Dupilumab improves the molecular signature in skin of patients with moderate-to-severe atopic dermatitis

Journal of Allergy and Clinical Immunology

Volumn 134, Issue 6, 2014, Pages 1293-1300

  Hamilton, Jennifer D ^a   Suárez Fariñas, Mayte ^b   Dhingra, Nikhil ^b   Cardinale, Irma ^b   Li, Xuan ^b   Kostic, Ana ^a   Ming, Jeffrey E ^c   Radin, Allen R ^a   Krueger, James G ^b   Graham, Neil ^a   Yancopoulos, George D ^a   Pirozzi, Gianluca ^c   Guttman Yassky, Emma ^b,d  

^a REGENERON PHARMACEUTICALS INC   (United States)

^b ROCKEFELLER UNIVERSITY   (United States)

^c SANOFI   (France)

^d MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Atopic dermatitis; dupilumab; gene expression; IL 4 receptor inhibition; skin; TH2 axis; transcriptome

Indexed keywords

ADIPONECTIN; CCL18 CHEMOKINE; CD1B ANTIGEN; CD1C ANTIGEN; CD83 ANTIGEN; CHEMOKINE; CXCL1 CHEMOKINE; CYTOKERATIN 16; CYTOKERATIN 6; DUPILUMAB; EOTAXIN 3; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GLYCOPROTEIN P 15095; IMMUNOGLOBULIN E; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 4 RECEPTOR ALPHA; INTERLEUKIN 5; INTERLEUKIN 6; INTERLEUKIN 7 RECEPTOR; INTERLEUKIN 8; MACROPHAGE DERIVED CHEMOKINE; MACROPHAGE ELASTASE; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 4; STAT6 PROTEIN; THYMUS AND ACTIVATION REGULATED CHEMOKINE; TRANSCRIPTION FACTOR GATA 3; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ANTIALLERGIC AGENT; ANTIASTHMATIC AGENT; CYTOKINE; MONOCLONAL ANTIBODY;

ADULT; ARTICLE; ATOPIC DERMATITIS; CLINICAL ARTICLE; DENDRITIC CELL; DISEASE ACTIVITY; DOWN REGULATION; EPIDERMIS HYPERPLASIA; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; MALE; MODERATE TO SEVERE ATOPIC DERMATITIS; MULTICENTER STUDY (TOPIC); PHASE 1 CLINICAL TRIAL (TOPIC); PROTEIN EXPRESSION; RANDOMIZED CONTROLLED TRIAL (TOPIC); SKIN BIOPSY; T LYMPHOCYTE; TH2 CELL; TRANSCRIPTOMICS; UPREGULATION; ANTAGONISTS AND INHIBITORS; CLINICAL TRIAL; CONTROLLED STUDY; DNA MICROARRAY; DOUBLE BLIND PROCEDURE; DRUG EFFECTS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; MIDDLE AGED; MULTICENTER STUDY; PHASE 1 CLINICAL TRIAL; RANDOMIZED CONTROLLED TRIAL; SKIN; YOUNG ADULT;

ADULT; ANTI-ALLERGIC AGENTS; ANTI-ASTHMATIC AGENTS; ANTIBODIES, MONOCLONAL; CYTOKINES; DERMATITIS, ATOPIC; DOUBLE-BLIND METHOD; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; MALE; MIDDLE AGED; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; SKIN; TH2 CELLS; YOUNG ADULT;

EID: 84919635394     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2014.10.013     Document Type: Article

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