An antibody raised against a pathogenic serpin variant induces mutant-like behaviour in the wild-type protein

Biochemical Journal

Volumn 468, Issue 1, 2015, Pages 99-108

  Irving, James A ^a   Miranda, Elena ^b   Haq, Imran ^a   Perez, Juan ^c   Kotov, Vadim R ^d   Faull, Sarah V ^a,e   Motamedi Shad, Neda ^a   Lomas, David A ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c UNIVERSITY OF MÁLAGA   (Spain)

^d RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^e UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Aggregation; Antibody; Polymerization; Protein stability; 1 antitrypsin

Indexed keywords

ALPHA 1 ANTITRYPSIN; EPITOPE; MONOCLONAL ANTIBODY; MONOMER; SERINE PROTEINASE INHIBITOR; IMMUNOGLOBULIN F(AB) FRAGMENT; SERPINA1 PROTEIN, HUMAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY PRODUCTION; ANTIGEN BINDING; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; MOUSE; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN STABILITY; THERMOSTABILITY; AMINO ACID SUBSTITUTION; ANIMAL; ANTIBODY SPECIFICITY; BAGG ALBINO MOUSE; CHEMICAL STRUCTURE; CHEMISTRY; GENETIC VARIABILITY; GENETICS; HUMAN; IMMUNOLOGY; MUTATION; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; PROTEIN QUATERNARY STRUCTURE; THERMODYNAMICS;

ALPHA 1-ANTITRYPSIN; AMINO ACID SUBSTITUTION; ANIMALS; ANTIBODIES, MONOCLONAL, MURINE-DERIVED; ANTIBODY SPECIFICITY; EPITOPES; GENETIC VARIATION; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; MICE; MICE, INBRED BALB C; MODELS, MOLECULAR; MUTATION; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; PROTEIN STABILITY; PROTEIN STRUCTURE, QUATERNARY; THERMODYNAMICS;

EID: 84934920503     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20141569     Document Type: Article

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