메뉴 건너뛰기




Volumn 4, Issue 1, 2015, Pages 4:5-

The interplay between metabolic homeostasis and neurodegeneration: Insights into the neurometabolic nature of amyotrophic lateral sclerosis

Author keywords

Amyotrophic lateral sclerosis; Hyperexcitability; Ion channels; KATP channels; Metabolism; Neurometabolism

Indexed keywords

ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; ADIPOCYTOKINE; COPPER ZINC SUPEROXIDE DISMUTASE;

EID: 85005992623     PISSN: None     EISSN: 20459769     Source Type: Journal    
DOI: 10.1186/s13619-015-0019-6     Document Type: Review
Times cited : (44)

References (193)
  • 1
    • 0000280462 scopus 로고
    • Deux cas d'atrophie musculaire progressive avec lesions de la substance grise et des faisceaux antero-lateraux de la moelle epiniere
    • Charcot JM, Joffory A. Deux cas d'atrophie musculaire progressive avec lesions de la substance grise et des faisceaux antero-lateraux de la moelle epiniere. Arch Physiol Neurol Pathol. 1869;2:744-54.
    • (1869) Arch Physiol Neurol Pathol , vol.2 , pp. 744-754
    • Charcot, J.M.1    Joffory, A.2
  • 4
    • 80054832080 scopus 로고    scopus 로고
    • Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS
    • DeJesus-Hernandez M, Mackenzie IR, Boeve BF, Boxer AL, Baker M, Rutherford NJ, et al. Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS. Neuron. 2011;72:245-56.
    • (2011) Neuron , vol.72 , pp. 245-256
    • DeJesus-Hernandez, M.1    Mackenzie, I.R.2    Boeve, B.F.3    Boxer, A.L.4    Baker, M.5    Rutherford, N.J.6
  • 7
    • 80054837386 scopus 로고    scopus 로고
    • A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD
    • Renton AE, Majounie E, Waite A, Simon-Sanchez J, Rollinson S, Gibbs JR, et al. A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD. Neuron. 2011;72:257-68.
    • (2011) Neuron , vol.72 , pp. 257-268
    • Renton, A.E.1    Majounie, E.2    Waite, A.3    Simon-Sanchez, J.4    Rollinson, S.5    Gibbs, J.R.6
  • 8
    • 77955036882 scopus 로고    scopus 로고
    • Mitochondrial respiratory chain dysfunction in muscle from patients with amyotrophic lateral sclerosis
    • Crugnola V, Lamperti C, Lucchini V, Ronchi D, Peverelli L, Prelle A, et al. Mitochondrial respiratory chain dysfunction in muscle from patients with amyotrophic lateral sclerosis. Arch Neurol. 2010;67:849-54.
    • (2010) Arch Neurol , vol.67 , pp. 849-854
    • Crugnola, V.1    Lamperti, C.2    Lucchini, V.3    Ronchi, D.4    Peverelli, L.5    Prelle, A.6
  • 11
    • 44949243975 scopus 로고    scopus 로고
    • Cortical hyperexcitability may precede the onset of familial amyotrophic lateral sclerosis
    • Vucic S, Nicholson GA, Kiernan MC. Cortical hyperexcitability may precede the onset of familial amyotrophic lateral sclerosis. Brain. 2008;131:1540-50.
    • (2008) Brain , vol.131 , pp. 1540-1550
    • Vucic, S.1    Nicholson, G.A.2    Kiernan, M.C.3
  • 12
    • 84898034713 scopus 로고    scopus 로고
    • Intrinsic membrane hyperexcitability of amyotrophic lateral sclerosis patient-derived motor neurons
    • Wainger BJ, Kiskinis E, Mellin C, Wiskow O, Han SS, Sandoe J, et al. Intrinsic membrane hyperexcitability of amyotrophic lateral sclerosis patient-derived motor neurons. Cell Rep. 2014;7:1-11.
    • (2014) Cell Rep , vol.7 , pp. 1-11
    • Wainger, B.J.1    Kiskinis, E.2    Mellin, C.3    Wiskow, O.4    Han, S.S.5    Sandoe, J.6
  • 13
    • 0030927075 scopus 로고    scopus 로고
    • Glutamate, excitotoxicity and amyotrophic lateral sclerosis
    • Shaw PJ, Ince PG. Glutamate, excitotoxicity and amyotrophic lateral sclerosis. J Neurol. 1997;244 Suppl 2:S3-14.
    • (1997) J Neurol , vol.244 , pp. S3-14
    • Shaw, P.J.1    Ince, P.G.2
  • 14
    • 3343020674 scopus 로고    scopus 로고
    • Evidence for defective energy homeostasis in amyotrophic lateral sclerosis: benefit of a high-energy diet in a transgenic mouse model
    • Dupuis L, Oudart H, Rene F, Gonzalez de Aguilar JL, Loeffler JP. Evidence for defective energy homeostasis in amyotrophic lateral sclerosis: benefit of a high-energy diet in a transgenic mouse model. Proc Natl Acad Sci U S A. 2004;101:11159-64.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 11159-11164
    • Dupuis, L.1    Oudart, H.2    Rene, F.3    Gonzalez de Aguilar, J.L.4    Loeffler, J.P.5
  • 15
    • 84893649256 scopus 로고    scopus 로고
    • State of play in amyotrophic lateral sclerosis genetics
    • Renton AE, Chio A, Traynor BJ. State of play in amyotrophic lateral sclerosis genetics. Nat Neurosci. 2014;17:17-23.
    • (2014) Nat Neurosci , vol.17 , pp. 17-23
    • Renton, A.E.1    Chio, A.2    Traynor, B.J.3
  • 16
    • 0035978743 scopus 로고    scopus 로고
    • Amyotrophic lateral sclerosis
    • Rowland LP, Schneider LA. Amyotrophic lateral sclerosis. N Engl J Med. 2001;344:1688-700.
    • (2001) N Engl J Med , vol.344 , pp. 1688-1700
    • Rowland, L.P.1    Schneider, L.A.2
  • 17
    • 0027401203 scopus 로고
    • Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis
    • Rosen DR, Siddique T, Patterson D, Figlewicz DA, Sapp P, Hentati A, et al. Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature. 1993;362:59-62.
    • (1993) Nature , vol.362 , pp. 59-62
    • Rosen, D.R.1    Siddique, T.2    Patterson, D.3    Figlewicz, D.A.4    Sapp, P.5    Hentati, A.6
  • 18
    • 41149180753 scopus 로고    scopus 로고
    • TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis
    • Sreedharan J, Blair IP, Tripathi VB, Hu X, Vance C, Rogelj B, et al. TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis. Science. 2008;319:1668-72.
    • (2008) Science , vol.319 , pp. 1668-1672
    • Sreedharan, J.1    Blair, I.P.2    Tripathi, V.B.3    Hu, X.4    Vance, C.5    Rogelj, B.6
  • 19
    • 61349156118 scopus 로고    scopus 로고
    • Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis
    • Kwiatkowski Jr TJ, Bosco DA, Leclerc AL, Tamrazian E, Vanderburg CR, Russ C, et al. Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis. Science. 2009;323:1205-8.
    • (2009) Science , vol.323 , pp. 1205-1208
    • Kwiatkowski, T.J.1    Bosco, D.A.2    Leclerc, A.L.3    Tamrazian, E.4    Vanderburg, C.R.5    Russ, C.6
  • 20
    • 61349162349 scopus 로고    scopus 로고
    • Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6
    • Vance C, Rogelj B, Hortobagyi T, De Vos KJ, Nishimura AL, Sreedharan J, et al. Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6. Science. 2009;323:1208-11.
    • (2009) Science , vol.323 , pp. 1208-1211
    • Vance, C.1    Rogelj, B.2    Hortobagyi, T.3    Vos, K.J.4    Nishimura, A.L.5    Sreedharan, J.6
  • 21
    • 84908012653 scopus 로고    scopus 로고
    • Analysis of amyotrophic lateral sclerosis as a multistep process: a population-based modelling study
    • Al-Chalabi A, Calvo A, Chio A, Colville S, Ellis CM, Hardiman O, et al. Analysis of amyotrophic lateral sclerosis as a multistep process: a population-based modelling study. Lancet Neurol. 2014;13:1108-13.
    • (2014) Lancet Neurol , vol.13 , pp. 1108-1113
    • Al-Chalabi, A.1    Calvo, A.2    Chio, A.3    Colville, S.4    Ellis, C.M.5    Hardiman, O.6
  • 22
    • 15044342282 scopus 로고    scopus 로고
    • Severely increased risk of amyotrophic lateral sclerosis among Italian professional football players
    • Chio A, Benzi G, Dossena M, Mutani R, Mora G. Severely increased risk of amyotrophic lateral sclerosis among Italian professional football players. Brain. 2005;128:472-6.
    • (2005) Brain , vol.128 , pp. 472-476
    • Chio, A.1    Benzi, G.2    Dossena, M.3    Mutani, R.4    Mora, G.5
  • 23
    • 70249131804 scopus 로고    scopus 로고
    • ALS in Italian professional soccer players: the risk is still present and could be soccer-specific
    • Chio A, Calvo A, Dossena M, Ghiglione P, Mutani R, Mora G. ALS in Italian professional soccer players: the risk is still present and could be soccer-specific. Amyotroph Lateral Scler. 2009;10:205-9.
    • (2009) Amyotroph Lateral Scler , vol.10 , pp. 205-209
    • Chio, A.1    Calvo, A.2    Dossena, M.3    Ghiglione, P.4    Mutani, R.5    Mora, G.6
  • 25
    • 84892628747 scopus 로고    scopus 로고
    • Investigation Dietary BMAA exposure in an amyotrophic lateral sclerosis cluster from southern France
    • Masseret E, Banack S, Boumediene F, Abadie E, Brient L, Pernet F, et al. Investigation Dietary BMAA exposure in an amyotrophic lateral sclerosis cluster from southern France. PLoS One. 2013;8:e83406.
    • (2013) PLoS One , vol.8
    • Masseret, E.1    Banack, S.2    Boumediene, F.3    Abadie, E.4    Brient, L.5    Pernet, F.6
  • 26
    • 0037438648 scopus 로고    scopus 로고
    • Amyotrophic lateral sclerosis and parkinsonism-dementia complex of Guam: changing incidence rates during the past 60 years
    • Plato CC, Garruto RM, Galasko D, Craig UK, Plato M, Gamst A, et al. Amyotrophic lateral sclerosis and parkinsonism-dementia complex of Guam: changing incidence rates during the past 60 years. Am J Epidemiol. 2003;157:149-57.
