006; 27:483–94.
-
(2006)
Eur Respir J
, vol.27
, pp. 483-494
-
-
Jayaram, L.1
Pizzichini, M.M.2
Cook, R.J.3
-
102
-
-
79960991106
-
Therapeutic strategies to reduce asthma exacerbations
-
O'Byrne PM. Therapeutic strategies to reduce asthma exacerbations. J Allergy Clin Immunol 2011; 128:257–63.
-
(2011)
J Allergy Clin Immunol
, vol.128
, pp. 257-263
-
-
O'Byrne, P.M.1
-
103
-
-
84961050904
-
Blood or sputum eosinophils to guide asthma therapy?
-
Mukherjee M, Nair P. Blood or sputum eosinophils to guide asthma therapy? Lancet Respir Med 2015; 3:824–5.
-
(2015)
Lancet Respir Med
, vol.3
, pp. 824-825
-
-
Mukherjee, M.1
Nair, P.2
-
104
-
-
50249109478
-
The course of persistent airflow limitation in subjects with and without asthma
-
Guerra S, Sherrill DL, Kurzius-Spencer M et al. The course of persistent airflow limitation in subjects with and without asthma. Respir Med 2008; 102:1473–82.
-
(2008)
Respir Med
, vol.102
, pp. 1473-1482
-
-
Guerra, S.1
Sherrill, D.L.2
Kurzius-Spencer, M.3
-
105
-
-
0035447569
-
Factors associated with persistent airflow limitation in severe asthma
-
ten Brinke A, Zwinderman AH, Sterk PJ et al. Factors associated with persistent airflow limitation in severe asthma. Am J Respir Crit Care Med 2001; 164:744–8.
-
(2001)
Am J Respir Crit Care Med
, vol.164
, pp. 744-748
-
-
ten Brinke, A.1
Zwinderman, A.H.2
Sterk, P.J.3
-
107
-
-
84878552068
-
Long-term mortality among adults with asthma: a 25-year follow-up of 1,075 outpatients with asthma
-
Ali Z, Dirks CG, Ulrik CS. Long-term mortality among adults with asthma: a 25-year follow-up of 1,075 outpatients with asthma. Chest 2013; 143:1649–55.
-
(2013)
Chest
, vol.143
, pp. 1649-1655
-
-
Ali, Z.1
Dirks, C.G.2
Ulrik, C.S.3
-
109
-
-
0032451168
-
Comparison between eosinophilic markers in induced sputum and blood in asthmatic patients
-
Bacci E, Cianchetti S, Ruocco L et al. Comparison between eosinophilic markers in induced sputum and blood in asthmatic patients. Clin Exp Allergy 1998; 28:1237–43.
-
(1998)
Clin Exp Allergy
, vol.28
, pp. 1237-1243
-
-
Bacci, E.1
Cianchetti, S.2
Ruocco, L.3
-
110
-
-
84903834828
-
Importance of concomitant local and systemic eosinophilia in uncontrolled asthma
-
Schleich FN, Chevremont A, Paulus V et al. Importance of concomitant local and systemic eosinophilia in uncontrolled asthma. Eur Respir J 2014; 44:97–108.
-
(2014)
Eur Respir J
, vol.44
, pp. 97-108
-
-
Schleich, F.N.1
Chevremont, A.2
Paulus, V.3
-
111
-
-
84924352683
-
High blood eosinophil counts predict sputum eosinophilia in patients with severe asthma
-
Fowler SJ, Tavernier G, Niven R. High blood eosinophil counts predict sputum eosinophilia in patients with severe asthma. J Allergy Clin Immunol 2015; 135:822–4.
-
(2015)
J Allergy Clin Immunol
, vol.135
, pp. 822-824
-
-
Fowler, S.J.1
Tavernier, G.2
Niven, R.3
-
112
-
-
84882896337
-
Biomarker surrogates do not accurately predict sputum eosinophil and neutrophil percentages in asthmatic subjects
-
Hastie AT, Moore WC, Li H et al. Biomarker surrogates do not accurately predict sputum eosinophil and neutrophil percentages in asthmatic subjects. J Allergy Clin Immunol 2013; 132:72–80.
-
(2013)
J Allergy Clin Immunol
, vol.132
, pp. 72-80
-
-
Hastie, A.T.1
Moore, W.C.2
Li, H.3
-
113
-
-
84921321823
-
External validation of blood eosinophils, FE(NO) and serum periostin as surrogates for sputum eosinophils in asthma
-
Wagener AH, de Nijs SB, Lutter R et al. External validation of blood eosinophils, FE(NO) and serum periostin as surrogates for sputum eosinophils in asthma. Thorax 2015; 70:115–20.
