메뉴 건너뛰기




Volumn 35, Issue 2, 2016, Pages 57-67

Paneth cell α-defensins and enteric microbiota in health and disease

Author keywords

Dysbiosis; Inflammatory bowel disease; Innate immunity; Intestinal microbiota; Lifestyle disease; Paneth cell; defensin

Indexed keywords


EID: 85008394146     PISSN: 21866953     EISSN: 21863342     Source Type: Journal    
DOI: 10.12938/bmfh.2015-019     Document Type: Review
Times cited : (82)

References (115)
  • 1
    • 0019386682 scopus 로고
    • Sequence and specificity of two antibacterial proteins involved in insect immunity
    • Steiner H, Hultmark D, Engström A, Bennich H, Boman HG. 1981. Sequence and specificity of two antibacterial proteins involved in insect immunity. Nature 292: 246-248
    • (1981) Nature , vol.292 , pp. 246-248
    • Steiner, H.1    Hultmark, D.2    Engström, A.3    Bennich, H.4    Boman, H.G.5
  • 3
    • 0037165196 scopus 로고    scopus 로고
    • Antimicrobial peptides of multicellular organisms
    • Zasloff M. 2002. Antimicrobial peptides of multicellular organisms. Nature 415: 389-395
    • (2002) Nature , vol.415 , pp. 389-395
    • Zasloff, M.1
  • 4
    • 0141799911 scopus 로고    scopus 로고
    • Defensins: antimicrobial peptides of innate immunity
    • Ganz T. 2003. Defensins: antimicrobial peptides of innate immunity. Nat Rev Immunol 3: 710-720
    • (2003) Nat Rev Immunol , vol.3 , pp. 710-720
    • Ganz, T.1
  • 5
    • 13844322065 scopus 로고    scopus 로고
    • The cathelicidins-structure, function and evolution
    • Tomasinsig L, Zanetti M. 2005. The cathelicidins-structure, function and evolution. Curr Protein Pept Sci 6: 23-34
    • (2005) Curr Protein Pept Sci , vol.6 , pp. 23-34
    • Tomasinsig, L.1    Zanetti, M.2
  • 6
    • 20644462344 scopus 로고    scopus 로고
    • Mammalian defensins in the antimicrobial immune response
    • Selsted ME, Ouellette AJ. 2005. Mammalian defensins in the antimicrobial immune response. Nat Immunol 6: 551-557
    • (2005) Nat Immunol , vol.6 , pp. 551-557
    • Selsted, M.E.1    Ouellette, A.J.2
  • 7
    • 84902657771 scopus 로고    scopus 로고
    • Diet, metabolites, and "western-lifestyle" inflammatory diseases
    • Thorburn AN, Macia L, Mackay CR. 2014. Diet, metabolites, and "western-lifestyle" inflammatory diseases. Immunity 40: 833-842
    • (2014) Immunity , vol.40 , pp. 833-842
    • Thorburn, A.N.1    Macia, L.2    Mackay, C.R.3
  • 8
    • 84903764706 scopus 로고    scopus 로고
    • The intestinal epithelium is an integral component of a communications network
    • Kagnoff MF. 2014. The intestinal epithelium is an integral component of a communications network. J Clin Invest 124: 2841-2843
    • (2014) J Clin Invest , vol.124 , pp. 2841-2843
    • Kagnoff, M.F.1
  • 9
    • 84961640848 scopus 로고    scopus 로고
    • Establishment of intestinal bacteriology
    • Mitsuoka T. 2014. Establishment of intestinal bacteriology. Biosci Microbiota Food Health 33: 99-116
    • (2014) Biosci Microbiota Food Health , vol.33 , pp. 99-116
    • Mitsuoka, T.1
  • 12
    • 84922720838 scopus 로고    scopus 로고
    • The intestinal epithelial cell cycle: uncovering its 'cryptic' nature
    • McKernan DP, Egan LJ. 2015. The intestinal epithelial cell cycle: uncovering its 'cryptic' nature. Curr Opin Gastroenterol 31: 124-129
    • (2015) Curr Opin Gastroenterol , vol.31 , pp. 124-129
    • McKernan, D.P.1    Egan, L.J.2
  • 13
    • 0016714237 scopus 로고
    • Kinetics and possible regulation of crypt cell populations under normal and stress conditions
