The structural basis of serpin polymerization studied by hydrogen/deuterium exchange and mass spectrometry

Journal of Biological Chemistry

Volumn 283, Issue 45, 2008, Pages 30804-30811

  Tsutsui, Yuko ^a   Kuri, Barbara ^a   Sengupta, Tanusree ^a   Wintrode, Patrick L ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL REACTIONS; ENZYME INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETERS; MASS SPECTROMETRY; MONOMERS; POLYMERIZATION; POLYMERS; SPECTROMETERS; SPECTROMETRY; SPECTRUM ANALYSIS; THEOREM PROVING;

ANTITRYPSIN; CONFORMATIONAL CHANGES; HYDROGEN/DEUTERIUM EXCHANGES; INHERITED DISORDERS; MISFOLDING; MODEL SYSTEMS; MODERATE TEMPERATURES; MOLECULAR BASES; MOLECULAR LEVELS; PROTEASE INHIBITORS; REACTIVE CENTER LOOPS; SERPINOPATHIES; SERPINS; STRUCTURAL BASES; STRUCTURAL INFORMATIONS;

FUNCTIONAL POLYMERS;

ALPHA 1 ANTITRYPSIN; POLYMER; SERINE PROTEINASE INHIBITOR;

ARTICLE; BETA SHEET; CHEMICAL STRUCTURE; CONFORMATIONAL TRANSITION; DEUTERIUM HYDROGEN EXCHANGE; MASS SPECTROMETRY; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN INTERACTION; STRUCTURE ANALYSIS; WILD TYPE;

ALPHA 1-ANTITRYPSIN; ALPHA 1-ANTITRYPSIN DEFICIENCY; CATALYTIC DOMAIN; DEUTERIUM EXCHANGE MEASUREMENT; HUMANS; MASS SPECTROMETRY; MODELS, MOLECULAR; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, SECONDARY;

EID: 57649219476     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M804048200     Document Type: Article

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