Functional role of metaplastic paneth cell defensins in Helicobacter pylori-infected stomach

Helicobacter

Volumn 13, Issue 5, 2008, Pages 370-379

  Tanabe, Hiroki ^a   Sato, Tomonobu ^a   Watari, Jiro ^a   Maemoto, Atsuo ^a   Fijiya, Mikihiko ^a   Kono, Toru ^a   Ashida, Toshifumi ^a   Ayabe, Tokiyoshi ^b   Kohgo, Yutaka ^a  

^a ASAHIKAWA MEDICAL COLLEGE   (Japan)

^b HOKKAIDO UNIVERSITY   (Japan)

Author keywords

Alpha defensin; Immune response; Innate immunity; Intestinal metaplasia; Paneth cells

Indexed keywords

DEFENSIN; PROTEIN; RECOMBINANT ENTERIC DEFENSIN; RNA; TRYPSIN;

ARTICLE; ATROPHY; BACTERICIDAL ACTIVITY; CELL FUNCTION; CLINICAL ARTICLE; CONCENTRATION RESPONSE; ENZYME ACTIVATION; GASTRITIS; HELICOBACTER INFECTION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; INFLAMMATION; INTESTINE METAPLASIA; METAPLASIA; NUCLEOTIDE SEQUENCE; PANETH CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; STOMACH MUCOSA; STOMACH PROTECTION;

BLOTTING, WESTERN; DEFENSINS; GASTRIC MUCOSA; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; METAPLASIA; PANETH CELLS; RECOMBINANT PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STOMACH;

BACTERIA (MICROORGANISMS); HELICOBACTER PYLORI;

EID: 49749136151     PISSN: 10834389     EISSN: 15235378     Source Type: Journal    
DOI: 10.1111/j.1523-5378.2008.00621.x     Document Type: Article

References (32)

1. Blaser MJ. Gastric Campylobacter-like organisms, gastritis, and peptic ulcer disease. Gastroenterology 1987 93: 371 83.
2. Malfertheiner P, Megraud F, O'Morain C et al. Current concepts in the management of Helicobacter pylori infection - The Maastricht 2-2000 Consensus Report. Aliment Pharmacol Ther 2002 16: 167 80.
3. Konturek PC, Brzozowski T, Konturek SJ et al. Functional and morphological aspects of Helicobacter pylori-induced gastric cancer in Mongolian gerbils. Eur J Gastroenterol Hepatol 2003 15: 745 54.
4. Nozaki K, Shimizu N, Ikehara Y et al. Effect of early eradication on Helicobacter pylori-related gastric carcinogenesis in Mongolian gerbils. Cancer Sci 2003 94: 235 9.
5. Genta RM, Gurer IE, Graham DY et al. Adherence of Helicobacter pylori to areas of incomplete intestinal metaplasia in the gastric mucosa. Gastroenterology 1996 111: 1206 11.
6. Bravo JC, Correa P. Sulphomucins favour adhesion of Helicobacter pylori to metaplastic gastric mucosa. J Clin Pathol 1999 52: 137 40.
7. Ayabe T, Satchell DP, Wilson CL et al. Secretion of microbicidal alpha-defensins by intestinal Paneth cells in response to bacteria. Nat Immunol 2000 1: 113 8.
8. Salzman NH, Ghosh D, Huttner KM et al. Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensin. Nature 2003 422: 522 6.
9. Sandow MJ, Whitehead R. The Paneth cell. Gut 1979 20: 420 31.
10. Cunliffe RN, Rose FR, Keyte J et al. Human defensin 5 is stored in precursor form in normal Paneth cells and is expressed by some villous epithelial cells and by metaplastic Paneth cells in the colon in inflammatory bowel disease. Gut 2001 48: 176 85.
11. Inada K, Tanaka H, Nakanishi H et al. Identification of Paneth cells in pyloric glands associated with gastric and intestinal mixed-type intestinal metaplasia of the human stomach. Virchows Arch 2001 439: 14 20.
12. Shen B, Porter EM, Reynoso E et al. Human defensin 5 expression in intestinal metaplasia of the upper gastrointestinal tract. J Clin Pathol 2005 58: 687 94.
13. Mallow EB, Harris A, Salzman N et al. Human enteric defensins. Gene structure and developmental expression. J Biol Chem 1996 271: 4038 45.
14. Tanabe H, Yokota K, Kohgo Y. Localization of syndecan-1 in human gastric mucosa associated with ulceration. J Pathol 1999 187: 338 44.
15. Satchell DP, Sheynis T, Shirafuji Y et al. Interactions of mouse Paneth cell alpha-defensins and alpha-defensin precursors with membranes. Prosegment inhibition of peptide association with biomimetic membranes. J Biol Chem 2003 278: 13838 46.
16. Tanabe H, Ayabe T, Maemoto A et al. Denatured human alpha-defensin attenuates the bactericidal activity and the stability against enzymatic digestion. Biochem Biophys Res Commun 2007 358: 349 55.
17. Porter EM, Poles MA, Lee JS et al. Isolation of human intestinal defensins from ileal neobladder urine. FEBS Lett 1998 434: 272 6.
18. Ghosh D, Porter E, Shen B et al. Paneth cell trypsin is the processing enzyme for human defensin-5. Nat Immunol 2002 3: 583 90.
19. Selsted ME, Miller SI, Henschen AH et al. Enteric defensins: antibiotic peptide components of intestinal host defense. J Cell Biol 1992 118: 929 36.
20. Lala S, Ogura Y, Osborne C et al. Crohn's disease and the NOD2 gene: a role for paneth cells. Gastroenterology 2003 125: 47 57.
21. Ogura Y, Bonen DK, Inohara N et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 2001 411: 603 6.
22. Hugot JP, Chamaillard M, Zouali H et al. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 2001 411: 599 603.
23. Wehkamp J, Harder J, Weichenthal M et al. NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal alpha-defensin expression. Gut 2004 53: 1658 64.
24. Del Giudice G, Michetti P. Inflammation, immunity and vaccines for Helicobacter pylori. Helicobacter 2004 9: 23 8.
25. Tatematsu M, Tsukamoto T, Inada K. Stem cells and gastric cancer: role of gastric and intestinal mixed intestinal metaplasia. Cancer Sci 2003 94: 135 41.
26. Mutoh H, Sakurai S, Satoh K et al. Cdx1 induced intestinal metaplasia in the transgenic mouse stomach: comparative study with Cdx2 transgenic mice. Gut 2004 53: 1416 23.
27. Silberg DG, Sullivan J, Kang E et al. Cdx2 ectopic expression induces gastric intestinal metaplasia in transgenic mice. Gastroenterology 2002 122: 689 96.
28. Yang Q, Bermingham NA, Finegold MJ et al. Requirement of Math1 for secretory cell lineage commitment in the mouse intestine. Science 2001 294: 2155 8.
29. Hase K, Murakami M, Iimura M et al. Expression of LL-37 by human gastric epithelial cells as a potential host defense mechanism against Helicobacter pylori. Gastroenterology 2003 125: 1613 25.
30. Bajaj-Elliott M, Fedeli P, Smith GV et al. Modulation of host antimicrobial peptide (beta-defensins 1 and 2) expression during gastritis. Gut 2002 51: 356 61.
31. Ouellette AJ, Bevins CL. Paneth cell defensins and innate immunity of the small bowel. Inflamm Bowel Dis 2001 7: 43 50.
32. Mutoh H, Sakurai S, Satoh K et al. Cdx1 induced intestinal metaplasia in the transgenic mouse stomach: comparative study with Cdx2 transgenic mice. Gut 2004 53: 1416-23.