    • (2003) Am J Epidemiol , vol.157 , pp. 149-157
    • Plato, C.C.1    Garruto, R.M.2    Galasko, D.3    Craig, U.K.4    Plato, M.5    Gamst, A.6
  • 28
    • 84864935425 scopus 로고    scopus 로고
    • Pesticide exposure as a risk factor for amyotrophic lateral sclerosis: a meta-analysis of epidemiological studies: pesticide exposure as a risk factor for ALS
    • Malek AM, Barchowsky A, Bowser R, Youk A, Talbott EO. Pesticide exposure as a risk factor for amyotrophic lateral sclerosis: a meta-analysis of epidemiological studies: pesticide exposure as a risk factor for ALS. Environ Res. 2012;117:112-9.
    • (2012) Environ Res , vol.117 , pp. 112-119
    • Malek, A.M.1    Barchowsky, A.2    Bowser, R.3    Youk, A.4    Talbott, E.O.5
  • 29
    • 0037604486 scopus 로고    scopus 로고
    • An evidence-based medicine approach to the evaluation of the role of exogenous risk factors in sporadic amyotrophic lateral sclerosis
    • Armon C. An evidence-based medicine approach to the evaluation of the role of exogenous risk factors in sporadic amyotrophic lateral sclerosis. Neuroepidemiology. 2003;22:217-28.
    • (2003) Neuroepidemiology , vol.22 , pp. 217-228
    • Armon, C.1
  • 30
    • 73449092818 scopus 로고    scopus 로고
    • Smoking may be considered an established risk factor for sporadic ALS
    • Armon C. Smoking may be considered an established risk factor for sporadic ALS. Neurology. 2009;73:1693-8.
    • (2009) Neurology , vol.73 , pp. 1693-1698
    • Armon, C.1
  • 35
    • 79954569513 scopus 로고    scopus 로고
    • Vitamin E intake and risk of amyotrophic lateral sclerosis: a pooled analysis of data from 5 prospective cohort studies
    • Wang H, O'Reilly EJ, Weisskopf MG, Logroscino G, McCullough ML, Schatzkin A, et al. Vitamin E intake and risk of amyotrophic lateral sclerosis: a pooled analysis of data from 5 prospective cohort studies. Am J Epidemiol. 2011;173:595-602.
    • (2011) Am J Epidemiol , vol.173 , pp. 595-602
    • Wang, H.1    O'Reilly, E.J.2    Weisskopf, M.G.3    Logroscino, G.4    McCullough, M.L.5    Schatzkin, A.6
  • 37
    • 77956676420 scopus 로고    scopus 로고
    • Malnutrition at the time of diagnosis is associated with a shorter disease duration in ALS
    • Limousin N, Blasco H, Corcia P, Gordon PH, De Toffol B, Andres C, et al. Malnutrition at the time of diagnosis is associated with a shorter disease duration in ALS. J Neurol Sci. 2010;297:36-9.
    • (2010) J Neurol Sci , vol.297 , pp. 36-39
    • Limousin, N.1    Blasco, H.2    Corcia, P.3    Gordon, P.H.4    Toffol, B.5    Andres, C.6
  • 38
    • 84876332015 scopus 로고    scopus 로고
    • Prediagnostic body fat and risk of death from amyotrophic lateral sclerosis: the EPIC cohort
    • Gallo V, Wark PA, Jenab M, Pearce N, Brayne C, Vermeulen R, et al. Prediagnostic body fat and risk of death from amyotrophic lateral sclerosis: the EPIC cohort. Neurology. 2013;80:829-38.
    • (2013) Neurology , vol.80 , pp. 829-838
    • Gallo, V.1    Wark, P.A.2    Jenab, M.3    Pearce, N.4    Brayne, C.5    Vermeulen, R.6
  • 39
    • 78649368924 scopus 로고    scopus 로고
    • A decrease in body mass index is associated with faster progression of motor symptoms and shorter survival in ALS
    • Jawaid A, Murthy SB, Wilson AM, Qureshi SU, Amro MJ, Wheaton M, et al. A decrease in body mass index is associated with faster progression of motor symptoms and shorter survival in ALS. Amyotroph Lateral Scler. 2010;11:542-8.
    • (2010) Amyotroph Lateral Scler , vol.11 , pp. 542-548
    • Jawaid, A.1    Murthy, S.B.2    Wilson, A.M.3    Qureshi, S.U.4    Amro, M.J.5    Wheaton, M.6
  • 41
    • 84861637471 scopus 로고    scopus 로고
    • Reduction rate of body mass index predicts prognosis for survival in amyotrophic lateral sclerosis: a multicenter study in Japan
    • Shimizu T, Nagaoka U, Nakayama Y, Kawata A, Kugimoto C, Kuroiwa Y, et al. Reduction rate of body mass index predicts prognosis for survival in amyotrophic lateral sclerosis: a multicenter study in Japan. Amyotroph Lateral Scler. 2012;13:363-6.
    • (2012) Amyotroph Lateral Scler , vol.13 , pp. 363-366
    • Shimizu, T.1    Nagaoka, U.2    Nakayama, Y.3    Kawata, A.4    Kugimoto, C.5    Kuroiwa, Y.6
  • 44
    • 0017628984 scopus 로고
    • Adipose tissue cellularity in patients with amyotrophic lateral sclerosis
    • Van den Bergh R, Swerts L, Hendrikx A, Boni L, Meulepas E. Adipose tissue cellularity in patients with amyotrophic lateral sclerosis. Clin Neurol Neurosurg. 1977;80:226-39.
    • (1977) Clin Neurol Neurosurg , vol.80 , pp. 226-239
    • Bergh, R.1    Swerts, L.2    Hendrikx, A.3    Boni, L.4    Meulepas, E.5
  • 45
    • 84859631896 scopus 로고    scopus 로고
    • Brain hypermetabolism in amyotrophic lateral sclerosis: a FDG PET study in ALS of spinal and bulbar onset
    • Cistaro A, Valentini MC, Chio A, Nobili F, Calvo A, Moglia C, et al. Brain hypermetabolism in amyotrophic lateral sclerosis: a FDG PET study in ALS of spinal and bulbar onset. Eur J Nucl Med Mol Imaging. 2012;39:251-9.
    • (2012) Eur J Nucl Med Mol Imaging , vol.39 , pp. 251-259
    • Cistaro, A.1    Valentini, M.C.2    Chio, A.3    Nobili, F.4    Calvo, A.5    Moglia, C.6
  • 46
    • 0023636605 scopus 로고
    • Lowered cerebral glucose utilization in amyotrophic lateral sclerosis
    • Dalakas MC, Hatazawa J, Brooks RA, Di Chiro G. Lowered cerebral glucose utilization in amyotrophic lateral sclerosis. Ann Neurol. 1987;22:580-6.
    • (1987) Ann Neurol , vol.22 , pp. 580-586
    • Dalakas, M.C.1    Hatazawa, J.2    Brooks, R.A.3    Chiro, G.4
  • 47
    • 0034875640 scopus 로고    scopus 로고
    • Factors correlated with hypermetabolism in patients with amyotrophic lateral sclerosis
    • Desport JC, Preux PM, Magy L, Boirie Y, Vallat JM, Beaufrere B, et al. Factors correlated with hypermetabolism in patients with amyotrophic lateral sclerosis. Am J Clin Nutr. 2001;74:328-34.
    • (2001) Am J Clin Nutr , vol.74 , pp. 328-334
    • Desport, J.C.1    Preux, P.M.2    Magy, L.3    Boirie, Y.4    Vallat, J.M.5    Beaufrere, B.6
  • 48
  • 50
    • 84887486310 scopus 로고    scopus 로고
    • High-caloric food supplements in the treatment of amyotrophic lateral sclerosis: a prospective interventional study
    • Dorst J, Cypionka J, Ludolph AC. High-caloric food supplements in the treatment of amyotrophic lateral sclerosis: a prospective interventional study. Amyotroph Lateral Scler Frontotemporal Degener. 2013;14:533-6.
    • (2013) Amyotroph Lateral Scler Frontotemporal Degener , vol.14 , pp. 533-536
    • Dorst, J.1    Cypionka, J.2    Ludolph, A.C.3
  • 51
    • 79953817635 scopus 로고    scopus 로고
    • Patients with elevated triglyceride and cholesterol serum levels have a prolonged survival in amyotrophic lateral sclerosis
    • Dorst J, Kuhnlein P, Hendrich C, Kassubek J, Sperfeld AD, Ludolph AC. Patients with elevated triglyceride and cholesterol serum levels have a prolonged survival in amyotrophic lateral sclerosis. J Neurol. 2011;258:613-7.
    • (2011) J Neurol , vol.258 , pp. 613-617
    • Dorst, J.1    Kuhnlein, P.2    Hendrich, C.3    Kassubek, J.4    Sperfeld, A.D.5    Ludolph, A.C.6
  • 55
    • 80053644974 scopus 로고    scopus 로고
    • Nutritional state, energy intakes and energy expenditure of amyotrophic lateral sclerosis (ALS) patients
    • Genton L, Viatte V, Janssens JP, Heritier AC, Pichard C. Nutritional state, energy intakes and energy expenditure of amyotrophic lateral sclerosis (ALS) patients. Clin Nutr. 2011;30:553-9.
    • (2011) Clin Nutr , vol.30 , pp. 553-559
    • Genton, L.1    Viatte, V.2    Janssens, J.P.3    Heritier, A.C.4    Pichard, C.5
  • 57
    • 0030042365 scopus 로고    scopus 로고
    • Nutritional status of patients with amyotrophic lateral sclerosis: relation to the proximity of death
    • Kasarskis EJ, Berryman S, Vanderleest JG, Schneider AR, McClain CJ. Nutritional status of patients with amyotrophic lateral sclerosis: relation to the proximity of death. Am J Clin Nutr. 1996;63:130-7.
    • (1996) Am J Clin Nutr , vol.63 , pp. 130-137
    • Kasarskis, E.J.1    Berryman, S.2    Vanderleest, J.G.3    Schneider, A.R.4    McClain, C.J.5
  • 58
    • 84899928471 scopus 로고    scopus 로고
    • Body mass index and dietary intervention: implications for prognosis of amyotrophic lateral sclerosis
    • Ngo ST, Steyn FJ, McCombe PA. Body mass index and dietary intervention: implications for prognosis of amyotrophic lateral sclerosis. J Neurol Sci. 2014;340:5-12.
