메뉴 건너뛰기




Volumn 11, Issue 1, 2010, Pages 76-83

Enteric defensins are essential regulators of intestinal microbial ecology

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA DEFENSIN; INTERLEUKIN 17; MATRILYSIN; RNA 16S;

EID: 74049122536     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.1825     Document Type: Article
Times cited : (953)

References (50)
  • 1
    • 33745594044 scopus 로고    scopus 로고
    • The gut flora as a forgotten organ
    • O'Hara, A.M. & Shanahan, F. The gut flora as a forgotten organ. EMBO Rep. 7, 688-693 (2006).
    • (2006) EMBO Rep. , vol.7 , pp. 688-693
    • O'Hara, A.M.1    Shanahan, F.2
  • 2
    • 39849102964 scopus 로고    scopus 로고
    • The role of microbiota in infectious disease
    • Stecher, B. & Hardt, W.D. The role of microbiota in infectious disease. Trends Microbiol. 16, 107-114 (2008).
    • (2008) Trends Microbiol. , vol.16 , pp. 107-114
    • Stecher, B.1    Hardt, W.D.2
  • 3
    • 2942625911 scopus 로고    scopus 로고
    • Interactions between commensal intestinal bacteria and the Immune system
    • Macpherson, A.J. & Harris, N.L. Interactions between commensal intestinal bacteria and the Immune system. Nat. Rev. Immunol. 4, 478-485 (2004).
    • (2004) Nat. Rev. Immunol. , vol.4 , pp. 478-485
    • MacPherson, A.J.1    Harris, N.L.2
  • 4
    • 67349250428 scopus 로고    scopus 로고
    • The gut microbiota shapes intestinal Immune responses during health and disease
    • Round, J.L. & Mazmanian, S.K. The gut microbiota shapes intestinal Immune responses during health and disease. Nat. Rev. Immunol. 9, 313-323 (2009).
    • (2009) Nat. Rev. Immunol. , vol.9 , pp. 313-323
    • Round, J.L.1    Mazmanian, S.K.2
  • 5
    • 33744804299 scopus 로고    scopus 로고
    • Metagenomic analysis of the human distal gut microbiome
    • GILl, S.R. et al. Metagenomic analysis of the human distal gut microbiome. Science 312, 1355-1359 (2006).
    • (2006) Science , vol.312 , pp. 1355-1359
    • Gill, S.R.1
  • 6
    • 20544444045 scopus 로고    scopus 로고
    • Diversity of the human intestinal microbial flora
    • Eckburg, P.B. et al. Diversity of the human intestinal microbial flora. Science 308, 1635-1638 (2005).
    • (2005) Science , vol.308 , pp. 1635-1638
    • Eckburg, P.B.1
  • 8
    • 33749997498 scopus 로고    scopus 로고
    • Reciprocal gut microbiota transplants from zebrafish and mice to germ-free recipients reveal host habitat selection
    • Rawls, J.F., Mahowald, M.A., Ley, R.E. & Gordon, J.I. Reciprocal gut microbiota transplants from zebrafish and mice to germ-free recipients reveal host habitat selection. Cell 127, 423-433 (2006).
    • (2006) Cell , vol.127 , pp. 423-433
    • Rawls, J.F.1    Mahowald, M.A.2    Ley, R.E.3    Gordon, J.I.4
  • 9
    • 23344442120 scopus 로고    scopus 로고
    • Obesity alters gut microbial ecology
    • Ley, R.E. et al. Obesity alters gut microbial ecology. Proc. Natl. Acad. Sci. USA 102, 11070-11075 (2005).
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 11070-11075
    • Ley, R.E.1
  • 10
    • 38949153861 scopus 로고    scopus 로고
    • Innate Immune homeostasis by the homeobox gene caudal and commensal-gut mutualism in DrosophILa
    • Ryu, J.H. et al. Innate Immune homeostasis by the homeobox gene caudal and commensal-gut mutualism in DrosophILa. Science 319, 777-782 (2008).
    • (2008) Science , vol.319 , pp. 777-782
    • Ryu, J.H.1
  • 11
    • 66449108669 scopus 로고    scopus 로고
    • Cd1d-dependent regulation of bacterial colonization in the intestine of mice
    • Nieuwenhuis, E.E. et al. Cd1d-dependent regulation of bacterial colonization in the intestine of mice. J. Clin. Invest. 119, 1241-1250 (2009).
