메뉴 건너뛰기




Volumn 242, Issue 1, 2011, Pages 220-232

Human asthma phenotypes: From the clinic, to cytokines, and back again

Author keywords

Asthma; Biomarker; Clinical trials; Cytokine; Phenotype

Indexed keywords

BIOLOGICAL MARKER; CORTICOSTEROID; CYTOKINE; FLUTICASONE; INTERLEUKIN 1; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 17F; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; INTERLEUKIN 8; LEUKOTRIENE RECEPTOR BLOCKING AGENT; MEPOLIZUMAB; MUCIN 5AC; MUCIN 5B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; TUMOR NECROSIS FACTOR ALPHA;

EID: 79959363586     PISSN: 01052896     EISSN: 1600065X     Source Type: Journal    
DOI: 10.1111/j.1600-065X.2011.01032.x     Document Type: Article
Times cited : (154)

References (137)
  • 1
    • 55149113944 scopus 로고    scopus 로고
    • Welcome to the neighborhood: epithelial cell-derived cytokines license innate and adaptive immune responses at mucosal sites
    • Saenz SA, Taylor BC, Artis D. Welcome to the neighborhood: epithelial cell-derived cytokines license innate and adaptive immune responses at mucosal sites. Immunol Rev 2008;226:172-190.
    • (2008) Immunol Rev , vol.226 , pp. 172-190
    • Saenz, S.A.1    Taylor, B.C.2    Artis, D.3
  • 3
    • 35348931194 scopus 로고    scopus 로고
    • National surveillance for asthma - United States, 1980-2004. MMWR Surveill Summ.
    • Jeanne EM, et al. National surveillance for asthma - United States, 1980-2004. MMWR Surveill Summ 2007;56:1-54.
    • (2007) , vol.56 , pp. 1-54
    • Jeanne, E.M.1
  • 4
    • 0023223039 scopus 로고
    • National trends in the morbidity and mortality of asthma in the US. Prevalence, hospitalization and death from asthma over two decades: 1965-1984
    • Evans R 3rd, et al. National trends in the morbidity and mortality of asthma in the US. Prevalence, hospitalization and death from asthma over two decades: 1965-1984. Chest 1987;91:65S-74S.
    • (1987) Chest , vol.91
    • Evans 3rd, R.1
  • 5
    • 0032562336 scopus 로고    scopus 로고
    • National surveillance for asthma - United States, 1960-1995. MMWR Surveill Summ.
    • Mannino DM, Homa DM, Pertowski CA National surveillance for asthma - United States, 1960-1995. MMWR Surveill Summ 1998;47:1-27.
    • (1998) , vol.47 , pp. 1-27
    • Mannino, D.M.1    Homa, D.M.2    Pertowski, C.A.3
  • 6
    • 0037192906 scopus 로고    scopus 로고
    • National surveillance for asthma - United States, 1980-1999. MMWR Surveill Summ.
    • Mannino DM, Homa DM, Akinbami LJ, Moorman JE, Gwynn C, Redd SC National surveillance for asthma - United States, 1980-1999. MMWR Surveill Summ 2002;51:1-13.
    • (2002) , vol.51 , pp. 1-13
    • Mannino, D.M.1    Homa, D.M.2    Akinbami, L.J.3    Moorman, J.E.4    Gwynn, C.5    Redd, S.C.6
  • 7
    • 0003427756 scopus 로고    scopus 로고
    • US Department of Health and Human Services. Washington, DC: US Government Printing Office
    • US Department of Health and Human Services. Healthy People 2010: Respiratory Diseases [Goal 24]. Washington, DC: US Government Printing Office, 2000.
    • (2000) Healthy People 2010: Respiratory Diseases [Goal 24]
  • 8
    • 77950350422 scopus 로고    scopus 로고
    • Asthma and allergic inflammation
    • Locksley RM. Asthma and allergic inflammation. Cell 2010;140:777-783.
    • (2010) Cell , vol.140 , pp. 777-783
    • Locksley, R.M.1
  • 9
    • 77953794345 scopus 로고    scopus 로고
    • The many paths to asthma: phenotype shaped by innate and adaptive immunity
    • Kim HY, DeKruyff RH, Umetsu DT. The many paths to asthma: phenotype shaped by innate and adaptive immunity. Nat Immunol 2010;11:577-584.
    • (2010) Nat Immunol , vol.11 , pp. 577-584
    • Kim, H.Y.1    DeKruyff, R.H.2    Umetsu, D.T.3
  • 10
    • 18244405108 scopus 로고    scopus 로고
    • IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo
    • Fort MM, et al. IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo. Immunity 2001;15:985-995.
    • (2001) Immunity , vol.15 , pp. 985-995
    • Fort, M.M.1
  • 11
    • 75749122181 scopus 로고    scopus 로고
    • Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells
    • Moro K, et al. Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells. Nature 2009;463:540-544.
    • (2009) Nature , vol.463 , pp. 540-544
    • Moro, K.1
  • 12
    • 77954926597 scopus 로고    scopus 로고
    • Systemically dispersed innate IL-13-expressing cells in type 2 immunity
    • Price AE, et al. Systemically dispersed innate IL-13-expressing cells in type 2 immunity. Proc Natl Acad Sci USA 2010;107:11489-11494.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 11489-11494
    • Price, A.E.1
  • 13
    • 0032545433 scopus 로고    scopus 로고
    • Requirement for IL-13 independently of IL-4 in experimental asthma
    • Grunig G, et al. Requirement for IL-13 independently of IL-4 in experimental asthma. Science 1998;282:2261-2263.
    • (1998) Science , vol.282 , pp. 2261-2263
    • Grunig, G.1
  • 14
    • 0030922389 scopus 로고    scopus 로고
    • Elevated expression of messenger ribonucleic acid encoding IL-13 in the bronchial mucosa of atopic and nonatopic subjects with asthma
    • Humbert M, et al. Elevated expression of messenger ribonucleic acid encoding IL-13 in the bronchial mucosa of atopic and nonatopic subjects with asthma. J Allergy Clin Immunol 1997;99:657-665.
    • (1997) J Allergy Clin Immunol , vol.99 , pp. 657-665
    • Humbert, M.1
  • 15
    • 0032545213 scopus 로고    scopus 로고
    • Interleukin-13: central mediator of allergic asthma
    • Wills-Karp M, et al. Interleukin-13: central mediator of allergic asthma. Science 1998;282:2258-2261.
    • (1998) Science , vol.282 , pp. 2258-2261
    • Wills-Karp, M.1
  • 16
    • 0035009330 scopus 로고    scopus 로고
    • IL-13 induces mucin production by stimulating epidermal growth factor receptors and by activating neutrophils
    • Shim JJ, et al. IL-13 induces mucin production by stimulating epidermal growth factor receptors and by activating neutrophils. Am J Physiol Lung Cell Mol Physiol 2001;280:L134-L140.
    • (2001) Am J Physiol Lung Cell Mol Physiol , vol.280
    • Shim, J.J.1
  • 17
    • 0033560126 scopus 로고    scopus 로고
    • Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production
    • Zhu Z, et al. Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. J Clin Invest 1999;103:779-788.
