-
1
-
-
4444339833
-
Oxidative DNA damage and disease: induction, repair and significance
-
Evans MD, Dizdaroglu M, Cooke MS. Oxidative DNA damage and disease: induction, repair and significance. Mutat Res. 2004; 567:1-61.
-
(2004)
Mutat Res.
, vol.567
, pp. 1-61
-
-
Evans, M.D.1
Dizdaroglu, M.2
Cooke, M.S.3
-
4
-
-
0024462967
-
Endogenous DNA damage as related to cancer and aging
-
Ames BN. Endogenous DNA damage as related to cancer and aging. Mutat Res. 1989; 214:41-46.
-
(1989)
Mutat Res.
, vol.214
, pp. 41-46
-
-
Ames, B.N.1
-
5
-
-
0027194309
-
Oxidative mechanisms in carcinogenesis
-
Guyton KZ, Kensler TW. Oxidative mechanisms in carcinogenesis. Br Med Bull. 1993; 49:523-544.
-
(1993)
Br Med Bull.
, vol.49
, pp. 523-544
-
-
Guyton, K.Z.1
Kensler, T.W.2
-
6
-
-
0037154121
-
Oxidation of 7, 8-dihydro-8-oxoguanine affords lesions that are potent sources of replication errors in vivo
-
Henderson PT, Delaney JC, Gu F, Tannenbaum SR, Essigmann JM. Oxidation of 7, 8-dihydro-8-oxoguanine affords lesions that are potent sources of replication errors in vivo. Biochemistry. 2002; 41:914-921.
-
(2002)
Biochemistry.
, vol.41
, pp. 914-921
-
-
Henderson, P.T.1
Delaney, J.C.2
Gu, F.3
Tannenbaum, S.R.4
Essigmann, J.M.5
-
7
-
-
0025981359
-
Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG
-
Shibutani S, Takeshita M, Grollman AP. Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG. Nature. 1991; 349:431-434.
-
(1991)
Nature.
, vol.349
, pp. 431-434
-
-
Shibutani, S.1
Takeshita, M.2
Grollman, A.P.3
-
9
-
-
31544467567
-
Glutathione depletion by buthionine sulfoximine induces DNA deletions in mice
-
Reliene R, Schiestl RH. Glutathione depletion by buthionine sulfoximine induces DNA deletions in mice. Carcinogenesis. 2006; 27:240-244.
-
(2006)
Carcinogenesis.
, vol.27
, pp. 240-244
-
-
Reliene, R.1
Schiestl, R.H.2
-
10
-
-
44649090121
-
The comet assay: topical issues
-
Collins AR, Oscoz AA, Brunborg G, Gaivao I, Giovannelli L, Kruszewski M, Smith CC, Stetina R. The comet assay: topical issues. Mutagenesis. 2008; 23:143-151.
-
(2008)
Mutagenesis.
, vol.23
, pp. 143-151
-
-
Collins, A.R.1
Oscoz, A.A.2
Brunborg, G.3
Gaivao, I.4
Giovannelli, L.5
Kruszewski, M.6
Smith, C.C.7
Stetina, R.8
-
11
-
-
24944464191
-
A non-radioactive, PFGE-based assay for low levels of DNA double-strand breaks in mammalian cells
-
Gradzka I, Iwanenko T. A non-radioactive, PFGE-based assay for low levels of DNA double-strand breaks in mammalian cells. DNA Repair (Amst). 2005; 4:1129-1139.
-
(2005)
DNA Repair (Amst).
, vol.4
, pp. 1129-1139
-
-
Gradzka, I.1
Iwanenko, T.2
-
12
-
-
77953166592
-
gammaH2AX foci analysis for monitoring DNA double-strand break repair: strengths, limitations and optimization
-
Lobrich M, Shibata A, Beucher A, Fisher A, Ensminger M, Goodarzi AA, Barton O, Jeggo PA. gammaH2AX foci analysis for monitoring DNA double-strand break repair: strengths, limitations and optimization. Cell Cycle. 2010; 9:662-669.
-
(2010)
Cell Cycle.