    • Potten CS. 1975. Kinetics and possible regulation of crypt cell populations under normal and stress conditions. Bull Cancer 62: 419-430
    • (1975) Bull Cancer , vol.62 , pp. 419-430
    • Potten, C.S.1
  • 15
    • 84866174523 scopus 로고    scopus 로고
    • Genomic approaches to studying the human microbiota
    • Weinstock GM. 2012. Genomic approaches to studying the human microbiota. Nature 489: 250-256
    • (2012) Nature , vol.489 , pp. 250-256
    • Weinstock, G.M.1
  • 16
    • 0026762844 scopus 로고
    • Purification and primary structure of murine cryptdin-1, a Paneth cell defensin
    • Ouellette AJ, Miller SI, Henschen AH, Selsted ME. 1992 Purification and primary structure of murine cryptdin-1, a Paneth cell defensin. FEBS Lett 304: 146-148
    • (1992) FEBS Lett , vol.304 , pp. 146-148
    • Ouellette, A.J.1    Miller, S.I.2    Henschen, A.H.3    Selsted, M.E.4
  • 20
    • 79955123282 scopus 로고    scopus 로고
    • Bactericidal activity of mouse a-defensin cryptdin-4 predominantly affects noncommensal bacteria
    • Masuda K, Sakai N, Nakamura K, Yoshioka S, Ayabe T. 2011. Bactericidal activity of mouse a-defensin cryptdin-4 predominantly affects noncommensal bacteria. J Innate Immun 3: 315-326
    • (2011) J Innate Immun , vol.3 , pp. 315-326
    • Masuda, K.1    Sakai, N.2    Nakamura, K.3    Yoshioka, S.4    Ayabe, T.5
  • 21
    • 0034886143 scopus 로고    scopus 로고
    • Toll-like receptors: critical proteins linking innate and acquired immunity
    • Akira S, Takeda K, Kaisho T. 2001. Toll-like receptors: critical proteins linking innate and acquired immunity. Nat Immunol 2: 675-680
    • (2001) Nat Immunol , vol.2 , pp. 675-680
    • Akira, S.1    Takeda, K.2    Kaisho, T.3
  • 22
    • 3142724031 scopus 로고    scopus 로고
    • Toll-like receptor signalling
    • Akira S, Takeda K. 2004. Toll-like receptor signalling. Nat Rev Immunol 4: 499-511
    • (2004) Nat Rev Immunol , vol.4 , pp. 499-511
    • Akira, S.1    Takeda, K.2
  • 23
    • 33751545243 scopus 로고    scopus 로고
    • Crystal structures of human alpha-defensins HNP4, HD5, and HD6
    • Szyk A, Wu Z, Tucker K, Yang D, Lu W, Lubkowski J. 2006. Crystal structures of human alpha-defensins HNP4, HD5, and HD6. Protein Sci 15: 2749-2760
    • (2006) Protein Sci , vol.15 , pp. 2749-2760
    • Szyk, A.1    Wu, Z.2    Tucker, K.3    Yang, D.4    Lu, W.5    Lubkowski, J.6
  • 24
    • 36248983841 scopus 로고    scopus 로고
    • Human defensins: synthesis and structural properties
    • Pazgier M, Li X, Lu W, Lubkowski J. 2007. Human defensins: synthesis and structural properties. Curr Pharm Des 13: 3096-3118
    • (2007) Curr Pharm Des , vol.13 , pp. 3096-3118
    • Pazgier, M.1    Li, X.2    Lu, W.3    Lubkowski, J.4
  • 25
    • 10844245595 scopus 로고    scopus 로고
    • Solution structure of cryptdin-4, a mouse paneth cell alpha-defensin
    • Jing W, Hunter HN, Tanabe H, Ouellette AJ, Vogel HJ. 2004 Solution structure of cryptdin-4, a mouse paneth cell alpha-defensin. Biochemistry 43: 15759-15766
    • (2004) Biochemistry , vol.43 , pp. 15759-15766
    • Jing, W.1    Hunter, H.N.2    Tanabe, H.3    Ouellette, A.J.4    Vogel, H.J.5
  • 26
    • 0026660392 scopus 로고
    • Enteric defensins: antibiotic peptide components of intestinal host defense
    • Selsted ME, Miller SI, Henschen AH, Ouellette AJ. 1992 Enteric defensins: antibiotic peptide components of intestinal host defense. J Cell Biol 118: 929-936
    • (1992) J Cell Biol , vol.118 , pp. 929-936
    • Selsted, M.E.1    Miller, S.I.2    Henschen, A.H.3    Ouellette, A.J.4