    • (1999) J Clin Invest , vol.103 , pp. 779-788
    • Zhu, Z.1
  • 18
  • 19
    • 13644257561 scopus 로고    scopus 로고
    • IL-13 may mediate allergen-induced hyperresponsiveness independently of IL-5 or eotaxin by effects on airway smooth muscle
    • Eum SY, Maghni K, Tolloczko B, Eidelman DH, Martin JG. IL-13 may mediate allergen-induced hyperresponsiveness independently of IL-5 or eotaxin by effects on airway smooth muscle. Am J Physiol Lung Cell Mol Physiol 2005;288:L576-L584.
    • (2005) Am J Physiol Lung Cell Mol Physiol , vol.288
    • Eum, S.Y.1    Maghni, K.2    Tolloczko, B.3    Eidelman, D.H.4    Martin, J.G.5
  • 20
    • 0036088040 scopus 로고    scopus 로고
    • IL-13-dependent autocrine signaling mediates altered responsiveness of IgE-sensitized airway smooth muscle
    • Grunstein MM, et al. IL-13-dependent autocrine signaling mediates altered responsiveness of IgE-sensitized airway smooth muscle. Am J Physiol Lung Cell Mol Physiol 2002;282:L520-L528.
    • (2002) Am J Physiol Lung Cell Mol Physiol , vol.282
    • Grunstein, M.M.1
  • 21
    • 1642545168 scopus 로고    scopus 로고
    • IL-13 enhances agonist-evoked calcium signals and contractile responses in airway smooth muscle
    • Tliba O, et al. IL-13 enhances agonist-evoked calcium signals and contractile responses in airway smooth muscle. Br J Pharmacol 2003;140:1159-1162.
    • (2003) Br J Pharmacol , vol.140 , pp. 1159-1162
    • Tliba, O.1
  • 22
    • 0038404961 scopus 로고    scopus 로고
    • CysLT1 receptor upregulation by TGF-beta and IL-13 is associated with bronchial smooth muscle cell proliferation in response to LTD4
    • Espinosa K, Bosse Y, Stankova J, Rola-Pleszczynski M. CysLT1 receptor upregulation by TGF-beta and IL-13 is associated with bronchial smooth muscle cell proliferation in response to LTD4. J Allergy Clin Immunol 2003;111:1032-1040.
    • (2003) J Allergy Clin Immunol , vol.111 , pp. 1032-1040
    • Espinosa, K.1    Bosse, Y.2    Stankova, J.3    Rola-Pleszczynski, M.4
  • 23
    • 0036126690 scopus 로고    scopus 로고
    • Significant variability in response to inhaled corticosteroids for persistent asthma
    • Szefler SJ, et al. Significant variability in response to inhaled corticosteroids for persistent asthma. J Allergy Clin Immunol 2002;109:410-418.
    • (2002) J Allergy Clin Immunol , vol.109 , pp. 410-418
    • Szefler, S.J.1
  • 24
    • 33845929075 scopus 로고    scopus 로고
    • The Predicting Response to Inhaled Corticosteroid Efficacy (PRICE) trial
    • Martin RJ, et al. The Predicting Response to Inhaled Corticosteroid Efficacy (PRICE) trial. J Allergy Clin Immunol 2007;119:73-80.
    • (2007) J Allergy Clin Immunol , vol.119 , pp. 73-80
    • Martin, R.J.1
  • 25
    • 79959366545 scopus 로고    scopus 로고
    • National Heart Lung and Blood Institute. Expert Panel Report 3: Guidelines for the Diagnosis and Management of Asthma. Washington, DC: US Department of Health and Human Services and the NIH
    • National Heart Lung and Blood Institute. Expert Panel Report 3: Guidelines for the Diagnosis and Management of Asthma. Washington, DC: US Department of Health and Human Services and the NIH, 2007.
    • (2007)
  • 26
    • 61849152860 scopus 로고    scopus 로고
    • Eosinophils in asthma - closing the loop or opening the door?
    • Wenzel SE. Eosinophils in asthma - closing the loop or opening the door? N Engl J Med 2009;360:1026-1028.
    • (2009) N Engl J Med , vol.360 , pp. 1026-1028
    • Wenzel, S.E.1
  • 27
    • 34247485053 scopus 로고    scopus 로고
    • Noneosinophilic asthma: a distinct clinical and pathologic phenotype
    • quiz 1053-1054.
    • Haldar P, Pavord ID. Noneosinophilic asthma: a distinct clinical and pathologic phenotype. J Allergy Clin Immunol 2007;119:1043-1052, quiz 1053-1054.
    • (2007) J Allergy Clin Immunol , vol.119 , pp. 1043-1052
    • Haldar, P.1    Pavord, I.D.2
  • 29
    • 0036795111 scopus 로고    scopus 로고
    • Analysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids
    • Green RH, Brightling CE, Woltmann G, Parker D, Wardlaw AJ, Pavord ID. Analysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids. Thorax 2002;57:875-879.
    • (2002) Thorax , vol.57 , pp. 875-879
    • Green, R.H.1    Brightling, C.E.2    Woltmann, G.3    Parker, D.4    Wardlaw, A.J.5    Pavord, I.D.6
  • 30
    • 0032875377 scopus 로고    scopus 로고
    • Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics
    • Wenzel SE, et al. Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics. Am J Respir Crit Care Med 1999;160:1001-1008.
    • (1999) Am J Respir Crit Care Med , vol.160 , pp. 1001-1008
    • Wenzel, S.E.1
  • 31
    • 77951665424 scopus 로고    scopus 로고
    • Analyses of asthma severity phenotypes and inflammatory proteins in subjects stratified by sputum granulocytes
    • e1013.
    • Hastie AT, et al. Analyses of asthma severity phenotypes and inflammatory proteins in subjects stratified by sputum granulocytes. J Allergy Clin Immunol 2010;125:1028-1036.e1013.
    • (2010) J Allergy Clin Immunol , vol.125 , pp. 1028-1036
    • Hastie, A.T.1
  • 32
    • 68849086058 scopus 로고    scopus 로고
    • Inflammatory subtypes in asthma are related to airway hyperresponsiveness to mannitol and exhaled NO
    • Porsbjerg C, Lund TK, Pedersen L, Backer V. Inflammatory subtypes in asthma are related to airway hyperresponsiveness to mannitol and exhaled NO. J Asthma 2009;46:606-612.
    • (2009) J Asthma , vol.46 , pp. 606-612
    • Porsbjerg, C.1    Lund, T.K.2    Pedersen, L.3    Backer, V.4
  • 33
    • 36749095585 scopus 로고    scopus 로고
    • Pathological features and inhaled corticosteroid response of eosinophilic and non-eosinophilic asthma
    • Berry M, et al. Pathological features and inhaled corticosteroid response of eosinophilic and non-eosinophilic asthma. Thorax 2007;62:1043-1049.
    • (2007) Thorax , vol.62 , pp. 1043-1049
    • Berry, M.1
  • 34
    • 31144451043 scopus 로고    scopus 로고
    • Biomarkers predicting response to corticosteroid therapy in asthma
    • Brightling CE, Green RH, Pavord ID. Biomarkers predicting response to corticosteroid therapy in asthma. Treat Respir Med 2005;4:309-316.