    • (2009) J. Clin. Invest. , vol.119 , pp. 1241-1250
    • Nieuwenhuis, E.E.1
  • 12
    • 34848889673 scopus 로고    scopus 로고
    • Communicable ulcerative colitis induced by T-bet deficiency in the innate Immune system
    • [see comment]
    • Garrett, W.S. et al. Communicable ulcerative colitis induced by T-bet deficiency in the innate Immune system. Cell [see comment] 131, 33-45 (2007).
    • (2007) Cell , vol.131 , pp. 33-45
    • Garrett, W.S.1
  • 13
    • 1242296822 scopus 로고    scopus 로고
    • Aberrant expansion of segmented fILamentous bacteria in IgA-deficient gut
    • Suzuki, K. et al. Aberrant expansion of segmented fILamentous bacteria in IgA-deficient gut. Proc. Natl. Acad. Sci. USA 101, 1981-1986 (2004).
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 1981-1986
    • Suzuki, K.1
  • 14
    • 0037165196 scopus 로고    scopus 로고
    • Antimicrobial peptides of multicellular organisms
    • Zasloff, M. Antimicrobial peptides of multicellular organisms. Nature 415, 389-395 (2002).
    • (2002) Nature , vol.415 , pp. 389-395
    • Zasloff, M.1
  • 15
    • 20644462344 scopus 로고    scopus 로고
    • Mammalian defensins in the antimicrobial Immune response
    • Selsted, M.E. & Ouellette, A.J. Mammalian defensins in the antimicrobial Immune response. Nat. Immunol. 6, 551-557 (2005).
    • (2005) Nat. Immunol. , vol.6 , pp. 551-557
    • Selsted, M.E.1    Ouellette, A.J.2
  • 17
    • 0033214433 scopus 로고    scopus 로고
    • Regulation of intestinal α-defensin activation by the metallopro-teinase matrILysin in innate host defense
    • WILson, C.L. et al. Regulation of intestinal α-defensin activation by the metallopro-teinase matrILysin in innate host defense. Science 286, 113-117 (1999).
    • (1999) Science , vol.286 , pp. 113-117
    • Wilson, C.L.1
  • 18
    • 0037417311 scopus 로고    scopus 로고
    • Protection against Enteric salmonellosis in transgenic mice expressing a human intestinal defensin
    • Salzman, N.H., Ghosh, D., Huttner, K.M., Paterson, Y. & Bevins, C.L. Protection against Enteric salmonellosis in transgenic mice expressing a human intestinal defensin. Nature 422, 522-526 (2003).
    • (2003) Nature , vol.422 , pp. 522-526
    • Salzman, N.H.1    Ghosh, D.2    Huttner, K.M.3    Paterson, Y.4    Bevins, C.L.5
  • 19
    • 13244292161 scopus 로고    scopus 로고
    • Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract
    • Kobayashi, K.S. et al. Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science 307, 731-734 (2005).
    • (2005) Science , vol.307 , pp. 731-734
    • Kobayashi, K.S.1
  • 20
    • 3543134126 scopus 로고    scopus 로고
    • Matrix metalloproteinases as modulators of inflammation and innate immunity
    • Parks, W.C., WILson, C.L. & Lopez-Boado, Y.S. Matrix metalloproteinases as modulators of inflammation and innate immunity. Nat. Rev. Immunol. 4, 617-629 (2004).
    • (2004) Nat. Rev. Immunol. , vol.4 , pp. 617-629
    • Parks, W.C.1    Wilson, C.L.2    Lopez-Boado, Y.S.3
  • 21
    • 56249135538 scopus 로고    scopus 로고
    • A key role for autophagy and the autophagy gene Atg16L1 in mouse and human intestinal Paneth cells
    • Cadwell, K. et al. A key role for autophagy and the autophagy gene Atg16L1 in mouse and human intestinal Paneth cells. Nature 456, 259-263 (2008).
    • (2008) Nature , vol.456 , pp. 259-263
    • Cadwell, K.1
  • 22
    • 50249086073 scopus 로고    scopus 로고
    • XBP1 links eR stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease
    • Kaser, A. et al. XBP1 links eR stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease. Cell 134, 743-756 (2008).
    • (2008) Cell , vol.134 , pp. 743-756
    • Kaser, A.1
  • 23
    • 29144483937 scopus 로고    scopus 로고
    • Reduced Paneth cell α-defensins in ILeal Crohn's disease
    • Wehkamp, J. et al. Reduced Paneth cell α-defensins in ILeal Crohn's disease. Proc. Natl. Acad. Sci. USA 102, 18129-18134 (2005).
