The Serpin Inhibitory Mechanism Is Critically Dependent on the Length of the Reactive Center Loop

Journal of Biological Chemistry

Volumn 276, Issue 29, 2001, Pages 27541-27547

  Zhou, Aiwu ^a   Carrell, Robin W ^a   Huntington, James A ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL BONDS; CRYSTALLOGRAPHY; ENZYMES; TISSUE;

CATALYTIC SITES;

BIOCHEMISTRY;

ALPHA 1 ANTITRYPSIN; BLOOD CLOTTING FACTOR 10A; SERINE PROTEINASE INHIBITOR; THROMBIN;

ARTICLE; COVALENT BOND; CRYSTALLOGRAPHY; ENZYME ACTIVE SITE; ENZYME INACTIVATION; HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN STABILITY; PROTEIN STRUCTURE; PROTEIN VARIANT; AMINO ACID SEQUENCE; CHEMISTRY; DRUG ANTAGONISM; GENETICS; KINETICS; METABOLISM; MUTAGENESIS; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY; X RAY CRYSTALLOGRAPHY;

ALPHA 1-ANTITRYPSIN; AMINO ACID SEQUENCE; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FACTOR XA; HUMANS; KINETICS; MUTAGENESIS; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY, AMINO ACID; SERPINS;

EID: 0035920162     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M102594200     Document Type: Article

References (28)

1. Potempa, J., Korzus, E., and Travis, J. (1994) J. Biol. Chem. 269, 15957-15960
2. Gettins, P. G. W., Patston, P. A., and Olson, S. T. (1996) Serpins: Structure, Function and Biology, R. G. Landes, Co., Austin, TX
3. Laskowski, M., and Qasim, M. A. (2000) Biochim. Biophys. Acta 1477, 324-337
4. Patston, P. A., Gettins, P., Beechem, J., and Schapira, M. (1991) Biochemistry 30, 8876-8882
5. Gettins, P., Patston, P. A., and Schapira, M. (1992) Hematol. Oncol. Clin. North Am. 6, 1393-1408
6. Kaslik, G., Patthy, A., Balint, M., and Graf, L. (1995) FEBS Lett. 370, 179-183
7. Stavridi, E. S., O'Malley, K., Lukacs, C. M., Moore, W. T., Lambris, J. D., Christianson, D. W., Rubin, H., and Cooperman, B. S. (1996) Biochemistry 35, 10608-10615
8. Egelund, R., Petersen, T. E., and Andreasen, P. A. (2001) Eur. J. Biochem. 268, 673-685
9. Huntington, J. A., Read, R. J., and Carrell, R. W. (2000) Nature 407, 923-926
10. Huber, R., and Bode, W. (1978) Acc. Chem. Res. 11, 114-122
11. Huber, R., and Carrell, R. W. (1989) Biochemistry 28, 8951-8966
12. Holmes, W. E., Nelles, L., Lijnen, H. R., and Collen, D. (1987) J. Biol. Chem. 262, 1659-1664
13. Carter, P. E., Dunbar, B., and Fothergill, J. E. (1988) Eur. J. Biochem. 173, 163-169
14. Pickup, D. J., Ink, B. S., Hu, W., Ray, C. A., and Joklik, W. K. (1986) Proc. Natl. Acad. Sci. U. S. A. 83, 7698-7702
15. Komiyama, T., Ray, C. A., Pickup, D. J., Howard, A. D., Thornberry, N. A., Peterson, E. P., and Salvesen, G. (1994) J. Biol. Chem. 269, 19331-19337
16. Holmes, W. E., Lijnen, H. R., Nelles, L., Kluft, C., Nieuwenhuis, H. K., Rijken, D. C., and Collen, D. (1987) Science 238, 209-211
17. Owen, M. C., Brennan, S. O., Lewis, J. H., and Carrell, R. W. (1983) N. Engl. J. Med. 309, 694-698
18. Zhou, A., Jiang, X., Dou, F., Zhu, D., and Xu, X. (1997) J. Biochem. (Tokyo) 121, 930-934
19. Zhou, A., Faint, R., Charlton, P., Dafforn, T. R., Carrell, R. W., and Lomas, D. A. (2001) J. Biol. Chem. 276, 9115-9122
20. Pannell, R., Johnson, D., and Travis, J. (1974) Biochemistry 13, 5439-5445
21. Laemmli, U. K. (1970) Nature 227, 680-685
22. Jesty, J. (1979) J. Biol. Chem. 254, 10044-10050
23. Olson, S. T., Bock, P. E., Kvassman, J., Shore, J. D., Lawrence, D. A., Ginsburg, D., and Bjork, I. (1995) J. Biol. Chem. 270, 30007-30017
24. Olson, S. T., Swanson, R., Patston, P. A., and Bjork, I. (1997) J. Biol. Chem. 272, 13338-13342
25. Chaillan-Huntington, C. E., Gettins, P. G. W., Huntington, J. A., and Patston, P. A. (1997) Biochemistry 36, 9562-9570
26. Huntington, J. A., Fan, B., Karlsson, K. E., Deinum, J., Lawrence, D. A., and Gettins, P. G. (1997) Biochemistry 36, 5432-5440
27. Bottomley, S. P., and Stone, S. R. (1998) Protein Eng. 11, 1243-1247
28. Schechter, I., and Berger, A. (1967) Biochem. Biophys. Res. Commun. 27, 157-162