, vol.9
, pp. 662-669
-
-
Lobrich, M.1
Shibata, A.2
Beucher, A.3
Fisher, A.4
Ensminger, M.5
Goodarzi, A.A.6
Barton, O.7
Jeggo, P.A.8
-
13
-
-
0018787368
-
X-ray induced DNA double strand break production and repair in mammalian cells as measured by neutral filter elution
-
Bradley MO, Kohn KW. X-ray induced DNA double strand break production and repair in mammalian cells as measured by neutral filter elution. Nucleic Acids Res. 1979; 7:793-804.
-
(1979)
Nucleic Acids Res.
, vol.7
, pp. 793-804
-
-
Bradley, M.O.1
Kohn, K.W.2
-
14
-
-
0037884963
-
Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses
-
Rothkamm K, Lobrich M. Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses. Proc Natl Acad Sci U S A. 2003; 100:5057-5062.
-
(2003)
Proc Natl Acad Sci U S A.
, vol.100
, pp. 5057-5062
-
-
Rothkamm, K.1
Lobrich, M.2
-
15
-
-
84905653320
-
Most hydrogen peroxide-induced histone H2AX phosphorylation is mediated by ATR and is not dependent on DNA double-strand breaks
-
Katsube T, Mori M, Tsuji H, Shiomi T, Wang B, Liu Q, Nenoi M, Onoda M. Most hydrogen peroxide-induced histone H2AX phosphorylation is mediated by ATR and is not dependent on DNA double-strand breaks. J Biochem. 2014; 156:85-95.
-
(2014)
J Biochem.
, vol.156
, pp. 85-95
-
-
Katsube, T.1
Mori, M.2
Tsuji, H.3
Shiomi, T.4
Wang, B.5
Liu, Q.6
Nenoi, M.7
Onoda, M.8
-
16
-
-
0037022534
-
Oxygen metabolism causes chromosome breaks and is associated with the neuronal apoptosis observed in DNA double-strand break repair mutants
-
Karanjawala ZE, Murphy N, Hinton DR, Hsieh CL, Lieber MR. Oxygen metabolism causes chromosome breaks and is associated with the neuronal apoptosis observed in DNA double-strand break repair mutants. Curr Biol. 2002; 12:397-402.
-
(2002)
Curr Biol.
, vol.12
, pp. 397-402
-
-
Karanjawala, Z.E.1
Murphy, N.2
Hinton, D.R.3
Hsieh, C.L.4
Lieber, M.R.5
-
17
-
-
79956225907
-
Clustered DNA lesion repair in eukaryotes: relevance to mutagenesis and cell survival
-
Sage E, Harrison L. Clustered DNA lesion repair in eukaryotes: relevance to mutagenesis and cell survival. Mutat Res. 2011; 711:123-133.
-
(2011)
Mutat Res.
, vol.711
, pp. 123-133
-
-
Sage, E.1
Harrison, L.2
-
19
-
-
77957828599
-
Abasic sites preferentially form at regions undergoing DNA replication
-
Chastain PD, 2nd, Nakamura J, Rao S, Chu H, IbrahimJG, Swenberg JA, Kaufman DG. Abasic sites preferentially form at regions undergoing DNA replication. FASEB J. 2009; 24:3674-3680.
-
(2009)
FASEB J.
, vol.24
, pp. 3674-3680
-
-
Chastain, P.D.1
Nakamura, J.2
Rao, S.3
Chu, H.4
Ibrahim, J.G.5
Swenberg, J.A.6
Kaufman, D.G.7
-
20
-
-
79956197636
-
Delayed repair of radiation induced clustered DNA damage: friend or foe?
-
Eccles LJ, O'Neill P, Lomax ME. Delayed repair of radiation induced clustered DNA damage: friend or foe? Mutat Res. 2011; 711:134-141.
-
(2011)
Mutat Res.
, vol.711
, pp. 134-141
-
-
Eccles, L.J.1
O'Neill, P.2
Lomax, M.E.3
-
21
-
-
0034564299
-
Enhanced sensitivity and long-term G2 arrest in hydrogen peroxide-treated Ku80-null cells are unrelated to DNA repair defects
-
Arrington ED, Caldwell MC, Kumaravel TS, LohaniA, Joshi A, Evans MK, Chen HT, Nussenzweig A, Holbrook NJ, Gorospe M. Enhanced sensitivity and long-term G2 arrest in hydrogen peroxide-treated Ku80-null cells are unrelated to DNA repair defects. Free Radic Biol Med. 2000; 29:1166-1176.