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 18129-18134
    • Wehkamp, J.1
  • 24
    • 0036854372 scopus 로고    scopus 로고
    • Analysis of 16S libraries of mouse gastrointestinal microflora reveals a large new group of mouse intestinal bacteria
    • Salzman, N.H. et al. Analysis of 16S libraries of mouse gastrointestinal microflora reveals a large new group of mouse intestinal bacteria. Microbiology 148, 3651-3660 (2002).
    • (2002) Microbiology , vol.148 , pp. 3651-3660
    • Salzman, N.H.1
  • 25
    • 15444362001 scopus 로고    scopus 로고
    • Introducing DOTUR a computer program for defining operational taxonomic units and estimating species richnesS
    • Schloss, P.D. & Handelsman, J. Introducing DOTUR, a computer program for defining operational taxonomic units and estimating species richness. Appl. Environ. Microbiol. 71, 1501-1506 (2005).
    • (2005) Appl. Environ. Microbiol. , vol.71 , pp. 1501-1506
    • Schloss, P.D.1    Handelsman, J.2
  • 26
    • 33845874101 scopus 로고    scopus 로고
    • An obesity-associated gut microbiome with increased capacity for energy harvest
    • Turnbaugh, P.J. et al. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 444, 1027-1031 (2006).
    • (2006) Nature , vol.444 , pp. 1027-1031
    • Turnbaugh, P.J.1
  • 27
    • 33845901507 scopus 로고    scopus 로고
    • Microbial ecology: Human gut microbes associated with obesity
    • Ley, R.E., Turnbaugh, P.J., Klein, S. & Gordon, J.I. Microbial ecology: human gut microbes associated with obesity. Nature 444, 1022-1023 (2006).
    • (2006) Nature , vol.444 , pp. 1022-1023
    • Ley, R.E.1    Turnbaugh, P.J.2    Klein, S.3    Gordon, J.I.4
  • 28
    • 41849127118 scopus 로고    scopus 로고
    • Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome
    • Turnbaugh, P.J., Backhed, F., Fulton, L. & Gordon, J.I. Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome. Cell Host Microbe 3, 213-223 (2008).
    • (2008) Cell Host Microbe , vol.3 , pp. 213-223
    • Turnbaugh, P.J.1    Backhed, F.2    Fulton, L.3    Gordon, J.I.4
  • 29
    • 0028800208 scopus 로고
    • Comparison of 16S rRNA sequences of segmented fILamentous bacteria Isolated from mice rats and chickens and proposal of "candidatus Arthromitus"
    • Snel, J. et al. Comparison of 16S rRNA sequences of segmented fILamentous bacteria Isolated from mice, rats, and chickens and proposal of "Candidatus Arthromitus". Int. J. Syst. Bacteriol. 45, 780-782 (1995).
    • (1995) Int. J. Syst. Bacteriol. , vol.45 , pp. 780-782
    • Snel, J.1
  • 30
    • 40749084834 scopus 로고    scopus 로고
    • Enteric salmonellosis disrupts the microbial ecology of the murine gastrointestinal tract
    • Barman, M. et al. Enteric salmonellosis disrupts the microbial ecology of the murine gastrointestinal tract. Infect. Immun. 76, 907-915 (2008).
    • (2008) Infect. Immun. , vol.76 , pp. 907-915
    • Barman, M.1
  • 31
    • 43049092274 scopus 로고    scopus 로고
    • Metalloproteinases and their inhibitors: Regulators of wound healing
    • GILl, S.E. & Parks, W.C. Metalloproteinases and their inhibitors: regulators of wound healing. Int. J. Biochem. Cell Biol. 40, 1334-1347 (2008).
    • (2008) Int. J. Biochem. Cell Biol. , vol.40 , pp. 1334-1347
    • Gill, S.E.1    Parks, W.C.2
  • 32
    • 45949086634 scopus 로고    scopus 로고
    • Matrix metalloproteinase-7 (matrILysin) controls neutrophIL egress by generating chemokine gradientS
    • Swee, M., WILson, C.L., Wang, Y., McGuire, J.K. & Parks, W.C. Matrix metalloproteinase-7 (matrILysin) controls neutrophIL egress by generating chemokine gradients. J. Leukoc. Biol. 83, 1404-1412 (2008).
