Inactive conformation of the serpin α1-antichymotrypsin indicates two-stage insertion of the reactive loop: Implications for inhibitory function and conformational disease

Proceedings of the National Academy of Sciences of the United States of America

Volumn 97, Issue 1, 2000, Pages 67-72

  Gooptu, Bibek ^a   Hazes, Bart ^a   Chang, Wun Shaing W ^a,b   Dafforn, Timothy R ^a   Carrell, Robin W ^a   Read, Randy J ^a   Lomas, David A ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 1 ANTICHYMOTRYPSIN; SERINE PROTEINASE INHIBITOR;

ANGIONEUROTIC EDEMA; ARTICLE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CRYSTALLIZATION; EMPHYSEMA; LIVER CIRRHOSIS; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN STRUCTURE; THROMBOSIS;

ALPHA 1-ANTICHYMOTRYPSIN; CHROMATOGRAPHY, AFFINITY; HUMANS; LUNG DISEASES, OBSTRUCTIVE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PLASMIDS; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; X-RAY DIFFRACTION;

EID: 0034602778     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.97.1.67     Document Type: Article

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