Blood or sputum eosinophils to guide asthma therapy?

The Lancet Respiratory Medicine

Volumn 3, Issue 11, 2015, Pages 824-825

  Mukherjee, Manali ^a   Nair, Parameswaran ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CORTICOSTEROID; INTERLEUKIN 13; INTERLEUKIN 13 ANTIBODY; INTERLEUKIN 5; INTERLEUKIN 5 ANTIBODY; MEPOLIZUMAB; PREDNISONE; ANTIASTHMATIC AGENT;

ASTHMA; BLOOD ANALYSIS; DISEASE ASSOCIATION; DISEASE CONTROL; DISEASE EXACERBATION; DISEASE SEVERITY; DOSE RESPONSE; EOSINOPHIL COUNT; EOSINOPHILIA; FORCED EXPIRATORY VOLUME; HUMAN; LEUKOCYTE ACTIVATION; LYMPHOID CELL; NOTE; PREDICTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); RESPIRATORY TRACT DISEASE; SPUTUM ANALYSIS; SYSTEMIC THERAPY; BLOOD; COST OF ILLNESS; EOSINOPHIL; FEMALE; LEUKOCYTE COUNT; MALE;

ANTI-ASTHMATIC AGENTS; ASTHMA; COST OF ILLNESS; EOSINOPHILS; FEMALE; HUMANS; LEUKOCYTE COUNT; MALE;

EID: 84961050904     PISSN: 22132600     EISSN: 22132619     Source Type: Journal    
DOI: 10.1016/S2213-2600(15)00419-1     Document Type: Note

References (14)

1. Nair P, Pizzichini M, Kjarsgaard M, et al. Mepolizumab for prednisone-dependent asthma with sputum eosinophilia. N Engl J Med 2009, 360:985-993.
2. Horn BR, Robin ED, Theodore J, Van Kessel A Total eosinophil counts in the management of bronchial asthma. N Engl J Med 1975, 292:1152-1155.
3. Pavord ID, Korn S, Howarth P, et al. Mepolizumab for severe eosinophilic asthma: a multi-centre, double-blind, placebo-controlled trial. Lancet 2012, 380:651-659.
4. Tran TN, Khatry DB, Ke X, et al. High blood eosinophil count is associated with more frequent asthma attacks in asthma patients. Ann Allergy Asthma Immunol 2014, 113:19-24.
5. Bousquet J, Chanez P, Lacoste JY, et al. Eosinophilic inflammation in asthma. N Engl J Med 1990, 323:1033-1039.
6. Belda J, Nair P, Lemiere C, Kamada D, O'Byrne PM, Hargreave FE Predictors of loss of asthma control induced by corticosteroid withdrawal. Can Respir J 2006, 13:129-133.
7. Price DB, Rigazio A, Campbell JD, et al. Blood eosinophil count and prospective annual asthma disease burden: a UK cohort study. Lancet Respir Med 2015, published online Oct 20. http://dx.doi.org/10.1016/S2213-2600(15)00367-7.
8. Pizzichini M, Pizzichini E, Clelland L, et al. Prednisone-dependent asthma: inflammatory indices in induced sputum. Eur Respir J 1999, 13:15-21.
9. Fowler SJ, Tavernier G, Niven R, et al. High blood eosinophil counts predict sputum eosinophilia in patients with severe asthma. J Allergy Clin Immunol 2015, 135:822. 24.e2.
10. Schleich FN, Chevremont A, Paulus V, et al. Importance of concomitant local and systemic eosinophilia in uncontrolled asthma. Eur Respir J 2014, 44:97-108.
11. Smith SG, Chen R, Kjarsgaard M, et al. Increased numbers of activated group 2 innate lymphoid cells in the airways of patients with severe asthma and persistent airway eosinophilia. J Allergy Clin Immunol 2015, published online July 17. 10.1016/j.jaci.2015.05.037.
12. Corren J, Lemanske RF, Hanania NA, et al. Lebrikizumab treatment in adults with asthma. N Engl J Med 2011, 365:1088-1098.
13. Nair P, Ochkur SI, Protheroe C, et al. Eosinophil peroxidase in sputum represents a unique biomarker of airway eosinophilia. Allergy 2013, 68:1177-1184.
14. Wark PAB, McDonald VM, Gibson PG Adjusting prednisone using blood eosinophils reduces exacerbations and improves asthma control in difficult patients with asthma. Respirology 2015, published online Aug 12. 10.1111/resp.12602.