Formation and repair of clustered damaged DNA sites in high LET irradiated cells

International Journal of Radiation Biology

Volumn 91, Issue 10, 2015, Pages 820-826

  Gustafsson, Ann Sofie ^a   Hartman, Torbjörn ^b   Stenerlöw, Bo ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

Clustered damage; DNA damage; DNA DSB repair; DNA repair; double strand breaks; High LET

Indexed keywords

CARBON; DNA FRAGMENT; NAKED DNA; NITROGEN;

ARTICLE; DNA FRAGMENTATION; DNA REPAIR; DOUBLE STRANDED DNA BREAK; GAMMA RADIATION; HUMAN; HUMAN CELL; IONIZING RADIATION; LINEAR ENERGY TRANSFER; NORMAL HUMAN; PRIORITY JOURNAL; PULSED FIELD GEL ELECTROPHORESIS; RADIATION DOSE DISTRIBUTION; RADIOACTIVITY; RELATIVE BIOLOGIC EFFECTIVENESS; SKIN FIBROBLAST; CYTOLOGY; DNA DAMAGE; FIBROBLAST; METABOLISM; RADIATION RESPONSE; SKIN;

CARBON; DNA BREAKS, DOUBLE-STRANDED; DNA DAMAGE; DNA FRAGMENTATION; DNA REPAIR; FIBROBLASTS; HUMANS; LINEAR ENERGY TRANSFER; NITROGEN; SKIN;

EID: 84948570525     PISSN: 09553002     EISSN: 13623095     Source Type: Journal    
DOI: 10.3109/09553002.2015.1068463     Document Type: Article

References (29)

1. Blocher D. 1990. In CHEF electrophoresis a linear induction of dsb corresponds to a nonlinear fraction of extracted DNA with dose. Int J Radiat Biol 57: 7-12.
2. Claesson AK, Stenerlöw B, Jacobsson L, Elmroth K. 2007. Relative biological effectiveness of the alpha-particle emitter (211)At for double-strand break induction in human fibroblasts. Radiat Res 167: 312-318.
3. Costes SV, Boissiere A, Ravani S, Romano R, Parvin B, Barcellos-Hoff MH. 2006. Imaging features that discriminate between foci induced by high-And low-LET radiation in human fibroblasts. Radiat Res 165: 505-515.
4. Elmroth K, Stenerlöw B. 2005. DNA-incorporated 125I induces more than one double-strand break per decay in mammalian cells. Radiat Res 163: 369-373.
5. Fakir H, Sachs RK, Stenerlöw B, Hofmann W. 2006. Clusters of DNA double-strand breaks induced by different doses of nitrogen ions for various LETs: Experimental measurements and theoretical analyses. Radiat Res 166: 917-927.
6. Georgakilas AG, ONeill P, Stewart RD. 2013. Induction and repair of clustered DNA lesions: What do we know so far? Radiat Res 180: 100-109.
7. Goodhead DT. 1994. Initial events in the cellular effects of ionizing radiations: Clustered damage in DNA. Int J Radiat Biol 65: 7-17.
8. Gulston M, de Lara C, Jenner T, Davis E, ONeill P. 2004. Processing of clustered DNA damage generates additional double-strand breaks in mammalian cells post-irradiation. Nucleic Acids Res 32: 1602-1609.
9. Henle ES, Roots R, Holley WR, Chatterjee A. 1995. DNA strand breakage is correlated with unaltered base release after gamma irradiation. Radiat Res 143: 144-150.
10. Höglund E, Blomquist E, Carlsson J, Stenerlöw B. 2000. DNA damage induced by radiation of different linear energy transfer: Initial fragmentation. Int J Radiat Biol 76: 539-547.
11. Jones GD, Boswell TV, Ward JF. 1994. Effects of postirradiation temperature on the yields of radiation-induced single-And double-strand breakage in SV40 DNA. Radiat Res 138: 291-296.
12. Karlsson KH, Radulescu I, Rydberg B, Stenerlöw B. 2008. Repair of radiation-induced heat-labile sites is independent of DNA-PKcs, XRCC1 and PARP. Radiat Res 169: 506-512.
13. Löbrich M, Cooper PK, Rydberg B. 1996. Non-random distribution of DNA double-strand breaks induced by particle irradiation. Int J Radiat Biol 70: 493-503.
14. Newman HC, Prise KM, Folkard M, Michael BD. 1997. DNA double-strand break distributions in X-ray and alpha-particle irradiated V79 cells: Evidence for non-random breakage. Int J Radiat Biol 71: 347-363.
15. Prise KM, Ahnström G, Belli M, Carlsson J, Frankenberg D, Kiefer J, L brich M, Michael BD, Nygren J, Simone G, Stenerlöw B. 1998. A review of DSB induction data for varying quality radiations. Int J Radiat Biol 74: 173-184.
16. Radulescu I, Elmroth K, Stenerlöw B. 2004. Chromatin organization contributes to non-randomly distributed double-strand breaks after exposure to high-LET radiation. Radiat Res 161: 1-8.
17. Rydberg B. 1996. Clusters of DNA damage induced by ionizing radiation: Formation of short DNA fragments. II. Experimental detection. Radiat Res 145: 200-209.
18. Rydberg, B. 2000. Radiation-induced heat-labile sites that convert into DNA double-strand breaks. Radiat Res 153: 805-812.
19. Singh SK, Wang M, Staudt C, Iliakis G. 2011. Post-irradiation chemical processing of DNA damage generates double-strand breaks in cells already engaged in repair. Nucleic Acids Res 39: 8416-8429.
20. Singh SK, Wu W, Wu W, Wang M, Iliakis G. 2009. Extensive repair of DNA double-strand breaks in cells deficient in the DNA-PK-dependent pathway of NHEJ after exclusion of heat-labile sites. Radiat Res 172: 152-164.
21. Singh SK, Wu W, Stuschke M, Bockisch A, Iliakis G. 2012. Reduced contribution of thermally-labile sugar lesions to DNA double-strand break formation after exposure to neutrons. Radiat Res 178: 581-590.
22. Singh SK, Bencsik-Dheilen A, Mladenov E, Jakob B, Taucher-Scholz G, Iliakis G. 2013. Reduced contribution of thermally labile sugar lesions to DNA double strand break formation after exposure to heavy ions. Radiat Oncol 8: 77.
23. Stenerlöw B, Höglund E, Carlsson J, Blomquist E. 2000. Rejoining of DNA fragments produced by radiations of different linear energy transfer. Int J Radiat Biol 76: 549-557.
24. Stenerlöw B, Karlsson KH, Cooper B, Rydberg B. 2003. Measurement of prompt DNA double-strand breaks in mammalian cells without including heat-labile sites: Results for cells deficient in nonhomologous end joining. Radiat Res 159: 502-510.
25. Ward JF. 1985. Biochemistry of DNA lesions. Radiat Res (Suppl. 8): S103-111.
26. Von Sonntag C, Schulte-Frohlinde D. 1978. Radiation-induced degradation of the sugar in model compounds and in DNA. Mol Biol Biochem Biophys 27: 204-226.
27. Yokoya A, Cunniffe SMT, Stevens DL, ONeill P. 2003. Effects of hydration on the induction of strand breaks, base lesions, and clustered damage in DNA films by a-radiation. J Phys Chem B 107: 832-837.
28. Zhou C, Greenberg MM. 2012. Histone-catalyzed cleavage of nucleosomal DNA containing 2-deoxyribonolactone. J Am Chem Soc 134: 8090-8093.
29. Ziegler JF, Manoyan JM. 1988. The stopping of ions in compounds. Nucl Instrum Methods B35: 215-228.