    • (2008) J. Leukoc. Biol. , vol.83 , pp. 1404-1412
    • Swee, M.1    Wilson, C.L.2    Wang, Y.3    McGuire, J.K.4    Parks, W.C.5
  • 33
    • 0034037603 scopus 로고    scopus 로고
    • Segmented fILamentous bacteria prevent colonization of enteropathogenic Escherichia coli 0103 in rabbitS
    • Heczko, U., Abe, A. & Finlay, B.B. Segmented fILamentous bacteria prevent colonization of enteropathogenic Escherichia coli 0103 in rabbits. J. Infect. Dis. 181, 1027-1033 (2000).
    • (2000) J. Infect. DiS. , vol.181 , pp. 1027-1033
    • Heczko, U.1    Abe, A.2    Finlay, B.B.3
  • 34
    • 0027411385 scopus 로고
    • Intestinal segmented fILamentous bacteria in a wide range of vertebrate specieS
    • Klaasen, H. et al. Intestinal segmented fILamentous bacteria in a wide range of vertebrate species. Lab. Anim. 27, 141-150 (1993).
    • (1993) Lab. Anim. , vol.27 , pp. 141-150
    • Klaasen, H.1
  • 35
    • 0034999247 scopus 로고    scopus 로고
    • Localization, and persistence of colonization by segmented fILamentous bacteria in the neonatal mouse gut depend on Immune status of mothers and pupS
    • Jiang, H.Q., Bos, N.A. & Cebra, J.J. Timing, localization, and persistence of colonization by segmented fILamentous bacteria in the neonatal mouse gut depend on Immune status of mothers and pups. Infect. Immun. 69, 3611-3617 (2001).
    • (2001) Infect. Immun. , vol.69 , pp. 3611-3617
    • Jiang, H.Q.1    Bos, N.A.2    Timing, J.C.J.3
  • 36
    • 33750631330 scopus 로고    scopus 로고
    • Interactions of intestinal epithelial cells with bacteria and Immune cells: Methods to characterize microflora and functional consequenceS
    • Canny, G., Swidsinski, A. & McCormick, B.A. Interactions of intestinal epithelial cells with bacteria and Immune cells: methods to characterize microflora and functional consequences. Methods Mol. Biol. 341, 17-35 (2006).
    • (2006) Methods Mol. Biol. , vol.341 , pp. 17-35
    • Canny, G.1    Swidsinski, A.2    McCormick, B.A.3
  • 37
    • 58549111588 scopus 로고    scopus 로고
    • Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface
    • Vaishnava, S., Behrendt, C.L., IsmaIL, A.S., eckmann, L. & Hooper, L.V. Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface. Proc. Natl. Acad. Sci. USA 105, 20858-20863 (2008).
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 20858-20863
    • Vaishnava, S.1    Behrendt, C.L.2    Ismail, A.S.3    Eckmann, L.4    Hooper, L.V.5
  • 38
    • 53349173070 scopus 로고    scopus 로고
    • Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine
    • Ivanov, I.I. et al. Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine. Cell Host Microbe 4, 337-349 (2008).
    • (2008) Cell Host Microbe , vol.4 , pp. 337-349
    • Ivanov, I.I.1
  • 39
    • 0037340434 scopus 로고    scopus 로고
    • Angiogenins: An new class of microbicidal proteins involved in innate immunity
    • Hooper, L.V., Stappenbeck, T.S., Hong, C.V. & Gordon, J.I. Angiogenins: an new class of microbicidal proteins involved in innate immunity. Nat. Immunol. 4, 269-273 (2003).
    • (2003) Nat. Immunol. , vol.4 , pp. 269-273
    • Hooper, L.V.1    Stappenbeck, T.S.2    Hong, C.V.3    Gordon, J.I.4
  • 40
    • 0035793372 scopus 로고    scopus 로고
    • Molecular analysis of commensal host-microbial relationships in the intestine
    • Hooper, L.V. et al. Molecular analysis of commensal host-microbial relationships in the intestine. Science 291, 881-884 (2001).
    • (2001) Science , vol.291 , pp. 881-884
    • Hooper, L.V.1
  • 41
    • 1542618118 scopus 로고    scopus 로고
    • Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria
    • Macpherson, A.J. & Uhr, T. Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria. Science 303, 1662-1665 (2004).
    • (2004) Science , vol.303 , pp. 1662-1665
    • MacPherson, A.J.1    Uhr, T.2
  • 42
    • 35848931007 scopus 로고    scopus 로고
    • IgA response to symbiotic bacteria as a mediator of gut homeostasis
    • Peterson, D.A., McNulty, N.P., Guruge, J.L. & Gordon, J.I. IgA response to symbiotic bacteria as a mediator of gut homeostasis. Cell Host Microbe 2, 328-339 (2007).