    • (2005) Treat Respir Med , vol.4 , pp. 309-316
    • Brightling, C.E.1    Green, R.H.2    Pavord, I.D.3
  • 35
    • 70349241725 scopus 로고    scopus 로고
    • Inflammatory phenotypes in adult asthma: clinical applications
    • Gibson PG. Inflammatory phenotypes in adult asthma: clinical applications. Clin Respir J 2009;3:198-206.
    • (2009) Clin Respir J , vol.3 , pp. 198-206
    • Gibson, P.G.1
  • 36
    • 0029278910 scopus 로고
    • Prominent neutrophilic inflammation in sputum from subjects with asthma exacerbation
    • Fahy JV, Kim KW, Liu J, Boushey HA. Prominent neutrophilic inflammation in sputum from subjects with asthma exacerbation. J Allergy Clin Immunol 1995;95:843-852.
    • (1995) J Allergy Clin Immunol , vol.95 , pp. 843-852
    • Fahy, J.V.1    Kim, K.W.2    Liu, J.3    Boushey, H.A.4
  • 37
    • 0035177659 scopus 로고    scopus 로고
    • Relationship between airway inflammation, hyperresponsiveness, and obstruction in asthma
    • Woodruff PG, et al. Relationship between airway inflammation, hyperresponsiveness, and obstruction in asthma. J Allergy Clin Immunol 2001;108:753-758.
    • (2001) J Allergy Clin Immunol , vol.108 , pp. 753-758
    • Woodruff, P.G.1
  • 38
    • 0037090910 scopus 로고    scopus 로고
    • A role for neutrophils in asthma?
    • Woodruff PG, Fahy JV. A role for neutrophils in asthma? Am J Med 2002;112:498-500.
    • (2002) Am J Med , vol.112 , pp. 498-500
    • Woodruff, P.G.1    Fahy, J.V.2
  • 39
    • 48249085691 scopus 로고    scopus 로고
    • Cluster analysis and clinical asthma phenotypes
    • Haldar P, et al. Cluster analysis and clinical asthma phenotypes. Am J Respir Crit Care Med 2008;178:218-224.
    • (2008) Am J Respir Crit Care Med , vol.178 , pp. 218-224
    • Haldar, P.1
  • 40
    • 0034526865 scopus 로고    scopus 로고
    • Proceedings of the ATS workshop on refractory asthma: current understanding, recommendations, and unanswered questions
    • American Thoracic Society.
    • American Thoracic Society. Proceedings of the ATS workshop on refractory asthma: current understanding, recommendations, and unanswered questions. Am J Respir Crit Care Med 2000;162:2341-2351.
    • (2000) Am J Respir Crit Care Med , vol.162 , pp. 2341-2351
  • 41
    • 67649160039 scopus 로고    scopus 로고
    • Body mass index and phenotype in subjects with mild-to-moderate persistent asthma
    • e1321.
    • Sutherland ER, Lehman EB, Teodorescu M, Wechsler ME. Body mass index and phenotype in subjects with mild-to-moderate persistent asthma. J Allergy Clin Immunol 2009;123:1328-1334.e1321.
    • (2009) J Allergy Clin Immunol , vol.123 , pp. 1328-1334
    • Sutherland, E.R.1    Lehman, E.B.2    Teodorescu, M.3    Wechsler, M.E.4
  • 42
    • 51349125818 scopus 로고    scopus 로고
    • The association between obesity and asthma: interactions between systemic and airway inflammation
    • Sutherland TJ, et al. The association between obesity and asthma: interactions between systemic and airway inflammation. Am J Respir Crit Care Med 2008;178:469-475.
    • (2008) Am J Respir Crit Care Med , vol.178 , pp. 469-475
    • Sutherland, T.J.1
  • 43
    • 76149146032 scopus 로고    scopus 로고
    • Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program
    • Moore WC, et al. Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program. Am J Respir Crit Care Med 2010;181:315-323.
    • (2010) Am J Respir Crit Care Med , vol.181 , pp. 315-323
    • Moore, W.C.1
  • 44
    • 0031782594 scopus 로고    scopus 로고
    • Variation in the measurements of basement membrane thickness and inflammatory cell number in bronchial biopsies
    • Sullivan P, Stephens D, Ansari T, Costello J, Jeffery P. Variation in the measurements of basement membrane thickness and inflammatory cell number in bronchial biopsies. Eur Respir J 1998;12:811-815.
    • (1998) Eur Respir J , vol.12 , pp. 811-815
    • Sullivan, P.1    Stephens, D.2    Ansari, T.3    Costello, J.4    Jeffery, P.5
  • 47
    • 0345734185 scopus 로고    scopus 로고
    • Applying stereology to measure thickness of the basement membrane zone in bronchial biopsy specimens
    • Ferrando RE, Nyengaard JR, Hays SR, Fahy JV, Woodruff PG. Applying stereology to measure thickness of the basement membrane zone in bronchial biopsy specimens. J Allergy Clin Immunol 2003;112:1243-1245.
    • (2003) J Allergy Clin Immunol , vol.112 , pp. 1243-1245
    • Ferrando, R.E.1    Nyengaard, J.R.2    Hays, S.R.3    Fahy, J.V.4    Woodruff, P.G.5
  • 49
    • 11144358047 scopus 로고    scopus 로고
    • Hyperplasia of smooth muscle in mild to moderate asthma without changes in cell size or gene expression
    • Woodruff PG, et al. Hyperplasia of smooth muscle in mild to moderate asthma without changes in cell size or gene expression. Am J Respir Crit Care Med 2004;169:1001-1006.
    • (2004) Am J Respir Crit Care Med , vol.169 , pp. 1001-1006
    • Woodruff, P.G.1
  • 51
    • 23244457836 scopus 로고    scopus 로고
    • Dissecting asthma using focused transgenic modeling and functional genomics
    • Kuperman DA, et al. Dissecting asthma using focused transgenic modeling and functional genomics. J Allergy Clin Immunol 2005;116:305-311.
    • (2005) J Allergy Clin Immunol , vol.116 , pp. 305-311
    • Kuperman, D.A.1
  • 52
    • 35649028488 scopus 로고    scopus 로고
    • Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids
    • Woodruff PG, et al. Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids. Proc Natl Acad Sci USA 2007;104:15858-15863.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 15858-15863
    • Woodruff, P.G.1
  • 53
    • 69249150516 scopus 로고    scopus 로고
    • T-helper type 2-driven inflammation defines major subphenotypes of asthma
    • Woodruff PG, et al. T-helper type 2-driven inflammation defines major subphenotypes of asthma. Am J Respir Crit Care Med 2009;180:388-395.
    • (2009) Am J Respir Crit Care Med , vol.180 , pp. 388-395
    • Woodruff, P.G.1
  • 54
    • 77956289251 scopus 로고    scopus 로고
    • Roles of epithelial cell-derived periostin in TGF-beta activation, collagen production, and collagen gel elasticity in asthma
    • Sidhu SS, et al. Roles of epithelial cell-derived periostin in TGF-beta activation, collagen production, and collagen gel elasticity in asthma. Proc Natl Acad Sci USA 2010;107:14170-14175.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 14170-14175
    • Sidhu, S.S.1
  • 55
    • 33745394558 scopus 로고    scopus 로고
    • Periostin: a novel component of subepithelial fibrosis of bronchial asthma downstream of IL-4 and IL-13 signals
    • Takayama G, et al. Periostin: a novel component of subepithelial fibrosis of bronchial asthma downstream of IL-4 and IL-13 signals. J Allergy Clin Immunol 2006;118:98-104.
