An AP site can protect against the mutagenic potential of 8-oxoG when present within a tandem clustered site in E. coli

DNA Repair

Volumn 6, Issue 12, 2007, Pages 1839-1849

  Cunniffe, Siobhan M T ^a   Lomax, Martine E ^a   O'Neill, Peter ^a  

^a MEDICAL RESEARCH COUNCIL   (United Kingdom)

Author keywords

8 oxo 7,8 dihydroguanine (8 oxoG); Abasic sites; Clustered damage repair; Mutagenicity; Tandem clustered damage

Indexed keywords

8 HYDROXYGUANINE; DNA FORMAMIDOPYRIMIDINE GLYCOSYLASE; EXODEOXYRIBONUCLEASE III;

ARTICLE; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; ESCHERICHIA COLI; MUTAGENIC ACTIVITY; MUTATION RATE; NONHUMAN; PRIORITY JOURNAL; TANDEM REPEAT;

BASE SEQUENCE; DEOXYGUANOSINE; DNA DAMAGE; DNA REPAIR; DNA, BACTERIAL; ESCHERICHIA COLI; MUTATION;

EID: 35748950964     PISSN: 15687864     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.dnarep.2007.07.003     Document Type: Article

References (39)

1. Nikjoo H., O'Neill P., Terrissol M., and Goodhead D.T. Quantitative modelling of DNA damage using Monte Carlo track structure method. Radiat. Environ. Biophys. 38 (1999) 31-38
2. Nikjoo H., O'Neill P., Wilson W.E., and Goodhead D.T. Computational approach for determining the spectrum of DNA damage induced by ionizing radiation. Radiat. Res. 156 (2001) 577-583
3. Gulston M., Fulford J., Jenner T., de Lara C., and O'Neill P. Clustered DNA damage induced by gamma radiation in human fibroblasts (HF19), hamster (V79-4) cells and plasmid DNA is revealed as Fpg and Nth sensitive sites. Nucleic Acids Res. 30 (2002) 3464-3472
4. Sutherland B.M., Bennett P.V., Sutherland J.C., and Laval J. Clustered DNA damages induced by X-rays in human cells. Radiat. Res. 157 (2002) 611-616
5. Blaisdell J.O., and Wallace S.S. Abortive base-excision repair of radiation-induced clustered DNA lesions in Escherichia coli. Proc. Natl. Acad. Sci. U.S.A. 98 (2001) 7426-7430
6. Gulston M., de Lara C., Jenner T., Davis E., and O'Neill P. Processing of clustered DNA damage generates additional double-strand breaks in mammalian cells post-irradiation. Nucleic Acids Res. 32 (2004) 1602-1609
7. Nilsen H., and Krokan H.E. Base excision repair in a network of defence and tolerance. Carcinogenesis 22 (2001) 987-998
8. Weinfeld M., Rasouli-Nia A., Chaudhry M.A., and Britten R.A. Response of base excision repair enzymes to complex DNA lesions. Radiat. Res. 156 (2001) 584-589
9. Lomax M.E., Gulston M., and O'Neill P. Chemical aspects of clustered DNA damage induction by ionising radiation. Radiat. Protect. Dosimetry 99 (2002) 63-68
10. Wallace S.S. Biological consequences of free radical-damaged DNA bases. Free Radic. Biol. Med. 33 (2002) 1-14
11. Eot-Houllier G., Eon-Marchais S., Gasparutto D., and Sage E. Processing of a complex multiply damaged DNA site by human cell extracts and purified repair proteins. Nucleic Acids Res. 33 (2005) 260-271
12. Eot-Houllie G., Gonera M., Gasparutto D., Giustranti C., and Sage E. Interplay between DNA N-glycosylases/AP lyases at multiply damaged sites and biological consequences. Nucleic Acids Res. 35 (2007) 3355-3366
13. Lomax M.E., Cunniffe S., and O'Neill P. 8-OxoG retards the activity of the ligase III/XRCC1 complex during the repair of a single-strand break, when present within a clustered DNA damage site. DNA Rep. 3 (2004) 289-299
14. Lomax M.E., Cunniffe S., and O'Neill P. Efficiency of repair of an abasic site within DNA clustered damage sites by mammalian cell nuclear extracts. Biochemistry 43 (2004) 11017-11026
15. David-Cordonnier M.H., Boiteux S., and O'Neill P. Efficiency of excision of 8-oxo-guanine within DNA clustered damage by XRS5 nuclear extracts and purified human OGG1 protein. Biochemistry 40 (2001) 11811-11818
16. David-Cordonnier M.H., Laval J., and O'Neill P. Recognition and kinetics for excision of a base lesion within clustered DNA damage by the Escherichia coli proteins Fpg and Nth. Biochemistry 40 (2001) 5738-5746
17. Chaudhry M.A., and Weinfeld M. Reactivity of human apurinic/apyrimidinic endonuclease and Escherichia coli exonuclease III with bistranded abasic sites in DNA. J. Biol. Chem. 272 (1997) 15650-15655
