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Volumn 107, Issue , 2017, Pages 125-135

Radiation-induced clustered DNA lesions: Repair and mutagenesis

Author keywords

Base excision repair; Clustered DNA lesions; Complex DSB; DNA repair; Ionizing radiation; Multiply damaged sites; Non DSB clustered lesions; Oxidatively generated DNA damage

Indexed keywords

DNA; PROTEIN;

EID: 85009177463     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2016.12.008     Document Type: Review
Times cited : (191)

References (129)
  • 1
    • 0027973491 scopus 로고
    • The complexity of DNA damage: relevance to biological consequences
    • Ward, J.F., The complexity of DNA damage: relevance to biological consequences. Int J. Radiat. Biol. 66 (1994), 427–432.
    • (1994) Int J. Radiat. Biol. , vol.66 , pp. 427-432
    • Ward, J.F.1
  • 2
    • 0016827580 scopus 로고
    • Estimation of life times and diffusion distances of radicals involved in x-ray-induced DNA strand breaks of killing of mammalian cells
    • Roots, R., Okada, S., Estimation of life times and diffusion distances of radicals involved in x-ray-induced DNA strand breaks of killing of mammalian cells. Radiat. Res. 64 (1975), 306–320.
    • (1975) Radiat. Res. , vol.64 , pp. 306-320
    • Roots, R.1    Okada, S.2
  • 3
    • 0024516338 scopus 로고
    • Cell killing and DNA damage in Chinese hamster V79 cells treated with hydrogen peroxide
    • Prise, K.M., Davies, S., Michael, B.D., Cell killing and DNA damage in Chinese hamster V79 cells treated with hydrogen peroxide. Int J. Radiat. Biol. 55 (1989), 583–592.
    • (1989) Int J. Radiat. Biol. , vol.55 , pp. 583-592
    • Prise, K.M.1    Davies, S.2    Michael, B.D.3
  • 4
    • 0035178567 scopus 로고    scopus 로고
    • Base excision repair processing of radiation-induced clustered DNA lesions
    • Blaisdell, J.O., Harrison, L., Wallace, S.S., Base excision repair processing of radiation-induced clustered DNA lesions. Radiat. Prot. Dosim. 97 (2001), 25–31.
    • (2001) Radiat. Prot. Dosim. , vol.97 , pp. 25-31
    • Blaisdell, J.O.1    Harrison, L.2    Wallace, S.S.3
  • 5
    • 0027976408 scopus 로고
    • Initial events in the cellular effects of ionizing radiations: clustered damage in DNA
    • Goodhead, D.T., Initial events in the cellular effects of ionizing radiations: clustered damage in DNA. Int. J. Radiat. Biol. 65 (1994), 7–17.
    • (1994) Int. J. Radiat. Biol. , vol.65 , pp. 7-17
    • Goodhead, D.T.1
  • 6
    • 84880544586 scopus 로고    scopus 로고
    • Induction and repair of clustered DNA lesions: what do we know so far?
    • Georgakilas, A.G., O'Neill, P., Stewart, R.D., Induction and repair of clustered DNA lesions: what do we know so far?. Radiat. Res. 180 (2013), 100–109.
    • (2013) Radiat. Res. , vol.180 , pp. 100-109
    • Georgakilas, A.G.1    O'Neill, P.2    Stewart, R.D.3
  • 7
    • 0032934091 scopus 로고    scopus 로고
    • A study of endonuclease III-sensitive sites in irradiated DNA: detection of alpha-particle-induced oxidative damage
    • Prise, K.M., Pullar, C.H., Michael, B.D., A study of endonuclease III-sensitive sites in irradiated DNA: detection of alpha-particle-induced oxidative damage. Carcinogenesis 20 (1999), 905–909.
    • (1999) Carcinogenesis , vol.20 , pp. 905-909
    • Prise, K.M.1    Pullar, C.H.2    Michael, B.D.3
  • 8
    • 0034602643 scopus 로고    scopus 로고
    • Clustered DNA damages induced in isolated DNA and in human cells by low doses of ionizing radiation
    • Sutherland, B.M., Bennett, P.V., Sidorkina, O., Laval, J., Clustered DNA damages induced in isolated DNA and in human cells by low doses of ionizing radiation. Proc. Natl. Acad. Sci. USA 97 (2000), 103–108.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 103-108
    • Sutherland, B.M.1    Bennett, P.V.2    Sidorkina, O.3    Laval, J.4
  • 9
    • 0034636776 scopus 로고    scopus 로고
    • Clustered damages and total lesions induced in DNA by ionizing radiation: oxidized bases and strand breaks
    • Sutherland, B.M., Bennett, P.V., Sidorkina, O., Laval, J., Clustered damages and total lesions induced in DNA by ionizing radiation: oxidized bases and strand breaks. Biochemistry 39 (2000), 8026–8031.
    • (2000) Biochemistry , vol.39 , pp. 8026-8031
    • Sutherland, B.M.1    Bennett, P.V.2    Sidorkina, O.3    Laval, J.4
  • 11
    • 0036639367 scopus 로고    scopus 로고
    • High efficiency detection of bi-stranded abasic clusters in gamma-irradiated DNA by putrescine
    • Georgakilas, A.G., Bennett, P.V., Sutherland, B.M., High efficiency detection of bi-stranded abasic clusters in gamma-irradiated DNA by putrescine. Nucleic Acids Res. 30 (2002), 2800–2808.
    • (2002) Nucleic Acids Res. , vol.30 , pp. 2800-2808
    • Georgakilas, A.G.1    Bennett, P.V.2    Sutherland, B.M.3
  • 12
    • 0036682280 scopus 로고    scopus 로고
    • Clustered DNA damage induced by gamma radiation in human fibroblasts (HF19), hamster (V79-4) cells and plasmid DNA is revealed as Fpg and Nth sensitive sites
    • Gulston, M., Fulford, J., Jenner, T., de Lara, C., O'Neill, P., Clustered DNA damage induced by gamma radiation in human fibroblasts (HF19), hamster (V79-4) cells and plasmid DNA is revealed as Fpg and Nth sensitive sites. Nucleic Acids Res. 30 (2002), 3464–3472.
    • (2002) Nucleic Acids Res. , vol.30 , pp. 3464-3472
    • Gulston, M.1    Fulford, J.2    Jenner, T.3    de Lara, C.4    O'Neill, P.5
  • 13
    • 78649449767 scopus 로고    scopus 로고
    • The influence of heterochromatin on DNA double strand break repair: getting the strong, silent type to relax
    • Goodarzi, A.A., Jeggo, P., Lobrich, M., The influence of heterochromatin on DNA double strand break repair: getting the strong, silent type to relax. DNA Repair 9 (2010), 1273–1282.
    • (2010) DNA Repair , vol.9 , pp. 1273-1282
    • Goodarzi, A.A.1    Jeggo, P.2    Lobrich, M.3
  • 14
    • 6944248997 scopus 로고    scopus 로고
    • Processing of bistranded abasic DNA clusters in gamma-irradiated human hematopoietic cells
    • Georgakilas, A.G., Bennett, P.V., Wilson, D.M. 3rd, Sutherland, B.M., Processing of bistranded abasic DNA clusters in gamma-irradiated human hematopoietic cells. Nucleic Acids Res. 32 (2004), 5609–5620.
    • (2004) Nucleic Acids Res. , vol.32 , pp. 5609-5620
    • Georgakilas, A.G.1    Bennett, P.V.2    Wilson, D.M.3    Sutherland, B.M.4
  • 15
    • 37149027578 scopus 로고    scopus 로고
    • Processing of DNA damage clusters in human cells: current status of knowledge
    • Georgakilas, A.G., Processing of DNA damage clusters in human cells: current status of knowledge. Mol. Biosyst. 4 (2008), 30–35.