  • 27
    • 0026457997 scopus 로고
    • Paneth cells of the human small intestine express an antimicrobial peptide gene
    • Jones DE, Bevins CL. 1992. Paneth cells of the human small intestine express an antimicrobial peptide gene. J Biol Chem 267: 23216-23225
    • (1992) J Biol Chem , vol.267 , pp. 23216-23225
    • Jones, D.E.1    Bevins, C.L.2
  • 30
    • 0035128862 scopus 로고    scopus 로고
    • Human defensin 5 is stored in precursor form in normal Paneth cells and is expressed by some villous epithelial cells and by metaplastic Paneth cells in the colon in inflammatory bowel disease
    • Cunliffe RN, Rose FR, Keyte J, Abberley L, Chan WC, Mahida YR. 2001. Human defensin 5 is stored in precursor form in normal Paneth cells and is expressed by some villous epithelial cells and by metaplastic Paneth cells in the colon in inflammatory bowel disease. Gut 48: 176-185
    • (2001) Gut , vol.48 , pp. 176-185
    • Cunliffe, R.N.1    Rose, F.R.2    Keyte, J.3    Abberley, L.4    Chan, W.C.5    Mahida, Y.R.6
  • 36
    • 6344249139 scopus 로고    scopus 로고
    • Differential effects on human immunodeficiency virus type 1 replication by alpha-defensins with comparable bactericidal activities
    • Tanabe H, Ouellette AJ, Cocco MJ, Robinson WE Jr. 2004 Differential effects on human immunodeficiency virus type 1 replication by alpha-defensins with comparable bactericidal activities. J Virol 78: 11622-11631
    • (2004) J Virol , vol.78 , pp. 11622-11631
    • Tanabe, H.1    Ouellette, A.J.2    Cocco, M.J.3    Robinson, W.E.4
  • 37
    • 0028907433 scopus 로고
    • Carbamylcholine-and catecholamine-induced intracellular calcium dynamics of epithelial cells in mouse ileal crypts
    • Satoh Y, Habara Y, Ono K, Kanno T. 1995. Carbamylcholine-and catecholamine-induced intracellular calcium dynamics of epithelial cells in mouse ileal crypts. Gastroenterology 108: 1345-1356
    • (1995) Gastroenterology , vol.108 , pp. 1345-1356
    • Satoh, Y.1    Habara, Y.2    Ono, K.3    Kanno, T.4
  • 38
    • 0036479232 scopus 로고    scopus 로고
    • Modulation of mouse Paneth cell alpha-defensin secretion by mIKCa1, a Ca2+-activated, intermediate conductance potassium channel
    • Ayabe T, Wulff H, Darmoul D, Cahalan MD, Chandy KG, Ouellette AJ. 2002. Modulation of mouse Paneth cell alpha-defensin secretion by mIKCa1, a Ca2+-activated, intermediate conductance potassium channel. J Biol Chem 277: 3793-3800
    • (2002) J Biol Chem , vol.277 , pp. 3793-3800
    • Ayabe, T.1    Wulff, H.2    Darmoul, D.3    Cahalan, M.D.4    Chandy, K.G.5    Ouellette, A.J.6
  • 39
    • 58549111588 scopus 로고    scopus 로고
    • Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface
    • Vaishnava S, Behrendt CL, Ismail AS, Eckmann L, Hooper LV. 2008. Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface. Proc Natl Acad Sci USA 105: 20858-20863
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 20858-20863
    • Vaishnava, S.1    Behrendt, C.L.2    Ismail, A.S.3    Eckmann, L.4    Hooper, L.V.5
  • 40
    • 79954915318 scopus 로고    scopus 로고
    • Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis
    • Bevins CL, Salzman NH. 2011. Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis. Nat Rev Microbiol 9: 356-368
    • (2011) Nat Rev Microbiol , vol.9 , pp. 356-368
    • Bevins, C.L.1    Salzman, N.H.2
  • 41
    • 0037340434 scopus 로고    scopus 로고
    • Angiogenins: a new class of microbicidal proteins involved in innate immunity