18. David-Cordonnier M.H., Cunniffe S.M., Hickson I.D., and O'Neill P. Efficiency of Incision of an AP Site within Clustered DNA Damage by the Major Human AP Endonuclease. Biochemistry 41 (2002) 634-642
19. David-Cordonnier M.H., Laval J., and O'Neill P. Clustered DNA damage, influence on damage excision by XRS5 nuclear extracts and Escherichia coli Nth and Fpg proteins. J. Biol. Chem. 275 (2000) 11865-11873
20. D'Souza D.I., and Harrison L. Repair of clustered uracil DNA damages in Escherichia coli. Nucleic Acids Res. 31 (2003) 4573-4581
21. Malyarchuk S., and Harrison L. DNA repair of clustered uracils in HeLa cells. J. Mol. Biol. 345 (2005) 731-743
22. Malyarchuk S., Youngblood R., Landry A.M., Quillin E., and Harrison L. The mutation frequency of 8-oxo-7,8-dihydroguanine (8-oxodG) situated in a multiply damaged site: comparison of a single and two closely opposed 8-oxodG in Escherichia coli. DNA Rep. (Amst.) 2 (2003) 695-705
23. Malyarchuk S., Brame K.L., Youngblood R., Shi R., and Harrison L. Two clustered 8-oxo-7,8-dihydroguanine (8-oxodG) lesions increase the point mutation frequency of 8-oxodG, but do not result in double strand breaks or deletions in Escherichia coli. Nucleic Acids Res. 32 (2004) 5721-5731
24. Pearson C.G., Shikazono N., Thacker J., and O' Neill P. Enhanced mutagenic potential of 8-oxo-7,8-dihydroguanine when present within a clustered DNA damage site. Nucleic Acids Res. 32 (2004) 263-270
25. Shikazono N., Pearson C., O'Neill P., and Thacker J. The roles of specific glycosylases in determining the mutagenic consequences of clustered DNA base damage. Nucleic Acids Res. 34 (2006) 3722-3730
26. Box H.C., Budzinski E.E., Dawidzik J.B., Wallace J.C., and Iijima H. Tandem lesions and other products in X-irradiated DNA oligomers. Radiat. Res. 149 (1998) 433-439
27. Box H.C., Patrzyc H.B., Dawidzik J.B., Wallace J.C., Freund H.G., Iijima H., and Budzinski E.E. Double base lesions in DNA X-irradiated in the presence or absence of oxygen. Radiat. Res. 153 (2000) 442-446
28. Cadet J., Douki T., Gasparutto D., and Ravanat J.L. Oxidative damage to DNA: formation, measurement and biochemical features. Mutat. Res. 531 (2003) 5-23
29. Budworth H., Matthewman G., O'Neill P., and Dianov G.L. Repair of tandem base lesions in DNA by human cell extracts generates persisting single-strand breaks. J. Mol. Biol. 351 (2005) 1020-1029
30. Venkhataraman R., Donald C.D., Roy R., You H.J., Doetsch P.W., and Kow Y.W. Enzymatic processing of DNA containing tandem dihydrouracil by endonucleases III and VIII. Nucleic Acids Res. 29 (2001) 407-414
31. Lomax M.E., Salje H., Cunniffe S., and O'Neill P. 8-OxoA inhibits the incision of an AP site by the DNA glycosylases Fpg, Nth and the AP endonuclease HAP1. Radiat. Res. 163 (2005) 79-84
32. Kunkel T.A., Schaaper R.M., and Loeb L.A. Depurination-induced infidelity of deoxyribonucleic acid synthesis with purified deoxyribonucleic acid replication proteins in vitro. Biochemistry 22 (1983) 2378-2384
33. Grollman A.P., and Moriya M. Mutagenesis by 8-oxoguanine: an enemy within. Trends Genet. 9 (1993) 246-249
34. Errami A., Smider V., Rathmell W.K., He D.M., Hendrickson E.A., Zdzienicka M.Z., and Chu G. Ku86 defines the genetic defect and restores X-ray resistance and V(D)J recombination to complementation group 5 hamster cell mutants. Mol. Cell. Biol. 16 (1996) 1519-1526
35. Calsou P., Frit P., and Salles B. Double strand breaks in DNA inhibit nucleotide excision repair in vitro. J. Biol. Chem. 271 (1996) 27601-27607
36. Hashimoto M., Donald C.D., Yannone S.M., Chen D.J., Roy R., and Kow Y.W. A possible role of Ku in mediating sequential repair of closely opposed lesions. J. Biol. Chem. 276 (2001) 12827-12831
37. Castaing B., Fourrey J.L., Hervouet N., Thomas M., Boiteux S., and Zelwer C. AP site structural determinants for Fpg specific recognition. Nucleic Acids Res. 27 (1999) 608-615
38. Shibutani S., Takeshita M., and Grollman A.P. Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG. Nature 349 (1991) 431-434
39. Alseth I., Korvald H., Osman F., Seeberg E., and Bjoras M. A general role of the DNA glycosylase Nth1 in the abasic sites cleavage step of base excision repair in Schizosaccharomyces pombe. Nucleic Acids Res. 32 (2004) 5119-5125