-
(2000)
Free Radic Biol Med.
, vol.29
, pp. 1166-1176
-
-
Arrington, E.D.1
Caldwell, M.C.2
Kumaravel, T.S.3
Lohani, A.4
Joshi, A.5
Evans, M.K.6
Chen, H.T.7
Nussenzweig, A.8
Holbrook, N.J.9
Gorospe, M.10
-
22
-
-
84967113230
-
Chapter 2.1. Enzymic Detoxification of Endogenously Produced Mutagenic Carcinogens Maintaining Cellular Homeostasis
-
Issues in Toxicology No. 13. ):Edited by Helmut Greim and Richard J. Albertini
-
Bolt HM. Chapter 2.1. Enzymic Detoxification of Endogenously Produced Mutagenic Carcinogens Maintaining Cellular Homeostasis. . The Cellular Response to the Genotoxic Insult : The Question of Threshold for Genotoxic Carcinogens. 2012; (Issues in Toxicology No. 13. ):Edited by Helmut Greim and Richard J. Albertini.
-
(2012)
The Cellular Response to the Genotoxic Insult : The Question of Threshold for Genotoxic Carcinogens.
-
-
Bolt, H.M.1
-
23
-
-
31444451689
-
H2O2 at physiological concentrations modulates Leydig cell function inducing oxidative stress and apoptosis
-
Gautam DK, Misro MM, Chaki SP, Sehgal N. H2O2 at physiological concentrations modulates Leydig cell function inducing oxidative stress and apoptosis. Apoptosis. 2006; 11:39-46.
-
(2006)
Apoptosis.
, vol.11
, pp. 39-46
-
-
Gautam, D.K.1
Misro, M.M.2
Chaki, S.P.3
Sehgal, N.4
-
24
-
-
0035478537
-
A real-time electrochemical technique for measurement of cellular hydrogen peroxide generation and consumption: evaluation in human polymorphonuclear leukocytes
-
Liu X, Zweier JL. A real-time electrochemical technique for measurement of cellular hydrogen peroxide generation and consumption: evaluation in human polymorphonuclear leukocytes. Free Radic Biol Med. 2001; 31:894-901.
-
(2001)
Free Radic Biol Med.
, vol.31
, pp. 894-901
-
-
Liu, X.1
Zweier, J.L.2
-
25
-
-
84876349128
-
Cell cycle stage-specific roles of Rad18 in tolerance and repair of oxidative DNA damage
-
Yang Y, Durando M, Smith-Roe SL, Sproul C, Greenwalt AM, Kaufmann W, Oh S, Hendrickson EA, Vaziri C. Cell cycle stage-specific roles of Rad18 in tolerance and repair of oxidative DNA damage. Nucleic Acids Res. 2013; 41:2296-2312.
-
(2013)
Nucleic Acids Res.
, vol.41
, pp. 2296-2312
-
-
Yang, Y.1
Durando, M.2
Smith-Roe, S.L.3
Sproul, C.4
Greenwalt, A.M.5
Kaufmann, W.6
Oh, S.7
Hendrickson, E.A.8
Vaziri, C.9
-
26
-
-
0033957577
-
Comparison of biological effects of DNA damage induced by ionizing radiation and hydrogen peroxide in CHO cells
-
Dahm-Daphi J, Sass C, Alberti W. Comparison of biological effects of DNA damage induced by ionizing radiation and hydrogen peroxide in CHO cells. Int J Radiat Biol. 2000; 76:67-75.
-
(2000)
Int J Radiat Biol.
, vol.76
, pp. 67-75
-
-
Dahm-Daphi, J.1
Sass, C.2
Alberti, W.3
-
27
-
-
0037444052
-
Micromolar concentrations of hydrogen peroxide induce oxidative DNA lesions more efficiently than millimolar concentrations in mammalian cells
-
Nakamura J, Purvis ER, Swenberg JA. Micromolar concentrations of hydrogen peroxide induce oxidative DNA lesions more efficiently than millimolar concentrations in mammalian cells. Nucleic Acids Res. 2003; 31:1790-1795.
