메뉴 건너뛰기




Volumn 110, Issue 26, 2013, Pages 10812-10817

Metabolic signatures of amyotrophic lateral sclerosis reveal insights into disease pathogenesis

Author keywords

Carbonic anhydrase; Electrolyte; Glucagon; Glycoproteins; Motor neuron disease

Indexed keywords

ALPHA GLUCOSIDASE; COPPER ZINC SUPEROXIDE DISMUTASE; COPPER ZINC SUPEROXIDE DISMUTASE 1; GLYCOGEN; UNCLASSIFIED DRUG;

EID: 84879528008     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1308421110     Document Type: Article
Times cited : (93)

References (46)
  • 1
    • 0027164824 scopus 로고
    • Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis
    • Rosen DR (1993) Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature 364(6435):362.
    • (1993) Nature , vol.364 , Issue.6435 , pp. 362
    • Rosen, D.R.1
  • 2
    • 0028284779 scopus 로고
    • Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation
    • Gurney ME, et al. (1994) Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation. Science 264(5166):1772-1775.
    • (1994) Science , vol.264 , Issue.5166 , pp. 1772-1775
    • Gurney, M.E.1
  • 3
    • 3943102116 scopus 로고    scopus 로고
    • Unraveling the mechanisms involved in motor neuron degeneration in ALS
    • Bruijn LI, Miller TM, Cleveland DW (2004) Unraveling the mechanisms involved in motor neuron degeneration in ALS. Annu Rev Neurosci 27:723-749.
    • (2004) Annu Rev Neurosci , vol.27 , pp. 723-749
    • Bruijn, L.I.1    Miller, T.M.2    Cleveland, D.W.3
  • 4
    • 84871497430 scopus 로고    scopus 로고
    • Multimodal actions of neural stem cells in a mouse model of ALS: A meta-analysis
    • Teng YD, et al. (2012) Multimodal actions of neural stem cells in a mouse model of ALS: A meta-analysis. Science Transl Med 4(165):165ra164.
    • (2012) Science Transl Med , vol.4 , Issue.165
    • Teng, Y.D.1
  • 5
    • 0028933324 scopus 로고
    • Protection against CNS ischemia by temporary interruption of function-related processes of neurons
    • Ames A, 3rd, Maynard KI, Kaplan S (1995) Protection against CNS ischemia by temporary interruption of function-related processes of neurons. J Cereb Blood Flow Metab 15(3): 433-439.
    • (1995) J Cereb Blood Flow Metab , vol.15 , Issue.3 , pp. 433-439
    • Ames Iii, A.1    Maynard, K.I.2    Kaplan, S.3
  • 6
    • 49349115297 scopus 로고    scopus 로고
    • Amiloride is neuroprotective in an MPTP model of Parkinson's disease
    • Arias RL, et al. (2008) Amiloride is neuroprotective in an MPTP model of Parkinson's disease. Neurobiol Dis 31(3):334-341.
    • (2008) Neurobiol Dis , vol.31 , Issue.3 , pp. 334-341
    • Arias, R.L.1
  • 7
    • 36849009834 scopus 로고    scopus 로고
    • Acid-sensing ion channel-1 contributes to axonal degeneration in autoimmune inflammation of the central nervous system
    • Friese MA, et al. (2007) Acid-sensing ion channel-1 contributes to axonal degeneration in autoimmune inflammation of the central nervous system. Nat Med 13(12):1483-1489.
    • (2007) Nat Med , vol.13 , Issue.12 , pp. 1483-1489
    • Friese, M.A.1
  • 8
    • 0028906351 scopus 로고
    • Acidosis causes failure of astrocyte glutamate uptake during hypoxia
    • Swanson RA, Farrell K, Simon RP (1995) Acidosis causes failure of astrocyte glutamate uptake during hypoxia. J Cereb Blood Flow Metab 15(3):417-424.
    • (1995) J Cereb Blood Flow Metab , vol.15 , Issue.3 , pp. 417-424
    • Swanson, R.A.1    Farrell, K.2    Simon, R.P.3
  • 9
    • 0024373791 scopus 로고
    • Influence of in vitro lactic acidosis on central nervous system neurons
    • Khan NA, Guevara P, Sotelo J (1989) Influence of in vitro lactic acidosis on central nervous system neurons. Pathol Biol (Paris) 37(6):725-729.