    • (2014) J Neurol Sci , vol.340 , pp. 5-12
    • Ngo, S.T.1    Steyn, F.J.2    McCombe, P.A.3
  • 59
    • 79959308245 scopus 로고    scopus 로고
    • Body mass index, not dyslipidemia, is an independent predictor of survival in amyotrophic lateral sclerosis
    • Paganoni S, Deng J, Jaffa M, Cudkowicz ME, Wills AM. Body mass index, not dyslipidemia, is an independent predictor of survival in amyotrophic lateral sclerosis. Muscle Nerve. 2011;44:20-4.
    • (2011) Muscle Nerve , vol.44 , pp. 20-24
    • Paganoni, S.1    Deng, J.2    Jaffa, M.3    Cudkowicz, M.E.4    Wills, A.M.5
  • 60
    • 84928982922 scopus 로고    scopus 로고
    • A metabolic switch towards lipid use in glycolytic muscle is an early pathologic event in a mouse model of amyotrophic lateral sclerosis
    • Palamiuc L, Schlagowski A, Ngo ST, Vernay A, Grosch S, Henriques A, et al. A metabolic switch towards lipid use in glycolytic muscle is an early pathologic event in a mouse model of amyotrophic lateral sclerosis. EMBO Mol Med. 2015;7:526-46.
    • (2015) EMBO Mol Med , vol.7 , pp. 526-546
    • Palamiuc, L.1    Schlagowski, A.2    Ngo, S.T.3    Vernay, A.4    Grosch, S.5    Henriques, A.6
  • 62
    • 84902314640 scopus 로고    scopus 로고
    • Hypercaloric enteral nutrition in patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled phase 2 trial
    • Wills AM, Hubbard J, Macklin EA, Glass J, Tandan R, Simpson EP, et al. Hypercaloric enteral nutrition in patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled phase 2 trial. Lancet. 2014;383:2065-72.
    • (2014) Lancet , vol.383 , pp. 2065-2072
    • Wills, A.M.1    Hubbard, J.2    Macklin, E.A.3    Glass, J.4    Tandan, R.5    Simpson, E.P.6
  • 63
    • 84877751465 scopus 로고    scopus 로고
    • Nutrition management of amyotrophic lateral sclerosis
    • Greenwood DI. Nutrition management of amyotrophic lateral sclerosis. Nutr Clin Pract. 2013;28:392-9.
    • (2013) Nutr Clin Pract , vol.28 , pp. 392-399
    • Greenwood, D.I.1
  • 65
    • 4344607526 scopus 로고    scopus 로고
    • Endocrine regulation of energy metabolism: review of pathobiochemical and clinical chemical aspects of leptin, ghrelin, adiponectin, and resistin
    • Meier U, Gressner AM. Endocrine regulation of energy metabolism: review of pathobiochemical and clinical chemical aspects of leptin, ghrelin, adiponectin, and resistin. Clin Chem. 2004;50:1511-25.
    • (2004) Clin Chem , vol.50 , pp. 1511-1525
    • Meier, U.1    Gressner, A.M.2
  • 66
    • 65249171425 scopus 로고    scopus 로고
    • Effects of growth hormone on glucose, lipid, and protein metabolism in human subjects
    • Moller N, Jorgensen JO. Effects of growth hormone on glucose, lipid, and protein metabolism in human subjects. Endocr Rev. 2009;30:152-77.
    • (2009) Endocr Rev , vol.30 , pp. 152-177
    • Moller, N.1    Jorgensen, J.O.2
  • 67
    • 85006048831 scopus 로고    scopus 로고
    • Nutrient sensing overrides somatostatin and GHRH to control pulsatile GH release
    • Steyn FJ. Nutrient sensing overrides somatostatin and GHRH to control pulsatile GH release. J Neuroendocrinol. 2015.
    • (2015) J Neuroendocrinol
    • Steyn, F.J.1
  • 71
  • 72
    • 84919396244 scopus 로고    scopus 로고
    • Functional pattern of brain FDG-PET in amyotrophic lateral sclerosis
    • Pagani M, Chio A, Valentini MC, Oberg J, Nobili F, Calvo A, et al. Functional pattern of brain FDG-PET in amyotrophic lateral sclerosis. Neurology. 2014;83:1067-74.
    • (2014) Neurology , vol.83 , pp. 1067-1074
    • Pagani, M.1    Chio, A.2    Valentini, M.C.3    Oberg, J.4    Nobili, F.5    Calvo, A.6
  • 73
    • 77958012134 scopus 로고    scopus 로고
    • Deletion of TDP-43 down-regulates Tbc1d1, a gene linked to obesity, and alters body fat metabolism
    • Chiang PM, Ling J, Jeong YH, Price DL, Aja SM, Wong PC. Deletion of TDP-43 down-regulates Tbc1d1, a gene linked to obesity, and alters body fat metabolism. Proc Natl Acad Sci U S A. 2010;107:16320-4.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 16320-16324
    • Chiang, P.M.1    Ling, J.2    Jeong, Y.H.3    Price, D.L.4    Aja, S.M.5    Wong, P.C.6
  • 75
    • 77958022745 scopus 로고    scopus 로고
    • Altered distributions of Gemini of coiled bodies and mitochondria in motor neurons of TDP-43 transgenic mice
    • Shan X, Chiang PM, Price DL, Wong PC. Altered distributions of Gemini of coiled bodies and mitochondria in motor neurons of TDP-43 transgenic mice. Proc Natl Acad Sci U S A. 2010;107:16325-30.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 16325-16330
    • Shan, X.1    Chiang, P.M.2    Price, D.L.3    Wong, P.C.4
  • 76
    • 77956199371 scopus 로고    scopus 로고
    • Wild-type human TDP-43 expression causes TDP-43 phosphorylation, mitochondrial aggregation, motor deficits, and early mortality in transgenic mice
    • Xu YF, Gendron TF, Zhang YJ, Lin WL, D'Alton S, Sheng H, et al. Wild-type human TDP-43 expression causes TDP-43 phosphorylation, mitochondrial aggregation, motor deficits, and early mortality in transgenic mice. J Neurosci. 2010;30:10851-9.
    • (2010) J Neurosci , vol.30 , pp. 10851-10859
    • Xu, Y.F.1    Gendron, T.F.2    Zhang, Y.J.3    Lin, W.L.4    D'Alton, S.5    Sheng, H.6
  • 77
    • 84920379368 scopus 로고    scopus 로고
    • Interaction of amyotrophic lateral sclerosis/frontotemporal lobar degeneration-associated fused-in-sarcoma with proteins involved in metabolic and protein degradation pathways
    • Wang T, Jiang X, Chen G, Xu J. Interaction of amyotrophic lateral sclerosis/frontotemporal lobar degeneration-associated fused-in-sarcoma with proteins involved in metabolic and protein degradation pathways. Neurobiol Aging. 2015;36:527-35.
    • (2015) Neurobiol Aging , vol.36 , pp. 527-535
    • Wang, T.1    Jiang, X.2    Chen, G.3    Xu, J.4
  • 78
    • 77954944275 scopus 로고    scopus 로고
    • Triacylglycerol lipases and metabolic control: implications for health and disease
    • Watt MJ, Spriet LL. Triacylglycerol lipases and metabolic control: implications for health and disease. Am J Physiol Endocrinol Metab. 2010;299:E162-168.
    • (2010) Am J Physiol Endocrinol Metab , vol.299 , pp. E162-168
    • Watt, M.J.1    Spriet, L.L.2
  • 80
    • 84940045319 scopus 로고    scopus 로고
    • Blood cell palmitoleate-palmitate ratio is an independent prognostic factor for amyotrophic lateral sclerosis
    • Henriques A, Blasco H, Fleury MC, Corcia P, Echaniz-Laguna A, Robelin L, et al. Blood cell palmitoleate-palmitate ratio is an independent prognostic factor for amyotrophic lateral sclerosis. PLoS One. 2015;10:e0131512.
    • (2015) PLoS One , vol.10
    • Henriques, A.1    Blasco, H.2    Fleury, M.C.3    Corcia, P.4    Echaniz-Laguna, A.5    Robelin, L.6
  • 83
    • 0018078439 scopus 로고
    • Hepatic ultrastructural study in amyotrophic lateral sclerosis (ALS). No to shinkei =
    • Araki H. Hepatic ultrastructural study in amyotrophic lateral sclerosis (ALS). No to shinkei = Brain Nerve. 1978;30:1073-81.
    • (1978) Brain Nerve , vol.30 , pp. 1073-1081
    • Araki, H.1
  • 84
    • 0020006767 scopus 로고
    • Electron microscopic, abnormalities of the liver in amyotrophic lateral sclerosis. No to shinkei =
    • Hirayama K. Electron microscopic, abnormalities of the liver in amyotrophic lateral sclerosis. No to shinkei = Brain Nerve. 1982;34:33-8.
    • (1982) Brain Nerve , vol.34 , pp. 33-38
    • Hirayama, K.1
  • 85
    • 0021816196 scopus 로고
    • Functional and morphometric study of the liver in motor neuron disease
    • Masui Y, Mozai T, Kakehi K. Functional and morphometric study of the liver in motor neuron disease. J Neurol. 1985;232:15-9.
    • (1985) J Neurol , vol.232 , pp. 15-19
    • Masui, Y.1    Mozai, T.2    Kakehi, K.3
  • 86
    • 0023270442 scopus 로고
    • Hepatic ultrastructural changes and liver dysfunction in amyotrophic lateral sclerosis
    • Nakano Y, Hirayama K, Terao K. Hepatic ultrastructural changes and liver dysfunction in amyotrophic lateral sclerosis. Arch Neurol. 1987;44:103-6.
    • (1987) Arch Neurol , vol.44 , pp. 103-106
    • Nakano, Y.1    Hirayama, K.2    Terao, K.3
  • 87
    • 84974548868 scopus 로고    scopus 로고
    • Frequent hepatic steatosis in amyotrophic lateral sclerosis: implication for systemic involvement
    • Nodera H, Takamatsu N, Muguruma N, Ukimoto K, Nishio S, Oda M, et al. Frequent hepatic steatosis in amyotrophic lateral sclerosis: implication for systemic involvement. Neurol Clin Neurosci. 2015;3:58-62.
    • (2015) Neurol Clin Neurosci , vol.3 , pp. 58-62
    • Nodera, H.1    Takamatsu, N.2    Muguruma, N.3    Ukimoto, K.4    Nishio, S.5    Oda, M.6
  • 88
    • 79960987739 scopus 로고    scopus 로고
    • Abnormal changes in NKT cells, the IGF-1 axis, and liver pathology in an animal model of ALS
    • Finkelstein A, Kunis G, Seksenyan A, Ronen A, Berkutzki T, Azoulay D, et al. Abnormal changes in NKT cells, the IGF-1 axis, and liver pathology in an animal model of ALS. PLoS One. 2011;6, e22374.