-
(2003)
Nucleic Acids Res.
, vol.31
, pp. 1790-1795
-
-
Nakamura, J.1
Purvis, E.R.2
Swenberg, J.A.3
-
28
-
-
84875904745
-
The shape of the radiation dose response for DNA double-strand break induction and repair
-
Barnard S, Bouffler S, Rothkamm K. The shape of the radiation dose response for DNA double-strand break induction and repair. Genome Integr. 2013; 4:1.
-
(2013)
Genome Integr.
, vol.4
, pp. 1
-
-
Barnard, S.1
Bouffler, S.2
Rothkamm, K.3
-
29
-
-
0025816652
-
Comparison between pulsed-field and constant-field gel electrophoresis for measurement of DNA double-strand breaks in irradiated Chinese hamster ovary cells
-
Wlodek D, Banath J, Olive PL. Comparison between pulsed-field and constant-field gel electrophoresis for measurement of DNA double-strand breaks in irradiated Chinese hamster ovary cells. Int J Radiat Biol. 1991; 60:779-790.
-
(1991)
Int J Radiat Biol.
, vol.60
, pp. 779-790
-
-
Wlodek, D.1
Banath, J.2
Olive, P.L.3
-
30
-
-
74849091341
-
Pseudo-DNA damage response in senescent cells
-
Pospelova TV, Demidenko ZN, Bukreeva EI, PospelovVA, Gudkov AV, Blagosklonny MV. Pseudo-DNA damage response in senescent cells. Cell Cycle. 2009; 8:4112-4118.
-
(2009)
Cell Cycle.
, vol.8
, pp. 4112-4118
-
-
Pospelova, T.V.1
Demidenko, Z.N.2
Bukreeva, E.I.3
Pospelov, V.A.4
Gudkov, A.V.5
Blagosklonny, M.V.6
-
31
-
-
79957686784
-
Unrepaired clustered DNA lesions induce chromosome breakage in human cells
-
Asaithamby A, Hu B, Chen DJ. Unrepaired clustered DNA lesions induce chromosome breakage in human cells. Proc Natl Acad Sci U S A. 2011; 108:8293-8298.
-
(2011)
Proc Natl Acad Sci U S A.
, vol.108
, pp. 8293-8298
-
-
Asaithamby, A.1
Hu, B.2
Chen, D.J.3
-
32
-
-
0028575839
-
Three chemically distinct types of oxidants formed by iron-mediated Fenton reactions in the presence of DNA
-
Luo Y, Han Z, Chin SM, Linn S. Three chemically distinct types of oxidants formed by iron-mediated Fenton reactions in the presence of DNA. Proc Natl Acad Sci U S A. 1994; 91:12438-12442.
-
(1994)
Proc Natl Acad Sci U S A.
, vol.91
, pp. 12438-12442
-
-
Luo, Y.1
Han, Z.2
Chin, S.M.3
Linn, S.4
-
33
-
-
0035093737
-
DNA double-strand breaks: signaling, repair and the cancer connection
-
Khanna KK, Jackson SP. DNA double-strand breaks: signaling, repair and the cancer connection. Nat Genet. 2001; 27:247-254.
-
(2001)
Nat Genet.
, vol.27
, pp. 247-254
-
-
Khanna, K.K.1
Jackson, S.P.2
-
34
-
-
0037430990
-
DNA double strand breaks (DSB) and non-homologous end joining (NHEJ) pathways in human leukemia
-
Rassool FV. DNA double strand breaks (DSB) and non-homologous end joining (NHEJ) pathways in human leukemia. Cancer Lett. 2003; 193:1-9.
-
(2003)
Cancer Lett.
, vol.193
, pp. 1-9
-
-
Rassool, F.V.1
-
35
-
-
34249945536
-
DNA double-strand break repair: from mechanistic understanding to cancer treatment
-
Helleday T, Lo J, van Gent DC, Engelward BP. DNA double-strand break repair: from mechanistic understanding to cancer treatment. DNA Repair (Amst). 2007; 6:923-935.
-
(2007)
DNA Repair (Amst).