    • (2008) Mol. Biosyst. , vol.4 , pp. 30-35
    • Georgakilas, A.G.1
  • 16
    • 62549083858 scopus 로고    scopus 로고
    • The yield, processing, and biological consequences of clustered DNA damage induced by ionizing radiation
    • Shikazono, N., Noguchi, M., Fujii, K., Urushibara, A., Yokoya, A., The yield, processing, and biological consequences of clustered DNA damage induced by ionizing radiation. J. Radiat. Res. 50 (2009), 27–36.
    • (2009) J. Radiat. Res. , vol.50 , pp. 27-36
    • Shikazono, N.1    Noguchi, M.2    Fujii, K.3    Urushibara, A.4    Yokoya, A.5
  • 17
    • 79956197636 scopus 로고    scopus 로고
    • Delayed repair of radiation induced clustered DNA damage: friend or foe?
    • Eccles, L.J., O'Neill, P., Lomax, M.E., Delayed repair of radiation induced clustered DNA damage: friend or foe?. Mutat. Res. 711 (2011), 134–141.
    • (2011) Mutat. Res. , vol.711 , pp. 134-141
    • Eccles, L.J.1    O'Neill, P.2    Lomax, M.E.3
  • 18
    • 79956225907 scopus 로고    scopus 로고
    • Clustered DNA lesion repair in eukaryotes: relevance to mutagenesis and cell survival
    • Sage, E., Harrison, L., Clustered DNA lesion repair in eukaryotes: relevance to mutagenesis and cell survival. Mutat. Res. 711 (2011), 123–133.
    • (2011) Mutat. Res. , vol.711 , pp. 123-133
    • Sage, E.1    Harrison, L.2
  • 19
    • 0035912756 scopus 로고    scopus 로고
    • Abortive base-excision repair of radiation-induced clustered DNA lesions in Escherichia coli
    • Blaisdell, J.O., Wallace, S.S., Abortive base-excision repair of radiation-induced clustered DNA lesions in Escherichia coli. Proc. Natl. Acad. Sci. USA 98 (2001), 7426–7430.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 7426-7430
    • Blaisdell, J.O.1    Wallace, S.S.2
  • 20
    • 29244473835 scopus 로고    scopus 로고
    • Base excision repair by hNTH1 and hOGG1: a two edged sword in the processing of DNA damage in gamma-irradiated human cells
    • Yang, N., Chaudhry, M.A., Wallace, S.S., Base excision repair by hNTH1 and hOGG1: a two edged sword in the processing of DNA damage in gamma-irradiated human cells. DNA Repair 5 (2006), 43–51.
    • (2006) DNA Repair , vol.5 , pp. 43-51
    • Yang, N.1    Chaudhry, M.A.2    Wallace, S.S.3
  • 21
    • 2542637919 scopus 로고    scopus 로고
    • Processing of clustered DNA damage generates additional double-strand breaks in mammalian cells post-irradiation
    • Gulston, M., de Lara, C., Jenner, T., Davis, E., O'Neill, P., Processing of clustered DNA damage generates additional double-strand breaks in mammalian cells post-irradiation. Nucleic Acids Res. 32 (2004), 1602–1609.
    • (2004) Nucleic Acids Res. , vol.32 , pp. 1602-1609
    • Gulston, M.1    de Lara, C.2    Jenner, T.3    Davis, E.4    O'Neill, P.5
  • 22
    • 0142043465 scopus 로고    scopus 로고
    • Low levels of endogenous oxidative damage cluster levels in unirradiated viral and human DNAs
    • Sutherland, B.M., Bennett, P.V., Cintron, N.S., Guida, P., Laval, J., Low levels of endogenous oxidative damage cluster levels in unirradiated viral and human DNAs. Free Radic. Biol. Med. 35 (2003), 495–503.
    • (2003) Free Radic. Biol. Med. , vol.35 , pp. 495-503
    • Sutherland, B.M.1    Bennett, P.V.2    Cintron, N.S.3    Guida, P.4    Laval, J.5
  • 24
    • 2442448170 scopus 로고    scopus 로고
    • A fast Monte Carlo algorithm to simulate the spectrum of DNA damages formed by ionizing radiation
    • Semenenko, V.A., Stewart, R.D., A fast Monte Carlo algorithm to simulate the spectrum of DNA damages formed by ionizing radiation. Radiat. Res. 161 (2004), 451–457.
    • (2004) Radiat. Res. , vol.161 , pp. 451-457
    • Semenenko, V.A.1    Stewart, R.D.2
  • 25
    • 0034753336 scopus 로고    scopus 로고
    • Computational approach for determining the spectrum of DNA damage induced by ionizing radiation
    • Nikjoo, H., O'Neill, P., Wilson, W.E., Goodhead, D.T., Computational approach for determining the spectrum of DNA damage induced by ionizing radiation. Radiat. Res. 156 (2001), 577–583.
    • (2001) Radiat. Res. , vol.156 , pp. 577-583
    • Nikjoo, H.1    O'Neill, P.2    Wilson, W.E.3    Goodhead, D.T.4
  • 26
    • 31444445899 scopus 로고    scopus 로고
    • Spectrum of complex DNA damages depends on the incident radiation
    • Hada, M., Sutherland, B.M., Spectrum of complex DNA damages depends on the incident radiation. Radiat. Res. 165 (2006), 223–230.
    • (2006) Radiat. Res. , vol.165 , pp. 223-230
    • Hada, M.1    Sutherland, B.M.2
  • 27
    • 84929736161 scopus 로고    scopus 로고
    • Spectrum of radiation-induced clustered Non-DSB damage – a Monte Carlo track structure modeling and calculations
    • Watanabe, R., Rahmanian, S., Nikjoo, H., Spectrum of radiation-induced clustered Non-DSB damage – a Monte Carlo track structure modeling and calculations. Radiat. Res. 183 (2015), 525–540.
    • (2015) Radiat. Res. , vol.183 , pp. 525-540
    • Watanabe, R.1    Rahmanian, S.2    Nikjoo, H.3
  • 28
    • 0036249832 scopus 로고    scopus 로고
    • Formation of modified DNA bases in cells exposed either to gamma radiation or to high-let particles
    • Pouget, J.P., Frelon, S., Ravanat, J.L., Testard, I., Odin, F., Cadet, J., Formation of modified DNA bases in cells exposed either to gamma radiation or to high-let particles. Radiat. Res. 157 (2002), 589–595.
    • (2002) Radiat. Res. , vol.157 , pp. 589-595
    • Pouget, J.P.1    Frelon, S.2    Ravanat, J.L.3    Testard, I.4    Odin, F.5    Cadet, J.6
  • 29
    • 34548575470 scopus 로고    scopus 로고
    • Induction and processing of oxidative clustered DNA lesions in 56Fe-ion-irradiated human monocytes
    • Tsao, D., Kalogerinis, P., Tabrizi, I., Dingfelder, M., Stewart, R.D., Georgakilas, A.G., Induction and processing of oxidative clustered DNA lesions in 56Fe-ion-irradiated human monocytes. Radiat. Res. 168 (2007), 87–97.
    • (2007) Radiat. Res. , vol.168 , pp. 87-97
    • Tsao, D.1    Kalogerinis, P.2    Tabrizi, I.3    Dingfelder, M.4    Stewart, R.D.5    Georgakilas, A.G.6
  • 30
    • 41549115014 scopus 로고    scopus 로고
    • Quantitative analysis of isolated and clustered DNA damage induced by gamma-rays, carbon ion beams, and iron ion beams
    • Terato, H., Tanaka, R., Nakaarai, Y., Nohara, T., Doi, Y., Iwai, S., Hirayama, R., Furusawa, Y., Ide, H., Quantitative analysis of isolated and clustered DNA damage induced by gamma-rays, carbon ion beams, and iron ion beams. J. Radiat. Res. 49 (2008), 133–146.