-
(2015)
Thorax
, vol.70
, pp. 115-120
-
-
Wagener, A.H.1
de Nijs, S.B.2
Lutter, R.3
-
114
-
-
84865696394
-
Periostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients
-
Jia G, Erickson RW, Choy DF et al. Periostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients. J Allergy Clin Immunol 2012; 130:647–54.
-
(2012)
J Allergy Clin Immunol
, vol.130
, pp. 647-654
-
-
Jia, G.1
Erickson, R.W.2
Choy, D.F.3
-
115
-
-
77956289251
-
Roles of epithelial cell-derived periostin in TGF-beta activation, collagen production, and collagen gel elasticity in asthma
-
Sidhu SS, Yuan S, Innes AL et al. Roles of epithelial cell-derived periostin in TGF-beta activation, collagen production, and collagen gel elasticity in asthma. Proc Natl Acad Sci USA 2010; 107:14170–5.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 14170-14175
-
-
Sidhu, S.S.1
Yuan, S.2
Innes, A.L.3
-
116
-
-
35649028488
-
Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids
-
Woodruff PG, Boushey HA, Dolganov GM et al. Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids. Proc Natl Acad Sci USA 2007; 104:15858–63.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 15858-15863
-
-
Woodruff, P.G.1
Boushey, H.A.2
Dolganov, G.M.3
-
117
-
-
45449118961
-
Periostin facilitates eosinophil tissue infiltration in allergic lung and esophageal responses
-
Blanchard C, Mingler MK, McBride M et al. Periostin facilitates eosinophil tissue infiltration in allergic lung and esophageal responses. Mucosal Immunol 2008; 1:289–96.
-
(2008)
Mucosal Immunol
, vol.1
, pp. 289-296
-
-
Blanchard, C.1
Mingler, M.K.2
McBride, M.3
-
118
-
-
79955010756
-
Periostin regulates goblet cell metaplasia in a model of allergic airway inflammation
-
Sehra S, Yao W, Nguyen ET et al. Periostin regulates goblet cell metaplasia in a model of allergic airway inflammation. J Immunol 2011; 186:4959–66.
-
(2011)
J Immunol
, vol.186
, pp. 4959-4966
-
-
Sehra, S.1
Yao, W.2
Nguyen, E.T.3
-
119
-
-
80053084755
-
Lebrikizumab treatment in adults with asthma
-
Corren J, Lemanske RF, Hanania NA et al. Lebrikizumab treatment in adults with asthma. N Engl J Med 2011; 365:1088–98.
-
(2011)
N Engl J Med
, vol.365
, pp. 1088-1098
-
-
Corren, J.1
Lemanske, R.F.2
Hanania, N.A.3
-
120
-
-
84940733208
-
Lebrikizumab in moderate-to-severe asthma: pooled data from two randomised placebo-controlled studies
-
Hanania NA, Noonan M, Corren J et al. Lebrikizumab in moderate-to-severe asthma: pooled data from two randomised placebo-controlled studies. Thorax 2015; 70:748–56.
-
(2015)
Thorax
, vol.70
, pp. 748-756
-
-
Hanania, N.A.1
Noonan, M.2
Corren, J.3
-
121
-
-
84988980324
-
Reference ranges for serum periostin in a population without asthma or chronic obstructive pulmonary disease
-
Caswell-Smith R, Hosking A, Cripps T et al. Reference ranges for serum periostin in a population without asthma or chronic obstructive pulmonary disease. Clin Exp Allergy 2016; 00:1–12.
-
(2016)
Clin Exp Allergy
, pp. 1-12
-
-
Caswell-Smith, R.1
Hosking, A.2
Cripps, T.3
-
122
-
-
84881180798
-
Increased periostin associates with greater airflow limitation in patients receiving inhaled corticosteroids
-
Kanemitsu Y, Matsumoto H, Izuhara K et al. Increased periostin associates with greater airflow limitation in patients receiving inhaled corticosteroids. J Allergy Clin Immunol 2013; 132:305–12.
-
(2013)
J Allergy Clin Immunol
, vol.132
, pp. 305-312
-
-
Kanemitsu, Y.1
Matsumoto, H.2
Izuhara, K.3
-
123
-
-
79959363586
-
Human asthma phenotypes: from the clinic, to cytokines, and back again
-
Bhakta NR, Woodruff PG. Human asthma phenotypes: from the clinic, to cytokines, and back again. Immunol Rev 2011; 242:220–32.