    • Hooper LV, Stappenbeck TS, Hong CV, Gordon JI. 2003. Angiogenins: a new class of microbicidal proteins involved in innate immunity. Nat Immunol 4: 269-273
    • (2003) Nat Immunol , vol.4 , pp. 269-273
    • Hooper, L.V.1    Stappenbeck, T.S.2    Hong, C.V.3    Gordon, J.I.4
  • 43
    • 67651159312 scopus 로고    scopus 로고
    • Stem cells, selfrenewal, and differentiation in the intestinal epithelium
    • van der Flier LG, Clevers H. 2009. Stem cells, selfrenewal, and differentiation in the intestinal epithelium. Annu Rev Physiol 71: 241-260
    • (2009) Annu Rev Physiol , vol.71 , pp. 241-260
    • van der Flier, L.G.1    Clevers, H.2
  • 44
    • 67649159967 scopus 로고    scopus 로고
    • Paneth cell development, differentiation, and function: new molecular cues
    • Stappenbeck TS. 2009. Paneth cell development, differentiation, and function: new molecular cues. Gastroenterology 137: 30-33
    • (2009) Gastroenterology , vol.137 , pp. 30-33
    • Stappenbeck, T.S.1
  • 50
    • 2542480000 scopus 로고    scopus 로고
    • Multiple roles of antimicrobial defensins, cathelicidins, and eosinophil-derived neurotoxin in host defense
    • Yang D, Biragyn A, Hoover DM, Lubkowski J, Oppenheim JJ. 2004. Multiple roles of antimicrobial defensins, cathelicidins, and eosinophil-derived neurotoxin in host defense. Annu Rev Immunol 22: 181-215
    • (2004) Annu Rev Immunol , vol.22 , pp. 181-215
    • Yang, D.1    Biragyn, A.2    Hoover, D.M.3    Lubkowski, J.4    Oppenheim, J.J.5
  • 51
    • 3342908873 scopus 로고    scopus 로고
    • The role of Paneth cells and their antimicrobial peptides in innate host defense
    • Ayabe T, Ashida T, Kohgo Y, Kono T. 2004. The role of Paneth cells and their antimicrobial peptides in innate host defense. Trends Microbiol 12: 394-398
    • (2004) Trends Microbiol , vol.12 , pp. 394-398
    • Ayabe, T.1    Ashida, T.2    Kohgo, Y.3    Kono, T.4
  • 52
    • 77958460117 scopus 로고    scopus 로고
    • Paneth cells and innate mucosal immunity
    • Ouellette AJ. 2010. Paneth cells and innate mucosal immunity. Curr Opin Gastroenterol 26: 547-553
    • (2010) Curr Opin Gastroenterol , vol.26 , pp. 547-553
    • Ouellette, A.J.1
  • 53
    • 79960940581 scopus 로고    scopus 로고
    • Paneth cell a-defensins in enteric innate immunity
    • Ouellette AJ. 2011. Paneth cell a-defensins in enteric innate immunity. Cell Mol Life Sci 68: 2215-2229
    • (2011) Cell Mol Life Sci , vol.68 , pp. 2215-2229
    • Ouellette, A.J.1
  • 54
    • 0037417311 scopus 로고    scopus 로고
    • Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensin
    • Salzman NH, Ghosh D, Huttner KM, Paterson Y, Bevins CL. 2003. Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensin. Nature 422: 522-526
    • (2003) Nature , vol.422 , pp. 522-526
    • Salzman, N.H.1    Ghosh, D.2    Huttner, K.M.3    Paterson, Y.4    Bevins, C.L.5
  • 55
    • 34547762705 scopus 로고    scopus 로고
    • MyD88-mediated signals induce the bactericidal lectin RegIII gamma and protect mice against intestinal Listeria monocytogenes infection
    • Brandl K, Plitas G, Schnabl B, DeMatteo RP, Pamer EG. 2007. MyD88-mediated signals induce the bactericidal lectin RegIII gamma and protect mice against intestinal Listeria monocytogenes infection. J Exp Med 204: 1891-1900
    • (2007) J Exp Med , vol.204 , pp. 1891-1900
    • Brandl, K.1    Plitas, G.2    Schnabl, B.3    DeMatteo, R.P.4    Pamer, E.G.5
  • 56
    • 56749146467 scopus 로고    scopus 로고
    • Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis
    • Bouskra D, Brézillon C, Bérard M, Werts C, Varona R, Boneca IG, Eberl G. 2008. Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis. Nature 456: 507-510
    • (2008) Nature , vol.456 , pp. 507-510
    • Bouskra, D.1    Brézillon, C.2    Bérard, M.3    Werts, C.4    Varona, R.5    Boneca, I.G.6    Eberl, G.7
  • 57
    • 39649087352 scopus 로고    scopus 로고
    • Dynamic interactions between bacteria and immune cells leading to intestinal IgA synthesis
    • Tsuji M, Suzuki K, Kinoshita K, Fagarasan S. 2008. Dynamic interactions between bacteria and immune cells leading to intestinal IgA synthesis. Semin Immunol 20: 59-66
    • (2008) Semin Immunol , vol.20 , pp. 59-66
    • Tsuji, M.1    Suzuki, K.2    Kinoshita, K.3    Fagarasan, S.4
  • 59
    • 84879402478 scopus 로고    scopus 로고
    • The role of the immune system in governing host-microbe interactions in the intestine
    • Brown EM, Sadarangani M, Finlay BB. 2013. The role of the immune system in governing host-microbe interactions in the intestine. Nat Immunol 14: 660-667
    • (2013) Nat Immunol , vol.14 , pp. 660-667
    • Brown, E.M.1    Sadarangani, M.2    Finlay, B.B.3
  • 60
    • 84861980130 scopus 로고    scopus 로고
    • Interactions between the microbiota and the immune system
    • Hooper LV, Littman DR, Macpherson AJ. 2012. Interactions between the microbiota and the immune system. Science 336: 1268-1273
    • (2012) Science , vol.336 , pp. 1268-1273
    • Hooper, L.V.1    Littman, D.R.2    Macpherson, A.J.3
  • 61
    • 84867658789 scopus 로고    scopus 로고
    • Intestinal commensal microbes as immune modulators
    • Ivanov II, Honda K. 2012. Intestinal commensal microbes as immune modulators. Cell Host Microbe 12: 496-508
    • (2012) Cell Host Microbe , vol.12 , pp. 496-508
    • Ivanov, I.I.1    Honda, K.2
  • 62
    • 84898679249 scopus 로고    scopus 로고
    • Segmented filamentous bacteria antigens presented by intestinal dendritic cells drive mucosal Th17 cell differentiation
    • Goto Y, Panea C, Nakato G, Cebula A, Lee C, Diez MG, Laufer TM, Ignatowicz L, Ivanov II. 2014. Segmented filamentous bacteria antigens presented by intestinal dendritic cells drive mucosal Th17 cell differentiation. Immunity 40: 594-607
    • (2014) Immunity , vol.40 , pp. 594-607
    • Goto, Y.1    Panea, C.2    Nakato, G.3    Cebula, A.4    Lee, C.5    Diez, M.G.6    Laufer, T.M.7    Ignatowicz, L.8    Ivanov, I.I.9
  • 67
    • 84902590969 scopus 로고    scopus 로고
    • The role of the adaptive immune system in regulation of gut microbiota
    • Kato LM, Kawamoto S, Maruya M, Fagarasan S. 2014. The role of the adaptive immune system in regulation of gut microbiota. Immunol Rev 260: 67-75
    • (2014) Immunol Rev , vol.260 , pp. 67-75
    • Kato, L.M.1    Kawamoto, S.2    Maruya, M.3    Fagarasan, S.4
  • 70
    • 56749146037 scopus 로고    scopus 로고
    • Mechanisms of a-defensin bactericidal action: comparative membrane disruption by Cryptdin-4 and its disulfide-null analogue
    • Hadjicharalambous C, Sheynis T, Jelinek R, Shanahan MT, Ouellette AJ, Gizeli E. 2008. Mechanisms of a-defensin bactericidal action: comparative membrane disruption by Cryptdin-4 and its disulfide-null analogue. Biochemistry 47: 12626-12634
    • (2008) Biochemistry , vol.47 , pp. 12626-12634
    • Hadjicharalambous, C.1    Sheynis, T.2    Jelinek, R.3    Shanahan, M.T.4    Ouellette, A.J.5    Gizeli, E.6
  • 71
    • 70350437264 scopus 로고    scopus 로고
    • a-defensins in enteric innate immunity: functional Paneth cell a-defensins in mouse colonic lumen