    • (2008) J. Radiat. Res. , vol.49 , pp. 133-146
    • Terato, H.1    Tanaka, R.2    Nakaarai, Y.3    Nohara, T.4    Doi, Y.5    Iwai, S.6    Hirayama, R.7    Furusawa, Y.8    Ide, H.9
  • 31
    • 84929938447 scopus 로고    scopus 로고
    • Role of isolated and clustered DNA damage and the post-irradiating repair process in the effects of heavy ion beam irradiation
    • Tokuyama, Y., Furusawa, Y., Ide, H., Yasui, A., Terato, H., Role of isolated and clustered DNA damage and the post-irradiating repair process in the effects of heavy ion beam irradiation. J. Radiat. Res. 56 (2015), 446–455.
    • (2015) J. Radiat. Res. , vol.56 , pp. 446-455
    • Tokuyama, Y.1    Furusawa, Y.2    Ide, H.3    Yasui, A.4    Terato, H.5
  • 32
    • 0030890368 scopus 로고    scopus 로고
    • Detection of DNA damage induced by low and high TEL ionizing radiations
    • Sage, E., Rousset, S., Perdiz, D., Martin, C., Balanzat, E., Detection of DNA damage induced by low and high TEL ionizing radiations. J. Chim. Phys. Pcb 94 (1997), 331–336.
    • (1997) J. Chim. Phys. Pcb , vol.94 , pp. 331-336
    • Sage, E.1    Rousset, S.2    Perdiz, D.3    Martin, C.4    Balanzat, E.5
  • 33
    • 0035064055 scopus 로고    scopus 로고
    • Quantifying DNA damage by gel electrophoresis, electronic imaging and number-average length analysis
    • Sutherland, J.C., Monteleone, D.C., Trunk, J.G., Bennett, P.V., Sutherland, B.M., Quantifying DNA damage by gel electrophoresis, electronic imaging and number-average length analysis. Electrophoresis 22 (2001), 843–854.
    • (2001) Electrophoresis , vol.22 , pp. 843-854
    • Sutherland, J.C.1    Monteleone, D.C.2    Trunk, J.G.3    Bennett, P.V.4    Sutherland, B.M.5
  • 34
    • 0345016976 scopus 로고    scopus 로고
    • Quantifying clustered DNA damage induction and repair by gel electrophoresis, electronic imaging and number average length analysis
    • Sutherland, B.M., Georgakilas, A.G., Bennett, P.V., Laval, J., Sutherland, J.C., Quantifying clustered DNA damage induction and repair by gel electrophoresis, electronic imaging and number average length analysis. Mutat. Res. 531 (2003), 93–107.
    • (2003) Mutat. Res. , vol.531 , pp. 93-107
    • Sutherland, B.M.1    Georgakilas, A.G.2    Bennett, P.V.3    Laval, J.4    Sutherland, J.C.5
  • 35
    • 0037306917 scopus 로고    scopus 로고
    • Quantifying double-strand breaks and clustered damages in DNA by single-molecule laser fluorescence sizing
    • Filippova, E.M., Monteleone, D.C., Trunk, J.G., Sutherland, B.M., Quake, S.R., Sutherland, J.C., Quantifying double-strand breaks and clustered damages in DNA by single-molecule laser fluorescence sizing. Biophys. J. 84 (2003), 1281–1290.
    • (2003) Biophys. J. , vol.84 , pp. 1281-1290
    • Filippova, E.M.1    Monteleone, D.C.2    Trunk, J.G.3    Sutherland, B.M.4    Quake, S.R.5    Sutherland, J.C.6
  • 36
    • 23044477801 scopus 로고    scopus 로고
    • Characterization of complex apurinic/apyrimidinic-site clustering associated with an authentic site-specific radiation-induced DNA double-strand break
    • Datta, K., Neumann, R.D., Winters, T.A., Characterization of complex apurinic/apyrimidinic-site clustering associated with an authentic site-specific radiation-induced DNA double-strand break. Proc. Natl. Acad. Sci. USA 102 (2005), 10569–10574.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 10569-10574
    • Datta, K.1    Neumann, R.D.2    Winters, T.A.3
  • 37
    • 33750736349 scopus 로고    scopus 로고
    • Molecular analysis of base damage clustering associated with a site-specific radiation-induced DNA double-strand break
    • Datta, K., Jaruga, P., Dizdaroglu, M., Neumann, R.D., Winters, T.A., Molecular analysis of base damage clustering associated with a site-specific radiation-induced DNA double-strand break. Radiat. Res. 166 (2006), 767–781.
    • (2006) Radiat. Res. , vol.166 , pp. 767-781
    • Datta, K.1    Jaruga, P.2    Dizdaroglu, M.3    Neumann, R.D.4    Winters, T.A.5
  • 38
    • 33846841032 scopus 로고    scopus 로고
    • Detection of oxidative clustered DNA lesions in X-irradiated mouse skin tissues and human MCF-7 breast cancer cells
    • Gollapalle, E., Wang, R., Adetolu, R., Tsao, D., Francisco, D., Sigounas, G., Georgakilas, A.G., Detection of oxidative clustered DNA lesions in X-irradiated mouse skin tissues and human MCF-7 breast cancer cells. Radiat. Res. 167 (2007), 207–216.
    • (2007) Radiat. Res. , vol.167 , pp. 207-216
    • Gollapalle, E.1    Wang, R.2    Adetolu, R.3    Tsao, D.4    Francisco, D.5    Sigounas, G.6    Georgakilas, A.G.7
  • 39
    • 77749270711 scopus 로고    scopus 로고
    • Clustered DNA damage in irradiated human diploid fibroblasts: influence of chromatin organization
    • Magnander, K., Hultborn, R., Claesson, K., Elmroth, K., Clustered DNA damage in irradiated human diploid fibroblasts: influence of chromatin organization. Radiat. Res. 173 (2010), 272–282.
    • (2010) Radiat. Res. , vol.173 , pp. 272-282
    • Magnander, K.1    Hultborn, R.2    Claesson, K.3    Elmroth, K.4
  • 40
    • 84870708457 scopus 로고    scopus 로고
    • A methodology for estimating localization of apurinic/apyrimidinic sites in DNA using fluorescence resonance energy transfer
    • Akamatsu, K., Shikazono, N., A methodology for estimating localization of apurinic/apyrimidinic sites in DNA using fluorescence resonance energy transfer. Anal. Biochem. 433 (2013), 171–180.
    • (2013) Anal. Biochem. , vol.433 , pp. 171-180
    • Akamatsu, K.1    Shikazono, N.2
  • 41
    • 84925282809 scopus 로고    scopus 로고
    • Localization estimation of ionizing radiation-induced abasic sites in DNA in the solid state using fluorescence resonance energy transfer
    • Akamatsu, K., Shikazono, N., Saito, T., Localization estimation of ionizing radiation-induced abasic sites in DNA in the solid state using fluorescence resonance energy transfer. Radiat. Res. 183 (2015), 105–113.
    • (2015) Radiat. Res. , vol.183 , pp. 105-113
    • Akamatsu, K.1    Shikazono, N.2    Saito, T.3
  • 45
    • 84893654009 scopus 로고    scopus 로고
    • The relative contributions of DNA strand breaks, base damage and clustered lesions to the loss of DNA functionality induced by ionizing radiation
    • Saloua, K.S., Sonia, G., Pierre, C., Leon, S., Darel, H.J., The relative contributions of DNA strand breaks, base damage and clustered lesions to the loss of DNA functionality induced by ionizing radiation. Radiat. Res. 181 (2014), 99–110.