-
(2011)
Immunol Rev
, vol.242
, pp. 220-232
-
-
Bhakta, N.R.1
Woodruff, P.G.2
-
124
-
-
27544490377
-
Interleukin 17-producing CD4 + effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
-
Harrington LE, Hatton RD, Mangan PR et al. Interleukin 17-producing CD4 + effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 2005; 6:1123–32.
-
(2005)
Nat Immunol
, vol.6
, pp. 1123-1132
-
-
Harrington, L.E.1
Hatton, R.D.2
Mangan, P.R.3
-
125
-
-
27544465354
-
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
-
Park H, Li Z, Yang XO et al. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol 2005; 6:1133–41.
-
(2005)
Nat Immunol
, vol.6
, pp. 1133-1141
-
-
Park, H.1
Li, Z.2
Yang, X.O.3
-
126
-
-
47249125726
-
Chronically inflamed human tissues are infiltrated by highly differentiated Th17 lymphocytes
-
Pene J, Chevalier S, Preisser L et al. Chronically inflamed human tissues are infiltrated by highly differentiated Th17 lymphocytes. J Immunol 2008; 180:7423–30.
-
(2008)
J Immunol
, vol.180
, pp. 7423-7430
-
-
Pene, J.1
Chevalier, S.2
Preisser, L.3
-
127
-
-
56149097181
-
TH17 cells mediate steroid-resistant airway inflammation and airway hyperresponsiveness in mice
-
McKinley L, Alcorn JF, Peterson A et al. TH17 cells mediate steroid-resistant airway inflammation and airway hyperresponsiveness in mice. J Immunol 2008; 181:4089–97.
-
(2008)
J Immunol
, vol.181
, pp. 4089-4097
-
-
McKinley, L.1
Alcorn, J.F.2
Peterson, A.3
-
128
-
-
77953913216
-
Increased serum IL-17 is an independent risk factor for severe asthma
-
Agache I, Ciobanu C, Agache C, Anghel M. Increased serum IL-17 is an independent risk factor for severe asthma. Respir Med 2010; 104:1131–7.
-
(2010)
Respir Med
, vol.104
, pp. 1131-1137
-
-
Agache, I.1
Ciobanu, C.2
Agache, C.3
Anghel, M.4
-
129
-
-
84980316459
-
An asthma-associated IL4R variant exacerbates airway inflammation by promoting conversion of regulatory T cells to TH17-like cells
-
Massoud AH, Charbonnier LM, Lopez D et al. An asthma-associated IL4R variant exacerbates airway inflammation by promoting conversion of regulatory T cells to TH17-like cells. Nat Med 2016; 22:1013–22.
-
(2016)
Nat Med
, vol.22
, pp. 1013-1022
-
-
Massoud, A.H.1
Charbonnier, L.M.2
Lopez, D.3
-
130
-
-
67349203306
-
T(H)17-associated cytokines (IL-17A and IL-17F) in severe asthma
-
Al Ramli W, Prefontaine D, Chouiali F et al. T(H)17-associated cytokines (IL-17A and IL-17F) in severe asthma. J Allergy Clin Immunol 2009; 123:1185–7.
-
(2009)
J Allergy Clin Immunol
, vol.123
, pp. 1185-1187
-
-
Al Ramli, W.1
Prefontaine, D.2
Chouiali, F.3
-
131
-
-
78349269946
-
Expression of the T helper 17-associated cytokines IL-17A and IL-17F in asthma and COPD
-
Doe C, Bafadhel M, Siddiqui S et al. Expression of the T helper 17-associated cytokines IL-17A and IL-17F in asthma and COPD. Chest 2010; 138:1140–7.
-
(2010)
Chest
, vol.138
, pp. 1140-1147
-
-
Doe, C.1
Bafadhel, M.2
Siddiqui, S.3
-
132
-
-
70349871248
-
Allergic sensitization through the airway primes Th17-dependent neutrophilia and airway hyperresponsiveness
-
Wilson RH, Whitehead GS, Nakano H et al. Allergic sensitization through the airway primes Th17-dependent neutrophilia and airway hyperresponsiveness. Am J Respir Crit Care Med 2009; 180:720–30.
-
(2009)
Am J Respir Crit Care Med
, vol.180
, pp. 720-730
-
-
Wilson, R.H.1
Whitehead, G.S.2
Nakano, H.3
-
133
-
-
84890026323
-
Randomized, double-blind, placebo-controlled study of brodalumab, a human anti-IL-17 receptor monoclonal antibody, in moderate to severe asthma
-
Busse WW, Holgate S, Kerwin E et al. Randomized, double-blind, placebo-controlled study of brodalumab, a human anti-IL-17 receptor monoclonal antibody, in moderate to severe asthma. Am J Respir Crit Care Med 2013; 188:1294–302.
