메뉴 건너뛰기




Volumn 26, Issue 6, 2010, Pages 547-553

Paneth cells and innate mucosal immunity

Author keywords

endoplasmic reticulum stress; homeostasis; inflammation; microbiome; necrotizing enterocolitis

Indexed keywords

ALPHA DEFENSIN; CALCIUM ACTIVATED POTASSIUM CHANNEL; TUMOR NECROSIS FACTOR ALPHA;

EID: 77958460117     PISSN: 02671379     EISSN: None     Source Type: Journal    
DOI: 10.1097/MOG.0b013e32833dccde     Document Type: Review
Times cited : (136)

References (53)
  • 1
    • 20644462344 scopus 로고    scopus 로고
    • Mammalian defensins in the antimicrobial immune response
    • Selsted ME, Ouellette AJ. Mammalian defensins in the antimicrobial immune response. Nat Immunol 2005; 6:551-557.
    • (2005) Nat Immunol , vol.6 , pp. 551-557
    • Selsted, M.E.1    Ouellette, A.J.2
  • 2
    • 53049087417 scopus 로고    scopus 로고
    • Multilayered regulation of intestinal antimicrobial defense
    • Mukherjee S, Vaishnava S, Hooper LV. Multilayered regulation of intestinal antimicrobial defense. Cell Mol Life Sci 2008; 65:3019-3027.
    • (2008) Cell Mol Life Sci , vol.65 , pp. 3019-3027
    • Mukherjee, S.1    Vaishnava, S.2    Hooper, L.V.3
  • 4
    • 67649159967 scopus 로고    scopus 로고
    • Paneth cell development, differentiation, and function: New molecular cues
    • StappenbeckTS. Paneth cell development, differentiation, and function: new molecular cues. Gastroenterology 2009; 137:30-33.
    • (2009) Gastroenterology , vol.137 , pp. 30-33
    • Stappenbeck, T.S.1
  • 5
    • 0014447697 scopus 로고
    • The Paneth cell in health and disease
    • Lewin K. The Paneth cell in health and disease. Ann R Coll Surg Engl 1969; 44:23-37.
    • (1969) Ann R Coll Surg Engl , vol.44 , pp. 23-37
    • Lewin, K.1
  • 6
    • 56249135538 scopus 로고    scopus 로고
    • A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells
    • Cadwell K, Liu JY, Brown SL, et al.A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature 2008; 456:259-263.
    • (2008) Nature , vol.456 , pp. 259-263
    • Cadwell, K.1    Liu, J.Y.2    Brown, S.L.3
  • 7
    • 49249112420 scopus 로고    scopus 로고
    • IL-17 produced by Paneth cells drives TNF-induced shock
    • Takahashi N, Vanlaere I, de Rycke R, et al. IL-17 produced by Paneth cells drives TNF-induced shock. J Exp Med 2008; 205:1755-1761.
    • (2008) J Exp Med , vol.205 , pp. 1755-1761
    • Takahashi, N.1    Vanlaere, I.2    De Rycke, R.3
  • 8
    • 50249086073 scopus 로고    scopus 로고
    • XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease
    • Kaser A, Lee AH, Franke A, et al. XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease. Cell 2008; 134:743-756.
    • (2008) Cell , vol.134 , pp. 743-756
    • Kaser, A.1    Lee, A.H.2    Franke, A.3
  • 9
    • 74749103667 scopus 로고    scopus 로고
    • Disruption of Paneth and goblet cell homeostasis and increased endoplasmic reticulum stress in Agr2\/\mice
    • Zhao F, Edwards R, Dizon D, et al. Disruption of Paneth and goblet cell homeostasis and increased endoplasmic reticulum stress in Agr2\/\mice. Dev Biol 2010; 338:270-279.
    • (2010) Dev Biol , vol.338 , pp. 270-279
    • Zhao, F.1    Edwards, R.2    Dizon, D.3
  • 10
    • 77449100633 scopus 로고    scopus 로고
    • Searching for adult stem cells in the intestine
    • Clevers H. Searching for adult stem cells in the intestine. EMBO Mol Med 2009; 1:255-259.