    • (1989) Pathol Biol (Paris) , vol.37 , Issue.6 , pp. 725-729
    • Khan, N.A.1    Guevara, P.2    Sotelo, J.3
  • 10
    • 0034307612 scopus 로고    scopus 로고
    • Potentiation of a voltage-gated proton current in acidosis-induced swelling of rat microglia
    • Morihata H, Nakamura F, Tsutada T, Kuno M (2000) Potentiation of a voltage-gated proton current in acidosis-induced swelling of rat microglia. J Neurosci 20(19):7220-7227.
    • (2000) J Neurosci , vol.20 , Issue.19 , pp. 7220-7227
    • Morihata, H.1    Nakamura, F.2    Tsutada, T.3    Kuno, M.4
  • 11
    • 14644412870 scopus 로고    scopus 로고
    • Acidosis causes endoplasmic reticulum stress and caspase- 12-mediated astrocyte death
    • Aoyama K, et al. (2005) Acidosis causes endoplasmic reticulum stress and caspase- 12-mediated astrocyte death. J Cereb Blood Flow Metab 25(3):358-370.
    • (2005) J Cereb Blood Flow Metab , vol.25 , Issue.3 , pp. 358-370
    • Aoyama, K.1
  • 12
    • 0027435233 scopus 로고
    • Relations between intracellular ions and energy metabolism under acidotic conditions: A study with nigericin in synaptosomes, neurons, and C6 glioma cells
    • Ereci-nska M, Nelson D, Dagani F, Deas J, Silver IA (1993) Relations between intracellular ions and energy metabolism under acidotic conditions: A study with nigericin in synaptosomes, neurons, and C6 glioma cells. J Neurochem 61(4):1356-1368.
    • (1993) J Neurochem , vol.61 , Issue.4 , pp. 1356-1368
    • Erecinska, M.1    Nelson, D.2    Dagani, F.3    Deas, J.4    Silver, I.A.5
  • 13
    • 79551690481 scopus 로고    scopus 로고
    • Phosphatase and tensin homologue/protein kinase B pathway linked to motor neuron survival in human superoxide dismutase 1-related amyotrophic lateral sclerosis
    • Kirby J, et al. (2011) Phosphatase and tensin homologue/protein kinase B pathway linked to motor neuron survival in human superoxide dismutase 1-related amyotrophic lateral sclerosis. Brain 134(Pt 2):506-517.
    • (2011) Brain , vol.134 , Issue.PART 2 , pp. 506-517
    • Kirby, J.1
  • 14
    • 84874950486 scopus 로고    scopus 로고
    • Acidotoxicity and acid-sensing ion channels contribute to motoneuron degeneration
    • Behan AT, et al. (2013) Acidotoxicity and acid-sensing ion channels contribute to motoneuron degeneration. Cell Death Differ 20(4):589-598.
    • (2013) Cell Death Differ , vol.20 , Issue.4 , pp. 589-598
    • Behan, A.T.1
  • 15
    • 33745728330 scopus 로고    scopus 로고
    • Strong ion difference and strong anion gap: The Stewart approach to acid base disturbances
    • Rinaldi S, De Gaudio AR (2005) Strong ion difference and strong anion gap: The Stewart approach to acid base disturbances. Curr Anaesth Crit Care 16(6):395-402.
    • (2005) Curr Anaesth Crit Care , vol.16 , Issue.6 , pp. 395-402
    • Rinaldi, S.1    De Gaudio, A.R.2
  • 16
    • 2342418280 scopus 로고    scopus 로고
    • Initial pH, base deficit, lactate, anion gap, strong ion difference, and strong ion gap predict outcome from major vascular injury
    • Kaplan LJ, Kellum JA (2004) Initial pH, base deficit, lactate, anion gap, strong ion difference, and strong ion gap predict outcome from major vascular injury. Crit Care Med 32(5):1120-1124.
    • (2004) Crit Care Med , vol.32 , Issue.5 , pp. 1120-1124
    • Kaplan, L.J.1    Kellum, J.A.2
  • 17
    • 78449276686 scopus 로고    scopus 로고
    • Fluids, pH, ions and electrolytes
    • Kaplan LJ, Kellum JA (2010) Fluids, pH, ions and electrolytes. Curr Opin Crit Care 16(4): 323-331.
