Reactive centre loop mutants of α-1-antitrypsin reveal position-specific effects on intermediate formation along the polymerization pathway

Bioscience Reports

Volumn 33, Issue 3, 2013, Pages 499-511

  Haq, Imran ^a   Irving, James A ^a   Faull, Sarah V ^a   Dickens, Jennifer A ^a   Órdñez, Adriana ^a   Belorgey, Didier ^a,c   Gooptu, Bibek ^b   Lomas, David A ^a,d  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF LONDON   (United Kingdom)

^c UNIVERSITÉ DE STRASBOURG   (France)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Cirrhosis; Emphysema; FRET; Intermediate; Polymerization; Serpin

Indexed keywords

ALPHA 1 ANTITRYPSIN; MUTANT PROTEIN; RECOMBINANT ALPHA 1 ANTITRYPSIN; RECOMBINANT ENZYME; UNCLASSIFIED DRUG; RECOMBINANT PROTEIN;

ACTIVATION ENERGY; ANIMAL CELL; ARTICLE; BETA SHEET; CONTROLLED STUDY; ENERGY; GENE INSERTION; GENE MUTATION; IN VITRO STUDY; NONHUMAN; POLYMERIZATION; PROTEIN CLEAVAGE; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN INTERACTION; PROTEIN STRUCTURE; REACTIVE CENTRE LOOP; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; CHLOROCEBUS AETHIOPS; COS 1 CELL LINE; GENETICS; HUMAN; METABOLISM; MUTATION; PROTEIN SECONDARY STRUCTURE;

ALPHA 1-ANTITRYPSIN; ANIMALS; CERCOPITHECUS AETHIOPS; COS CELLS; HUMANS; MODELS, MOLECULAR; MUTATION; POLYMERIZATION; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT PROTEINS;

EID: 84879633515     PISSN: 01448463     EISSN: 15734935     Source Type: Journal    
DOI: 10.1042/BSR20130038     Document Type: Article

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