    • (2007) Cell Host Microbe , vol.2 , pp. 328-339
    • Peterson, D.A.1    McNulty, N.P.2    Guruge, J.L.3    Gordon, J.I.4
  • 43
    • 34249313567 scopus 로고    scopus 로고
    • Paneth cells, defensins, and the commensal microbiota: A hypothesis on intimate interplay at the intestinal mucosa
    • Salzman, N.H., Underwood, M.A. & Bevins, C.L. Paneth cells, defensins, and the commensal microbiota: a hypothesis on intimate interplay at the intestinal mucosa. Semin. Immunol. 19, 70-83 (2007).
    • (2007) Semin. Immunol. , vol.19 , pp. 70-83
    • Salzman, N.H.1    Underwood, M.A.2    Bevins, C.L.3
  • 44
    • 0028051542 scopus 로고
    • Mouse Paneth cell defensins: Primary structures and antibacterial activities of numerous cryptdin isoformS
    • Ouellette, A.J. et al. Mouse Paneth cell defensins: primary structures and antibacterial activities of numerous cryptdin isoforms. Infect. Immun. 62, 5040-5047 (1994).
    • (1994) Infect. Immun. , vol.62 , pp. 5040-5047
    • Ouellette, A.J.1
  • 45
    • 0030913746 scopus 로고    scopus 로고
    • Broad-spectrum antimicrobial activity of human intestinal defensin 5
    • Porter, E.M., van Dam, E., Valore, E.V. & Ganz, T. Broad-spectrum antimicrobial activity of human intestinal defensin 5. Infect. Immun. 65, 2396-2401 (1997). (Pubitemid 27237326)
    • (1997) Infection and Immunity , vol.65 , Issue.6 , pp. 2396-2401
    • Porter, E.M.1    Van Dam, E.2    Valore, E.V.3    Ganz, T.4
  • 46
    • 38649115342 scopus 로고    scopus 로고
    • Microbial influences in inflammatory bowel diseases
    • Sartor, R.B. Microbial influences in inflammatory bowel diseases. Gastroenterology 134, 577-594 (2008).
    • (2008) Gastroenterology , vol.134 , pp. 577-594
    • Sartor, R.B.1
  • 47
    • 67650076454 scopus 로고    scopus 로고
    • Prolonged impact of antibiotics on intestinal microbial ecology and susceptibILity to Enteric Salmonella infection
    • Croswell, A., Amir, E., Teggatz, P., Barman, M. & Salzman, N.H. Prolonged impact of antibiotics on intestinal microbial ecology and susceptibILity to Enteric Salmonella infection. Infect. Immun. 77, 2741-2753 (2009).
    • (2009) Infect. Immun. , Issue.77 , pp. 2741-2753
    • Croswell, A.1    Amir, E.2    Teggatz, P.3    Barman, M.4    Salzman, N.H.5
  • 48
    • 33748861096 scopus 로고    scopus 로고
    • Paneth cell antimicrobial peptides: Topographical distribution and quantification in human gastrointestinal tissues
    • Wehkamp, J. et al. Paneth cell antimicrobial peptides: topographical distribution and quantification in human gastrointestinal tissues. FEBS Lett. 580, 5344-5350 (2006).
    • (2006) FEBS Lett. , vol.580 , pp. 5344-5350
    • Wehkamp, J.1
  • 49
    • 38449084962 scopus 로고    scopus 로고
    • Isolation and subsequent analysis of murine lamina propria mono-nuclear cells from colonic tissue
    • Weigmann, B. et al. Isolation and subsequent analysis of murine lamina propria mono-nuclear cells from colonic tissue. Nat. Protoc. 2, 2307-2311 (2007).
    • (2007) Nat. Protoc. , vol.2 , pp. 2307-2311
    • Weigmann, B.1
  • 50
    • 10644281093 scopus 로고    scopus 로고
    • Functional reprogramming of the primary Immune response by T cell receptor antagonism
    • Haribhai, D., Edwards, B., WILliams, M.L. & WILliams, C.B. Functional reprogramming of the primary Immune response by T cell receptor antagonism. J. Exp. Med. 200, 1371-1382 (2004).
    • (2004) J. Exp. Med. , vol.200 , pp. 1371-1382
    • Haribhai, D.1    Edwards, B.2    Williams, M.L.3    Williams, C.B.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.