    • (2010) Curr Opin Crit Care , vol.16 , Issue.4 , pp. 323-331
    • Kaplan, L.J.1    Kellum, J.A.2
  • 18
    • 0020960982 scopus 로고
    • Biochemistry and differential diagnosis of metabolic acidoses
    • Sestoft L, Bartels PD (1983) Biochemistry and differential diagnosis of metabolic acidoses. Clin Endocrinol Metab 12(2):287-302.
    • (1983) Clin Endocrinol Metab , vol.12 , Issue.2 , pp. 287-302
    • Sestoft, L.1    Bartels, P.D.2
  • 19
    • 80052928827 scopus 로고    scopus 로고
    • Dysregulation of astrocyte-motoneuron cross-talk in mutant superoxide dismutase 1-related amyotrophic lateral sclerosis
    • Ferraiuolo L, et al. (2011) Dysregulation of astrocyte-motoneuron cross-talk in mutant superoxide dismutase 1-related amyotrophic lateral sclerosis. Brain 134(Pt 9):2627-2641.
    • (2011) Brain , vol.134 , Issue.PART 9 , pp. 2627-2641
    • Ferraiuolo, L.1
  • 22
    • 0000995321 scopus 로고    scopus 로고
    • Glycogen storage disease type II: Acid alpha-glucosidase (acid maltase) deficiency
    • eds Scriver CA, Beaudet AL, Valle D, Sly WS McGraw-Hill, New York), 8th Ed
    • Hirshhorn R, Reuser AJJ (2001) Glycogen storage disease type II: Acid alpha-glucosidase (acid maltase) deficiency. The Metabolic and Molecular Bases of Inherited Disease, eds Scriver CA, Beaudet AL, Valle D, Sly WS (McGraw-Hill, New York), 8th Ed, pp 3389-3420.
    • (2001) The Metabolic and Molecular Bases of Inherited Disease , pp. 3389-3420
    • Hirshhorn, R.1    Ajj, R.2
  • 23
    • 52249123294 scopus 로고    scopus 로고
    • Temporal neuropathologic and behavioral phenotype of 6neo/6neo Pompe disease mice
    • Sidman RL, et al. (2008) Temporal neuropathologic and behavioral phenotype of 6neo/6neo Pompe disease mice. J Neuropathol Exp Neurol 67(8):803-818.
    • (2008) J Neuropathol Exp Neurol , vol.67 , Issue.8 , pp. 803-818
    • Sidman, R.L.1
  • 24
    • 0032714568 scopus 로고    scopus 로고
    • Importance of glycosidases in mammalian glycoprotein biosynthesis
    • Herscovics A (1999) Importance of glycosidases in mammalian glycoprotein biosynthesis. Biochim Biophys Acta 1473(1):96-107.
    • (1999) Biochim Biophys Acta , vol.1473 , Issue.1 , pp. 96-107
    • Herscovics, A.1
  • 25
    • 80052783545 scopus 로고    scopus 로고
    • Astrocytes from familial and sporadic ALS patients are toxic to motor neurons
    • Haidet-Phillips AM, et al. (2011) Astrocytes from familial and sporadic ALS patients are toxic to motor neurons. Nat Biotechnol 29(9):824-828.
    • (2011) Nat Biotechnol , vol.29 , Issue.9 , pp. 824-828
    • Haidet-Phillips, A.M.1
  • 26
    • 0029661207 scopus 로고    scopus 로고
    • A controlled trial of amino acid therapy in amyotrophic lateral sclerosis: I. Clinical, functional, and maximum isometric torque data
    • Tandan R, et al. (1996) A controlled trial of amino acid therapy in amyotrophic lateral sclerosis: I. Clinical, functional, and maximum isometric torque data. Neurology 47(5): 1220-1226.
    • (1996) Neurology , vol.47 , Issue.5 , pp. 1220-1226
    • Tandan, R.1
  • 27
    • 10744222650 scopus 로고    scopus 로고
    • A randomized, placebo-controlled trial of topiramate in amyotrophic lateral sclerosis
    • Northeast ALS Consortium
    • CudkowiczME, et al.; Northeast ALS Consortium (2003) A randomized, placebo-controlled trial of topiramate in amyotrophic lateral sclerosis. Neurology 61(4):456-464.