, vol.6
, pp. 923-935
-
-
Helleday, T.1
Lo, J.2
van Gent, D.C.3
Engelward, B.P.4
-
36
-
-
84858134469
-
Detection of PIGO-deficient cells using proaerolysin: a valuable tool to investigate mechanisms of mutagenesis in the DT40 cell system
-
Nakamura J, Gul H, Tian X, Bultman SJ, Swenberg JA. Detection of PIGO-deficient cells using proaerolysin: a valuable tool to investigate mechanisms of mutagenesis in the DT40 cell system. PLoS One. 2012; 7:e33563.
-
(2012)
PLoS One.
, vol.7
-
-
Nakamura, J.1
Gul, H.2
Tian, X.3
Bultman, S.J.4
Swenberg, J.A.5
-
37
-
-
84865620494
-
Recognition, signaling, and repair of DNA double-strand breaks produced by ionizing radiation in mammalian cells: the molecular choreography
-
Thompson LH. Recognition, signaling, and repair of DNA double-strand breaks produced by ionizing radiation in mammalian cells: the molecular choreography. Mutat Res. 2012; 751:158-246.
-
(2012)
Mutat Res.
, vol.751
, pp. 158-246
-
-
Thompson, L.H.1
-
38
-
-
78149251956
-
Tumors induce complex DNA damage in distant proliferative tissues in vivo
-
Redon CE, Dickey JS, Nakamura AJ, Kareva IG, Naf D, Nowsheen S, Kryston TB, Bonner WM, Georgakilas AG, Sedelnikova OA. Tumors induce complex DNA damage in distant proliferative tissues in vivo. Proc Natl Acad Sci U S A. 2010; 107:17992-17997.
-
(2010)
Proc Natl Acad Sci U S A.
, vol.107
, pp. 17992-17997
-
-
Redon, C.E.1
Dickey, J.S.2
Nakamura, A.J.3
Kareva, I.G.4
Naf, D.5
Nowsheen, S.6
Kryston, T.B.7
Bonner, W.M.8
Georgakilas, A.G.9
Sedelnikova, O.A.10
-
39
-
-
0035886839
-
Oxidative stress increases frameshift mutations in human colorectal cancer cells
-
Gasche C, Chang CL, Rhees J, Goel A, Boland CR. Oxidative stress increases frameshift mutations in human colorectal cancer cells. Cancer Res. 2001; 61:7444-7448.
-
(2001)
Cancer Res.
, vol.61
, pp. 7444-7448
-
-
Gasche, C.1
Chang, C.L.2
Rhees, J.3
Goel, A.4
Boland, C.R.5
-
40
-
-
5644270239
-
Non-homologous end joining dependency of gamma-irradiation-induced adaptive frameshift mutation formation in cell cycle-arrested yeast cells
-
Heidenreich E, Eisler H. Non-homologous end joining dependency of gamma-irradiation-induced adaptive frameshift mutation formation in cell cycle-arrested yeast cells. Mutat Res. 2004; 556:201-208.
-
(2004)
Mutat Res.
, vol.556
, pp. 201-208
-
-
Heidenreich, E.1
Eisler, H.2
-
41
-
-
77952882508
-
The relevance of oxidative stress and cytotoxic DNA lesions for spontaneous mutagenesis in non-replicating yeast cells
-
Steinboeck F, Hubmann M, Bogusch A, Dorninger P, Lengheimer T, Heidenreich E. The relevance of oxidative stress and cytotoxic DNA lesions for spontaneous mutagenesis in non-replicating yeast cells. Mutat Res. 2010; 688:47-52.
-
(2010)
Mutat Res.
, vol.688
, pp. 47-52
-
-
Steinboeck, F.1
Hubmann, M.2
Bogusch, A.3
Dorninger, P.4
Lengheimer, T.5
Heidenreich, E.6
-
42
-
-
7444250721
-
TOR kinase and Ran are downstream from PI3K/Akt in H2O2-induced mitosis
-
Radisavljevic ZM, Gonzalez-Flecha B. TOR kinase and Ran are downstream from PI3K/Akt in H2O2-induced mitosis. J Cell Biochem. 2004; 91:1293-1300.
-
(2004)
J Cell Biochem.