-
(2013)
Am J Respir Crit Care Med
, vol.188
, pp. 1294-1302
-
-
Busse, W.W.1
Holgate, S.2
Kerwin, E.3
-
134
-
-
84939795095
-
TH2 and TH17 inflammatory pathways are reciprocally regulated in asthma
-
Choy DF, Hart KM, Borthwick LA et al. TH2 and TH17 inflammatory pathways are reciprocally regulated in asthma. Sci Transl Med 2015; 7:301ra129.
-
(2015)
Sci Transl Med
, vol.7
, pp. 301ra129
-
-
Choy, D.F.1
Hart, K.M.2
Borthwick, L.A.3
-
135
-
-
34548247694
-
Changing pattern of sputum cell counts during successive exacerbations of airway disease
-
D'silva L, Cook RJ, Allen CJ et al. Changing pattern of sputum cell counts during successive exacerbations of airway disease. Respir Med 2007; 101:2217–20.
-
(2007)
Respir Med
, vol.101
, pp. 2217-2220
-
-
D'silva, L.1
Cook, R.J.2
Allen, C.J.3
-
136
-
-
67049144615
-
Eosinophilic and neutrophilic inflammation in asthma: insights from clinical studies
-
Fahy JV. Eosinophilic and neutrophilic inflammation in asthma: insights from clinical studies. Proc Am Thorac Soc 2009; 6:256–9.
-
(2009)
Proc Am Thorac Soc
, vol.6
, pp. 256-259
-
-
Fahy, J.V.1
-
137
-
-
84906226684
-
Full blood count parameters for the detection of asthma inflammatory phenotypes
-
Zhang XY, Simpson JL, Powell H et al. Full blood count parameters for the detection of asthma inflammatory phenotypes. Clin Exp Allergy 2014; 44:1137–45.
-
(2014)
Clin Exp Allergy
, vol.44
, pp. 1137-1145
-
-
Zhang, X.Y.1
Simpson, J.L.2
Powell, H.3
-
138
-
-
36148981436
-
A chitinase-like protein in the lung and circulation of patients with severe asthma
-
Chupp GL, Lee CG, Jarjour N et al. A chitinase-like protein in the lung and circulation of patients with severe asthma. N Engl J Med 2007; 357:2016–27.
-
(2007)
N Engl J Med
, vol.357
, pp. 2016-2027
-
-
Chupp, G.L.1
Lee, C.G.2
Jarjour, N.3
-
139
-
-
84881193710
-
The chitinase-like protein YKL-40: a possible biomarker of inflammation and airway remodeling in severe pediatric asthma
-
Konradsen JR, James A, Nordlund B et al. The chitinase-like protein YKL-40: a possible biomarker of inflammation and airway remodeling in severe pediatric asthma. J Allergy Clin Immunol 2013; 132:328–35.
-
(2013)
J Allergy Clin Immunol
, vol.132
, pp. 328-335
-
-
Konradsen, J.R.1
James, A.2
Nordlund, B.3
-
140
-
-
84908149906
-
The chitinase-like protein YKL-40 is not a useful biomarker for severe persistent asthma in children
-
Santos CB, Davidson J, Covar RA, Spahn JD. The chitinase-like protein YKL-40 is not a useful biomarker for severe persistent asthma in children. Ann Allergy Asthma Immunol 2014; 113:263–6.
-
(2014)
Ann Allergy Asthma Immunol
, vol.113
, pp. 263-266
-
-
Santos, C.B.1
Davidson, J.2
Covar, R.A.3
Spahn, J.D.4
-
141
-
-
84958886796
-
Research in progress: Medical Research Council United Kingdom Refractory Asthma Stratification Programme (RASP-UK)
-
Heaney LG, Djukanovic R, Woodcock A et al. Research in progress: Medical Research Council United Kingdom Refractory Asthma Stratification Programme (RASP-UK). Thorax 2016; 71:187–9.
-
(2016)
Thorax
, vol.71
, pp. 187-189
-
-
Heaney, L.G.1
Djukanovic, R.2
Woodcock, A.3
-
142
-
-
73149118287
-
Identification of a novel subset of human circulating memory CD4(+) T cells that produce both IL-17A and IL-4
-
Cosmi L, Maggi L, Santarlasci V et al. Identification of a novel subset of human circulating memory CD4(+) T cells that produce both IL-17A and IL-4. J Allergy Clin Immunol 2010; 125:222–30.