    • (2006) J Allergy Clin Immunol , vol.118 , pp. 98-104
    • Takayama, G.1
  • 56
    • 78650470207 scopus 로고    scopus 로고
    • SerpinB2 deficiency modulates Th1Th2 responses after schistosome infection
    • Schroder WA, et al. SerpinB2 deficiency modulates Th1Th2 responses after schistosome infection. Parasite Immunol 2010;32:764-768.
    • (2010) Parasite Immunol , vol.32 , pp. 764-768
    • Schroder, W.A.1
  • 57
    • 77951904395 scopus 로고    scopus 로고
    • A physiological function of inflammation-associated SerpinB2 is regulation of adaptive immunity
    • Schroder WA, et al. A physiological function of inflammation-associated SerpinB2 is regulation of adaptive immunity. J Immunol 2010;184:2663-2670.
    • (2010) J Immunol , vol.184 , pp. 2663-2670
    • Schroder, W.A.1
  • 58
    • 0034755576 scopus 로고    scopus 로고
    • Characterization of a calcium-activated chloride channel as a shared target of Th2 cytokine pathways and its potential involvement in asthma
    • Zhou Y, et al. Characterization of a calcium-activated chloride channel as a shared target of Th2 cytokine pathways and its potential involvement in asthma. Am J Respir Cell Mol Biol 2001;25:486-491.
    • (2001) Am J Respir Cell Mol Biol , vol.25 , pp. 486-491
    • Zhou, Y.1
  • 59
    • 0034618130 scopus 로고    scopus 로고
    • Mast cells can amplify airway reactivity and features of chronic inflammation in an asthma model in mice
    • Williams CM, Galli SJ. Mast cells can amplify airway reactivity and features of chronic inflammation in an asthma model in mice. J Exp Med 2000;192:455-462.
    • (2000) J Exp Med , vol.192 , pp. 455-462
    • Williams, C.M.1    Galli, S.J.2
  • 60
    • 33745225217 scopus 로고    scopus 로고
    • Mast cells can promote the development of multiple features of chronic asthma in mice
    • Yu M, Tsai M, Tam SY, Jones C, Zehnder J, Galli SJ. Mast cells can promote the development of multiple features of chronic asthma in mice. J Clin Invest 2006;116:1633-1641.
    • (2006) J Clin Invest , vol.116 , pp. 1633-1641
    • Yu, M.1    Tsai, M.2    Tam, S.Y.3    Jones, C.4    Zehnder, J.5    Galli, S.J.6
  • 61
    • 33745830136 scopus 로고    scopus 로고
    • A brief update on lung stereology
    • Ochs M. A brief update on lung stereology. J Microsc 2006;222:188-200.
    • (2006) J Microsc , vol.222 , pp. 188-200
    • Ochs, M.1
  • 62
    • 33846167119 scopus 로고    scopus 로고
    • How much is there really? Why stereology is essential in lung morphometry
    • Weibel ER, Hsia CC, Ochs M. How much is there really? Why stereology is essential in lung morphometry. J Appl Physiol 2007;102:459-467.
    • (2007) J Appl Physiol , vol.102 , pp. 459-467
    • Weibel, E.R.1    Hsia, C.C.2    Ochs, M.3
  • 63
    • 77951672627 scopus 로고    scopus 로고
    • Accumulation of intraepithelial mast cells with a unique protease phenotype in T(H)2-high asthma
    • e1048.
    • Dougherty RH, et al. Accumulation of intraepithelial mast cells with a unique protease phenotype in T(H)2-high asthma. J Allergy Clin Immunol 2010;125:1046-1053.e1048.
    • (2010) J Allergy Clin Immunol , vol.125 , pp. 1046-1053
    • Dougherty, R.H.1
  • 64
    • 79551511756 scopus 로고    scopus 로고
    • Mast cell phenotype, location and activation in severe asthma. Data from the Severe Asthma Research Program
    • Balzar S, et al. Mast cell phenotype, location and activation in severe asthma. Data from the Severe Asthma Research Program. Am J Respir Crit Care Med 2011;183:299-309.
    • (2011) Am J Respir Crit Care Med , vol.183 , pp. 299-309
    • Balzar, S.1
  • 65
    • 0029972142 scopus 로고    scopus 로고
    • Opposing effects of glucocorticoids on the rate of apoptosis in neutrophilic and eosinophilic granulocytes
    • Meagher LC, Cousin JM, Seckl JR, Haslett C. Opposing effects of glucocorticoids on the rate of apoptosis in neutrophilic and eosinophilic granulocytes. J Immunol 1996;156:4422-4428.
    • (1996) J Immunol , vol.156 , pp. 4422-4428
    • Meagher, L.C.1    Cousin, J.M.2    Seckl, J.R.3    Haslett, C.4
  • 66
    • 17844393640 scopus 로고    scopus 로고
    • Preclinical efficacy and safety of mepolizumab (SB-240563), a humanized monoclonal antibody to IL-5, in cynomolgus monkeys
    • Hart TK, et al. Preclinical efficacy and safety of mepolizumab (SB-240563), a humanized monoclonal antibody to IL-5, in cynomolgus monkeys. J Allergy Clin Immunol 2001;108:250-257.
    • (2001) J Allergy Clin Immunol , vol.108 , pp. 250-257
    • Hart, T.K.1
  • 67
    • 0033004943 scopus 로고    scopus 로고
    • The late asthmatic response is associated with baseline allergen-specific proliferative responsiveness of peripheral T lymphocytes in vitro and serum interleukin-5
    • van der Veen MJ, Van Neerven RJ, De Jong EC, Aalberse RC, Jansen HM, van der Zee JS. The late asthmatic response is associated with baseline allergen-specific proliferative responsiveness of peripheral T lymphocytes in vitro and serum interleukin-5. Clin Exp Allergy 1999;29:217-227.
    • (1999) Clin Exp Allergy , vol.29 , pp. 217-227
    • van der Veen, M.J.1    Van Neerven, R.J.2    De Jong, E.C.3    Aalberse, R.C.4    Jansen, H.M.5    van der Zee, J.S.6
  • 68
    • 6644229440 scopus 로고    scopus 로고
    • Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response
    • Leckie MJ, et al. Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response. Lancet 2000;356:2144-2148.
    • (2000) Lancet , vol.356 , pp. 2144-2148
    • Leckie, M.J.1
  • 69
    • 36749065556 scopus 로고    scopus 로고
    • A study to evaluate safety and efficacy of mepolizumab in patients with moderate persistent asthma
    • Flood-Page P, et al. A study to evaluate safety and efficacy of mepolizumab in patients with moderate persistent asthma. Am J Respir Crit Care Med 2007;176:1062-1071.
    • (2007) Am J Respir Crit Care Med , vol.176 , pp. 1062-1071
    • Flood-Page, P.1
  • 70
    • 0037438409 scopus 로고    scopus 로고
    • Eosinophil's role remains uncertain as anti-interleukin-5 only partially depletes numbers in asthmatic airway
    • Flood-Page PT, Menzies-Gow AN, Kay AB, Robinson DS. Eosinophil's role remains uncertain as anti-interleukin-5 only partially depletes numbers in asthmatic airway. Am J Respir Crit Care Med 2003;167:199-204.