, vol.91
, pp. 1293-1300
-
-
Radisavljevic, Z.M.1
Gonzalez-Flecha, B.2
-
43
-
-
0032731347
-
Hydrogen peroxide activates p70(S6k) signaling pathway
-
Bae GU, Seo DW, Kwon HK, Lee HY, Hong S, Lee ZW, Ha KS, Lee HW, Han JW. Hydrogen peroxide activates p70(S6k) signaling pathway. J Biol Chem. 1999; 274:32596-32602.
-
(1999)
J Biol Chem.
, vol.274
, pp. 32596-32602
-
-
Bae, G.U.1
Seo, D.W.2
Kwon, H.K.3
Lee, H.Y.4
Hong, S.5
Lee, Z.W.6
Ha, K.S.7
Lee, H.W.8
Han, J.W.9
-
44
-
-
0037108711
-
Ultraviolet-induced phosphorylation of p70(S6K) at Thr and Thr/Ser involves hydrogen peroxide and mammalian target of rapamycin but not Akt and atypical protein kinase C
-
Huang C, Li J, Ke Q, Leonard SS, Jiang BH, ZhongXS, Costa M, Castranova V, Shi X. Ultraviolet-induced phosphorylation of p70(S6K) at Thr and Thr/Ser involves hydrogen peroxide and mammalian target of rapamycin but not Akt and atypical protein kinase C. Cancer Res. 2002; 62:5689-5697.
-
(2002)
Cancer Res.
, vol.62
, pp. 5689-5697
-
-
Huang, C.1
Li, J.2
Ke, Q.3
Leonard, S.S.4
Jiang, B.H.5
Zhong, X.S.6
Costa, M.7
Castranova, V.8
Shi, X.9
-
45
-
-
20844448882
-
Activation of the PI3K/mTOR pathway by BCR-ABL contributes to increased production of reactive oxygen species
-
Kim JH, Chu SC, Gramlich JL, Pride YB, BabendreierE, Chauhan D, Salgia R, Podar K, Griffin JD, Sattler M. Activation of the PI3K/mTOR pathway by BCR-ABL contributes to increased production of reactive oxygen species. Blood. 2005; 105:1717-1723.
-
(2005)
Blood.
, vol.105
, pp. 1717-1723
-
-
Kim, J.H.1
Chu, S.C.2
Gramlich, J.L.3
Pride, Y.B.4
Babendreier, E.5
Chauhan, D.6
Salgia, R.7
Podar, K.8
Griffin, J.D.9
Sattler, M.10
-
46
-
-
0041695625
-
Effects of FK506 and rapamycin on generation of reactive oxygen species, nitric oxide production and nuclear factor kappa B activation in rat hepatocytes
-
Tunon MJ, Sanchez-Campos S, Gutierrez B, CulebrasJM, Gonzalez-Gallego J. Effects of FK506 and rapamycin on generation of reactive oxygen species, nitric oxide production and nuclear factor kappa B activation in rat hepatocytes. Biochem Pharmacol. 2003; 66:439-445.
-
(2003)
Biochem Pharmacol.
, vol.66
, pp. 439-445
-
-
Tunon, M.J.1
Sanchez-Campos, S.2
Gutierrez, B.3
Culebras, J.M.4
Gonzalez-Gallego, J.5
-
47
-
-
35649011943
-
Reactive oxygen species (ROS) mediate the effects of leucine on translation regulation and type I collagen production in hepatic stellate cells
-
Perez de Obanos MP, Lopez-Zabalza MJ, Arriazu E, Modol T, Prieto J, Herraiz MT, Iraburu MJ. Reactive oxygen species (ROS) mediate the effects of leucine on translation regulation and type I collagen production in hepatic stellate cells. Biochim Biophys Acta. 2007; 1773:1681-1688.
-
(2007)
Biochim Biophys Acta.
, vol.1773
, pp. 1681-1688
-
-
Perez de Obanos, M.P.1
Lopez-Zabalza, M.J.2
Arriazu, E.3
Modol, T.4
Prieto, J.5
Herraiz, M.T.6
Iraburu, M.J.7
-
48
-
-
84884941853
-
Rapamycin extends life-and health span because it slows aging
-
Blagosklonny MV. Rapamycin extends life-and health span because it slows aging. Aging (Albany NY). 5:592-598.