    • (2014) Radiat. Res. , vol.181 , pp. 99-110
    • Saloua, K.S.1    Sonia, G.2    Pierre, C.3    Leon, S.4    Darel, H.J.5
  • 46
    • 84899510688 scopus 로고    scopus 로고
    • Non-DSB clustered DNA lesions induced by ionizing radiation are largely responsible for the loss of plasmid DNA functionality in the presence of cisplatin
    • Sahbani, S.K., Rezaee, M., Cloutier, P., Sanche, L., Hunting, D.J., Non-DSB clustered DNA lesions induced by ionizing radiation are largely responsible for the loss of plasmid DNA functionality in the presence of cisplatin. Chem.-Biol. Interact. 217 (2014), 9–18.
    • (2014) Chem.-Biol. Interact. , vol.217 , pp. 9-18
    • Sahbani, S.K.1    Rezaee, M.2    Cloutier, P.3    Sanche, L.4    Hunting, D.J.5
  • 48
    • 84982803577 scopus 로고    scopus 로고
    • Short DNA fragments are a hallmark of heavy charged-particle irradiation and may underlie their greater therapeutic efficacy
    • Pang, D., Chasovskikh, S., Rodgers, J.E., Dritschilo, A., Short DNA fragments are a hallmark of heavy charged-particle irradiation and may underlie their greater therapeutic efficacy. Front. Oncol., 6, 2016, 130.
    • (2016) Front. Oncol. , vol.6 , pp. 130
    • Pang, D.1    Chasovskikh, S.2    Rodgers, J.E.3    Dritschilo, A.4
  • 49
    • 84912553548 scopus 로고    scopus 로고
    • Loss of cellular transformation efficiency induced by DNA irradiation with low-energy (10 eV) electrons
    • Kouass Sahbani, S., Sanche, L., Cloutier, P., Bass, A.D., Hunting, D.J., Loss of cellular transformation efficiency induced by DNA irradiation with low-energy (10 eV) electrons. J. Phys. Chem. B 118 (2014), 13123–13131.
    • (2014) J. Phys. Chem. B , vol.118 , pp. 13123-13131
    • Kouass Sahbani, S.1    Sanche, L.2    Cloutier, P.3    Bass, A.D.4    Hunting, D.J.5
  • 50
    • 0037884963 scopus 로고    scopus 로고
    • Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses
    • Rothkamm, K., Lobrich, M., Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses. Proc. Natl. Acad. Sci. USA 100 (2003), 5057–5062.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 5057-5062
    • Rothkamm, K.1    Lobrich, M.2
  • 51
    • 79956187736 scopus 로고    scopus 로고
    • Mechanism of cluster DNA damage repair in response to high-atomic number and energy particles radiation
    • Asaithamby, A., Chen, D.J., Mechanism of cluster DNA damage repair in response to high-atomic number and energy particles radiation. Mutat. Res. 711 (2011), 87–99.
    • (2011) Mutat. Res. , vol.711 , pp. 87-99
    • Asaithamby, A.1    Chen, D.J.2
  • 53
    • 79957686784 scopus 로고    scopus 로고
    • Unrepaired clustered DNA lesions induce chromosome breakage in human cells
    • Asaithamby, A., Hu, B.R., Chen, D.J., Unrepaired clustered DNA lesions induce chromosome breakage in human cells. Proc. Natl. Acad. Sci. USA 108 (2011), 8293–8298.
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 8293-8298
    • Asaithamby, A.1    Hu, B.R.2    Chen, D.J.3
  • 54
    • 84939994633 scopus 로고    scopus 로고
    • Nanoscale analysis of clustered DNA damage after high-LET irradiation by quantitative electron microscopy – the heavy burden to repair
    • Lorat, Y., Brunner, C.U., Schanz, S., Jakob, B., Taucher-Scholz, G., Rube, C.E., Nanoscale analysis of clustered DNA damage after high-LET irradiation by quantitative electron microscopy – the heavy burden to repair. DNA Repair 28 (2015), 93–106.
    • (2015) DNA Repair , vol.28 , pp. 93-106
    • Lorat, Y.1    Brunner, C.U.2    Schanz, S.3    Jakob, B.4    Taucher-Scholz, G.5    Rube, C.E.6
  • 57
    • 0033914527 scopus 로고    scopus 로고
    • DNA damage induced in cells by gamma and UVA radiation as measured by HPLC/GC-MS and HPLC-EC and Comet assay
    • Pouget, J.P., Douki, T., Richard, M.J., Cadet, J., DNA damage induced in cells by gamma and UVA radiation as measured by HPLC/GC-MS and HPLC-EC and Comet assay. Chem. Res. Toxicol. 13 (2000), 541–549.
    • (2000) Chem. Res. Toxicol. , vol.13 , pp. 541-549
    • Pouget, J.P.1    Douki, T.2    Richard, M.J.3    Cadet, J.4
  • 58
    • 79954609897 scopus 로고    scopus 로고
    • Oxidatively generated damage to DNA by UVA radiation in cells and human skin
    • Cadet, J., Douki, T., Oxidatively generated damage to DNA by UVA radiation in cells and human skin. J. Investig. Dermatol. 131 (2011), 1005–1007.
    • (2011) J. Investig. Dermatol. , vol.131 , pp. 1005-1007
    • Cadet, J.1    Douki, T.2
  • 60
    • 84967332920 scopus 로고    scopus 로고
    • Oxidative stress at low levels can induce clustered DNA lesions leading to NHEJ mediated mutations
    • Sharma, V., Collins, L.B., Chen, T.H., Herr, N., Takeda, S., Sun, W., Swenberg, J.A., Nakamura, J., Oxidative stress at low levels can induce clustered DNA lesions leading to NHEJ mediated mutations. Oncotarget 7 (2016), 25377–25390.
    • (2016) Oncotarget , vol.7 , pp. 25377-25390
    • Sharma, V.1    Collins, L.B.2    Chen, T.H.3    Herr, N.4    Takeda, S.5    Sun, W.6    Swenberg, J.A.7    Nakamura, J.8
  • 61
    • 35348826722 scopus 로고    scopus 로고
    • Oxidation of the sugar radiation or bleomycin of a cluster DNA lesion moiety of DNA by ionizing could induce the formation
    • Regulus, P., Duroux, B., Baylet, P.A., Favier, A., Cadet, J., Ravanat, J.L., Oxidation of the sugar radiation or bleomycin of a cluster DNA lesion moiety of DNA by ionizing could induce the formation. Proc. Natl. Acad. Sci. USA 104 (2007), 14032–14037.
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 14032-14037
    • Regulus, P.1    Duroux, B.2    Baylet, P.A.3    Favier, A.4    Cadet, J.5    Ravanat, J.L.6
  • 62
    • 84904717958 scopus 로고    scopus 로고
    • Oxidatively generated base damage to cellular DNA by hydroxyl radical and one-electron oxidants: similarities and differences
    • Cadet, J., Wagner, J.R., Oxidatively generated base damage to cellular DNA by hydroxyl radical and one-electron oxidants: similarities and differences. Arch. Biochem. Biophys. 557 (2014), 47–54.
    • (2014) Arch. Biochem. Biophys. , vol.557 , pp. 47-54
    • Cadet, J.1    Wagner, J.R.2
  • 63
    • 0035957519 scopus 로고    scopus 로고
    • NMR characterization of clustered bistrand abasic site lesions: effect of orientation on their solution structure
    • Lin, Z., de Los Santos, C., NMR characterization of clustered bistrand abasic site lesions: effect of orientation on their solution structure. J. Mol. Biol. 308 (2001), 341–352.