    • (2009) EMBO Mol Med , vol.1 , pp. 255-259
    • Clevers, H.1
  • 11
    • 20544447734 scopus 로고    scopus 로고
    • Notch signals control the fate of immature progenitor cells in the intestine
    • Fre S, Huyghe M, Mourikis P, et al. Notch signals control the fate of immature progenitor cells in the intestine. Nature 2005; 435:964-968.
    • (2005) Nature , vol.435 , pp. 964-968
    • Fre, S.1    Huyghe, M.2    Mourikis, P.3
  • 12
    • 58249123433 scopus 로고    scopus 로고
    • Requirement of Notch activation during regeneration of the intestinal epithelia
    • Okamoto R, Tsuchiya K, Nemoto Y, et al. Requirement of Notch activation during regeneration of the intestinal epithelia. Am J Physiol Gastrointest Liver Physiol 2009; 296:G23-G35.
    • (2009) Am J Physiol Gastrointest Liver Physiol , vol.296
    • Okamoto, R.1    Tsuchiya, K.2    Nemoto, Y.3
  • 13
    • 0016333713 scopus 로고
    • Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. IV. Paneth cells
    • Cheng H. Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. IV. Paneth cells. Am J Anat 1974; 141:521-535.
    • (1974) Am J Anat , vol.141 , pp. 521-535
    • Cheng, H.1
  • 14
    • 20244364236 scopus 로고    scopus 로고
    • Wnt signalling induces maturation of Paneth cells in intestinal crypts
    • van Es JH, Jay P, Gregorieff A, et al. Wnt signalling induces maturation of Paneth cells in intestinal crypts. Nat Cell Biol 2005; 7:381-386.
    • (2005) Nat Cell Biol , vol.7 , pp. 381-386
    • Van Es, J.H.1    Jay, P.2    Gregorieff, A.3
  • 15
    • 0019509229 scopus 로고
    • The stem-cell zone of the small intestinal epithelium. IV. Effects of resecting 30% of the small intestine
    • Bjerknes M, Cheng H. The stem-cell zone of the small intestinal epithelium. IV. Effects of resecting 30% of the small intestine. Am J Anat 1981; 160:93-103.
    • (1981) Am J Anat , vol.160 , pp. 93-103
    • Bjerknes, M.1    Cheng, H.2
  • 16
    • 67651159312 scopus 로고    scopus 로고
    • Stem cells, self-renewal, and differentiation in the intestinal epithelium
    • van der Flier LG, Clevers H. Stem cells, self-renewal, and differentiation in the intestinal epithelium. Annu Rev Physiol 2009; 71:241-260.
    • (2009) Annu Rev Physiol , vol.71 , pp. 241-260
    • Van Der Flier, L.G.1    Clevers, H.2
  • 17
    • 67349157318 scopus 로고    scopus 로고
    • Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche
    • Ootani A, Li X, Sangiorgi E, et al. Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche. Nat Med 2009; 15:701-706.
    • (2009) Nat Med , vol.15 , pp. 701-706
    • Ootani, A.1    Li, X.2    Sangiorgi, E.3
  • 18
    • 67349123408 scopus 로고    scopus 로고
    • Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
    • Sato T, Vries RG, Snippert HJ, et al. Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature 2009; 459:262-265.
    • (2009) Nature , vol.459 , pp. 262-265
    • Sato, T.1    Vries, R.G.2    Snippert, H.J.3
  • 19
    • 0016794772 scopus 로고
    • The Paneth cell: A source of intestinal lysozyme
    • Peeters T, Vantrappen G.The Paneth cell: a source of intestinal lysozyme.Gut 1975; 16:553-558.
    • (1975) Gut , vol.16 , pp. 553-558
    • Peeters, T.1    Vantrappen, G.2
  • 20
    • 0014208256 scopus 로고
    • Localization of lysozyme activity in a Paneth cell granule fraction
    • Deckx RJ, Vantrappen GR, Parein MM. Localization of lysozyme activity in a Paneth cell granule fraction. Biochim Biophys Acta 1967; 139:204-207.