-
Aging (Albany NY).
, vol.5
, pp. 592-598
-
-
Blagosklonny, M.V.1
-
49
-
-
84898625747
-
Lifespan extension and cancer prevention in HER-2/neu transgenic mice treated with low intermittent doses of rapamycin
-
Popovich IG, Anisimov VN, Zabezhinski MA, Semenchenko AV, Tyndyk ML, Yurova MN, Blagosklonny MV. Lifespan extension and cancer prevention in HER-2/neu transgenic mice treated with low intermittent doses of rapamycin. Cancer Biol Ther. 15:586-592.
-
Cancer Biol Ther.
, vol.15
, pp. 586-592
-
-
Popovich, I.G.1
Anisimov, V.N.2
Zabezhinski, M.A.3
Semenchenko, A.V.4
Tyndyk, M.L.5
Yurova, M.N.6
Blagosklonny, M.V.7
-
50
-
-
55849152355
-
Aging: ROS or TOR
-
Blagosklonny MV. Aging: ROS or TOR. Cell Cycle. 2008; 7:3344-3354.
-
(2008)
Cell Cycle.
, vol.7
, pp. 3344-3354
-
-
Blagosklonny, M.V.1
-
51
-
-
84859778293
-
mTOR signaling in growth control and disease
-
Laplante M, Sabatini DM. mTOR signaling in growth control and disease. Cell. 2012; 149:274-293.
-
(2012)
Cell.
, vol.149
, pp. 274-293
-
-
Laplante, M.1
Sabatini, D.M.2
-
52
-
-
33846817351
-
Protein kinase C beta and prolyl isomerase 1regulate mitochondrial effects of the life-span determinant p66Shc
-
Pinton P, Rimessi A, Marchi S, Orsini F, MigliaccioE, GiorgioM, Contursi C, Minucci S, Mantovani F, WieckowskiMR, Del Sal G, Pelicci PG, Rizzuto R. Protein kinase C beta and prolyl isomerase 1regulate mitochondrial effects of the life-span determinant p66Shc. Science. 2007; 315:659-663.
-
(2007)
Science.
, vol.315
, pp. 659-663
-
-
Pinton, P.1
Rimessi, A.2
Marchi, S.3
Orsini, F.4
Migliaccio, E.5
Giorgio, M.6
Contursi, C.7
Minucci, S.8
Mantovani, F.9
Wieckowski, M.R.10
Del Sal, G.11
Pelicci, P.G.12
Rizzuto, R.13
-
53
-
-
34047151226
-
Life extension through neurofibromin mitochondrial regulation and antioxidant therapy for neurofibromatosis-1 in Drosophila melanogaster
-
Tong JJ, Schriner SE, McCleary D, Day BJ, WallaceDC. Life extension through neurofibromin mitochondrial regulation and antioxidant therapy for neurofibromatosis-1 in Drosophila melanogaster. Nat Genet. 2007; 39:476-485.
-
(2007)
Nat Genet.
, vol.39
, pp. 476-485
-
-
Tong, J.J.1
Schriner, S.E.2
McCleary, D.3
Day, B.J.4
Wallace, D.C.5
-
54
-
-
0033826512
-
New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathway
-
Gu H, Maeda H, Moon JJ, Lord JD, Yoakim M, Nelson BH, Neel BG. New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathway. Mol Cell Biol. 2000; 20:7109-7120.
-
(2000)
Mol Cell Biol.
, vol.20
, pp. 7109-7120
-
-
Gu, H.1
Maeda, H.2
Moon, J.J.3
Lord, J.D.4
Yoakim, M.5
Nelson, B.H.6
Neel, B.G.7
-
55
-
-
18844371178
-
Oxidative damage and defective DNA repair is linked to apoptosis of migrating neurons and progenitors during cerebral cortex development in Ku70-deficient mice
-
Narasimhaiah R, Tuchman A, Lin SL, Naegele JR. Oxidative damage and defective DNA repair is linked to apoptosis of migrating neurons and progenitors during cerebral cortex development in Ku70-deficient mice. Cereb Cortex. 2005; 15:696-707.
-
(2005)
Cereb Cortex.
