Characterising the association of latency with α1-antitrypsin polymerisation using a novel monoclonal antibody

International Journal of Biochemistry and Cell Biology

Volumn 58, Issue , 2015, Pages 81-91

  Tan, Lu ^a,b   Perez, Juan ^c   Mela, Marianna ^d   Miranda, Elena ^e   Burling, Keith A ^d   Rouhani, Farshid N ^f   DeMeo, Dawn L ^g   Haq, Imran ^h   Irving, James A ^h   Ordóñez, Adriana ^a   Dickens, Jennifer A ^a   Brantly, Mark ^f   Marciniak, Stefan J ^a   Alexander, Graeme J M ^d   Gooptu, Bibek ⁱ   Lomas, David A ^h  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b SWISS FEDERAL INSTITUTE OF AQUATIC SCIENCE AND TECHNOLOGY   (Switzerland)

^c UNIVERSITY OF MÁLAGA   (Spain)

^d CAMBRIDGE UNIVERSITY HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

^e Pasteur Institute   (Italy)

^f UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^g BRIGHAM AND WOMEN S HOSPITAL   (United States)

^h UNIVERSITY COLLEGE LONDON   (United Kingdom)

ⁱ GUY S HOSPITAL   (United Kingdom)

Author keywords

Augmentation therapy; Latency; Monoclonal antibodies; Polymerisation; 1 Antitrypsin

Indexed keywords

ALPHA 1 ANTITRYPSIN; ALPHA 1 ANTITRYPSIN CONCENTRATE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 1C12; POLYMER; PROTEIN ANTIBODY; UNCLASSIFIED DRUG;

ALPHA ANTITRYPSIN DEFICIENCY; ANALYTIC METHOD; ANIMAL CELL; ANTIBODY SPECIFICITY; ARTICLE; BLOOD SAMPLING; CHO CELL LINE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; LIVER; LIVER CELL; MICROENVIRONMENT; MOLECULAR PROBE; NONHUMAN; PROTEIN FOLDING; PROTEIN POLYMERIZATION; REACTION TIME; SECRETORY PATHWAY; CHEMISTRY; ENDOPLASMIC RETICULUM; KINETICS; METABOLISM; POLYMERIZATION; PROTEIN SECONDARY STRUCTURE;

ALPHA 1-ANTITRYPSIN; ANTIBODIES, MONOCLONAL; ENDOPLASMIC RETICULUM; KINETICS; POLYMERIZATION; PROTEIN STRUCTURE, SECONDARY;

EID: 84915758694     PISSN: 13572725     EISSN: 18785875     Source Type: Journal    
DOI: 10.1016/j.biocel.2014.11.005     Document Type: Article

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