    • Mastroianni JR, Ouellette AJ. 2009. a-defensins in enteric innate immunity: functional Paneth cell a-defensins in mouse colonic lumen. J Biol Chem 284: 27848-27856
    • (2009) J Biol Chem , vol.284 , pp. 27848-27856
    • Mastroianni, J.R.1    Ouellette, A.J.2
  • 73
    • 84885769879 scopus 로고    scopus 로고
    • A monoclonal antibody-based sandwich enzyme-linked immunosorbent assay for detection of secreted a-defensin
    • Nakamura K, Sakuragi N, Ayabe T. 2013. A monoclonal antibody-based sandwich enzyme-linked immunosorbent assay for detection of secreted a-defensin. Anal Biochem 443: 124-131
    • (2013) Anal Biochem , vol.443 , pp. 124-131
    • Nakamura, K.1    Sakuragi, N.2    Ayabe, T.3
  • 74
    • 77956285486 scopus 로고    scopus 로고
    • Expression of the antimicrobial peptide alpha-defensin/cryptdins in intestinal crypts decreases at the initial phase of intestinal inflammation in a model of inflammatory bowel disease, IL-10-deficient mice
    • Inaba Y, Ashida T, Ito T, Ishikawa C, Tanabe H, Maemoto A, Watari J, Ayabe T, Mizukami Y, Fujiya M, Kohgo Y. 2010. Expression of the antimicrobial peptide alpha-defensin/cryptdins in intestinal crypts decreases at the initial phase of intestinal inflammation in a model of inflammatory bowel disease, IL-10-deficient mice. Inflamm Bowel Dis 16: 1488-1495
    • (2010) Inflamm Bowel Dis , vol.16 , pp. 1488-1495
    • Inaba, Y.1    Ashida, T.2    Ito, T.3    Ishikawa, C.4    Tanabe, H.5    Maemoto, A.6    Watari, J.7    Ayabe, T.8    Mizukami, Y.9    Fujiya, M.10    Kohgo, Y.11
  • 76
    • 74249119678 scopus 로고    scopus 로고
    • Obesity and the human microbiome
    • Ley RE. 2010. Obesity and the human microbiome. Curr Opin Gastroenterol 26: 5-11
    • (2010) Curr Opin Gastroenterol , vol.26 , pp. 5-11
    • Ley, R.E.1
  • 79
    • 84866168894 scopus 로고    scopus 로고
    • Functional interactions between the gut microbiota and host metabolism
    • Tremaroli V, Bäckhed F. 2012. Functional interactions between the gut microbiota and host metabolism. Nature 489: 242-249
    • (2012) Nature , vol.489 , pp. 242-249
    • Tremaroli, V.1    Bäckhed, F.2
  • 81
    • 78649908827 scopus 로고    scopus 로고
    • The role of the gut microbiota in nonalcoholic fatty liver disease
    • Abu-Shanab A, Quigley EM. 2010. The role of the gut microbiota in nonalcoholic fatty liver disease. Nat Rev Gastroenterol Hepatol 7: 691-701
    • (2010) Nat Rev Gastroenterol Hepatol , vol.7 , pp. 691-701
    • Abu-Shanab, A.1    Quigley, E.M.2
  • 88
    • 84898809123 scopus 로고    scopus 로고
    • The microbiome in inflammatory bowel disease: current status and the future ahead
    • Kostic AD, Xavier RJ, Gevers D. 2014. The microbiome in inflammatory bowel disease: current status and the future ahead. Gastroenterology 146: 1489-1499
    • (2014) Gastroenterology , vol.146 , pp. 1489-1499
    • Kostic, A.D.1    Xavier, R.J.2    Gevers, D.3
  • 90
    • 84929308764 scopus 로고    scopus 로고
    • Microbiota in allergy and asthma and the emerging relationship with the gut microbiome
    • Fujimura KE, Lynch SV. 2015. Microbiota in allergy and asthma and the emerging relationship with the gut microbiome. Cell Host Microbe 17: 592-602
    • (2015) Cell Host Microbe , vol.17 , pp. 592-602
    • Fujimura, K.E.1    Lynch, S.V.2
  • 91
    • 84931295496 scopus 로고    scopus 로고
    • Update on fecal microbiota transplantation 2015: indications, methodologies, mechanisms, and outlook