    • (2003) Neurology , vol.61 , Issue.4 , pp. 456-464
    • Cudkowicz, M.E.1
  • 28
    • 0025320647 scopus 로고
    • The regulation and modulation of pH in the nervous system
    • Chesler M (1990) The regulation and modulation of pH in the nervous system. Prog Neurobiol 34(5):401-427.
    • (1990) Prog Neurobiol , vol.34 , Issue.5 , pp. 401-427
    • Chesler, M.1
  • 29
    • 33847701197 scopus 로고    scopus 로고
    • Respiratory impairment in a mouse model of amyotrophic lateral sclerosis
    • Tankersley CG, Haenggeli C, Rothstein JD (2007) Respiratory impairment in a mouse model of amyotrophic lateral sclerosis. J Appl Physiol 102(3):926-932.
    • (2007) J Appl Physiol , vol.102 , Issue.3 , pp. 926-932
    • Tankersley, C.G.1    Haenggeli, C.2    Rothstein, J.D.3
  • 30
    • 66149099232 scopus 로고    scopus 로고
    • Integration of cerebrovascular CO2 reactivity and chemoreflex control of breathing: Mechanisms of regulation, measurement, and interpretation
    • Ainslie PN, Duffin J (2009) Integration of cerebrovascular CO2 reactivity and chemoreflex control of breathing: Mechanisms of regulation, measurement, and interpretation. Am J Physiol Regul Integr Comp Physiol 296(5):R1473-R1495.
    • (2009) Am J Physiol Regul Integr Comp Physiol , vol.296 , Issue.5
    • Ainslie, P.N.1    Duffin, J.2
  • 31
    • 41149097086 scopus 로고    scopus 로고
    • ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration
    • Zhong Z, et al. (2008) ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration. Nat Neurosci 11(4):420-422.
    • (2008) Nat Neurosci , vol.11 , Issue.4 , pp. 420-422
    • Zhong, Z.1
  • 32
    • 84857790779 scopus 로고    scopus 로고
    • Early and progressive impairment of spinal blood flow-glucose metabolism coupling in motor neuron degeneration of ALS model mice
    • Miyazaki K, et al. (2012) Early and progressive impairment of spinal blood flow-glucose metabolism coupling in motor neuron degeneration of ALS model mice. J Cereb Blood Flow Metab 32(3):456-467.
    • (2012) J Cereb Blood Flow Metab , vol.32 , Issue.3 , pp. 456-467
    • Miyazaki, K.1
  • 33
    • 82655173728 scopus 로고    scopus 로고
    • Disease progression in a mouse model of amyotrophic lateral sclerosis: The influence of chronic stress and corticosterone
    • Fidler JA, et al. (2011) Disease progression in a mouse model of amyotrophic lateral sclerosis: The influence of chronic stress and corticosterone. FASEB J 25(12):4369-4377.
    • (2011) FASEB J , vol.25 , Issue.12 , pp. 4369-4377
    • Fidler, J.A.1
  • 34
    • 51349120583 scopus 로고    scopus 로고
    • Messenger RNA oxidation occurs early in disease pathogenesis and promotes motor neuron degeneration in ALS
    • Chang Y, et al. (2008) Messenger RNA oxidation occurs early in disease pathogenesis and promotes motor neuron degeneration in ALS. PLoS ONE 3(8):e2849.
    • (2008) PLoS ONE , vol.3 , Issue.8
    • Chang, Y.1
  • 35
    • 0025753891 scopus 로고
    • Ischemic brain slice glucose utilization: Effects of slice thickness, acidosis, and K+
    • Newman GC, Hospod FE, Schissel SL (1991) Ischemic brain slice glucose utilization: Effects of slice thickness, acidosis, and K+. J Cereb Blood Flow Metab 11(3):398-406.
    • (1991) J Cereb Blood Flow Metab , vol.11 , Issue.3 , pp. 398-406
    • Newman, G.C.1    Hospod, F.E.2    Schissel, S.L.3
  • 36
    • 79851508750 scopus 로고    scopus 로고
    • Control of MCT1 function in cerebrovascular endothelial cells by intracellular pH
    • Uhernik AL, Tucker C, Smith JP (2011) Control of MCT1 function in cerebrovascular endothelial cells by intracellular pH. Brain Res 1376:10-22.