-
(2010)
J Allergy Clin Immunol
, vol.125
, pp. 222-230
-
-
Cosmi, L.1
Maggi, L.2
Santarlasci, V.3
-
143
-
-
84952880530
-
Antibiotics for preschool wheeze
-
Grigg J. Antibiotics for preschool wheeze. Lancet Respir Med 2016; 4:2–3.
-
(2016)
Lancet Respir Med
, vol.4
, pp. 2-3
-
-
Grigg, J.1
-
144
-
-
84952942871
-
Azithromycin for episodes with asthma-like symptoms in young children aged 1–3 years: a randomised, double-blind, placebo-controlled trial
-
Stokholm J, Chawes BL, Vissing NH et al. Azithromycin for episodes with asthma-like symptoms in young children aged 1–3 years: a randomised, double-blind, placebo-controlled trial. Lancet Respir Med 2016; 4:19–26.
-
(2016)
Lancet Respir Med
, vol.4
, pp. 19-26
-
-
Stokholm, J.1
Chawes, B.L.2
Vissing, N.H.3
-
145
-
-
2542618298
-
Phenotype-specific treatment of difficult asthma in children
-
Payne D, Bush A. Phenotype-specific treatment of difficult asthma in children. Paediatr Respir Rev 2004; 5:116–23.
-
(2004)
Paediatr Respir Rev
, vol.5
, pp. 116-123
-
-
Payne, D.1
Bush, A.2
-
146
-
-
84990184051
-
Infection and inflammation in induced sputum from preschool children with chronic airways diseases
-
Jochmann A, Artusio L, Robson K et al. Infection and inflammation in induced sputum from preschool children with chronic airways diseases. Pediatr Pulmonol 2016; 51:778–86.
-
(2016)
Pediatr Pulmonol
, vol.51
, pp. 778-786
-
-
Jochmann, A.1
Artusio, L.2
Robson, K.3
-
147
-
-
0035987316
-
Accuracy of eosinophils and eosinophil cationic protein to predict steroid improvement in asthma
-
Meijer RJ, Postma DS, Kauffman HF et al. Accuracy of eosinophils and eosinophil cationic protein to predict steroid improvement in asthma. Clin Exp Allergy 2002; 32:1096–103.
-
(2002)
Clin Exp Allergy
, vol.32
, pp. 1096-1103
-
-
Meijer, R.J.1
Postma, D.S.2
Kauffman, H.F.3
-
148
-
-
13444254245
-
Characterization of within-subject responses to fluticasone and montelukast in childhood asthma
-
Szefler SJ, Phillips BR, Martinez FD et al. Characterization of within-subject responses to fluticasone and montelukast in childhood asthma. J Allergy Clin Immunol 2005; 115:233–42.
-
(2005)
J Allergy Clin Immunol
, vol.115
, pp. 233-242
-
-
Szefler, S.J.1
Phillips, B.R.2
Martinez, F.D.3
-
149
-
-
84876883293
-
Exploring the effects of omalizumab in allergic asthma: an analysis of biomarkers in the EXTRA study
-
Hanania NA, Wenzel S, Rosen K et al. Exploring the effects of omalizumab in allergic asthma: an analysis of biomarkers in the EXTRA study. Am J Respir Crit Care Med 2013; 187:804–11.
-
(2013)
Am J Respir Crit Care Med
, vol.187
, pp. 804-811
-
-
Hanania, N.A.1
Wenzel, S.2
Rosen, K.3
-
150
-
-
84871394062
-
Predicting airway hyperreactivity to mannitol using exhaled nitric oxide in an unselected sample of adolescents and young adults
-
Sverrild A, Malinovschi A, Porsbjerg C et al. Predicting airway hyperreactivity to mannitol using exhaled nitric oxide in an unselected sample of adolescents and young adults. Respir Med 2013; 107:150–2.
-
(2013)
Respir Med
, vol.107
, pp. 150-152
-
-
Sverrild, A.1
Malinovschi, A.2
Porsbjerg, C.3
-
151
-
-
84929851026
-
Serum periostin levels correlate with airway hyper-responsiveness to methacholine and mannitol in children with asthma
-
Song JS, You JS, Jeong SI et al. Serum periostin levels correlate with airway hyper-responsiveness to methacholine and mannitol in children with asthma. Allergy 2015; 70:674–81.
-
(2015)
Allergy
, vol.70
, pp. 674-681
-
-
Song, J.S.1
You, J.S.2
Jeong, S.I.3
-
152
-
-
84919876754
-
Periostin is required for maximal airways inflammation and hyperresponsiveness in mice1
-
Bentley JK, Chen Q, Hong JY et al. Periostin is required for maximal airways inflammation and hyperresponsiveness in mice1. J Allergy Clin Immunol 2014; 134:1433–42.