    • (2001) J. Mol. Biol. , vol.308 , pp. 341-352
    • Lin, Z.1    de Los Santos, C.2
  • 64
    • 56249148167 scopus 로고    scopus 로고
    • NMR solution structures of bistranded abasic site lesions in DNA
    • Hazel, R.D., Tian, K., de Los Santos, C., NMR solution structures of bistranded abasic site lesions in DNA. Biochemistry 47 (2008), 11909–11919.
    • (2008) Biochemistry , vol.47 , pp. 11909-11919
    • Hazel, R.D.1    Tian, K.2    de Los Santos, C.3
  • 65
    • 19644391375 scopus 로고    scopus 로고
    • Molecular dynamics simulation of clustered DNA damage sites containing 8-oxoguanine and abasic site
    • Fujimoto, H., Pinak, M., Nemoto, T., O'Neill, P., Kume, E., Saito, K., Maekawa, H., Molecular dynamics simulation of clustered DNA damage sites containing 8-oxoguanine and abasic site. J. Comput. Chem. 26 (2005), 788–798.
    • (2005) J. Comput. Chem. , vol.26 , pp. 788-798
    • Fujimoto, H.1    Pinak, M.2    Nemoto, T.3    O'Neill, P.4    Kume, E.5    Saito, K.6    Maekawa, H.7
  • 66
    • 84895923915 scopus 로고    scopus 로고
    • Structure and dynamics of DNA duplexes containing a cluster of mutagenic 8-oxoguanine and abasic site lesions
    • Zalesak, J., Lourdin, M., Krejci, L., Constant, J.F., Jourdan, M., Structure and dynamics of DNA duplexes containing a cluster of mutagenic 8-oxoguanine and abasic site lesions. J. Mol. Biol. 426 (2014), 1524–1538.
    • (2014) J. Mol. Biol. , vol.426 , pp. 1524-1538
    • Zalesak, J.1    Lourdin, M.2    Krejci, L.3    Constant, J.F.4    Jourdan, M.5
  • 67
    • 84990820015 scopus 로고    scopus 로고
    • Correlation of bistranded clustered abasic DNA lesion processing with structural and dynamic DNA helix distortion
    • Bignon, E., Gattuso, H., Morell, C., Dehez, F., Georgakilas, A.G., Monari, A., Dumont, E., Correlation of bistranded clustered abasic DNA lesion processing with structural and dynamic DNA helix distortion. Nucleic Acids Res. 44 (2016), 8588–8599.
    • (2016) Nucleic Acids Res. , vol.44 , pp. 8588-8599
    • Bignon, E.1    Gattuso, H.2    Morell, C.3    Dehez, F.4    Georgakilas, A.G.5    Monari, A.6    Dumont, E.7
  • 68
    • 4644289815 scopus 로고    scopus 로고
    • Efficiency of repair of an abasic site within DNA clustered damage sites by mammalian cell nuclear extracts
    • Lomax, M.E., Cunniffe, S., O'Neill, P., Efficiency of repair of an abasic site within DNA clustered damage sites by mammalian cell nuclear extracts. Biochemistry 43 (2004), 11017–11026.
    • (2004) Biochemistry , vol.43 , pp. 11017-11026
    • Lomax, M.E.1    Cunniffe, S.2    O'Neill, P.3
  • 69
    • 34250831508 scopus 로고    scopus 로고
    • Interplay between DNA N-glycosylases/AP lyases at multiply damaged sites and biological consequences
    • Eot-Houllier, G., Gonera, M., Gasparutto, D., Giustranti, C., Sage, E., Interplay between DNA N-glycosylases/AP lyases at multiply damaged sites and biological consequences. Nucleic Acids Res. 35 (2007), 3355–3366.
    • (2007) Nucleic Acids Res. , vol.35 , pp. 3355-3366
    • Eot-Houllier, G.1    Gonera, M.2    Gasparutto, D.3    Giustranti, C.4    Sage, E.5
  • 70
    • 33748749077 scopus 로고    scopus 로고
    • The roles of specific glycosylases in determining the mutagenic consequences of clustered DNA base damage
    • Shikazono, N., Pearson, C., O'Neill, P., Thacker, J., The roles of specific glycosylases in determining the mutagenic consequences of clustered DNA base damage. Nucleic Acids Res. 34 (2006), 3722–3730.
    • (2006) Nucleic Acids Res. , vol.34 , pp. 3722-3730
    • Shikazono, N.1    Pearson, C.2    O'Neill, P.3    Thacker, J.4
  • 71
    • 84155163991 scopus 로고    scopus 로고
    • Repair of DNA damage induced by accelerated heavy ions—a mini review
    • Okayasu, R., Repair of DNA damage induced by accelerated heavy ions—a mini review. Int. J. Cancer 130 (2012), 991–1000.
    • (2012) Int. J. Cancer , vol.130 , pp. 991-1000
    • Okayasu, R.1
  • 72
    • 0027494358 scopus 로고
    • Induction and rejoining of DNA double-strand breaks in V79-4 mammalian cells following gamma- and alpha-irradiation
    • Jenner, T.J., deLara, C.M., O'Neill, P., Stevens, D.L., Induction and rejoining of DNA double-strand breaks in V79-4 mammalian cells following gamma- and alpha-irradiation. Int. J. Radiat. Biol. 64 (1993), 265–273.
    • (1993) Int. J. Radiat. Biol. , vol.64 , pp. 265-273
    • Jenner, T.J.1    deLara, C.M.2    O'Neill, P.3    Stevens, D.L.4
  • 73
    • 0030027313 scopus 로고    scopus 로고
    • Rejoining of gamma-radiation-induced single-strand breaks in plasmid DNA by human cell extracts: dependence on the concentration of the hydroxyl radical scavenger, Tris
    • Hodgkins, P.S., Fairman, M.P., O'Neill, P., Rejoining of gamma-radiation-induced single-strand breaks in plasmid DNA by human cell extracts: dependence on the concentration of the hydroxyl radical scavenger, Tris. Radiat. Res. 145 (1996), 24–30.
    • (1996) Radiat. Res. , vol.145 , pp. 24-30
    • Hodgkins, P.S.1    Fairman, M.P.2    O'Neill, P.3
  • 74
    • 0032852993 scopus 로고    scopus 로고
    • The complexity of radiation-induced DNA damage as revealed by exposure to cell extracts
    • Cunniffe, S., O'Neill, P., The complexity of radiation-induced DNA damage as revealed by exposure to cell extracts. Radiat. Res. 152 (1999), 421–427.
    • (1999) Radiat. Res. , vol.152 , pp. 421-427
    • Cunniffe, S.1    O'Neill, P.2
  • 77
    • 0037314536 scopus 로고    scopus 로고
    • Repair of radiation-induced DNA double-strand breaks is dependent upon radiation quality and the structural complexity of double-strand breaks
    • Pastwa, E., Neumann, R.D., Mezhevaya, K., Winters, T.A., Repair of radiation-induced DNA double-strand breaks is dependent upon radiation quality and the structural complexity of double-strand breaks. Radiat. Res. 159 (2003), 251–261.
    • (2003) Radiat. Res. , vol.159 , pp. 251-261
    • Pastwa, E.1    Neumann, R.D.2    Mezhevaya, K.3    Winters, T.A.4
  • 78
    • 78650603715 scopus 로고    scopus 로고
    • Base damage immediately upstream from double-strand break ends is a more severe impediment to nonhomologous end joining than blocked 3'-termini
    • Datta, K., Purkayastha, S., Neumann, R.D., Pastwa, E., Winters, T.A., Base damage immediately upstream from double-strand break ends is a more severe impediment to nonhomologous end joining than blocked 3'-termini. Radiat. Res. 175 (2011), 97–112.
