Reduced repair capacity of a DNA clustered damage site comprised of 8-oxo-7,8-dihydro-2'-deoxyguanosine and 2-deoxyribonolactone results in an increased mutagenic potential of these lesions

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 762, Issue 1, 2014, Pages 32-39

  Cunniffe, Siobhan ^a   O'Neill, Peter ^a   Greenberg, Marc M ^b   Lomax, Martine E ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

2 Deoxyribonolactone; 8 Oxo 7,8 dihydro 2' deoxyguanosine; 8 oxodGuo; Base excision repair; Clustered DNA damage; Mutation; Oxidized abasic sites

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; DNA; LIGASE; PLASMID DNA; SINGLE STRANDED DNA; TETRAHYDROFURAN;

ARTICLE; DNA DAMAGE; DNA FLANKING REGION; DNA REPAIR; DNA REPLICATION; DNA STRAND; ENZYME ACTIVITY; ESCHERICHIA COLI; EXCISION REPAIR; GENE MUTATION; GENE SEQUENCE; HUMAN; IN VITRO STUDY; IONIZING RADIATION; MUTAGENIC ACTIVITY; MUTATION RATE; PRIORITY JOURNAL; PROTEIN PURIFICATION; SEQUENCE ANALYSIS;

ESCHERICHIA COLI;

2-DEOXYRIBONOLACTONE; 8-OXO-7,8-DIHYDRO-2′-DEOXYGUANOSINE; BASE EXCISION REPAIR; CLUSTERED DNA DAMAGE; MUTATION; OXIDIZED ABASIC SITES;

BIOLOGICAL ASSAY; DEOXYGUANOSINE; DNA BREAKS, DOUBLE-STRANDED; DNA POLYMERASE BETA; DNA REPAIR; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; FLAP ENDONUCLEASES; FURANS; GAMMA RAYS; GENE EXPRESSION REGULATION, BACTERIAL; MUTAGENESIS; MUTATION; PLASMIDS; SUGAR ACIDS;

EID: 84897417171     PISSN: 00275107     EISSN: 09218262     Source Type: Journal    
DOI: 10.1016/j.mrfmmm.2014.02.005     Document Type: Article

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