    • (2011) PLoS One , vol.6
    • Finkelstein, A.1    Kunis, G.2    Seksenyan, A.3    Ronen, A.4    Berkutzki, T.5    Azoulay, D.6
  • 89
    • 0019762341 scopus 로고
    • The effect of insulin on the disposal of intravenous glucose. Results from indirect calorimetry and hepatic and femoral venous catheterization
    • DeFronzo RA, Jacot E, Jequier E, Maeder E, Wahren J, Felber JP. The effect of insulin on the disposal of intravenous glucose. Results from indirect calorimetry and hepatic and femoral venous catheterization. Diabetes. 1981;30:1000-7.
    • (1981) Diabetes , vol.30 , pp. 1000-1007
    • DeFronzo, R.A.1    Jacot, E.2    Jequier, E.3    Maeder, E.4    Wahren, J.5    Felber, J.P.6
  • 90
    • 0024237258 scopus 로고
    • Rates and tissue sites of non-insulin- and insulin-mediated glucose uptake in humans
    • Baron AD, Brechtel G, Wallace P, Edelman SV. Rates and tissue sites of non-insulin- and insulin-mediated glucose uptake in humans. Am J Physiol. 1988;255:E769-774.
    • (1988) Am J Physiol , vol.255 , pp. E769-774
    • Baron, A.D.1    Brechtel, G.2    Wallace, P.3    Edelman, S.V.4
  • 92
    • 77953530958 scopus 로고    scopus 로고
    • Skeletal muscle-restricted expression of human SOD1 causes motor neuron degeneration in transgenic mice
    • Wong M, Martin LJ. Skeletal muscle-restricted expression of human SOD1 causes motor neuron degeneration in transgenic mice. Hum Mol Genet. 2010;19:2284-302.
    • (2010) Hum Mol Genet , vol.19 , pp. 2284-2302
    • Wong, M.1    Martin, L.J.2
  • 93
    • 65549128133 scopus 로고    scopus 로고
    • Muscle mitochondrial uncoupling dismantles neuromuscular junction and triggers distal degeneration of motor neurons
    • Dupuis L, Gonzalez de Aguilar JL, Echaniz-Laguna A, Eschbach J, Rene F, Oudart H, et al. Muscle mitochondrial uncoupling dismantles neuromuscular junction and triggers distal degeneration of motor neurons. PLoS One. 2009;4, e5390.
    • (2009) PLoS One , vol.4
    • Dupuis, L.1    Gonzalez de Aguilar, J.L.2    Echaniz-Laguna, A.3    Eschbach, J.4    Rene, F.5    Oudart, H.6
  • 94
    • 84866491615 scopus 로고    scopus 로고
    • Disruption of skeletal muscle mitochondrial network genes and miRNAs in amyotrophic lateral sclerosis
    • Russell AP, Wada S, Vergani L, Hock MB, Lamon S, Leger B, et al. Disruption of skeletal muscle mitochondrial network genes and miRNAs in amyotrophic lateral sclerosis. Neurobiol Dis. 2013;49C:107-17.
    • (2013) Neurobiol Dis , vol.49C , pp. 107-117
    • Russell, A.P.1    Wada, S.2    Vergani, L.3    Hock, M.B.4    Lamon, S.5    Leger, B.6
  • 95
    • 0032716335 scopus 로고    scopus 로고
    • Visualization of defective mitochondrial function in skeletal muscle fibers of patients with sporadic amyotrophic lateral sclerosis
    • Vielhaber S, Winkler K, Kirches E, Kunz D, Buchner M, Feistner H, et al. Visualization of defective mitochondrial function in skeletal muscle fibers of patients with sporadic amyotrophic lateral sclerosis. J Neurol Sci. 1999;169:133-9.
    • (1999) J Neurol Sci , vol.169 , pp. 133-139
    • Vielhaber, S.1    Winkler, K.2    Kirches, E.3    Kunz, D.4    Buchner, M.5    Feistner, H.6
  • 96
    • 0032539791 scopus 로고    scopus 로고
    • Impairment of mitochondrial function in skeletal muscle of patients with amyotrophic lateral sclerosis
    • Wiedemann FR, Winkler K, Kuznetsov AV, Bartels C, Vielhaber S, Feistner H, et al. Impairment of mitochondrial function in skeletal muscle of patients with amyotrophic lateral sclerosis. J Neurol Sci. 1998;156:65-72.
    • (1998) J Neurol Sci , vol.156 , pp. 65-72
    • Wiedemann, F.R.1    Winkler, K.2    Kuznetsov, A.V.3    Bartels, C.4    Vielhaber, S.5    Feistner, H.6
  • 97
    • 0043095290 scopus 로고    scopus 로고
    • Skeletal muscle properties in a transgenic mouse model for amyotrophic lateral sclerosis: effects of creatine treatment
    • Derave W, Van Den Bosch L, Lemmens G, Eijnde BO, Robberecht W, Hespel P. Skeletal muscle properties in a transgenic mouse model for amyotrophic lateral sclerosis: effects of creatine treatment. Neurobiol Dis. 2003;13:264-72.
    • (2003) Neurobiol Dis , vol.13 , pp. 264-272
    • Derave, W.1    Bosch, L.2    Lemmens, G.3    Eijnde, B.O.4    Robberecht, W.5    Hespel, P.6
  • 100
    • 84891139057 scopus 로고    scopus 로고
    • SOD1-G93A mice exhibit muscle-fiber-type-specific decreases in glucose uptake in the absence of whole-body changes in metabolism
    • Smittkamp SE, Morris JK, Bomhoff GL, Chertoff ME, Geiger PC, Stanford JA. SOD1-G93A mice exhibit muscle-fiber-type-specific decreases in glucose uptake in the absence of whole-body changes in metabolism. Neurodegener Dis. 2014;13:29-37.
    • (2014) Neurodegener Dis , vol.13 , pp. 29-37
    • Smittkamp, S.E.1    Morris, J.K.2    Bomhoff, G.L.3    Chertoff, M.E.4    Geiger, P.C.5    Stanford, J.A.6
  • 101
    • 32644434546 scopus 로고    scopus 로고
    • Muscular mitochondrial function in amyotrophic lateral sclerosis is progressively altered as the disease develops: a temporal study in man
    • Echaniz-Laguna A, Zoll J, Ponsot E, N'Guessan B, Tranchant C, Loeffler JP, et al. Muscular mitochondrial function in amyotrophic lateral sclerosis is progressively altered as the disease develops: a temporal study in man. Exp Neurol. 2006;198:25-30.
    • (2006) Exp Neurol , vol.198 , pp. 25-30
    • Echaniz-Laguna, A.1    Zoll, J.2    Ponsot, E.3    N'Guessan, B.4    Tranchant, C.5    Loeffler, J.P.6
  • 102
    • 84893554356 scopus 로고    scopus 로고
    • Skeletal muscle degeneration and regeneration in mice and flies
    • Rai M, Nongthomba U, Grounds MD. Skeletal muscle degeneration and regeneration in mice and flies. Curr Top Dev Biol. 2014;108:247-81.
    • (2014) Curr Top Dev Biol , vol.108 , pp. 247-281
    • Rai, M.1    Nongthomba, U.2    Grounds, M.D.3
  • 103
    • 33646466296 scopus 로고    scopus 로고
    • Conversion to the amyotrophic lateral sclerosis phenotype is associated with intermolecular linked insoluble aggregates of SOD1 in mitochondria
    • Deng HX, Shi Y, Furukawa Y, Zhai H, Fu R, Liu E, et al. Conversion to the amyotrophic lateral sclerosis phenotype is associated with intermolecular linked insoluble aggregates of SOD1 in mitochondria. Proc Natl Acad Sci U S A. 2006;103:7142-7.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 7142-7147
    • Deng, H.X.1    Shi, Y.2    Furukawa, Y.3    Zhai, H.4    Fu, R.5    Liu, E.6
  • 104
    • 84871236850 scopus 로고    scopus 로고
    • Expression of wild-type human superoxide dismutase-1 in mice causes amyotrophic lateral sclerosis
    • Graffmo KS, Forsberg K, Bergh J, Birve A, Zetterstrom P, Andersen PM, et al. Expression of wild-type human superoxide dismutase-1 in mice causes amyotrophic lateral sclerosis. Hum Mol Genet. 2013;22:51-60.
    • (2013) Hum Mol Genet , vol.22 , pp. 51-60
    • Graffmo, K.S.1    Forsberg, K.2    Bergh, J.3    Birve, A.4    Zetterstrom, P.5    Andersen, P.M.6
  • 105
    • 64549124726 scopus 로고    scopus 로고
    • Wild-type SOD1 overexpression accelerates disease onset of a G85R SOD1 mouse
    • Wang L, Deng HX, Grisotti G, Zhai H, Siddique T, Roos RP. Wild-type SOD1 overexpression accelerates disease onset of a G85R SOD1 mouse. Hum Mol Genet. 2009;18:1642-51.
    • (2009) Hum Mol Genet , vol.18 , pp. 1642-1651
    • Wang, L.1    Deng, H.X.2    Grisotti, G.3    Zhai, H.4    Siddique, T.5    Roos, R.P.6
  • 106
    • 43049132896 scopus 로고    scopus 로고
    • Heterodimer formation of wild-type and amyotrophic lateral sclerosis-causing mutant Cu/Zn-superoxide dismutase induces toxicity independent of protein aggregation
    • Witan H, Kern A, Koziollek-Drechsler I, Wade R, Behl C, Clement AM. Heterodimer formation of wild-type and amyotrophic lateral sclerosis-causing mutant Cu/Zn-superoxide dismutase induces toxicity independent of protein aggregation. Hum Mol Genet. 2008;17:1373-85.
    • (2008) Hum Mol Genet , vol.17 , pp. 1373-1385
    • Witan, H.1    Kern, A.2    Koziollek-Drechsler, I.3    Wade, R.4    Behl, C.5    Clement, A.M.6
  • 107
    • 84861873152 scopus 로고    scopus 로고
    • Lipid metabolism in skeletal muscle: generation of adaptive and maladaptive intracellular signals for cellular function
    • Watt MJ, Hoy AJ. Lipid metabolism in skeletal muscle: generation of adaptive and maladaptive intracellular signals for cellular function. Am J Physiol Endocrinol Metab. 2012;302:E1315-1328.