    • (1967) Biochim Biophys Acta , vol.139 , pp. 204-207
    • Deckx, R.J.1    Vantrappen, G.R.2    Parein, M.M.3
  • 21
    • 0026660392 scopus 로고
    • Enteric defensins: Antibiotic peptide components of intestinal host defense
    • Selsted ME, Miller SI, Henschen AH, Ouellette AJ. Enteric defensins: antibiotic peptide components of intestinal host defense. J Cell Biol 1992; 118:929-936.
    • (1992) J Cell Biol , vol.118 , pp. 929-936
    • Selsted, M.E.1    Miller, S.I.2    Henschen, A.H.3    Ouellette, A.J.4
  • 22
    • 0030914439 scopus 로고    scopus 로고
    • Localization of human intestinal defensin 5 in Paneth cell granules
    • Porter EM, Liu L, Oren A, et al. Localization of human intestinal defensin 5 in Paneth cell granules. Infect Immun 1997; 65:2389-2395.
    • (1997) Infect Immun , vol.65 , pp. 2389-2395
    • Porter, E.M.1    Liu, L.2    Oren, A.3
  • 23
    • 0037085279 scopus 로고    scopus 로고
    • Activation of Paneth cell alpha-defensins in mouse small intestine
    • Ayabe T, Satchell DP, Pesendorfer P, et al. Activation of Paneth cell alpha-defensins in mouse small intestine. J Biol Chem 2002; 277:5219-5228.
    • (2002) J Biol Chem , vol.277 , pp. 5219-5228
    • Ayabe, T.1    Satchell, D.P.2    Pesendorfer, P.3
  • 24
    • 64149129422 scopus 로고    scopus 로고
    • Regulation of C-type lectin antimicrobial activity by a flexible N-terminal prosegment
    • Mukherjee S, Partch CL, Lehotzky RE, et al. Regulation of C-type lectin antimicrobial activity by a flexible N-terminal prosegment. J Biol Chem 2009; 284:4881-4888.
    • (2009) J Biol Chem , vol.284 , pp. 4881-4888
    • Mukherjee, S.1    Partch, C.L.2    Lehotzky, R.E.3
  • 25
    • 0032732928 scopus 로고    scopus 로고
    • Defensins and innate host defence of the gastrointestinal tract
    • Bevins CL, Martin-Porter E, GanzT. Defensins and innate host defence of the gastrointestinal tract. Gut 1999; 45:911-915.
    • (1999) Gut , vol.45 , pp. 911-915
    • Bevins, C.L.1    Martin-Porter, E.2    Ganz, T.3
  • 26
    • 0030029451 scopus 로고    scopus 로고
    • Human enteric defensins. Gene structure and developmental expression
    • Mallow EB, Harris A, Salzman N, et al. Human enteric defensins. Gene structure and developmental expression. J Biol Chem 1996; 271:4038-4045.
    • (1996) J Biol Chem , vol.271 , pp. 4038-4045
    • Mallow, E.B.1    Harris, A.2    Salzman, N.3
  • 27
    • 0031844367 scopus 로고    scopus 로고
    • Enteric defensin expression in necrotizing enterocolitis
    • Salzman NH, Polin RA, Harris MC, et al. Enteric defensin expression in necrotizing enterocolitis. Pediatr Res 1998; 44:20-26.
    • (1998) Pediatr Res , vol.44 , pp. 20-26
    • Salzman, N.H.1    Polin, R.A.2    Harris, M.C.3
  • 28
    • 0037417311 scopus 로고    scopus 로고
    • Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensin
    • Salzman NH, Ghosh D, Huttner KM, et al. Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensin. Nature 2003; 422:522-526.
    • (2003) Nature , vol.422 , pp. 522-526
    • Salzman, N.H.1    Ghosh, D.2    Huttner, K.M.3
  • 29
    • 74049122536 scopus 로고    scopus 로고
    • Enteric defensins are essential regulators of intestinal microbial ecology
    • Salzman NH, Hung K, Haribhai D, et al. Enteric defensins are essential regulators of intestinal microbial ecology. Nat Immunol 2010; 11:76-83.