    • (2003) Am J Respir Crit Care Med , vol.167 , pp. 199-204
    • Flood-Page, P.T.1    Menzies-Gow, A.N.2    Kay, A.B.3    Robinson, D.S.4
  • 71
    • 61849086181 scopus 로고    scopus 로고
    • Mepolizumab and exacerbations of refractory eosinophilic asthma
    • Haldar P, et al. Mepolizumab and exacerbations of refractory eosinophilic asthma. N Engl J Med 2009;360:973-984.
    • (2009) N Engl J Med , vol.360 , pp. 973-984
    • Haldar, P.1
  • 72
    • 61849155730 scopus 로고    scopus 로고
    • Mepolizumab for prednisone-dependent asthma with sputum eosinophilia
    • Nair P, et al. Mepolizumab for prednisone-dependent asthma with sputum eosinophilia. N Engl J Med 2009;360:985-993.
    • (2009) N Engl J Med , vol.360 , pp. 985-993
    • Nair, P.1
  • 73
    • 0028787397 scopus 로고
    • Glucocorticoids inhibit apoptosis of human neutrophils
    • Liles WC, Dale DC, Klebanoff SJ. Glucocorticoids inhibit apoptosis of human neutrophils. Blood 1995;86:3181-3188.
    • (1995) Blood , vol.86 , pp. 3181-3188
    • Liles, W.C.1    Dale, D.C.2    Klebanoff, S.J.3
  • 74
    • 35348909044 scopus 로고    scopus 로고
    • Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: results of two phase 2a studies
    • Wenzel S, Wilbraham D, Fuller R, Getz EB, Longphre M. Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: results of two phase 2a studies. Lancet 2007;370:1422-1431.
    • (2007) Lancet , vol.370 , pp. 1422-1431
    • Wenzel, S.1    Wilbraham, D.2    Fuller, R.3    Getz, E.B.4    Longphre, M.5
  • 75
    • 79954583416 scopus 로고    scopus 로고
    • The effects of IL-13 blockade on allergen-induced airway responses in mild atopic asthma
    • Gauvreau GM, et al. The effects of IL-13 blockade on allergen-induced airway responses in mild atopic asthma. Am J Respir Crit Care Med 2011;183:1007-1014.
    • (2011) Am J Respir Crit Care Med , vol.183 , pp. 1007-1014
    • Gauvreau, G.M.1
  • 76
    • 0036434681 scopus 로고    scopus 로고
    • Expression and activation of 15-lipoxygenase pathway in severe asthma: relationship to eosinophilic phenotype and collagen deposition
    • Chu HW, et al. Expression and activation of 15-lipoxygenase pathway in severe asthma: relationship to eosinophilic phenotype and collagen deposition. Clin Exp Allergy 2002;32:1558-1565.
    • (2002) Clin Exp Allergy , vol.32 , pp. 1558-1565
    • Chu, H.W.1
  • 77
    • 77954725559 scopus 로고    scopus 로고
    • DP(2) receptor antagonists in development
    • Norman P. DP(2) receptor antagonists in development. Expert Opin Investig Drugs 2010;19:947-961.
    • (2010) Expert Opin Investig Drugs , vol.19 , pp. 947-961
    • Norman, P.1
  • 78
    • 77953544246 scopus 로고    scopus 로고
    • Therapeutic efficacy of AM156, a novel prostanoid DP2 receptor antagonist, in murine models of allergic rhinitis and house dust mite-induced pulmonary inflammation
    • Stebbins KJ, et al. Therapeutic efficacy of AM156, a novel prostanoid DP2 receptor antagonist, in murine models of allergic rhinitis and house dust mite-induced pulmonary inflammation. Eur J Pharmacol 2010;638:142-149.
    • (2010) Eur J Pharmacol , vol.638 , pp. 142-149
    • Stebbins, K.J.1
  • 79
    • 73549084724 scopus 로고    scopus 로고
    • Identification and characterisation of new inhibitors for the human hematopoietic prostaglandin D2 synthase
    • Weber JE, et al. Identification and characterisation of new inhibitors for the human hematopoietic prostaglandin D2 synthase. Eur J Med Chem 2009;45:447-454.
    • (2009) Eur J Med Chem , vol.45 , pp. 447-454
    • Weber, J.E.1
  • 80
    • 59549107363 scopus 로고    scopus 로고
    • Correlation between the prostaglandin D(2)/E(2) ratio in nasal polyps and the recalcitrant pathophysiology of chronic rhinosinusitis associated with bronchial asthma
    • Yoshimura T, Yoshikawa M, Otori N, Haruna S, Moriyama H. Correlation between the prostaglandin D(2)/E(2) ratio in nasal polyps and the recalcitrant pathophysiology of chronic rhinosinusitis associated with bronchial asthma. Allergol Int 2008;57:429-436.
    • (2008) Allergol Int , vol.57 , pp. 429-436
    • Yoshimura, T.1    Yoshikawa, M.2    Otori, N.3    Haruna, S.4    Moriyama, H.5
  • 81
    • 0027231657 scopus 로고
    • Cellular and biochemical analysis of induced sputum from asthmatic and from healthy subjects
    • Fahy JV, Liu J, Wong H, Boushey HA. Cellular and biochemical analysis of induced sputum from asthmatic and from healthy subjects. Am Rev Respir Dis 1993;147:1126-1131.
    • (1993) Am Rev Respir Dis , vol.147 , pp. 1126-1131
    • Fahy, J.V.1    Liu, J.2    Wong, H.3    Boushey, H.A.4
  • 82
    • 0029152965 scopus 로고
    • Comparison of samples collected by sputum induction and bronchoscopy from asthmatic and healthy subjects
    • Fahy JV, Wong H, Liu J, Boushey HA. Comparison of samples collected by sputum induction and bronchoscopy from asthmatic and healthy subjects. Am J Respir Crit Care Med 1995;152:53-58.
    • (1995) Am J Respir Crit Care Med , vol.152 , pp. 53-58
    • Fahy, J.V.1    Wong, H.2    Liu, J.3    Boushey, H.A.4
  • 83
    • 0031011133 scopus 로고    scopus 로고
    • Cellular profiles in asthmatic airways: a comparison of induced sputum, bronchial washings, and bronchoalveolar lavage fluid
    • Keatings VM, Evans DJ, O'Connor BJ, Barnes PJ. Cellular profiles in asthmatic airways: a comparison of induced sputum, bronchial washings, and bronchoalveolar lavage fluid. Thorax 1997;52:372-374.
    • (1997) Thorax , vol.52 , pp. 372-374
    • Keatings, V.M.1    Evans, D.J.2    O'Connor, B.J.3    Barnes, P.J.4
  • 84
    • 0032990182 scopus 로고    scopus 로고
    • Prednisone-dependent asthma: inflammatory indices in induced sputum
    • Pizzichini MM, et al. Prednisone-dependent asthma: inflammatory indices in induced sputum. Eur Respir J 1999;13:15-21.
    • (1999) Eur Respir J , vol.13 , pp. 15-21
    • Pizzichini, M.M.1
  • 85
    • 0033956855 scopus 로고    scopus 로고
    • Changes in sputum eosinophils predict loss of asthma control
    • Jatakanon A, Lim S, Barnes PJ. Changes in sputum eosinophils predict loss of asthma control. Am J Respir Crit Care Med 2000;161:64-72.