    • (2012) Am J Physiol Endocrinol Metab , vol.302 , pp. E1315-1328
    • Watt, M.J.1    Hoy, A.J.2
  • 108
    • 0033400713 scopus 로고    scopus 로고
    • Ketone bodies: a review of physiology, pathophysiology and application of monitoring to diabetes
    • Laffel L. Ketone bodies: a review of physiology, pathophysiology and application of monitoring to diabetes. Diabetes Metab Res Rev. 1999;15:412-26.
    • (1999) Diabetes Metab Res Rev , vol.15 , pp. 412-426
    • Laffel, L.1
  • 109
    • 84930948765 scopus 로고    scopus 로고
    • The patient experience of fatigue in motor neurone disease
    • Gibbons CJ, Thornton EW, Young CA. The patient experience of fatigue in motor neurone disease. Front Psychol. 2013;4:788.
    • (2013) Front Psychol , vol.4 , pp. 788
    • Gibbons, C.J.1    Thornton, E.W.2    Young, C.A.3
  • 110
    • 84925227188 scopus 로고    scopus 로고
    • An alpha2-Na/K ATPase/alpha-adducin complex in astrocytes triggers non-cell autonomous neurodegeneration
    • Gallardo G, Barowski J, Ravits J, Siddique T, Lingrel JB, Robertson J, et al. An alpha2-Na/K ATPase/alpha-adducin complex in astrocytes triggers non-cell autonomous neurodegeneration. Nat Neurosci. 2014;17:1710-9.
    • (2014) Nat Neurosci , vol.17 , pp. 1710-1719
    • Gallardo, G.1    Barowski, J.2    Ravits, J.3    Siddique, T.4    Lingrel, J.B.5    Robertson, J.6
  • 112
    • 84900482527 scopus 로고    scopus 로고
    • Value of 18fluorodeoxyglucose-positron-emission tomography in amyotrophic lateral sclerosis: a prospective study
    • Van Laere K, Vanhee A, Verschueren J, De Coster L, Driesen A, Dupont P, et al. Value of 18fluorodeoxyglucose-positron-emission tomography in amyotrophic lateral sclerosis: a prospective study. JAMA Neurol. 2014;71:553-61.
    • (2014) JAMA Neurol , vol.71 , pp. 553-561
    • Laere, K.1    Vanhee, A.2    Verschueren, J.3    Coster, L.4    Driesen, A.5    Dupont, P.6
  • 113
    • 84857790779 scopus 로고    scopus 로고
    • Early and progressive impairment of spinal blood flow-glucose metabolism coupling in motor neuron degeneration of ALS model mice
    • Miyazaki K, Masamoto K, Morimoto N, Kurata T, Mimoto T, Obata T, et al. Early and progressive impairment of spinal blood flow-glucose metabolism coupling in motor neuron degeneration of ALS model mice. J Cereb Blood Flow Metab. 2012;32:456-67.
    • (2012) J Cereb Blood Flow Metab , vol.32 , pp. 456-467
    • Miyazaki, K.1    Masamoto, K.2    Morimoto, N.3    Kurata, T.4    Mimoto, T.5    Obata, T.6
  • 114
    • 84879536538 scopus 로고    scopus 로고
    • The effect of SOD1 mutation on cellular bioenergetic profile and viability in response to oxidative stress and influence of mutation-type
    • Richardson K, Allen SP, Mortiboys H, Grierson AJ, Wharton SB, Ince PG, et al. The effect of SOD1 mutation on cellular bioenergetic profile and viability in response to oxidative stress and influence of mutation-type. PLoS One. 2013;8, e68256.
    • (2013) PLoS One , vol.8
    • Richardson, K.1    Allen, S.P.2    Mortiboys, H.3    Grierson, A.J.4    Wharton, S.B.5    Ince, P.G.6
  • 115
    • 0034784359 scopus 로고    scopus 로고
    • An energy budget for signaling in the grey matter of the brain
    • Attwell D, Laughlin SB. An energy budget for signaling in the grey matter of the brain. J Cereb Blood Flow Metab. 2001;21:1133-45.
    • (2001) J Cereb Blood Flow Metab , vol.21 , pp. 1133-1145
    • Attwell, D.1    Laughlin, S.B.2
  • 116
    • 34247185200 scopus 로고    scopus 로고
    • A coherent neurobiological framework for functional neuroimaging provided by a model integrating compartmentalized energy metabolism
    • Aubert A, Pellerin L, Magistretti PJ, Costalat R. A coherent neurobiological framework for functional neuroimaging provided by a model integrating compartmentalized energy metabolism. Proc Natl Acad Sci U S A. 2007;104:4188-93.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 4188-4193
    • Aubert, A.1    Pellerin, L.2    Magistretti, P.J.3    Costalat, R.4
  • 117
    • 0032904685 scopus 로고    scopus 로고
    • Energetics of functional activation in neural tissues
    • Sokoloff L. Energetics of functional activation in neural tissues. Neurochem Res. 1999;24:321-9.
    • (1999) Neurochem Res , vol.24 , pp. 321-329
    • Sokoloff, L.1
  • 118
    • 0027328680 scopus 로고
    • Combined oxygen and glucose deprivation in cortical cell culture: calcium-dependent and calcium-independent mechanisms of neuronal injury
    • Goldberg MP, Choi DW. Combined oxygen and glucose deprivation in cortical cell culture: calcium-dependent and calcium-independent mechanisms of neuronal injury. J Neurosci. 1993;13:3510-24.
    • (1993) J Neurosci , vol.13 , pp. 3510-3524
    • Goldberg, M.P.1    Choi, D.W.2
  • 119
    • 84864200035 scopus 로고    scopus 로고
    • Oligodendroglia metabolically support axons and contribute to neurodegeneration
    • Lee Y, Morrison BM, Li Y, Lengacher S, Farah MH, Hoffman PN, et al. Oligodendroglia metabolically support axons and contribute to neurodegeneration. Nature. 2012;487:443-8.
    • (2012) Nature , vol.487 , pp. 443-448
    • Lee, Y.1    Morrison, B.M.2    Li, Y.3    Lengacher, S.4    Farah, M.H.5    Hoffman, P.N.6
  • 120
    • 33846423878 scopus 로고    scopus 로고
    • Energy metabolism in astrocytes: high rate of oxidative metabolism and spatiotemporal dependence on glycolysis/glycogenolysis
    • Hertz L, Peng L, Dienel GA. Energy metabolism in astrocytes: high rate of oxidative metabolism and spatiotemporal dependence on glycolysis/glycogenolysis. J Cereb Blood Flow Metab. 2007;27:219-49.
    • (2007) J Cereb Blood Flow Metab , vol.27 , pp. 219-249
    • Hertz, L.1    Peng, L.2    Dienel, G.A.3
  • 121
    • 0029927343 scopus 로고    scopus 로고
    • Metabolic coupling between glia and neurons
    • Tsacopoulos M, Magistretti PJ. Metabolic coupling between glia and neurons. J Neurosci. 1996;16:877-85.
    • (1996) J Neurosci , vol.16 , pp. 877-885
    • Tsacopoulos, M.1    Magistretti, P.J.2
  • 122
    • 0035577699 scopus 로고    scopus 로고
    • Glucose and lactate metabolism during brain activation
    • Dienel GA, Hertz L. Glucose and lactate metabolism during brain activation. J Neurosci Res. 2001;66:824-38.
    • (2001) J Neurosci Res , vol.66 , pp. 824-838
    • Dienel, G.A.1    Hertz, L.2
  • 123
  • 124
    • 36448955388 scopus 로고    scopus 로고
    • Lactate uptake contributes to the NAD(P)H biphasic response and tissue oxygen response during synaptic stimulation in area CA1 of rat hippocampal slices
    • Galeffi F, Foster KA, Sadgrove MP, Beaver CJ, Turner DA. Lactate uptake contributes to the NAD(P)H biphasic response and tissue oxygen response during synaptic stimulation in area CA1 of rat hippocampal slices. J Neurochem. 2007;103:2449-61.
    • (2007) J Neurochem , vol.103 , pp. 2449-2461
    • Galeffi, F.1    Foster, K.A.2    Sadgrove, M.P.3    Beaver, C.J.4    Turner, D.A.5
  • 125
    • 0030931102 scopus 로고    scopus 로고
    • A temporary local energy pool coupled to neuronal activity: fluctuations of extracellular lactate levels in rat brain monitored with rapid-response enzyme-based sensor
    • Hu Y, Wilson GS. A temporary local energy pool coupled to neuronal activity: fluctuations of extracellular lactate levels in rat brain monitored with rapid-response enzyme-based sensor. J Neurochem. 1997;69:1484-90.
    • (1997) J Neurochem , vol.69 , pp. 1484-1490
    • Hu, Y.1    Wilson, G.S.2
  • 126
    • 0035346949 scopus 로고    scopus 로고
    • Is there an astrocyte-neuron ketone body shuttle?
    • Guzman M, Blazquez C. Is there an astrocyte-neuron ketone body shuttle? Trends Endocrinol Metab. 2001;12:169-73.
    • (2001) Trends Endocrinol Metab , vol.12 , pp. 169-173
    • Guzman, M.1    Blazquez, C.2
  • 127
    • 0028080101 scopus 로고
    • Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization
    • Pellerin L, Magistretti PJ. Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization. Proc Natl Acad Sci U S A. 1994;91:10625-9.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 10625-10629
    • Pellerin, L.1    Magistretti, P.J.2
  • 128
    • 0031731776 scopus 로고    scopus 로고
    • Evidence supporting the existence of an activity-dependent astrocyte-neuron lactate shuttle
    • Pellerin L, Pellegri G, Bittar PG, Charnay Y, Bouras C, Martin JL, et al. Evidence supporting the existence of an activity-dependent astrocyte-neuron lactate shuttle. Dev Neurosci. 1998;20:291-9.
    • (1998) Dev Neurosci , vol.20 , pp. 291-299
    • Pellerin, L.1    Pellegri, G.2    Bittar, P.G.3    Charnay, Y.4    Bouras, C.5    Martin, J.L.6
  • 129
    • 34547823399 scopus 로고    scopus 로고
    • Activity-dependent regulation of energy metabolism by astrocytes: an update
    • Pellerin L, Bouzier-Sore AK, Aubert A, Serres S, Merle M, Costalat R, et al. Activity-dependent regulation of energy metabolism by astrocytes: an update. Glia. 2007;55:1251-62.