, vol.15
, pp. 696-707
-
-
Narasimhaiah, R.1
Tuchman, A.2
Lin, S.L.3
Naegele, J.R.4
-
56
-
-
37049021795
-
Cells deficient in the FANC/BRCA pathway are hypersensitive to plasma levels of formaldehyde
-
Ridpath JR, Nakamura A, Tano K, Luke AM, SonodaE, Arakawa H, Buerstedde JM, Gillespie DA, Sale JE, Yamazoe M, Bishop DK, Takata M, Takeda S, et al. Cells deficient in the FANC/BRCA pathway are hypersensitive to plasma levels of formaldehyde. Cancer Res. 2007; 67:11117-11122.
-
(2007)
Cancer Res.
, vol.67
, pp. 11117-11122
-
-
Ridpath, J.R.1
Nakamura, A.2
Tano, K.3
Luke, A.M.4
Sonoda, E.5
Arakawa, H.6
Buerstedde, J.M.7
Gillespie, D.A.8
Sale, J.E.9
Yamazoe, M.10
Bishop, D.K.11
Takata, M.12
Takeda, S.13
-
57
-
-
84902077250
-
The endogenous exposome
-
Nakamura J, Mutlu E, Sharma V, Collins L, Bodnar W, YuR, Lai Y, Moeller B, Lu K, Swenberg J. The endogenous exposome. DNA Repair (Amst). 2014; 19:3-13.
-
(2014)
DNA Repair (Amst).
, vol.19
, pp. 3-13
-
-
Nakamura, J.1
Mutlu, E.2
Sharma, V.3
Collins, L.4
Bodnar, W.5
Yu, R.6
Lai, Y.7
Moeller, B.8
Lu, K.9
Swenberg, J.10
-
58
-
-
38849134202
-
Induction and processing of complex DNA damage in human breast cancer cells MCF-7 and nonmalignant MCF-10A cells
-
Francisco DC, Peddi P, Hair JM, Flood BA, Cecil AM, Kalogerinis PT, Sigounas G, Georgakilas AG. Induction and processing of complex DNA damage in human breast cancer cells MCF-7 and nonmalignant MCF-10A cells. Free Radic Biol Med. 2008; 44:558-569.
-
(2008)
Free Radic Biol Med.
, vol.44
, pp. 558-569
-
-
Francisco, D.C.1
Peddi, P.2
Hair, J.M.3
Flood, B.A.4
Cecil, A.M.5
Kalogerinis, P.T.6
Sigounas, G.7
Georgakilas, A.G.8
-
59
-
-
80455149665
-
Post-irradiation chemical processing of DNA damage generates double-strand breaks in cells already engaged in repair
-
Singh SK, Wang M, Staudt C, Iliakis G. Post-irradiation chemical processing of DNA damage generates double-strand breaks in cells already engaged in repair. Nucleic Acids Res. 2011; 39:8416-8429.
-
(2011)
Nucleic Acids Res.
, vol.39
, pp. 8416-8429
-
-
Singh, S.K.1
Wang, M.2
Staudt, C.3
Iliakis, G.4
-
60
-
-
0034008136
-
5′-nicked apurinic/apyrimidinic sites are resistant to beta-elimination by beta-polymerase and are persistent in human cultured cells after oxidative stress
-
Nakamura J, La DK, Swenberg JA. 5′-nicked apurinic/apyrimidinic sites are resistant to beta-elimination by beta-polymerase and are persistent in human cultured cells after oxidative stress. J Biol Chem. 2000; 275:5323-5328.
-
(2000)
J Biol Chem.
, vol.275
, pp. 5323-5328
-
-
Nakamura, J.1
La, D.K.2
Swenberg, J.A.3
-
61
-
-
0019404906
-
Quantitative assay for mutation in diploid human lymphoblasts using microtiter plates
-
Furth EE, Thilly WG, Penman BW, Liber HL, RandWM. Quantitative assay for mutation in diploid human lymphoblasts using microtiter plates. Anal Biochem. 1981; 110:1-8.
-
(1981)
Anal Biochem.
, vol.110
, pp. 1-8
-
-
Furth, E.E.1
Thilly, W.G.2
Penman, B.W.3
Liber, H.L.4
Rand, W.M.5
|