    • (2011) Radiat. Res. , vol.175 , pp. 97-112
    • Datta, K.1    Purkayastha, S.2    Neumann, R.D.3    Pastwa, E.4    Winters, T.A.5
  • 79
    • 0037385724 scopus 로고    scopus 로고
    • Measurement of prompt DNA double-strand breaks in mammalian cells without including heat-labile sites: Results for cells deficient in nonhomologous end joining
    • Stenerlow, B., Karlsson, K.H., Cooper, B., Rydberg, B., Measurement of prompt DNA double-strand breaks in mammalian cells without including heat-labile sites: Results for cells deficient in nonhomologous end joining. Radiat. Res. 159 (2003), 502–510.
    • (2003) Radiat. Res. , vol.159 , pp. 502-510
    • Stenerlow, B.1    Karlsson, K.H.2    Cooper, B.3    Rydberg, B.4
  • 80
    • 84948570525 scopus 로고    scopus 로고
    • Formation and repair of clustered damaged DNA sites in high LET irradiated cells
    • Gustafsson, A.S., Hartman, T., Stenerlow, B., Formation and repair of clustered damaged DNA sites in high LET irradiated cells. Int. J. Radiat. Biol. 91 (2015), 820–826.
    • (2015) Int. J. Radiat. Biol. , vol.91 , pp. 820-826
    • Gustafsson, A.S.1    Hartman, T.2    Stenerlow, B.3
  • 81
    • 77952089468 scopus 로고    scopus 로고
    • Spatiotemporal analysis of DNA repair using charged particle radiation
    • Tobias, F., Durante, M., Taucher-Scholz, G., Jakob, B., Spatiotemporal analysis of DNA repair using charged particle radiation. Mutat. Res. 704 (2010), 54–60.
    • (2010) Mutat. Res. , vol.704 , pp. 54-60
    • Tobias, F.1    Durante, M.2    Taucher-Scholz, G.3    Jakob, B.4
  • 82
    • 84900433077 scopus 로고    scopus 로고
    • The repair of environmentally relevant DNA double strand breaks caused by high linear energy transfer irradiation-no simple task
    • Moore, S., Stanley, F.K.T., Goodarzi, A.A., The repair of environmentally relevant DNA double strand breaks caused by high linear energy transfer irradiation-no simple task. DNA Repair 17 (2014), 64–73.
    • (2014) DNA Repair , vol.17 , pp. 64-73
    • Moore, S.1    Stanley, F.K.T.2    Goodarzi, A.A.3
  • 83
    • 77952095382 scopus 로고    scopus 로고
    • Spatiotemporal characterization of ionizing radiation induced DNA damage foci and their relation to chromatin organization
    • Costes, S.V., Chiolo, I., Pluth, J.M., Barcellos-Hoff, M.H., Jakob, B., Spatiotemporal characterization of ionizing radiation induced DNA damage foci and their relation to chromatin organization. Mutat. Res. 704 (2010), 78–87.
    • (2010) Mutat. Res. , vol.704 , pp. 78-87
    • Costes, S.V.1    Chiolo, I.2    Pluth, J.M.3    Barcellos-Hoff, M.H.4    Jakob, B.5
  • 84
    • 77951977394 scopus 로고    scopus 로고
    • Radiation-induced DNA repair foci: spatio-temporal aspects of formation, application for assessment of radiosensitivity and biological dosimetry
    • Belyaev, I.Y., Radiation-induced DNA repair foci: spatio-temporal aspects of formation, application for assessment of radiosensitivity and biological dosimetry,. Mutat. Res. 704 (2010), 132–141.
    • (2010) Mutat. Res. , vol.704 , pp. 132-141
    • Belyaev, I.Y.1
  • 86
    • 47349107760 scopus 로고    scopus 로고
    • ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin
    • Goodarzi, A.A., Noon, A.T., Deckbar, D., Ziv, Y., Shiloh, Y., Lobrich, M., Jeggo, P.A., ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin. Mol. Cell 31 (2008), 167–177.
    • (2008) Mol. Cell , vol.31 , pp. 167-177
    • Goodarzi, A.A.1    Noon, A.T.2    Deckbar, D.3    Ziv, Y.4    Shiloh, Y.5    Lobrich, M.6    Jeggo, P.A.7
  • 87
    • 79961207835 scopus 로고    scopus 로고
    • DNA double-strand breaks in heterochromatin elicit fast repair protein recruitment, histone H2AX phosphorylation and relocation to euchromatin
    • Jakob, B., Splinter, J., Conrad, S., Voss, K.O., Zink, D., Durante, M., Lobrich, M., Taucher-Scholz, G., DNA double-strand breaks in heterochromatin elicit fast repair protein recruitment, histone H2AX phosphorylation and relocation to euchromatin. Nucleic Acids Res. 39 (2011), 6489–6499.
    • (2011) Nucleic Acids Res. , vol.39 , pp. 6489-6499
    • Jakob, B.1    Splinter, J.2    Conrad, S.3    Voss, K.O.4    Zink, D.5    Durante, M.6    Lobrich, M.7    Taucher-Scholz, G.8
  • 89
    • 79952314830 scopus 로고    scopus 로고
    • Double-strand breaks in heterochromatin move outside of a dynamic HP1a domain to complete recombinational repair
    • Chiolo, I., Minoda, A., Colmenares, S.U., Polyzos, A., Costes, S.V., Karpen, G.H., Double-strand breaks in heterochromatin move outside of a dynamic HP1a domain to complete recombinational repair. Cell 144 (2011), 732–744.
    • (2011) Cell , vol.144 , pp. 732-744
    • Chiolo, I.1    Minoda, A.2    Colmenares, S.U.3    Polyzos, A.4    Costes, S.V.5    Karpen, G.H.6
  • 91
    • 84870587195 scopus 로고    scopus 로고
    • The dynamics of Ku70/80 and DNA-PKcs at DSBs induced by ionizing radiation is dependent on the complexity of damage
    • Reynolds, P., Anderson, J.A., Harper, J.V., Hill, M.A., Botchway, S.W., Parker, A.W., O'Neill, P., The dynamics of Ku70/80 and DNA-PKcs at DSBs induced by ionizing radiation is dependent on the complexity of damage. Nucleic Acids Res. 40 (2012), 10821–10831.
    • (2012) Nucleic Acids Res. , vol.40 , pp. 10821-10831
    • Reynolds, P.1    Anderson, J.A.2    Harper, J.V.3    Hill, M.A.4    Botchway, S.W.5    Parker, A.W.6    O'Neill, P.7
  • 92
    • 29644443959 scopus 로고    scopus 로고
    • Repair of DNA damage induced by accelerated heavy ions in mammalian cells proficient and deficient in the non-homologous end-joining pathway
    • Okayasu, R., Okada, M., Okabe, A., Noguchi, M., Takakura, K., Takahashi, S., Repair of DNA damage induced by accelerated heavy ions in mammalian cells proficient and deficient in the non-homologous end-joining pathway. Radiat. Res 165 (2006), 59–67.
    • (2006) Radiat. Res , vol.165 , pp. 59-67
    • Okayasu, R.1    Okada, M.2    Okabe, A.3    Noguchi, M.4    Takakura, K.5    Takahashi, S.6
  • 96
    • 84907513351 scopus 로고    scopus 로고
    • DNA end resection is needed for the repair of complex lesions in G1-phase human cells
    • Averbeck, N.B., Ringel, O., Herrlitz, M., Jakob, B., Durante, M., Taucher-Scholz, G., DNA end resection is needed for the repair of complex lesions in G1-phase human cells. Cell Cycle 13 (2014), 2509–2516.