    • (2007) Glia , vol.55 , pp. 1251-1262
    • Pellerin, L.1    Bouzier-Sore, A.K.2    Aubert, A.3    Serres, S.4    Merle, M.5    Costalat, R.6
  • 131
    • 12244295472 scopus 로고    scopus 로고
    • Lactate transport and transporters: general principles and functional roles in brain cells
    • Hertz L, Dienel GA. Lactate transport and transporters: general principles and functional roles in brain cells. J Neurosci Res. 2005;79:11-8.
    • (2005) J Neurosci Res , vol.79 , pp. 11-18
    • Hertz, L.1    Dienel, G.A.2
  • 132
    • 34047112720 scopus 로고    scopus 로고
    • Neuronal-glial networks as substrate for CNS integration
    • Verkhratsky A, Toescu EC. Neuronal-glial networks as substrate for CNS integration. J Cell Mol Med. 2006;10:826-36.
    • (2006) J Cell Mol Med , vol.10 , pp. 826-836
    • Verkhratsky, A.1    Toescu, E.C.2
  • 133
    • 0029990892 scopus 로고    scopus 로고
    • Selective distribution of lactate dehydrogenase isoenzymes in neurons and astrocytes of human brain
    • Bittar PG, Charnay Y, Pellerin L, Bouras C, Magistretti PJ. Selective distribution of lactate dehydrogenase isoenzymes in neurons and astrocytes of human brain. J Cereb Blood Flow Metab. 1996;16:1079-89.
    • (1996) J Cereb Blood Flow Metab , vol.16 , pp. 1079-1089
    • Bittar, P.G.1    Charnay, Y.2    Pellerin, L.3    Bouras, C.4    Magistretti, P.J.5
  • 134
    • 33947608441 scopus 로고    scopus 로고
    • Kinetic parameters and lactate dehydrogenase isozyme activities support possible lactate utilization by neurons
    • O'Brien J, Kla KM, Hopkins IB, Malecki EA, McKenna MC. Kinetic parameters and lactate dehydrogenase isozyme activities support possible lactate utilization by neurons. Neurochem Res. 2007;32:597-607.
    • (2007) Neurochem Res , vol.32 , pp. 597-607
    • O'Brien, J.1    Kla, K.M.2    Hopkins, I.B.3    Malecki, E.A.4    McKenna, M.C.5
  • 135
    • 33744816535 scopus 로고    scopus 로고
    • Bioenergetic abnormalities in discrete cerebral motor pathways presage spinal cord pathology in the G93A SOD1 mouse model of ALS
    • Browne SE, Yang L, DiMauro JP, Fuller SW, Licata SC, Beal MF. Bioenergetic abnormalities in discrete cerebral motor pathways presage spinal cord pathology in the G93A SOD1 mouse model of ALS. Neurobiol Dis. 2006;22:599-610.
    • (2006) Neurobiol Dis , vol.22 , pp. 599-610
    • Browne, S.E.1    Yang, L.2    DiMauro, J.P.3    Fuller, S.W.4    Licata, S.C.5    Beal, M.F.6
  • 136
    • 0026515287 scopus 로고
    • Frontal lobe function in amyotrophic lateral sclerosis: a neuropsychologic and positron emission tomography study
    • Ludolph AC, Langen KJ, Regard M, Herzog H, Kemper B, Kuwert T, et al. Frontal lobe function in amyotrophic lateral sclerosis: a neuropsychologic and positron emission tomography study. Acta Neurol Scand. 1992;85:81-9.
    • (1992) Acta Neurol Scand , vol.85 , pp. 81-89
    • Ludolph, A.C.1    Langen, K.J.2    Regard, M.3    Herzog, H.4    Kemper, B.5    Kuwert, T.6
  • 137
    • 34047245280 scopus 로고    scopus 로고
    • Metabolic progression markers of neurodegeneration in the transgenic G93A-SOD1 mouse model of amyotrophic lateral sclerosis
    • Niessen HG, Debska-Vielhaber G, Sander K, Angenstein F, Ludolph AC, Hilfert L, et al. Metabolic progression markers of neurodegeneration in the transgenic G93A-SOD1 mouse model of amyotrophic lateral sclerosis. Eur J Neurosci. 2007;25:1669-77.
    • (2007) Eur J Neurosci , vol.25 , pp. 1669-1677
    • Niessen, H.G.1    Debska-Vielhaber, G.2    Sander, K.3    Angenstein, F.4    Ludolph, A.C.5    Hilfert, L.6
  • 138
    • 84894387057 scopus 로고    scopus 로고
    • Abnormal mitochondrial transport and morphology are common pathological denominators in SOD1 and TDP43 ALS mouse models
    • Magrane J, Cortez C, Gan WB, Manfredi G. Abnormal mitochondrial transport and morphology are common pathological denominators in SOD1 and TDP43 ALS mouse models. Hum Mol Genet. 2014;23:1413-24.
    • (2014) Hum Mol Genet , vol.23 , pp. 1413-1424
    • Magrane, J.1    Cortez, C.2    Gan, W.B.3    Manfredi, G.4
  • 139
    • 84898604798 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and decrease in body weight of a transgenic knock-in mouse model for TDP-43
    • Stribl C, Samara A, Trumbach D, Peis R, Neumann M, Fuchs H, et al. Mitochondrial dysfunction and decrease in body weight of a transgenic knock-in mouse model for TDP-43. J Biol Chem. 2014;289:10769-84.
    • (2014) J Biol Chem , vol.289 , pp. 10769-10784
    • Stribl, C.1    Samara, A.2    Trumbach, D.3    Peis, R.4    Neumann, M.5    Fuchs, H.6
  • 140
    • 84923250517 scopus 로고    scopus 로고
    • Oxidative stress and mitochondrial damage: importance in non-SOD1 ALS
    • Carri MT, Valle C, Bozzo F, Cozzolino M. Oxidative stress and mitochondrial damage: importance in non-SOD1 ALS. Front Cell Neurosci. 2015;9:41.
    • (2015) Front Cell Neurosci , vol.9 , pp. 41
    • Carri, M.T.1    Valle, C.2    Bozzo, F.3    Cozzolino, M.4
  • 141
    • 0036830072 scopus 로고    scopus 로고
    • Mitochondrial electron transport chain complex dysfunction in a transgenic mouse model for amyotrophic lateral sclerosis
    • Jung C, Higgins CM, Xu Z. Mitochondrial electron transport chain complex dysfunction in a transgenic mouse model for amyotrophic lateral sclerosis. J Neurochem. 2002;83:535-45.
    • (2002) J Neurochem , vol.83 , pp. 535-545
    • Jung, C.1    Higgins, C.M.2    Xu, Z.3
  • 142
    • 0036321382 scopus 로고    scopus 로고
    • Mitochondrial DNA and respiratory chain function in spinal cords of ALS patients
    • Wiedemann FR, Manfredi G, Mawrin C, Beal MF, Schon EA. Mitochondrial DNA and respiratory chain function in spinal cords of ALS patients. J Neurochem. 2002;80:616-25.
    • (2002) J Neurochem , vol.80 , pp. 616-625
    • Wiedemann, F.R.1    Manfredi, G.2    Mawrin, C.3    Beal, M.F.4    Schon, E.A.5
  • 143
    • 80052928827 scopus 로고    scopus 로고
    • Dysregulation of astrocyte-motoneuron cross-talk in mutant superoxide dismutase 1-related amyotrophic lateral sclerosis
    • Ferraiuolo L, Higginbottom A, Heath PR, Barber S, Greenald D, Kirby J, et al. Dysregulation of astrocyte-motoneuron cross-talk in mutant superoxide dismutase 1-related amyotrophic lateral sclerosis. Brain. 2011;134:2627-41.
    • (2011) Brain , vol.134 , pp. 2627-2641
    • Ferraiuolo, L.1    Higginbottom, A.2    Heath, P.R.3    Barber, S.4    Greenald, D.5    Kirby, J.6
  • 145
    • 33745816384 scopus 로고    scopus 로고
    • A ketogenic diet as a potential novel therapeutic intervention in amyotrophic lateral sclerosis
    • Zhao Z, Lange DJ, Voustianiouk A, MacGrogan D, Ho L, Suh J, et al. A ketogenic diet as a potential novel therapeutic intervention in amyotrophic lateral sclerosis. BMC Neurosci. 2006;7:29.
    • (2006) BMC Neurosci , vol.7 , pp. 29
    • Zhao, Z.1    Lange, D.J.2    Voustianiouk, A.3    MacGrogan, D.4    Ho, L.5    Suh, J.6
  • 146
    • 84907351846 scopus 로고    scopus 로고
    • A computational model of motor neuron degeneration
    • Le Masson G, Przedborski S, Abbott LF. A computational model of motor neuron degeneration. Neuron. 2014;83:975-88.
    • (2014) Neuron , vol.83 , pp. 975-988
    • Masson, G.1    Przedborski, S.2    Abbott, L.F.3
  • 147
    • 0028931049 scopus 로고
    • Axonal ion channel dysfunction in amyotrophic lateral sclerosis
    • Bostock H, Sharief MK, Reid G, Murray NM. Axonal ion channel dysfunction in amyotrophic lateral sclerosis. Brain. 1995;118(Pt 1):217-25.
    • (1995) Brain , vol.118 , Issue.PT 1 , pp. 217-225
    • Bostock, H.1    Sharief, M.K.2    Reid, G.3    Murray, N.M.4
  • 148
    • 33645075174 scopus 로고    scopus 로고
    • Altered axonal excitability properties in amyotrophic lateral sclerosis: impaired potassium channel function related to disease stage
    • Kanai K, Kuwabara S, Misawa S, Tamura N, Ogawara K, Nakata M, et al. Altered axonal excitability properties in amyotrophic lateral sclerosis: impaired potassium channel function related to disease stage. Brain. 2006;129:953-62.
    • (2006) Brain , vol.129 , pp. 953-962
    • Kanai, K.1    Kuwabara, S.2    Misawa, S.3    Tamura, N.4    Ogawara, K.5    Nakata, M.6
  • 149
  • 150
    • 33749239968 scopus 로고    scopus 로고
    • Novel threshold tracking techniques suggest that cortical hyperexcitability is an early feature of motor neuron disease
    • Vucic S, Kiernan MC. Novel threshold tracking techniques suggest that cortical hyperexcitability is an early feature of motor neuron disease. Brain. 2006;129:2436-46.
    • (2006) Brain , vol.129 , pp. 2436-2446
    • Vucic, S.1    Kiernan, M.C.2
  • 151
    • 84920973559 scopus 로고    scopus 로고
    • Motor cortex layer V pyramidal neurons exhibit dendritic regression, spine loss, and increased synaptic excitation in the presymptomatic hSOD1G93A mouse model of amyotrophic lateral sclerosis
    • Fogarty MJ, Noakes PG, Bellingham MC. Motor cortex layer V pyramidal neurons exhibit dendritic regression, spine loss, and increased synaptic excitation in the presymptomatic hSOD1G93A mouse model of amyotrophic lateral sclerosis. J Neurosci. 2015;35:643-7.