-
(2014)
J Allergy Clin Immunol
, vol.134
, pp. 1433-1442
-
-
Bentley, J.K.1
Chen, Q.2
Hong, J.Y.3
-
153
-
-
25444503744
-
Dissociation by steroids of eosinophilic inflammation from airway hyperresponsiveness in murine airways
-
Birrell MA, Battram CH, Woodman P et al. Dissociation by steroids of eosinophilic inflammation from airway hyperresponsiveness in murine airways. Respir Res 2003; 4:3.
-
(2003)
Respir Res
, vol.4
, pp. 3
-
-
Birrell, M.A.1
Battram, C.H.2
Woodman, P.3
-
154
-
-
0033961855
-
Airway eosinophilia is not a requirement for allergen-induced airway hyperresponsiveness
-
Tournoy KG, Kips JC, Schou C, Pauwels RA. Airway eosinophilia is not a requirement for allergen-induced airway hyperresponsiveness. Clin Exp Allergy 2000; 30:79–85.
-
(2000)
Clin Exp Allergy
, vol.30
, pp. 79-85
-
-
Tournoy, K.G.1
Kips, J.C.2
Schou, C.3
Pauwels, R.A.4
-
155
-
-
61849086181
-
Mepolizumab and exacerbations of refractory eosinophilic asthma
-
Haldar P, Brightling CE, Hargadon B et al. Mepolizumab and exacerbations of refractory eosinophilic asthma. N Engl J Med 2009; 360:973–84.
-
(2009)
N Engl J Med
, vol.360
, pp. 973-984
-
-
Haldar, P.1
Brightling, C.E.2
Hargadon, B.3
-
156
-
-
84989904460
-
Fevipiprant, a prostaglandin D2 receptor 2 antagonist, in patients with persistent eosinophilic asthma: a single-centre, randomised, double-blind, parallel-group, placebo-controlled trial
-
Gonem S, Berair R, Singapuri A, et al. Fevipiprant, a prostaglandin D2 receptor 2 antagonist, in patients with persistent eosinophilic asthma: a single-centre, randomised, double-blind, parallel-group, placebo-controlled trial. Lancet Respir Med 2016; 4:699–707.
-
(2016)
Lancet Respir Med
, vol.4
, pp. 699-707
-
-
Gonem, S.1
Berair, R.2
Singapuri, A.3
-
157
-
-
79952309777
-
Metabolomic profiling of asthma: diagnostic utility of urine nuclear magnetic resonance spectroscopy
-
Saude EJ, Skappak CD, Regush S et al. Metabolomic profiling of asthma: diagnostic utility of urine nuclear magnetic resonance spectroscopy. J Allergy Clin Immunol 2011; 127:757–64.
-
(2011)
J Allergy Clin Immunol
, vol.127
, pp. 757-764
-
-
Saude, E.J.1
Skappak, C.D.2
Regush, S.3
-
158
-
-
79958715161
-
Point: is measuring sputum eosinophils useful in the management of severe asthma? Yes
-
Hargreave FE, Nair P. Point: is measuring sputum eosinophils useful in the management of severe asthma? Yes. Chest 2011; 139:1270–3.
-
(2011)
Chest
, vol.139
, pp. 1270-1273
-
-
Hargreave, F.E.1
Nair, P.2
-
159
-
-
84865421859
-
Inhibition of interleukin-5 for the treatment of eosinophilic diseases
-
Corren J. Inhibition of interleukin-5 for the treatment of eosinophilic diseases. Discov Med 2012; 13:305–12.
-
(2012)
Discov Med
, vol.13
, pp. 305-312
-
-
Corren, J.1
-
160
-
-
84919635394
-
Dupilumab improves the molecular signature in skin of patients with moderate-to-severe atopic dermatitis
-
Hamilton JD, Suarez-Farinas M, Dhingra N et al. Dupilumab improves the molecular signature in skin of patients with moderate-to-severe atopic dermatitis. J Allergy Clin Immunol 2014; 134:1293–300.
-
(2014)
J Allergy Clin Immunol
, vol.134
, pp. 1293-1300
-
-
Hamilton, J.D.1
Suarez-Farinas, M.2
Dhingra, N.3
-
161
-
-
84969940711
-
External validity of trials should be taken into account before asthma drug candidates reach market authorisation
-
Briasoulis O, Breckenridge R, Nunn A. External validity of trials should be taken into account before asthma drug candidates reach market authorisation. Lancet Respir Med 2016; 4:601–3.