    • (2010) Nat Immunol , vol.11 , pp. 76-83
    • Salzman, N.H.1    Hung, K.2    Haribhai, D.3
  • 30
    • 0033214433 scopus 로고    scopus 로고
    • Regulation of intestinal alpha-defensin activation by the met alloproteinase matrilysin in innate host defense
    • Wilson CL, Ouellette AJ, Satchell DP, et al. Regulation of intestinal alpha-defensin activation by the met alloproteinase matrilysin in innate host defense. Science 1999; 286:113-117.
    • (1999) Science , vol.286 , pp. 113-117
    • Wilson, C.L.1    Ouellette, A.J.2    Satchell, D.P.3
  • 31
    • 2642541851 scopus 로고    scopus 로고
    • Abnormal Paneth cell granule dissolution and compromised resistance to bacterial colonization in the intestine of CF mice
    • Clarke LL, Gawenis LR, Bradford EM, et al. Abnormal Paneth cell granule dissolution and compromised resistance to bacterial colonization in the intestine of CF mice. Am J Physiol Gastrointest Liver Physiol 2004; 286:G1050-G1058.
    • (2004) Am J Physiol Gastrointest Liver Physiol , vol.286
    • Clarke, L.L.1    Gawenis, L.R.2    Bradford, E.M.3
  • 32
    • 4644246657 scopus 로고    scopus 로고
    • Bacterial overgrowth in the cystic fibrosis transmembrane conductance regulator null mouse small intestine
    • NorkinaO, Burnett TG, De Lisle RC. Bacterial overgrowth in the cystic fibrosis transmembrane conductance regulator null mouse small intestine. Infect Immun 2004; 72:6040-6049.
    • (2004) Infect Immun , vol.72 , pp. 6040-6049
    • Norkina, O.1    Burnett, T.G.2    De Lisle, R.C.3
  • 33
    • 65549129496 scopus 로고    scopus 로고
    • Commensal bacteria, traditional and opportunistic pathogens, dysbiosis and bacterial killing in inflammatory bowel diseases
    • Packey CD, Sartor RB. Commensal bacteria, traditional and opportunistic pathogens, dysbiosis and bacterial killing in inflammatory bowel diseases. Curr Opin Infect Dis 2009; 22:292-301.
    • (2009) Curr Opin Infect Dis , vol.22 , pp. 292-301
    • Packey, C.D.1    Sartor, R.B.2
  • 34
    • 0037470975 scopus 로고    scopus 로고
    • A genomic view of the human-Bacteroides thetaiotaomicron symbiosis
    • Xu J, Bjursell MK, Himrod J, et al. A genomic view of the human-Bacteroides thetaiotaomicron symbiosis. Science 2003; 299:2074-2076.
    • (2003) Science , vol.299 , pp. 2074-2076
    • Xu, J.1    Bjursell, M.K.2    Himrod, J.3
  • 35
    • 0037340434 scopus 로고    scopus 로고
    • Angiogenins: A new class of microbicidal proteins involved in innate immunity
    • Hooper LV, StappenbeckTS, Hong CV, Gordon JI. Angiogenins: a new class of microbicidal proteins involved in innate immunity. Nat Immunol 2003; 4:269-273.
    • (2003) Nat Immunol , vol.4 , pp. 269-273
    • Hooper, L.V.1    Stappenbeck, T.S.2    Hong, C.V.3    Gordon, J.I.4
  • 36
    • 0036408132 scopus 로고    scopus 로고
    • Laser capture microdissection of mouse intestine: Characterizing mRNA and protein expression, and profiling intermediary metabolism in specified cell populations
    • Stappenbeck TS, Hooper LV, Manchester JK, et al. Laser capture microdissection of mouse intestine: characterizing mRNA and protein expression, and profiling intermediary metabolism in specified cell populations. Methods Enzymol 2002; 356:167-196.
    • (2002) Methods Enzymol , vol.356 , pp. 167-196
    • Stappenbeck, T.S.1    Hooper, L.V.2    Manchester, J.K.3
  • 37
    • 0035843993 scopus 로고    scopus 로고
    • Commensal host-bacteria l relationships in the gut
    • Hooper LV, Gordon JI. Commensal host-bacteria l relationships in the gut. Science 2001; 292:111 5-1118.