    • (2015) J Neurosci , vol.35 , pp. 643-647
    • Fogarty, M.J.1    Noakes, P.G.2    Bellingham, M.C.3
  • 152
    • 33644916404 scopus 로고    scopus 로고
    • Modulation of potassium channels as a therapeutic approach
    • Lawson K, McKay NG. Modulation of potassium channels as a therapeutic approach. Curr Pharm Des. 2006;12:459-70.
    • (2006) Curr Pharm Des , vol.12 , pp. 459-470
    • Lawson, K.1    McKay, N.G.2
  • 154
    • 0030609143 scopus 로고    scopus 로고
    • Octameric stoichiometry of the KATP channel complex
    • Shyng S, Nichols CG. Octameric stoichiometry of the KATP channel complex. J Gen Physiol. 1997;110:655-64.
    • (1997) J Gen Physiol , vol.110 , pp. 655-664
    • Shyng, S.1    Nichols, C.G.2
  • 157
    • 0037107408 scopus 로고    scopus 로고
    • Dynamic imaging of free cytosolic ATP concentration during fuel sensing by rat hypothalamic neurones: evidence for ATP-independent control of ATP-sensitive K(+) channels
    • Ainscow EK, Mirshamsi S, Tang T, Ashford ML, Rutter GA. Dynamic imaging of free cytosolic ATP concentration during fuel sensing by rat hypothalamic neurones: evidence for ATP-independent control of ATP-sensitive K(+) channels. J Physiol. 2002;544:429-45.
    • (2002) J Physiol , vol.544 , pp. 429-445
    • Ainscow, E.K.1    Mirshamsi, S.2    Tang, T.3    Ashford, M.L.4    Rutter, G.A.5
  • 158
    • 23244458439 scopus 로고    scopus 로고
    • Regulation of blood glucose by hypothalamic pyruvate metabolism
    • Lam TK, Gutierrez-Juarez R, Pocai A, Rossetti L. Regulation of blood glucose by hypothalamic pyruvate metabolism. Science. 2005;309:943-7.
    • (2005) Science , vol.309 , pp. 943-947
    • Lam, T.K.1    Gutierrez-Juarez, R.2    Pocai, A.3    Rossetti, L.4
  • 159
    • 77953778872 scopus 로고    scopus 로고
    • ATP-sensitive potassium channel-mediated lactate effect on orexin neurons: implications for brain energetics during arousal
    • Parsons MP, Hirasawa M. ATP-sensitive potassium channel-mediated lactate effect on orexin neurons: implications for brain energetics during arousal. J Neurosci. 2010;30:8061-70.
    • (2010) J Neurosci , vol.30 , pp. 8061-8070
    • Parsons, M.P.1    Hirasawa, M.2
  • 160
    • 33947644899 scopus 로고    scopus 로고
    • Glial Nax channels control lactate signaling to neurons for brain [Na+] sensing
    • Shimizu H, Watanabe E, Hiyama TY, Nagakura A, Fujikawa A, Okado H, et al. Glial Nax channels control lactate signaling to neurons for brain [Na+] sensing. Neuron. 2007;54:59-72.
    • (2007) Neuron , vol.54 , pp. 59-72
    • Shimizu, H.1    Watanabe, E.2    Hiyama, T.Y.3    Nagakura, A.4    Fujikawa, A.5    Okado, H.6
  • 161
    • 82955168362 scopus 로고    scopus 로고
    • Brain energy metabolism: focus on astrocyte-neuron metabolic cooperation
    • Belanger M, Allaman I, Magistretti PJ. Brain energy metabolism: focus on astrocyte-neuron metabolic cooperation. Cell Metab. 2011;14:724-38.
    • (2011) Cell Metab , vol.14 , pp. 724-738
    • Belanger, M.1    Allaman, I.2    Magistretti, P.J.3
  • 162
    • 28044469874 scopus 로고    scopus 로고
    • K-ATP channels promote the differential degeneration of dopaminergic midbrain neurons
    • Liss B, Haeckel O, Wildmann J, Miki T, Seino S, Roeper J. K-ATP channels promote the differential degeneration of dopaminergic midbrain neurons. Nat Neurosci. 2005;8:1742-51.
    • (2005) Nat Neurosci , vol.8 , pp. 1742-1751
    • Liss, B.1    Haeckel, O.2    Wildmann, J.3    Miki, T.4    Seino, S.5    Roeper, J.6
  • 163
    • 78650844057 scopus 로고    scopus 로고
    • The KATP channel activator diazoxide ameliorates amyloid-beta and tau pathologies and improves memory in the 3xTgAD mouse model of Alzheimer's disease
    • Liu D, Pitta M, Lee JH, Ray B, Lahiri DK, Furukawa K, et al. The KATP channel activator diazoxide ameliorates amyloid-beta and tau pathologies and improves memory in the 3xTgAD mouse model of Alzheimer's disease. J Alzheimers Dis. 2010;22:443-57.
    • (2010) J Alzheimers Dis , vol.22 , pp. 443-457
    • Liu, D.1    Pitta, M.2    Lee, J.H.3    Ray, B.4    Lahiri, D.K.5    Furukawa, K.6
  • 164
    • 36249010402 scopus 로고    scopus 로고
    • Role of K(ATP) channels in protection against neuronal excitatory insults
    • Soundarapandian MM, Zhong X, Peng L, Wu D, Lu Y. Role of K(ATP) channels in protection against neuronal excitatory insults. J Neurochem. 2007;103:1721-9.
    • (2007) J Neurochem , vol.103 , pp. 1721-1729
    • Soundarapandian, M.M.1    Zhong, X.2    Peng, L.3    Wu, D.4    Lu, Y.5
  • 165
    • 0025162079 scopus 로고
    • Glucose-induced excitation of hypothalamic neurones is mediated by ATP-sensitive K+ channels
    • Ashford ML, Boden PR, Treherne JM. Glucose-induced excitation of hypothalamic neurones is mediated by ATP-sensitive K+ channels. Pflugers Arch. 1990;415:479-83.
    • (1990) Pflugers Arch , vol.415 , pp. 479-483
    • Ashford, M.L.1    Boden, P.R.2    Treherne, J.M.3
  • 167
    • 0035709033 scopus 로고    scopus 로고
    • Glucosensing neurons do more than just sense glucose
    • Levin BE. Glucosensing neurons do more than just sense glucose. Int J Obes Relat Metab Disord. 2001;25 Suppl 5:S68-72.
    • (2001) Int J Obes Relat Metab Disord , vol.25 , pp. S68-72
    • Levin, B.E.1
  • 168
    • 14644395509 scopus 로고    scopus 로고
    • Pore-forming subunits of K-ATP channels, Kir6.1 and Kir6.2, display prominent differences in regional and cellular distribution in the rat brain
    • Thomzig A, Laube G, Pruss H, Veh RW. Pore-forming subunits of K-ATP channels, Kir6.1 and Kir6.2, display prominent differences in regional and cellular distribution in the rat brain. J Comp Neurol. 2005;484:313-30.
    • (2005) J Comp Neurol , vol.484 , pp. 313-330
    • Thomzig, A.1    Laube, G.2    Pruss, H.3    Veh, R.W.4
  • 169
    • 0035684068 scopus 로고    scopus 로고
    • Kir6.1 is the principal pore-forming subunit of astrocyte but not neuronal plasma membrane K-ATP channels
    • Thomzig A, Wenzel M, Karschin C, Eaton MJ, Skatchkov SN, Karschin A, et al. Kir6.1 is the principal pore-forming subunit of astrocyte but not neuronal plasma membrane K-ATP channels. Mol Cell Neurosci. 2001;18:671-90.
    • (2001) Mol Cell Neurosci , vol.18 , pp. 671-690
    • Thomzig, A.1    Wenzel, M.2    Karschin, C.3    Eaton, M.J.4    Skatchkov, S.N.5    Karschin, A.6
  • 170
    • 0031886709 scopus 로고    scopus 로고
    • ATP-sensitive K+ channels in pancreatic, cardiac, and vascular smooth muscle cells
    • Yokoshiki H, Sunagawa M, Seki T, Sperelakis N. ATP-sensitive K+ channels in pancreatic, cardiac, and vascular smooth muscle cells. Am J Physiol. 1998;274:C25-37.
    • (1998) Am J Physiol , vol.274 , pp. C25-37
    • Yokoshiki, H.1    Sunagawa, M.2    Seki, T.3    Sperelakis, N.4
  • 171
    • 77955629618 scopus 로고    scopus 로고
    • Muscle KATP channels: recent insights to energy sensing and myoprotection
    • Flagg TP, Enkvetchakul D, Koster JC, Nichols CG. Muscle KATP channels: recent insights to energy sensing and myoprotection. Physiol Rev. 2010;90:799-829.
    • (2010) Physiol Rev , vol.90 , pp. 799-829
    • Flagg, T.P.1    Enkvetchakul, D.2    Koster, J.C.3    Nichols, C.G.4
  • 172
    • 0028972501 scopus 로고
    • Reconstitution of IKATP: an inward rectifier subunit plus the sulfonylurea receptor
    • Inagaki N, Gonoi T, Clement JP, Namba N, Inazawa J, Gonzalez G, et al. Reconstitution of IKATP: an inward rectifier subunit plus the sulfonylurea receptor. Science. 1995;270:1166-70.
    • (1995) Science , vol.270 , pp. 1166-1170
    • Inagaki, N.1    Gonoi, T.2    Clement, J.P.3    Namba, N.4    Inazawa, J.5    Gonzalez, G.6
  • 173
    • 0029561629 scopus 로고
    • Cloning and functional expression of the cDNA encoding a novel ATP-sensitive potassium channel subunit expressed in pancreatic beta-cells, brain, heart and skeletal muscle
    • Sakura H, Ammala C, Smith PA, Gribble FM, Ashcroft FM. Cloning and functional expression of the cDNA encoding a novel ATP-sensitive potassium channel subunit expressed in pancreatic beta-cells, brain, heart and skeletal muscle. FEBS Lett. 1995;377:338-44.