    • (2014) Cell Cycle , vol.13 , pp. 2509-2516
    • Averbeck, N.B.1    Ringel, O.2    Herrlitz, M.3    Jakob, B.4    Durante, M.5    Taucher-Scholz, G.6
  • 99
    • 50849105384 scopus 로고    scopus 로고
    • DNA repair of clustered lesions in mammalian cells: involvement of non-homologous end-joining
    • Malyarchuk, S., Castore, R., Harrison, L., DNA repair of clustered lesions in mammalian cells: involvement of non-homologous end-joining. Nucleic Acids Res. 36 (2008), 4872–4882.
    • (2008) Nucleic Acids Res. , vol.36 , pp. 4872-4882
    • Malyarchuk, S.1    Castore, R.2    Harrison, L.3
  • 100
    • 70450222719 scopus 로고    scopus 로고
    • Apex1 can cleave complex clustered DNA lesions in cells
    • Malyarchuk, S., Castore, R., Harrison, L., Apex1 can cleave complex clustered DNA lesions in cells. DNA Repair 8 (2009), 1343–1354.
    • (2009) DNA Repair , vol.8 , pp. 1343-1354
    • Malyarchuk, S.1    Castore, R.2    Harrison, L.3
  • 101
    • 84876562851 scopus 로고    scopus 로고
    • Artemis is required to improve the accuracy of repair of double-strand breaks with 5'-blocked termini generated from non-DSB-clustered lesions
    • Malyarchuk, S., Castore, R., Shi, R., Harrison, L., Artemis is required to improve the accuracy of repair of double-strand breaks with 5'-blocked termini generated from non-DSB-clustered lesions. Mutagenesis 28 (2013), 357–366.
    • (2013) Mutagenesis , vol.28 , pp. 357-366
    • Malyarchuk, S.1    Castore, R.2    Shi, R.3    Harrison, L.4
  • 102
    • 64549162745 scopus 로고    scopus 로고
    • The formation of double-strand breaks at multiply damaged sites is driven by the kinetics of excision/incision at base damage in eukaryotic cells
    • Kozmin, S.G., Sedletska, Y., Reynaud-Angelin, A., Gasparutto, D., Sage, E., The formation of double-strand breaks at multiply damaged sites is driven by the kinetics of excision/incision at base damage in eukaryotic cells. Nucleic Acids Res. 37 (2009), 1767–1777.
    • (2009) Nucleic Acids Res. , vol.37 , pp. 1767-1777
    • Kozmin, S.G.1    Sedletska, Y.2    Reynaud-Angelin, A.3    Gasparutto, D.4    Sage, E.5
  • 104
    • 84858800636 scopus 로고    scopus 로고
    • The mutagenic potential of 8-oxoG/single strand break-containing clusters depends on their relative positions
    • Noguchi, M., Urushibara, A., Yokoya, A., O'Neill, P., Shikazono, N., The mutagenic potential of 8-oxoG/single strand break-containing clusters depends on their relative positions. Mutat. Res. 732 (2012), 34–42.
    • (2012) Mutat. Res. , vol.732 , pp. 34-42
    • Noguchi, M.1    Urushibara, A.2    Yokoya, A.3    O'Neill, P.4    Shikazono, N.5
  • 105
    • 84901920381 scopus 로고    scopus 로고
    • Increased mutability and decreased repairability of a three-lesion clustered DNA-damaged site comprised of an AP site and bi-stranded 8-oxoG lesions
    • Cunniffe, S., Walker, A., Stabler, R., O'Neill, P., Lomax, M.E., Increased mutability and decreased repairability of a three-lesion clustered DNA-damaged site comprised of an AP site and bi-stranded 8-oxoG lesions. Int. J. Radiat. Biol. 90 (2014), 468–479.
    • (2014) Int. J. Radiat. Biol. , vol.90 , pp. 468-479
    • Cunniffe, S.1    Walker, A.2    Stabler, R.3    O'Neill, P.4    Lomax, M.E.5
  • 106
    • 84897417171 scopus 로고    scopus 로고
    • Reduced repair capacity of a DNA clustered damage site comprised of 8-oxo-7,8-dihydro-2'-deoxyguanosine and 2-deoxyribonolactone results in an increased mutagenic potential of these lesions
    • Cunniffe, S., O'Neill, P., Greenberg, M.M., Lomax, M.E., Reduced repair capacity of a DNA clustered damage site comprised of 8-oxo-7,8-dihydro-2'-deoxyguanosine and 2-deoxyribonolactone results in an increased mutagenic potential of these lesions. Mutat. Res. 762 (2014), 32–39.
    • (2014) Mutat. Res. , vol.762 , pp. 32-39
    • Cunniffe, S.1    O'Neill, P.2    Greenberg, M.M.3    Lomax, M.E.4
  • 107
    • 84890061270 scopus 로고    scopus 로고
    • Replication fork collapse is a major cause of the high mutation frequency at three-base lesion clusters
    • Sedletska, Y., Radicella, J.P., Sage, E., Replication fork collapse is a major cause of the high mutation frequency at three-base lesion clusters. Nucleic Acids Res. 41 (2013), 9339–9348.
    • (2013) Nucleic Acids Res. , vol.41 , pp. 9339-9348
    • Sedletska, Y.1    Radicella, J.P.2    Sage, E.3
  • 108
    • 35748950964 scopus 로고    scopus 로고
    • An AP site can protect against the mutagenic potential of 8-oxoG when present within a tandem clustered site in E. coli
    • Cunniffe, S.M., Lomax, M.E., O'Neill, P., An AP site can protect against the mutagenic potential of 8-oxoG when present within a tandem clustered site in E. coli. DNA Repair 6 (2007), 1839–1849.
    • (2007) DNA Repair , vol.6 , pp. 1839-1849
    • Cunniffe, S.M.1    Lomax, M.E.2    O'Neill, P.3
  • 109
    • 13744259832 scopus 로고    scopus 로고
    • Processing of a complex multiply damaged DNA site by human cell extracts and purified repair proteins
    • Eot-Houllier, G., Eon-Marchais, S., Gasparutto, D., Sage, E., Processing of a complex multiply damaged DNA site by human cell extracts and purified repair proteins. Nucleic Acids Res. 33 (2005), 260–271.
    • (2005) Nucleic Acids Res. , vol.33 , pp. 260-271
    • Eot-Houllier, G.1    Eon-Marchais, S.2    Gasparutto, D.3    Sage, E.4
  • 111
    • 84939633687 scopus 로고    scopus 로고
    • Repair of clustered damage and DNA polymerase iota
    • Belousova, E.A., Lavrik, O.I., Repair of clustered damage and DNA polymerase iota. Biochemistry 80 (2015), 1010–1018.
    • (2015) Biochemistry , vol.80 , pp. 1010-1018
    • Belousova, E.A.1    Lavrik, O.I.2
  • 112
    • 77950360354 scopus 로고    scopus 로고
    • Hierarchy of lesion processing governs the repair, double-strand break formation and mutability of three-lesion clustered DNA damage
    • Eccles, L.J., Lomax, M.E., O'Neill, P., Hierarchy of lesion processing governs the repair, double-strand break formation and mutability of three-lesion clustered DNA damage. Nucleic Acids Res. 38 (2010), 1123–1134.