-
(2016)
Lancet Respir Med
, vol.4
, pp. 601-603
-
-
Briasoulis, O.1
Breckenridge, R.2
Nunn, A.3
-
162
-
-
84978064544
-
Adaptive designs for clinical trials
-
Bhatt DL, Mehta C. Adaptive designs for clinical trials. N Engl J Med 2016; 375:65–74.
-
(2016)
N Engl J Med
, vol.375
, pp. 65-74
-
-
Bhatt, D.L.1
Mehta, C.2
-
163
-
-
0034881877
-
The anti-IgE antibody omalizumab reduces exacerbations and steroid requirement in allergic asthmatics
-
Soler M, Matz J, Townley R et al. The anti-IgE antibody omalizumab reduces exacerbations and steroid requirement in allergic asthmatics. Eur Respir J 2001; 18:254–61.
-
(2001)
Eur Respir J
, vol.18
, pp. 254-261
-
-
Soler, M.1
Matz, J.2
Townley, R.3
-
164
-
-
20044362008
-
Benefits of omalizumab as add-on therapy in patients with severe persistent asthma who are inadequately controlled despite best available therapy (GINA 2002 step 4 treatment): INNOVATE
-
Humbert M, Beasley R, Ayres J et al. Benefits of omalizumab as add-on therapy in patients with severe persistent asthma who are inadequately controlled despite best available therapy (GINA 2002 step 4 treatment): INNOVATE. Allergy 2005; 60:309–16.
-
(2005)
Allergy
, vol.60
, pp. 309-316
-
-
Humbert, M.1
Beasley, R.2
Ayres, J.3
-
165
-
-
79955751312
-
Omalizumab in severe allergic asthma inadequately controlled with standard therapy: a randomized trial
-
Hanania NA, Alpan O, Hamilos DL et al. Omalizumab in severe allergic asthma inadequately controlled with standard therapy: a randomized trial. Ann Intern Med 2011; 154:573–82.
-
(2011)
Ann Intern Med
, vol.154
, pp. 573-582
-
-
Hanania, N.A.1
Alpan, O.2
Hamilos, D.L.3
-
166
-
-
84929026123
-
Reslizumab for inadequately controlled asthma with elevated blood eosinophil counts: results from two multicentre, parallel, double-blind, randomised, placebo-controlled, phase 3 trials
-
Castro M, Zangrilli J, Wechsler ME et al. Reslizumab for inadequately controlled asthma with elevated blood eosinophil counts: results from two multicentre, parallel, double-blind, randomised, placebo-controlled, phase 3 trials. Lancet Respir Med 2015; 3:355–66.
-
(2015)
Lancet Respir Med
, vol.3
, pp. 355-366
-
-
Castro, M.1
Zangrilli, J.2
Wechsler, M.E.3
-
167
-
-
84994519179
-
Reslizumab for inadequately controlled asthma with elevated blood eosinophil levels: a randomized phase 3 study
-
Bjermer L, Lemiere C, Maspero J et al. Reslizumab for inadequately controlled asthma with elevated blood eosinophil levels: a randomized phase 3 study. Chest 2016; 150:789–98.
-
(2016)
Chest
, vol.150
, pp. 789-798
-
-
Bjermer, L.1
Lemiere, C.2
Maspero, J.3
-
168
-
-
84994509864
-
Phase 3 study of reslizumab in patients with poorly controlled asthma: effects across a broad range of eosinophil counts
-
Corren J, Weinstein S, Janka L et al. Phase 3 study of reslizumab in patients with poorly controlled asthma: effects across a broad range of eosinophil counts. Chest 2016; 150:799–810.
-
(2016)
Chest
, vol.150
, pp. 799-810
-
-
Corren, J.1
Weinstein, S.2
Janka, L.3
-
169
-
-
84907424177
-
Mepolizumab treatment in patients with severe eosinophilic asthma
-
Ortega HG, Liu MC, Pavord ID et al. Mepolizumab treatment in patients with severe eosinophilic asthma. N Engl J Med 2014; 371:1198–207.
-
(2014)
N Engl J Med
, vol.371
, pp. 1198-1207
-
-
Ortega, H.G.1
Liu, M.C.2
Pavord, I.D.3
-
170
-
-
84907423833
-
Oral glucocorticoid-sparing effect of mepolizumab in eosinophilic asthma
-
Bel EH, Wenzel SE, Thompson PJ et al. Oral glucocorticoid-sparing effect of mepolizumab in eosinophilic asthma. N Engl J Med 2014; 371:1189–97.