    • (2001) Science , vol.292 , Issue.111 , pp. 5-1118
    • Hooper, L.V.1    Gordon, J.I.2
  • 38
    • 33748039462 scopus 로고    scopus 로고
    • Symbiotic bacteria direct expression of an intestinal bactericidal lectin
    • Cash HL, Whitham CV, Behrendt CL, Hooper LV. Symbiotic bacteria direct expression of an intestinal bactericidal lectin. Science 2006; 313:1126-1130.
    • (2006) Science , vol.313 , pp. 1126-1130
    • Cash, H.L.1    Whitham, C.V.2    Behrendt, C.L.3    Hooper, L.V.4
  • 39
    • 58549111588 scopus 로고    scopus 로고
    • Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface
    • Vaishnava S, Behrendt CL, Ismail AS, et al. Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface. Proc Natl Acad Sci USA 2008; 105:20858-20863.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 20858-20863
    • Vaishnava, S.1    Behrendt, C.L.2    Ismail, A.S.3
  • 40
    • 34547762705 scopus 로고    scopus 로고
    • MyD88-mediated signals induce the bactericidal lectin RegIII gamma and protect mice against intestinal Listeria monocytogenes infection
    • Brandl K, Plitas G, Schnabl B, et al. MyD88-mediated signals induce the bactericidal lectin RegIII gamma and protect mice against intestinal Listeria monocytogenes infection. J Exp Med 2007; 204:1891-1900.
    • (2007) J Exp Med , vol.204 , pp. 1891-1900
    • Brandl, K.1    Plitas, G.2    Schnabl, B.3
  • 41
    • 74549164145 scopus 로고    scopus 로고
    • Manual annotation and analysis of the defensin gene cluster in the C57BL/6J mouse reference genome
    • Amid C, Rehaume LM, Brown KL, et al. Manual annotation and analysis of the defensin gene cluster in the C57BL/6J mouse reference genome. BMC Genomics 2009; 10:606.
    • (2009) BMC Genomics , vol.10 , pp. 606
    • Amid, C.1    Rehaume, L.M.2    Brown, K.L.3
  • 42
    • 0028907433 scopus 로고
    • Carbamylcholine-and catecholamine-induced intracellular calcium dynamics of epithelial cells in mouse ileal crypts
    • Satoh Y, Habara Y, Ono K, Kanno T. Carbamylcholine-and catecholamine-induced intracellular calcium dynamics of epithelial cells in mouse ileal crypts. Gastroenterology 1995; 108:1345-1356.
    • (1995) Gastroenterology , vol.108 , pp. 1345-1356
    • Satoh, Y.1    Habara, Y.2    Ono, K.3    Kanno, T.4
  • 43
    • 0026638027 scopus 로고
    • Bethanechol and a G-protein activator, NaF/AlCl3, induce secretory response in Paneth cells of mouse intestine
    • Satoh Y, Ishikawa K, Oomori Y, et al. Bethanechol and a G-protein activator, NaF/AlCl3, induce secretory response in Paneth cells of mouse intestine. Cell Tissue Res 1992; 269:213-220.
    • (1992) Cell Tissue Res , vol.269 , pp. 213-220
    • Satoh, Y.1    Ishikawa, K.2    Oomori, Y.3
  • 44
    • 0024414474 scopus 로고
    • Effects of cholecystokinin and carbamylcholine on Paneth cell secretion in mice: A comparison with pancreatic acinar cells
    • Satoh Y, Ishikawa K, Oomori Y, et al. Effects of cholecystokinin and carbamylcholine on Paneth cell secretion in mice: a comparison with pancreatic acinar cells. Anat Rec 1989; 225:124-132.
    • (1989) Anat Rec , vol.225 , pp. 124-132
    • Satoh, Y.1    Ishikawa, K.2    Oomori, Y.3
  • 45
    • 0034252293 scopus 로고    scopus 로고
    • Secretion of microbicidal alpha-defensins by intestinal Paneth cells in response to bacteria
    • Ayabe T, Satchell DP, Wilson CL, et al. Secretion of microbicidal alpha-defensins by intestinal Paneth cells in response to bacteria. Nat Immunol 2000; 1:113-118.
