Asthma heterogeneity and severity-why is comprehensive phenotyping important?

The Lancet Respiratory Medicine

Volumn 2, Issue 1, 2014, Pages 10-11

  Moore, Wendy C ^a   Bleecker, Eugene R ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASTHMA; BODY MASS; COMPUTER ASSISTED TOMOGRAPHY; DISEASE SEVERITY; EOSINOPHILIA; EXPIRATORY RESERVE VOLUME; GENETIC ASSOCIATION; GRANULOCYTOSIS; HUMAN; NEUTROPHILIA; NOTE; OBESITY; PHENOTYPE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RESPIRATORY TRACT INFLAMMATION; BREATHING MECHANICS; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; PNEUMONIA;

ASTHMA; HUMANS; PHENOTYPE; PNEUMONIA; RESPIRATORY MECHANICS;

EID: 84891371611     PISSN: 22132600     EISSN: None     Source Type: Journal    
DOI: 10.1016/S2213-2600(13)70288-1     Document Type: Note

References (10)

1. Gupta S, Hartley R, Khan UT, et al. Quantitative computed tomography-derived clusters: Redefining airway remodeling in asthmatic patients. J Allergy Clin Immunol 2013, published online Nov 12. http://dx.doi.org/10.1016/j.jaci.2013.09.039.
2. Desai D, Newby C, Symon FA, et al. Elevated sputum interleukin-5 and submucosal eosinophilia in obese individuals with severe asthma. Am J Respir Crit Care Med 2013, 188:657-663.
3. Schleich FN, Manise M, Sele J, Henket M, Seidel L, Louis R Distribution of sputum cellular phenotype in a large asthma cohort: predicting factors for eosinophilic vs neutrophilic inflammation. BMC Pulm Med 2013, 13:11.
4. Moore WC, Hastie AT, Li X, et al. Sputum neutrophil counts are associated with more severe asthma phenotypes using cluster analysis. J Allergy Clin Immunol 2013, published online Dec 10. http://dx.doi.org.10.1016/j.jaci.2013.10.011.
5. Li X, Hawkins GA, Ampleford EJ, et al. Genome-wide association study identifies Th1 pathway genes associated with lung function in asthmatic patients. J Allergy Clin Immunol 2013, 132:313-320.
6. Bonnelykke K, Sleiman P, Nielsen K, et al. A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations. Nat Genet 2013, published online Nov 17. http://dx.doi.org.10.1016/10.1038/ng.2830.
7. Hastie A, Moore WC, Li H, et al. Biomarker surrogates do not accurately predict sputum eosinophil and neutrophil percentages in asthmatic subjects. J Allergy Clin Immunol 2013, 132:72-80.
8. Wenzel SE, Wang L, Pirozzi G Dupilumab in persistent asthma. N Engl J Med 2013, 369:1276.
9. Pavord ID, Korn S, Howarth P, et al. Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial. Lancet 2012, 380:651-659.
10. Corren J, Lemanske RF, Hanania NA, et al. Lebrikizumab treatment in adults with asthma. N Engl J Med 2011, 365:1088-1098.