    • (2010) Nucleic Acids Res. , vol.38 , pp. 1123-1134
    • Eccles, L.J.1    Lomax, M.E.2    O'Neill, P.3
  • 113
    • 55149112815 scopus 로고    scopus 로고
    • Chromatin structure influences the sensitivity of DNA to gamma-radiation
    • Falk, M., Lukasova, E., Kozubek, S., Chromatin structure influences the sensitivity of DNA to gamma-radiation. Biochim Biophys. Acta 1783 (2008), 2398–2414.
    • (2008) Biochim Biophys. Acta , vol.1783 , pp. 2398-2414
    • Falk, M.1    Lukasova, E.2    Kozubek, S.3
  • 115
    • 84904480116 scopus 로고    scopus 로고
    • Nucleosomes suppress the formation of double-strand DNA breaks during attempted base excision repair of clustered oxidative damages
    • Cannan, W.J., Tsang, B.P., Wallace, S.S., Pederson, D.S., Nucleosomes suppress the formation of double-strand DNA breaks during attempted base excision repair of clustered oxidative damages. J. Biol. Chem. 289 (2014), 19881–19893.
    • (2014) J. Biol. Chem. , vol.289 , pp. 19881-19893
    • Cannan, W.J.1    Tsang, B.P.2    Wallace, S.S.3    Pederson, D.S.4
  • 116
    • 84926226411 scopus 로고    scopus 로고
    • Repair efficiency of clustered abasic sites by APE1 in nucleosome core particles is sequence and position dependent
    • Singh, V., Kumari, B., Das, P., Repair efficiency of clustered abasic sites by APE1 in nucleosome core particles is sequence and position dependent. RSC Adv. 5 (2015), 23691–23698.
    • (2015) RSC Adv. , vol.5 , pp. 23691-23698
    • Singh, V.1    Kumari, B.2    Das, P.3
  • 117
    • 84943375861 scopus 로고    scopus 로고
    • Efficient cleavage of single and clustered AP site lesions within mono-nucleosome templates by CHO-K1 nuclear extract contrasts with retardation of incision by purified APE1
    • Eccles, L.J., Menoni, H., Angelov, D., Lomax, M.E., O'Neill, P., Efficient cleavage of single and clustered AP site lesions within mono-nucleosome templates by CHO-K1 nuclear extract contrasts with retardation of incision by purified APE1. DNA Repair 35 (2015), 27–36.
    • (2015) DNA Repair , vol.35 , pp. 27-36
    • Eccles, L.J.1    Menoni, H.2    Angelov, D.3    Lomax, M.E.4    O'Neill, P.5
  • 118
    • 73349132033 scopus 로고    scopus 로고
    • Homologous recombination contributes to the repair of DNA double-strand breaks induced by high-energy iron ions
    • Zafar, F., Seidler, S.B., Kronenberg, A., Schild, D., Wiese, C., Homologous recombination contributes to the repair of DNA double-strand breaks induced by high-energy iron ions. Radiat. Res. 173 (2010), 27–39.
    • (2010) Radiat. Res. , vol.173 , pp. 27-39
    • Zafar, F.1    Seidler, S.B.2    Kronenberg, A.3    Schild, D.4    Wiese, C.5
  • 119
    • 35548978945 scopus 로고    scopus 로고
    • The impact of a negligent G2/M checkpoint on genomic instability and cancer induction
    • Lobrich, M., Jeggo, P.A., The impact of a negligent G2/M checkpoint on genomic instability and cancer induction. Nat. Rev. Cancer 7 (2007), 861–869.
    • (2007) Nat. Rev. Cancer , vol.7 , pp. 861-869
    • Lobrich, M.1    Jeggo, P.A.2
  • 120
    • 84876271460 scopus 로고    scopus 로고
    • The LET dependence of unrepaired chromosome damage in human cells: a break too far?
    • Loucas, B.D., Cornforth, M.N., The LET dependence of unrepaired chromosome damage in human cells: a break too far?. Radiat. Res. 179 (2013), 393–405.
    • (2013) Radiat. Res. , vol.179 , pp. 393-405
    • Loucas, B.D.1    Cornforth, M.N.2
  • 122
    • 0036391767 scopus 로고    scopus 로고
    • Heavy-ion-induced mutations in the gpt delta transgenic mouse: comparison of mutation spectra induced by heavy-ion, X-ray, and gamma-ray radiation
    • Masumura, K., Kuniya, K., Kurobe, T., Fukuoka, M., Yatagai, F., Nohmi, T., Heavy-ion-induced mutations in the gpt delta transgenic mouse: comparison of mutation spectra induced by heavy-ion, X-ray, and gamma-ray radiation. Environ. Mol. Mutagen. 40 (2002), 207–215.
    • (2002) Environ. Mol. Mutagen. , vol.40 , pp. 207-215
    • Masumura, K.1    Kuniya, K.2    Kurobe, T.3    Fukuoka, M.4    Yatagai, F.5    Nohmi, T.6
  • 123
    • 0036829211 scopus 로고    scopus 로고
    • Clustered DNA damage leads to complex genetic changes in irradiated human cells
    • Singleton, B.K., Griffin, C.S., Thacker, J., Clustered DNA damage leads to complex genetic changes in irradiated human cells. Cancer Res. 62 (2002), 6263–6269.
    • (2002) Cancer Res. , vol.62 , pp. 6263-6269
    • Singleton, B.K.1    Griffin, C.S.2    Thacker, J.3
  • 125
    • 84925812822 scopus 로고    scopus 로고
    • The genome-wide effects of ionizing radiation on mutation induction in the mammalian germline
    • Adewoye, A.B., Lindsay, S.J., Dubrova, Y.E., Hurles, M.E., The genome-wide effects of ionizing radiation on mutation induction in the mammalian germline. Nat. Commun., 6, 2015, 6684.
    • (2015) Nat. Commun. , vol.6 , pp. 6684
    • Adewoye, A.B.1    Lindsay, S.J.2    Dubrova, Y.E.3    Hurles, M.E.4
  • 126
    • 0024195429 scopus 로고
    • DNA damage produced by ionizing radiation in mammalian cells: identities, mechanisms of formation, and reparability
    • Ward, J.F., DNA damage produced by ionizing radiation in mammalian cells: identities, mechanisms of formation, and reparability. Prog. Nucleic Acid Res. Mol. Biol. 35 (1988), 95–125.
    • (1988) Prog. Nucleic Acid Res. Mol. Biol. , vol.35 , pp. 95-125
    • Ward, J.F.1
  • 127
    • 0033303887 scopus 로고    scopus 로고
    • Damage pattern as a function of radiation quality and other factors
    • Burkart, W., Jung, T., Frasch, G., Damage pattern as a function of radiation quality and other factors. C.R. Acad. Sci. III 322 (1999), 89–101.
    • (1999) C.R. Acad. Sci. III , vol.322 , pp. 89-101
    • Burkart, W.1    Jung, T.2    Frasch, G.3
  • 128
    • 0242300088 scopus 로고    scopus 로고
    • Endogenous DNA double-strand breaks: production, fidelity of repair, and induction of cancer
    • Vilenchik, M.M., Knudson, A.G., Endogenous DNA double-strand breaks: production, fidelity of repair, and induction of cancer. Proc. Natl. Acad. Sci. USA 100 (2003), 12871–12876.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 12871-12876
    • Vilenchik, M.M.1    Knudson, A.G.2
  • 129
    • 85018649934 scopus 로고    scopus 로고
    • Oxidative DNA damage & repair: an introduction
    • Cadet, J., Davies, K.J.A., Oxidative DNA damage & repair: an introduction. Free Radic. Biol. Med. 107 (2017), 2–12.
    • (2017) Free Radic. Biol. Med. , vol.107 , pp. 2-12
    • Cadet, J.1    Davies, K.J.A.2


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