    • (2000) Am J Respir Crit Care Med , vol.161 , pp. 64-72
    • Jatakanon, A.1    Lim, S.2    Barnes, P.J.3
  • 87
    • 0033007431 scopus 로고    scopus 로고
    • Sputum analysis, bronchial hyperresponsiveness, and airway function in asthma: results of a factor analysis
    • Rosi E, Ronchi MC, Grazzini M, Duranti R, Scano G. Sputum analysis, bronchial hyperresponsiveness, and airway function in asthma: results of a factor analysis. J Allergy Clin Immunol 1999;103:232-237.
    • (1999) J Allergy Clin Immunol , vol.103 , pp. 232-237
    • Rosi, E.1    Ronchi, M.C.2    Grazzini, M.3    Duranti, R.4    Scano, G.5
  • 88
    • 0037202790 scopus 로고    scopus 로고
    • Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial
    • Green RH, et al. Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial. Lancet 2002;360:1715-1721.
    • (2002) Lancet , vol.360 , pp. 1715-1721
    • Green, R.H.1
  • 89
    • 33646787430 scopus 로고    scopus 로고
    • Strategy aimed at reduction of sputum eosinophils decreases exacerbation rate in patients with asthma
    • Chlumsky J, Striz I, Terl M, Vondracek J. Strategy aimed at reduction of sputum eosinophils decreases exacerbation rate in patients with asthma. J Int Med Res 2006;34:129-139.
    • (2006) J Int Med Res , vol.34 , pp. 129-139
    • Chlumsky, J.1    Striz, I.2    Terl, M.3    Vondracek, J.4
  • 90
    • 33344476409 scopus 로고    scopus 로고
    • Determining asthma treatment by monitoring sputum cell counts: effect on exacerbations
    • Jayaram L, et al. Determining asthma treatment by monitoring sputum cell counts: effect on exacerbations. Eur Respir J 2006;27:483-494.
    • (2006) Eur Respir J , vol.27 , pp. 483-494
    • Jayaram, L.1
  • 91
    • 0037339282 scopus 로고    scopus 로고
    • Reproducibility of exhaled nitric oxide measurements in healthy and asthmatic adults and children
    • Kharitonov SA, Gonio F, Kelly C, Meah S, Barnes PJ. Reproducibility of exhaled nitric oxide measurements in healthy and asthmatic adults and children. Eur Respir J 2003;21:433-438.
    • (2003) Eur Respir J , vol.21 , pp. 433-438
    • Kharitonov, S.A.1    Gonio, F.2    Kelly, C.3    Meah, S.4    Barnes, P.J.5
  • 93
    • 0027427353 scopus 로고
    • Increased amount of nitric oxide in exhaled air of asthmatics
    • Alving K, Weitzberg E, Lundberg JM. Increased amount of nitric oxide in exhaled air of asthmatics. Eur Respir J 1993;6:1368-1370.
    • (1993) Eur Respir J , vol.6 , pp. 1368-1370
    • Alving, K.1    Weitzberg, E.2    Lundberg, J.M.3
  • 94
    • 0031900026 scopus 로고    scopus 로고
    • Correlation between exhaled nitric oxide, sputum eosinophils, and methacholine responsiveness in patients with mild asthma
    • Jatakanon A, Lim S, Kharitonov SA, Chung KF, Barnes PJ. Correlation between exhaled nitric oxide, sputum eosinophils, and methacholine responsiveness in patients with mild asthma. Thorax 1998;53:91-95.
    • (1998) Thorax , vol.53 , pp. 91-95
    • Jatakanon, A.1    Lim, S.2    Kharitonov, S.A.3    Chung, K.F.4    Barnes, P.J.5
  • 95
    • 0035888740 scopus 로고    scopus 로고
    • Relationship between exhaled nitric oxide and mucosal eosinophilic inflammation in children with difficult asthma, after treatment with oral prednisolone
    • Payne DN, Adcock IM, Wilson NM, Oates T, Scallan M, Bush A. Relationship between exhaled nitric oxide and mucosal eosinophilic inflammation in children with difficult asthma, after treatment with oral prednisolone. Am J Respir Crit Care Med 2001;164:1376-1381.
    • (2001) Am J Respir Crit Care Med , vol.164 , pp. 1376-1381
    • Payne, D.N.1    Adcock, I.M.2    Wilson, N.M.3    Oates, T.4    Scallan, M.5    Bush, A.6
  • 96
    • 33644773052 scopus 로고    scopus 로고
    • The use of exhaled nitric oxide concentration to identify eosinophilic airway inflammation: an observational study in adults with asthma
    • Berry MA, Shaw DE, Green RH, Brightling CE, Wardlaw AJ, Pavord ID. The use of exhaled nitric oxide concentration to identify eosinophilic airway inflammation: an observational study in adults with asthma. Clin Exp Allergy 2005;35:1175-1179.
    • (2005) Clin Exp Allergy , vol.35 , pp. 1175-1179
    • Berry, M.A.1    Shaw, D.E.2    Green, R.H.3    Brightling, C.E.4    Wardlaw, A.J.5    Pavord, I.D.6
  • 97
    • 34547557916 scopus 로고    scopus 로고
    • The use of exhaled nitric oxide to guide asthma management: a randomized controlled trial
    • Shaw DE, et al. The use of exhaled nitric oxide to guide asthma management: a randomized controlled trial. Am J Respir Crit Care Med 2007;176:231-237.
    • (2007) Am J Respir Crit Care Med , vol.176 , pp. 231-237
    • Shaw, D.E.1
  • 98
  • 99
    • 24644519265 scopus 로고    scopus 로고
    • Titrating steroids on exhaled nitric oxide in children with asthma: a randomized controlled trial
    • Pijnenburg MW, Bakker EM, Hop WC, De Jongste JC. Titrating steroids on exhaled nitric oxide in children with asthma: a randomized controlled trial. Am J Respir Crit Care Med 2005;172:831-836.
    • (2005) Am J Respir Crit Care Med , vol.172 , pp. 831-836
    • Pijnenburg, M.W.1    Bakker, E.M.2    Hop, W.C.3    De Jongste, J.C.4
  • 100
    • 77949500839 scopus 로고    scopus 로고
    • Determinants of exhaled nitric oxide in chronic rhinosinusitis
    • Guida G, et al. Determinants of exhaled nitric oxide in chronic rhinosinusitis. Chest 2010;137:658-664.
    • (2010) Chest , vol.137 , pp. 658-664
    • Guida, G.1
  • 101
    • 75649142498 scopus 로고    scopus 로고
    • External oligonucleotide standards enable cross laboratory comparison and exchange of real-time quantitative PCR data
    • Vermeulen J, et al. External oligonucleotide standards enable cross laboratory comparison and exchange of real-time quantitative PCR data. Nucleic Acids Res 2009;37:e138.
    • (2009) Nucleic Acids Res , vol.37
    • Vermeulen, J.1
  • 102
    • 23944492134 scopus 로고    scopus 로고
    • Overview of the HUPO Plasma Proteome Project: results from the pilot phase with 35 collaborating laboratories and multiple analytical groups, generating a core dataset of 3020 proteins and a publicly-available database
    • Omenn GS, et al. Overview of the HUPO Plasma Proteome Project: results from the pilot phase with 35 collaborating laboratories and multiple analytical groups, generating a core dataset of 3020 proteins and a publicly-available database. Proteomics 2005;5:3226-3245.
