An antibody that prevents serpin polymerisation acts by inducing a novel allosteric behavior

Biochemical Journal

Volumn 473, Issue 19, 2016, Pages 3269-3290

  Motamedi Shad, Neda ^a,b   Jagger, Alistair M ^a,b   Liedtke, Maximilian ^a   Faull, Sarah V ^a,b,c   Nanda, Arjun Scott ^b   Salvadori, Enrico ^b,d,e   Wort, Joshua L ^b   Kay, Christopher W M ^b,d   Heyer Chauhan, Narinder ^a,b   Miranda, Elena ^f   Perez, Juan ^g   Ordóñez, Adriana ^c   Haq, Imran ^a,b   Irving, James A ^a,b   Lomas, David A ^a,b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF LONDON   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d LONDON CENTRE FOR NANOTECHNOLOGY   (United Kingdom)

^e QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^f SAPIENZA UNIVERSITY OF ROME   (Italy)

^g UNIVERSITY OF MÁLAGA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; EPITOPE; LIGAND; PEPTIDE; POLYMER; SERINE PROTEINASE INHIBITOR; ALPHA 1 ANTITRYPSIN; MONOCLONAL ANTIBODY;

ALLOSTERISM; ANTIGEN BINDING; ARTICLE; BETA SHEET; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ESCHERICHIA COLI; MOLECULE; NONHUMAN; POLYMERIZATION; PRIORITY JOURNAL; CHEMISTRY; ELECTRON SPIN RESONANCE; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENETICS; METABOLISM; SITE DIRECTED MUTAGENESIS; TEMPERATURE;

ALLOSTERIC REGULATION; ALPHA 1-ANTITRYPSIN; ANTIBODIES, MONOCLONAL; ELECTRON SPIN RESONANCE SPECTROSCOPY; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLUORESCENCE RESONANCE ENERGY TRANSFER; MUTAGENESIS, SITE-DIRECTED; POLYMERIZATION; SERPINS; TEMPERATURE;

EID: 85010004900     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BCJ20160159     Document Type: Article

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