    • (2000) Nat Immunol , vol.1 , pp. 113-118
    • Ayabe, T.1    Satchell, D.P.2    Wilson, C.L.3
  • 46
    • 0035128862 scopus 로고    scopus 로고
    • Human defensin 5 is stored in precursor form in normal Paneth cells and is expressed by some villous epithelial cells and by metaplastic Paneth cells in the colon in inflammatory bowel disease
    • Cunliffe RN, Rose FR, Keyte J, et al. Human defensin 5 is stored in precursor form in normal Paneth cells and is expressed by some villous epithelial cells and by metaplastic Paneth cells in the colon in inflammatory bowel disease. Gut 2001; 48:176-185.
    • (2001) Gut , vol.48 , pp. 176-185
    • Cunliffe, R.N.1    Rose, F.R.2    Keyte, J.3
  • 47
    • 49749136151 scopus 로고    scopus 로고
    • Functional role of metaplastic Paneth cell defensins in Helicobacter pylori-infected stomach
    • Tanabe H, Sato T, Watari J, et al. Functional role of metaplastic Paneth cell defensins in Helicobacter pylori-infected stomach. Helicobacter 2008; 13:370-379.
    • (2008) Helicobacter , vol.13 , pp. 370-379
    • Tanabe, H.1    Sato, T.2    Watari, J.3
  • 48
    • 0036479232 scopus 로고    scopus 로고
    • Modulation of mouse Paneth cell alpha-defensin secretion by mIKCa1, aCa2+-activated, intermediate conductance potassium channel
    • Ayabe T, Wulff H, Darmoul D, et al. Modulation of mouse Paneth cell alpha-defensin secretion by mIKCa1, aCa2+-activated, intermediate conductance potassium channel. J Biol Chem 2002; 277:3793-3800.
    • (2002) J Biol Chem , vol.277 , pp. 3793-3800
    • Ayabe, T.1    Wulff, H.2    Darmoul, D.3
  • 49
    • 76549083562 scopus 로고    scopus 로고
    • Inhibition of the K+ channel KCa3.1 ameliorates T cell-mediated colitis
    • Di L, Srivastava S, Zhdanova O, et al. Inhibition of the K+ channel KCa3.1 ameliorates T cell-mediated colitis. Proc Natl Acad Sci USA 2010; 107: 1541-1546.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 1541-1546
    • Di Srivastava, L.S.1    Zhdanova, O.2
  • 50
    • 77957834845 scopus 로고    scopus 로고
    • KCNN4 gene variant is associated with Ileal Crohn's disease in the Australian and New Zealand population
    • Epub ahead of print
    • Simms LA, Doecke JD, Roberts RL, et al. KCNN4 gene variant is associated with Ileal Crohn's disease in the Australian and New Zealand population. Am J Gastroenterol. [Epub ahead of print]
    • Am J Gastroenterol
    • Simms, L.A.1    Doecke, J.D.2    Roberts, R.L.3
  • 51
    • 70949107842 scopus 로고    scopus 로고
    • Inflammatory bowel disease
    • Abraham C, Cho JH. Inflammatory bowel disease. N Engl J Med 2009; 361:2066-2078.
    • (2009) N Engl J Med , vol.361 , pp. 2066-2078
    • Abraham, C.1    Cho, J.H.2
  • 52
    • 66349091311 scopus 로고    scopus 로고
    • The protein disulfide isomerase AGR2 is essential for production of intestinal mucus
    • Park SW, Zhen G, Verhaeghe C, et al. The protein disulfide isomerase AGR2 is essential for production of intestinal mucus. Proc Natl Acad Sci USA 2009; 106:6950-6955.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 6950-6955
    • Park, S.W.1    Zhen, G.2    Verhaeghe, C.3
  • 53
    • 74049093945 scopus 로고    scopus 로고
    • Localization of the lipopolysaccharide recognition complex in the human healthy and inflamed premature and adult gut
    • Wolfs TG, Derikx JP, Hodin CM, et al. Localization of the lipopolysaccharide recognition complex in the human healthy and inflamed premature and adult gut. Inflamm Bowel Dis 2010; 16:68-75.
    • (2010) Inflamm Bowel Dis , vol.16 , pp. 68-75
    • Wolfs, T.G.1    Derikx, J.P.2    Hodin, C.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.