    • (2005) Proteomics , vol.5 , pp. 3226-3245
    • Omenn, G.S.1
  • 103
    • 2542568705 scopus 로고    scopus 로고
    • The human plasma proteome: a nonredundant list developed by combination of four separate sources
    • Anderson NL, et al. The human plasma proteome: a nonredundant list developed by combination of four separate sources. Mol Cell Proteomics 2004;3:311-326.
    • (2004) Mol Cell Proteomics , vol.3 , pp. 311-326
    • Anderson, N.L.1
  • 104
    • 77951634577 scopus 로고    scopus 로고
    • Cell type-specific gene expression differences in complex tissues
    • Shen-Orr SS, et al. Cell type-specific gene expression differences in complex tissues. Nat Methods 2010;7:287-289.
    • (2010) Nat Methods , vol.7 , pp. 287-289
    • Shen-Orr, S.S.1
  • 105
    • 77952470787 scopus 로고    scopus 로고
    • Gene-expression profiling for rejection surveillance after cardiac transplantation
    • Pham MX, et al. Gene-expression profiling for rejection surveillance after cardiac transplantation. N Engl J Med 2010;362:1890-1900.
    • (2010) N Engl J Med , vol.362 , pp. 1890-1900
    • Pham, M.X.1
  • 106
    • 75749099357 scopus 로고    scopus 로고
    • Systemic sclerosis and lupus: points in an interferon-mediated continuum
    • Assassi S, et al. Systemic sclerosis and lupus: points in an interferon-mediated continuum. Arthritis Rheum 2010;62:589-598.
    • (2010) Arthritis Rheum , vol.62 , pp. 589-598
    • Assassi, S.1
  • 107
    • 77955894773 scopus 로고    scopus 로고
    • An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis
    • Berry MP, et al. An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis. Nature 2010;466:973-977.
    • (2010) Nature , vol.466 , pp. 973-977
    • Berry, M.P.1
  • 108
    • 46749152178 scopus 로고    scopus 로고
    • A modular analysis framework for blood genomics studies: application to systemic lupus erythematosus
    • Chaussabel D, et al. A modular analysis framework for blood genomics studies: application to systemic lupus erythematosus. Immunity 2008;29:150-164.
    • (2008) Immunity , vol.29 , pp. 150-164
    • Chaussabel, D.1
  • 110
    • 55849148482 scopus 로고    scopus 로고
    • The cytokine network in asthma and chronic obstructive pulmonary disease
    • Barnes PJ. The cytokine network in asthma and chronic obstructive pulmonary disease. J Clin Invest 2008;118:3546-3556.
    • (2008) J Clin Invest , vol.118 , pp. 3546-3556
    • Barnes, P.J.1
  • 111
    • 19344362988 scopus 로고    scopus 로고
    • Oligonucleotide-microarray analysis of peripheral-blood lymphocytes in severe asthma
    • Hansel NN, et al. Oligonucleotide-microarray analysis of peripheral-blood lymphocytes in severe asthma. J Lab Clin Med 2005;145:263-274.
    • (2005) J Lab Clin Med , vol.145 , pp. 263-274
    • Hansel, N.N.1
  • 112
    • 26844520628 scopus 로고    scopus 로고
    • Profiling of genes expressed in peripheral blood mononuclear cells predicts glucocorticoid sensitivity in asthma patients
    • Hakonarson H, et al. Profiling of genes expressed in peripheral blood mononuclear cells predicts glucocorticoid sensitivity in asthma patients. Proc Natl Acad Sci USA 2005;102:14789-14794.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 14789-14794
    • Hakonarson, H.1
  • 113
    • 0033569406 scopus 로고    scopus 로고
    • Molecular classification of cancer: class discovery and class prediction by gene expression monitoring
    • Golub TR, et al. Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. Science 1999;286:531-537.
    • (1999) Science , vol.286 , pp. 531-537
    • Golub, T.R.1
  • 114
    • 33748693297 scopus 로고    scopus 로고
    • Validation and clinical utility of a 70-gene prognostic signature for women with node-negative breast cancer
    • Buyse M, et al. Validation and clinical utility of a 70-gene prognostic signature for women with node-negative breast cancer. J Natl Cancer Inst 2006;98:1183-1192.
    • (2006) J Natl Cancer Inst , vol.98 , pp. 1183-1192
    • Buyse, M.1
  • 115
    • 33644610514 scopus 로고    scopus 로고
    • Noninvasive discrimination of rejection in cardiac allograft recipients using gene expression profiling
    • Deng MC, et al. Noninvasive discrimination of rejection in cardiac allograft recipients using gene expression profiling. Am J Transplant 2006;6:150-160.
    • (2006) Am J Transplant , vol.6 , pp. 150-160
    • Deng, M.C.1
  • 116
    • 38749130138 scopus 로고    scopus 로고
    • Interlaboratory performance of a microarray-based gene expression test to determine tissue of origin in poorly differentiated and undifferentiated cancers
    • Dumur CI, et al. Interlaboratory performance of a microarray-based gene expression test to determine tissue of origin in poorly differentiated and undifferentiated cancers. J Mol Diagn 2008;10:67-77.
    • (2008) J Mol Diagn , vol.10 , pp. 67-77
    • Dumur, C.I.1
  • 117
    • 0037059509 scopus 로고    scopus 로고
    • Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet
    • Finotto S, et al. Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet. Science 2002;295:336-338.
    • (2002) Science , vol.295 , pp. 336-338
    • Finotto, S.1
  • 118
    • 13444257864 scopus 로고    scopus 로고
    • TH1-mediated airway hyperresponsiveness independent of neutrophilic inflammation
    • Cui J, et al. TH1-mediated airway hyperresponsiveness independent of neutrophilic inflammation. J Allergy Clin Immunol 2005;115:309-315.
    • (2005) J Allergy Clin Immunol , vol.115 , pp. 309-315
    • Cui, J.1
  • 119
    • 35548946223 scopus 로고    scopus 로고
    • T helper 1 cells stimulated with ovalbumin and IL-18 induce airway hyperresponsiveness and lung fibrosis by IFN-gamma and IL-13 production
    • Hayashi N, Yoshimoto T, Izuhara K, Matsui K, Tanaka T, Nakanishi K. T helper 1 cells stimulated with ovalbumin and IL-18 induce airway hyperresponsiveness and lung fibrosis by IFN-gamma and IL-13 production. Proc Natl Acad Sci USA 2007;104:14765-14770.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 14765-14770
    • Hayashi, N.1    Yoshimoto, T.2    Izuhara, K.3    Matsui, K.4    Tanaka, T.5    Nakanishi, K.6
  • 120
    • 65249179610 scopus 로고    scopus 로고
    • Pathogenesis of steroid-resistant airway hyperresponsiveness: interaction between IFN-gamma and TLR4/MyD88 pathways
    • Yang M, Kumar RK, Foster PS. Pathogenesis of steroid-resistant airway hyperresponsiveness: interaction between IFN-gamma and TLR4/MyD88 pathways. J Immunol 2009;182:5107-5115.