    • Kelly CR, Kahn S, Kashyap P, Laine L, Rubin D, Atreja A, Moore T, Wu G. 2015. Update on fecal microbiota transplantation 2015: indications, methodologies, mechanisms, and outlook. Gastroenterology 149: 223-237
    • (2015) Gastroenterology , vol.149 , pp. 223-237
    • Kelly, C.R.1    Kahn, S.2    Kashyap, P.3    Laine, L.4    Rubin, D.5    Atreja, A.6    Moore, T.7    Wu, G.8
  • 92
    • 0027369395 scopus 로고
    • Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene
    • Sadlack B, Merz H, Schorle H, Schimpl A, Feller AC, Horak I. 1993. Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell 75: 253-261
    • (1993) Cell , vol.75 , pp. 253-261
    • Sadlack, B.1    Merz, H.2    Schorle, H.3    Schimpl, A.4    Feller, A.C.5    Horak, I.6
  • 94
    • 0027521572 scopus 로고
    • Interleukin-10-deficient mice develop chronic enterocolitis
    • Kühn R, Löhler J, Rennick D, Rajewsky K, Müller W. 1993 Interleukin-10-deficient mice develop chronic enterocolitis. Cell 75: 263-274
    • (1993) Cell , vol.75 , pp. 263-274
    • Kühn, R.1    Löhler, J.2    Rennick, D.3    Rajewsky, K.4    Müller, W.5
  • 95
    • 38649115342 scopus 로고    scopus 로고
    • Microbial influences in inflammatory bowel diseases
    • Sartor RB. 2008. Microbial influences in inflammatory bowel diseases. Gastroenterology 134: 577-594
    • (2008) Gastroenterology , vol.134 , pp. 577-594
    • Sartor, R.B.1
  • 100
    • 34249313567 scopus 로고    scopus 로고
    • Paneth cells, defensins, and the commensal microbiota: a hypothesis on intimate interplay at the intestinal mucosa
    • Salzman NH, Underwood MA, Bevins CL. 2007. Paneth cells, defensins, and the commensal microbiota: a hypothesis on intimate interplay at the intestinal mucosa. Semin Immunol 19: 70-83
    • (2007) Semin Immunol , vol.19 , pp. 70-83
    • Salzman, N.H.1    Underwood, M.A.2    Bevins, C.L.3
  • 107
    • 46349102893 scopus 로고    scopus 로고
    • Reduced alpha-defensin expression is associated with inflammation and not NOD2 mutation status in ileal Crohn's disease
    • Simms LA, Doecke JD, Walsh MD, Huang N, Fowler EV, Radford-Smith GL. 2008. Reduced alpha-defensin expression is associated with inflammation and not NOD2 mutation status in ileal Crohn's disease. Gut 57: 903-910
    • (2008) Gut , vol.57 , pp. 903-910
    • Simms, L.A.1    Doecke, J.D.2    Walsh, M.D.3    Huang, N.4    Fowler, E.V.5    Radford-Smith, G.L.6
  • 109
    • 77951224862 scopus 로고    scopus 로고
    • Elevated expression of Paneth cell CRS4C in ileitis-prone SAMP1/YitFc mice: regional distribution, subcellular localization, and mechanism of action
    • Shanahan MT, Vidrich A, Shirafuji Y, Dubois CL, Henschen-Edman A, Hagen SJ, Cohn SM, Ouellette AJ. 2010. Elevated expression of Paneth cell CRS4C in ileitis-prone SAMP1/YitFc mice: regional distribution, subcellular localization, and mechanism of action. J Biol Chem 285: 7493-7504
    • (2010) J Biol Chem , vol.285 , pp. 7493-7504
    • Shanahan, M.T.1    Vidrich, A.2    Shirafuji, Y.3    Dubois, C.L.4    Henschen-Edman, A.5    Hagen, S.J.6    Cohn, S.M.7    Ouellette, A.J.8
  • 115
    • 85074179256 scopus 로고    scopus 로고
    • Paneth cells and stem cells in the intestinal stem cell niche and their association with inflammatory bowel disease
    • Nakamura K, Ayabe T. 2012. Paneth cells and stem cells in the intestinal stem cell niche and their association with inflammatory bowel disease. Inflammation Regeneration 32: 53-60
    • (2012) Inflammation Regeneration , vol.32 , pp. 53-60
    • Nakamura, K.1    Ayabe, T.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.