    • (2011) Brain Res , vol.1376 , pp. 10-22
    • Uhernik, A.L.1    Tucker, C.2    Smith, J.P.3
  • 37
    • 0023636605 scopus 로고
    • Lowered cerebral glucose utilization in amyotrophic lateral sclerosis
    • Dalakas MC, Hatazawa J, Brooks RA, Di Chiro G (1987) Lowered cerebral glucose utilization in amyotrophic lateral sclerosis. Ann Neurol 22(5):580-586.
    • (1987) Ann Neurol , vol.22 , Issue.5 , pp. 580-586
    • Dalakas, M.C.1    Hatazawa, J.2    Brooks, R.A.3    Di Chiro, G.4
  • 38
    • 33744816535 scopus 로고    scopus 로고
    • Bioenergetic abnormalities in discrete cerebral motor pathways presage spinal cord pathology in the G93A SOD1 mouse model of ALS
    • Browne SE, et al. (2006) Bioenergetic abnormalities in discrete cerebral motor pathways presage spinal cord pathology in the G93A SOD1 mouse model of ALS. Neurobiol Dis 22(3):599-610.
    • (2006) Neurobiol Dis , vol.22 , Issue.3 , pp. 599-610
    • Browne, S.E.1
  • 40
    • 77954659191 scopus 로고    scopus 로고
    • Inhibition of glycogen biosynthesis via mTORC1 suppression as an adjunct therapy for Pompe disease
    • Ashe KM, et al. (2010) Inhibition of glycogen biosynthesis via mTORC1 suppression as an adjunct therapy for Pompe disease. Mol Genet Metab 100(4):309-315.
    • (2010) Mol Genet Metab , vol.100 , Issue.4 , pp. 309-315
    • Ashe, K.M.1
  • 41
    • 79953647105 scopus 로고    scopus 로고
    • Rapamycin treatment augments motor neuron degeneration in SOD1(G93A) mouse model of amyotrophic lateral sclerosis
    • Zhang X, et al. (2011) Rapamycin treatment augments motor neuron degeneration in SOD1(G93A) mouse model of amyotrophic lateral sclerosis. Autophagy 7(4):412-425.
    • (2011) Autophagy , vol.7 , Issue.4 , pp. 412-425
    • Zhang, X.1
  • 43
    • 34249980373 scopus 로고    scopus 로고
    • An immunological epitope selective for pathological monomermisfolded SOD1 in ALS
    • Rakhit R, et al. (2007) An immunological epitope selective for pathological monomermisfolded SOD1 in ALS. Nat Med 13(6):754-759.
    • (2007) Nat Med , vol.13 , Issue.6 , pp. 754-759
    • Rakhit, R.1
  • 44
    • 35348874857 scopus 로고    scopus 로고
    • Soluble misfolded subfractions of mutant superoxide dismutase-1s are enriched in spinal cords throughout life in murine ALS models
    • Zetterström P, et al. (2007) Soluble misfolded subfractions of mutant superoxide dismutase-1s are enriched in spinal cords throughout life in murine ALS models. Proc Natl Acad Sci USA 104(35):14157-14162.
    • (2007) Proc Natl Acad Sci USA , vol.104 , Issue.35 , pp. 14157-14162
    • Zetterström, P.1
  • 45
    • 0029134532 scopus 로고
    • Amyotrophic lateral sclerosis: Predictors for prolongation of life by noninvasive respiratory aids
    • Bach JR (1995) Amyotrophic lateral sclerosis: Predictors for prolongation of life by noninvasive respiratory aids. Arch Phys Med Rehabil 76(9):828-832.
    • (1995) Arch Phys Med Rehabil , vol.76 , Issue.9 , pp. 828-832
    • Bach, J.R.1
  • 46
    • 77951819187 scopus 로고    scopus 로고
    • Prolonging survival in amyotrophic lateral sclerosis: Efficacy of noninvasive ventilation and uncuffed tracheostomy tubes
    • Sancho J, Servera E, Bañuls P, Marín J (2010) Prolonging survival in amyotrophic lateral sclerosis: Efficacy of noninvasive ventilation and uncuffed tracheostomy tubes. Am J Phys Med Rehabil 89(5):407-411.
    • (2010) Am J Phys Med Rehabil , vol.89 , Issue.5 , pp. 407-411
    • Sancho, J.1    Servera, E.2    Bañuls, P.3    Marín, J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.