    • (1995) FEBS Lett , vol.377 , pp. 338-344
    • Sakura, H.1    Ammala, C.2    Smith, P.A.3    Gribble, F.M.4    Ashcroft, F.M.5
  • 174
    • 0029898253 scopus 로고    scopus 로고
    • A family of sulfonylurea receptors determines the pharmacological properties of ATP-sensitive K+ channels
    • Inagaki N, Gonoi T, Clement JP, Wang CZ, Aguilar-Bryan L, Bryan J, et al. A family of sulfonylurea receptors determines the pharmacological properties of ATP-sensitive K+ channels. Neuron. 1996;16:1011-7.
    • (1996) Neuron , vol.16 , pp. 1011-1017
    • Inagaki, N.1    Gonoi, T.2    Clement, J.P.3    Wang, C.Z.4    Aguilar-Bryan, L.5    Bryan, J.6
  • 175
    • 0035823614 scopus 로고    scopus 로고
    • Identification and properties of a novel intracellular (mitochondrial) ATP-sensitive potassium channel in brain
    • Bajgar R, Seetharaman S, Kowaltowski AJ, Garlid KD, Paucek P. Identification and properties of a novel intracellular (mitochondrial) ATP-sensitive potassium channel in brain. J Biol Chem. 2001;276:33369-74.
    • (2001) J Biol Chem , vol.276 , pp. 33369-33374
    • Bajgar, R.1    Seetharaman, S.2    Kowaltowski, A.J.3    Garlid, K.D.4    Paucek, P.5
  • 176
    • 0344012088 scopus 로고    scopus 로고
    • Investigation of the subunit composition and the pharmacology of the mitochondrial ATP-dependent K+ channel in the brain
    • Lacza Z, Snipes JA, Kis B, Szabo C, Grover G, Busija DW. Investigation of the subunit composition and the pharmacology of the mitochondrial ATP-dependent K+ channel in the brain. Brain Res. 2003;994:27-36.
    • (2003) Brain Res , vol.994 , pp. 27-36
    • Lacza, Z.1    Snipes, J.A.2    Kis, B.3    Szabo, C.4    Grover, G.5    Busija, D.W.6
  • 178
    • 0033556338 scopus 로고    scopus 로고
    • Cell-type specific expression of ATP-sensitive potassium channels in the rat hippocampus
    • Zawar C, Plant TD, Schirra C, Konnerth A, Neumcke B. Cell-type specific expression of ATP-sensitive potassium channels in the rat hippocampus. J Physiol. 1999;514(Pt 2):327-41.
    • (1999) J Physiol , vol.514 , Issue.PT 2 , pp. 327-341
    • Zawar, C.1    Plant, T.D.2    Schirra, C.3    Konnerth, A.4    Neumcke, B.5
  • 179
    • 33644866501 scopus 로고    scopus 로고
    • Towards selective Kir6.2/SUR1 potassium channel openers, medicinal chemistry and therapeutic perspectives
    • Hansen JB. Towards selective Kir6.2/SUR1 potassium channel openers, medicinal chemistry and therapeutic perspectives. Curr Med Chem. 2006;13:361-76.
    • (2006) Curr Med Chem , vol.13 , pp. 361-376
    • Hansen, J.B.1
  • 180
    • 33646535884 scopus 로고    scopus 로고
    • The mitochondrial K-ATP channel opener, diazoxide, prevents ischemia-reperfusion injury in the rabbit spinal cord
    • Roseborough G, Gao D, Chen L, Trush MA, Zhou S, Williams GM, et al. The mitochondrial K-ATP channel opener, diazoxide, prevents ischemia-reperfusion injury in the rabbit spinal cord. Am J Pathol. 2006;168:1443-51.
    • (2006) Am J Pathol , vol.168 , pp. 1443-1451
    • Roseborough, G.1    Gao, D.2    Chen, L.3    Trush, M.A.4    Zhou, S.5    Williams, G.M.6
  • 181
    • 0038507050 scopus 로고    scopus 로고
    • Mitochondrial ATP-sensitive potassium channel activation protects cerebellar granule neurons from apoptosis induced by oxidative stress
    • Teshima Y, Akao M, Li RA, Chong TH, Baumgartner WA, Johnston MV, et al. Mitochondrial ATP-sensitive potassium channel activation protects cerebellar granule neurons from apoptosis induced by oxidative stress. Stroke. 2003;34:1796-802.
    • (2003) Stroke , vol.34 , pp. 1796-1802
    • Teshima, Y.1    Akao, M.2    Li, R.A.3    Chong, T.H.4    Baumgartner, W.A.5    Johnston, M.V.6
  • 182
    • 79951513548 scopus 로고    scopus 로고
    • The protective roles of mitochondrial ATP-sensitive potassium channels during hypoxia-ischemia-reperfusion in brain
    • Wang L, Zhu QL, Wang GZ, Deng TZ, Chen R, Liu MH, et al. The protective roles of mitochondrial ATP-sensitive potassium channels during hypoxia-ischemia-reperfusion in brain. Neurosci Lett. 2011;491:63-7.
    • (2011) Neurosci Lett , vol.491 , pp. 63-67
    • Wang, L.1    Zhu, Q.L.2    Wang, G.Z.3    Deng, T.Z.4    Chen, R.5    Liu, M.H.6
  • 183
    • 0036209260 scopus 로고    scopus 로고
    • Activation of mitochondrial ATP-dependent potassium channels protects neurons against ischemia-induced death by a mechanism involving suppression of Bax translocation and cytochrome c release
    • Liu D, Lu C, Wan R, Auyeung WW, Mattson MP. Activation of mitochondrial ATP-dependent potassium channels protects neurons against ischemia-induced death by a mechanism involving suppression of Bax translocation and cytochrome c release. J Cereb Blood Flow Metab. 2002;22:431-43.
    • (2002) J Cereb Blood Flow Metab , vol.22 , pp. 431-443
    • Liu, D.1    Lu, C.2    Wan, R.3    Auyeung, W.W.4    Mattson, M.P.5
  • 184
    • 0029951630 scopus 로고    scopus 로고
    • Modulation of GABA transmission by diazoxide and cromakalim in the globus pallidus: implications for the treatment of Parkinson's disease
    • Maneuf YP, Duty S, Hille CJ, Crossman AR, Brotchie JM. Modulation of GABA transmission by diazoxide and cromakalim in the globus pallidus: implications for the treatment of Parkinson's disease. Exp Neurol. 1996;139:12-6.
    • (1996) Exp Neurol , vol.139 , pp. 12-16
    • Maneuf, Y.P.1    Duty, S.2    Hille, C.J.3    Crossman, A.R.4    Brotchie, J.M.5
  • 185
    • 66449135704 scopus 로고    scopus 로고
    • Iptakalim protects against MPP+-induced degeneration of dopaminergic neurons in association with astrocyte activation
    • Yang YJ, Zhang S, Ding JH, Zhou F, Hu G. Iptakalim protects against MPP+-induced degeneration of dopaminergic neurons in association with astrocyte activation. Int J Neuropsychopharmacol. 2009;12:317-27.
    • (2009) Int J Neuropsychopharmacol , vol.12 , pp. 317-327
    • Yang, Y.J.1    Zhang, S.2    Ding, J.H.3    Zhou, F.4    Hu, G.5
  • 186
    • 54049142448 scopus 로고    scopus 로고
    • Opening of microglial K(ATP) channels inhibits rotenone-induced neuroinflammation
    • Zhou F, Yao HH, Wu JY, Ding JH, Sun T, Hu G. Opening of microglial K(ATP) channels inhibits rotenone-induced neuroinflammation. J Cell Mol Med. 2008;12:1559-70.
    • (2008) J Cell Mol Med , vol.12 , pp. 1559-1570
    • Zhou, F.1    Yao, H.H.2    Wu, J.Y.3    Ding, J.H.4    Sun, T.5    Hu, G.6
  • 187
    • 0030050677 scopus 로고    scopus 로고
    • K+ channel openers protect hippocampal neurons against oxidative injury and amyloid beta-peptide toxicity
    • Goodman Y, Mattson MP. K+ channel openers protect hippocampal neurons against oxidative injury and amyloid beta-peptide toxicity. Brain Res. 1996;706:328-32.
    • (1996) Brain Res , vol.706 , pp. 328-332
    • Goodman, Y.1    Mattson, M.P.2
  • 188
    • 36249024818 scopus 로고    scopus 로고
    • Expression of functional Kir6.1 channels regulates glutamate release at CA3 synapses in generation of epileptic form of seizures
    • Soundarapandian MM, Wu D, Zhong X, Petralia RS, Peng L, Tu W, et al. Expression of functional Kir6.1 channels regulates glutamate release at CA3 synapses in generation of epileptic form of seizures. J Neurochem. 2007;103:1982-8.
    • (2007) J Neurochem , vol.103 , pp. 1982-1988
    • Soundarapandian, M.M.1    Wu, D.2    Zhong, X.3    Petralia, R.S.4    Peng, L.5    Tu, W.6
  • 189
    • 84896785359 scopus 로고    scopus 로고
    • K(ATP) channel opener diazoxide prevents neurodegeneration: a new mechanism of action via antioxidative pathway activation
    • Virgili N, Mancera P, Wappenhans B, Sorrosal G, Biber K, Pugliese M, et al. K(ATP) channel opener diazoxide prevents neurodegeneration: a new mechanism of action via antioxidative pathway activation. PLoS One. 2013;8, e75189.
    • (2013) PLoS One , vol.8
    • Virgili, N.1    Mancera, P.2    Wappenhans, B.3    Sorrosal, G.4    Biber, K.5    Pugliese, M.6
  • 191
    • 0036302868 scopus 로고    scopus 로고
    • Chronic suppression of insulin by diazoxide alters the activities of key enzymes regulating hepatic gluconeogenesis in Zucker rats
    • Alemzadeh R, Holshouser S, Massey P, Koontz J. Chronic suppression of insulin by diazoxide alters the activities of key enzymes regulating hepatic gluconeogenesis in Zucker rats. Eur J Endocrinol. 2002;146:871-9.
    • (2002) Eur J Endocrinol , vol.146 , pp. 871-879
    • Alemzadeh, R.1    Holshouser, S.2    Massey, P.3    Koontz, J.4
  • 193
    • 84940324288 scopus 로고    scopus 로고
    • KATP channels modulate intrinsic firing activity of immature entorhinal cortex layer III neurons
    • Lemak MS, Voloshanenko O, Draguhn A, Egorov AV. KATP channels modulate intrinsic firing activity of immature entorhinal cortex layer III neurons. Front Cell Neurosci. 2014;8:255.
    • (2014) Front Cell Neurosci , vol.8 , pp. 255
    • Lemak, M.S.1    Voloshanenko, O.2    Draguhn, A.3    Egorov, A.V.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.