-
(2014)
N Engl J Med
, vol.371
, pp. 1189-1197
-
-
Bel, E.H.1
Wenzel, S.E.2
Thompson, P.J.3
-
171
-
-
84994908383
-
Efficacy and safety of benralizumab for patients with severe asthma uncontrolled with high-dosage inhaled corticosteroids and long-acting β2 agonists: a randomised, multicentre, placebo-controlled phase III trial
-
Bleecker ER, FitzGerald JM, Chanez P et al. Efficacy and safety of benralizumab for patients with severe asthma uncontrolled with high-dosage inhaled corticosteroids and long-acting β2 agonists: a randomised, multicentre, placebo-controlled phase III trial. Lancet 2016; 388:2115–17.
-
(2016)
Lancet
, vol.388
, pp. 2115-2117
-
-
Bleecker, E.R.1
FitzGerald, J.M.2
Chanez, P.3
-
172
-
-
84919382915
-
Benralizumab, an anti-interleukin 5 receptor alpha monoclonal antibody, versus placebo for uncontrolled eosinophilic asthma: a phase 2b randomised dose-ranging study
-
Castro M, Wenzel SE, Bleecker ER et al. Benralizumab, an anti-interleukin 5 receptor alpha monoclonal antibody, versus placebo for uncontrolled eosinophilic asthma: a phase 2b randomised dose-ranging study. Lancet Respir Med 2014; 2:879–90.
-
(2014)
Lancet Respir Med
, vol.2
, pp. 879-890
-
-
Castro, M.1
Wenzel, S.E.2
Bleecker, E.R.3
-
173
-
-
84994910846
-
Benralizumab, an anti-interleukin-5 receptor α monoclonal antibody, as add-on treatment for patients with severe, uncontrolled, eosinophilic asthma (CALIMA): a randomised, double-blind, placebo-controlled phase 3 trial
-
FitzGerald JM, Bleecker E, Nair P et al. Benralizumab, an anti-interleukin-5 receptor α monoclonal antibody, as add-on treatment for patients with severe, uncontrolled, eosinophilic asthma (CALIMA): a randomised, double-blind, placebo-controlled phase 3 trial. Lancet 2016; 388:2128–41.
-
(2016)
Lancet
, vol.388
, pp. 2128-2141
-
-
FitzGerald, J.M.1
Bleecker, E.2
Nair, P.3
-
174
-
-
84989808988
-
Efficacy and safety of lebrikizumab in patients with uncontrolled asthma (LAVOLTA I and LAVOLTA II): replicate, phase 3, randomised, double-blind, placebo-controlled trials
-
Hanania NA, Korenblat P, Chapman KR et al. Efficacy and safety of lebrikizumab in patients with uncontrolled asthma (LAVOLTA I and LAVOLTA II): replicate, phase 3, randomised, double-blind, placebo-controlled trials. Lancet Respir Med 2016; 4:781–96.
-
(2016)
Lancet Respir Med
, vol.4
, pp. 781-796
-
-
Hanania, N.A.1
Korenblat, P.2
Chapman, K.R.3
-
175
-
-
84941182925
-
Efficacy and safety of tralokinumab in patients with severe uncontrolled asthma: a randomised, double-blind, placebo-controlled, phase 2b trial
-
Brightling CE, Chanez P, Leigh R et al. Efficacy and safety of tralokinumab in patients with severe uncontrolled asthma: a randomised, double-blind, placebo-controlled, phase 2b trial. Lancet Respir Med 2015; 3:692–701.
-
(2015)
Lancet Respir Med
, vol.3
, pp. 692-701
-
-
Brightling, C.E.1
Chanez, P.2
Leigh, R.3
-
176
-
-
84879401471
-
Dupilumab in persistent asthma with elevated eosinophil levels
-
Wenzel S, Ford L, Pearlman D et al. Dupilumab in persistent asthma with elevated eosinophil levels. N Engl J Med 2013; 368:2455–66.
-
(2013)
N Engl J Med
, vol.368
, pp. 2455-2466
-
-
Wenzel, S.1
Ford, L.2
Pearlman, D.3
-
177
-
-
84964573673
-
Dupilumab efficacy and safety in adults with uncontrolled persistent asthma despite use of medium-to-high-dose inhaled corticosteroids plus a long-acting beta2 agonist: a randomised double-blind placebo-controlled pivotal phase 2b dose-ranging trial
-
Wenzel S, Castro M, Corren J et al. Dupilumab efficacy and safety in adults with uncontrolled persistent asthma despite use of medium-to-high-dose inhaled corticosteroids plus a long-acting beta2 agonist: a randomised double-blind placebo-controlled pivotal phase 2b dose-ranging trial. Lancet 2016; 388:31–44.
-
(2016)
Lancet
, vol.388
, pp. 31-44
-
-
Wenzel, S.1
Castro, M.2
Corren, J.3
|