    • (2009) J Immunol , vol.182 , pp. 5107-5115
    • Yang, M.1    Kumar, R.K.2    Foster, P.S.3
  • 121
    • 27544465354 scopus 로고    scopus 로고
    • A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
    • Park H, et al. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol 2005;6:1133-1141.
    • (2005) Nat Immunol , vol.6 , pp. 1133-1141
    • Park, H.1
  • 122
    • 27544490377 scopus 로고    scopus 로고
    • Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
    • Harrington LE, et al. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 2005;6:1123-1132.
    • (2005) Nat Immunol , vol.6 , pp. 1123-1132
    • Harrington, L.E.1
  • 123
    • 69349093225 scopus 로고    scopus 로고
    • Interleukin-17 and type 17 helper T cells
    • Miossec P, Korn T, Kuchroo VK. Interleukin-17 and type 17 helper T cells. N Engl J Med 2009;361:888-898.
    • (2009) N Engl J Med , vol.361 , pp. 888-898
    • Miossec, P.1    Korn, T.2    Kuchroo, V.K.3
  • 124
    • 0034833339 scopus 로고    scopus 로고
    • IL-17 is increased in asthmatic airways and induces human bronchial fibroblasts to produce cytokines
    • Molet S, et al. IL-17 is increased in asthmatic airways and induces human bronchial fibroblasts to produce cytokines. J Allergy Clin Immunol 2001;108:430-438.
    • (2001) J Allergy Clin Immunol , vol.108 , pp. 430-438
    • Molet, S.1
  • 125
    • 33751180809 scopus 로고    scopus 로고
    • IL-17 mRNA in sputum of asthmatic patients: linking T cell driven inflammation and granulocytic influx?
    • Bullens DM, et al. IL-17 mRNA in sputum of asthmatic patients: linking T cell driven inflammation and granulocytic influx? Respir Res 2006;7:135.
    • (2006) Respir Res , vol.7 , pp. 135
    • Bullens, D.M.1
  • 126
    • 0037636682 scopus 로고    scopus 로고
    • Interleukin-17 in sputum correlates with airway hyperresponsiveness to methacholine
    • Barczyk A, Pierzchala W, Sozanska E. Interleukin-17 in sputum correlates with airway hyperresponsiveness to methacholine. Respir Med 2003;97:726-733.
    • (2003) Respir Med , vol.97 , pp. 726-733
    • Barczyk, A.1    Pierzchala, W.2    Sozanska, E.3
  • 127
    • 20944441664 scopus 로고    scopus 로고
    • Sputum interleukin-17 is increased and associated with airway neutrophilia in patients with severe asthma
    • Sun YC, Zhou QT, Yao WZ. Sputum interleukin-17 is increased and associated with airway neutrophilia in patients with severe asthma. Chin Med J (Engl) 2005;118:953-956.
    • (2005) Chin Med J (Engl) , vol.118 , pp. 953-956
    • Sun, Y.C.1    Zhou, Q.T.2    Yao, W.Z.3
  • 128
    • 67349203306 scopus 로고    scopus 로고
    • T(H)17-associated cytokines (IL-17A and IL-17F) in severe asthma
    • Al-Ramli W, et al. T(H)17-associated cytokines (IL-17A and IL-17F) in severe asthma. J Allergy Clin Immunol 2009;123:1185-1187.
    • (2009) J Allergy Clin Immunol , vol.123 , pp. 1185-1187
    • Al-Ramli, W.1
  • 129
    • 47249125726 scopus 로고    scopus 로고
    • Chronically inflamed human tissues are infiltrated by highly differentiated Th17 lymphocytes
    • Pene J, et al. Chronically inflamed human tissues are infiltrated by highly differentiated Th17 lymphocytes. J Immunol 2008;180:7423-7430.
    • (2008) J Immunol , vol.180 , pp. 7423-7430
    • Pene, J.1
  • 130
    • 78349269946 scopus 로고    scopus 로고
    • Expression of the T helper 17-associated cytokines IL-17A and IL-17F in asthma and COPD
    • Doe C, et al. Expression of the T helper 17-associated cytokines IL-17A and IL-17F in asthma and COPD. Chest 2010;138:1140-1147.
    • (2010) Chest , vol.138 , pp. 1140-1147
    • Doe, C.1
  • 131
    • 77953913216 scopus 로고    scopus 로고
    • Increased serum IL-17 is an independent risk factor for severe asthma
    • Agache I, Ciobanu C, Agache C, Anghel M. Increased serum IL-17 is an independent risk factor for severe asthma. Respir Med 2010;104:1131-1137.
    • (2010) Respir Med , vol.104 , pp. 1131-1137
    • Agache, I.1    Ciobanu, C.2    Agache, C.3    Anghel, M.4
  • 133
    • 0037592950 scopus 로고    scopus 로고
    • Stimulation of airway mucin gene expression by interleukin (IL)-17 through IL-6 paracrine/autocrine loop
    • Chen Y, Thai P, Zhao YH, Ho YS, DeSouza MM, Wu R. Stimulation of airway mucin gene expression by interleukin (IL)-17 through IL-6 paracrine/autocrine loop. J Biol Chem 2003;278:17036-17043.
    • (2003) J Biol Chem , vol.278 , pp. 17036-17043
    • Chen, Y.1    Thai, P.2    Zhao, Y.H.3    Ho, Y.S.4    DeSouza, M.M.5    Wu, R.6
  • 134
    • 77954239363 scopus 로고    scopus 로고
    • Regulation of airway MUC5AC expression by IL-1beta and IL-17A; the NF-kappaB paradigm
    • Fujisawa T, Velichko S, Thai P, Hung LY, Huang F, Wu R. Regulation of airway MUC5AC expression by IL-1beta and IL-17A; the NF-kappaB paradigm. J Immunol 2009;183:6236-6243.
    • (2009) J Immunol , vol.183 , pp. 6236-6243
    • Fujisawa, T.1    Velichko, S.2    Thai, P.3    Hung, L.Y.4    Huang, F.5    Wu, R.6
  • 135
    • 56149097181 scopus 로고    scopus 로고
    • TH17 cells mediate steroid-resistant airway inflammation and airway hyperresponsiveness in mice
    • McKinley L, et al. TH17 cells mediate steroid-resistant airway inflammation and airway hyperresponsiveness in mice. J Immunol 2008;181:4089-4097.
    • (2008) J Immunol , vol.181 , pp. 4089-4097
    • McKinley, L.1
  • 136
    • 43549110961 scopus 로고    scopus 로고
    • Regulation of inflammatory responses by IL-17F
    • Yang XO, et al. Regulation of inflammatory responses by IL-17F. J Exp Med 2008;205:1063-1075.
    • (2008) J Exp Med , vol.205 , pp. 1063-1075
    • Yang, X.O.1
  • 137
    • 78149326083 scopus 로고    scopus 로고
    • A novel subset of CD4(+) T(H)2 memory/effector cells that produce inflammatory IL-17 cytokine and promote the exacerbation of chronic allergic asthma
    • Wang YH, et al. A novel subset of CD4(+) T(H)2 memory/effector cells that produce inflammatory IL-17 cytokine and promote the exacerbation of chronic allergic asthma. J Exp Med 2010;207:2479-2491.
    • (2010) J Exp Med , vol.207 , pp. 2479-2491
    • Wang, Y.H.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.