Functional pattern of brain FDG-PET in amyotrophic lateral sclerosis

Neurology

Volumn 83, Issue 12, 2014, Pages 1067-1074

  Pagani, Marco ^a,b   Chiò, Adriano ^c   Valentini, Maria Consuelo ^d   Öberg, Johanna ^b   Nobili, Flavio ^e   Calvo, Andrea ^c   Moglia, Cristina ^c   Bertuzzo, Davide ^c   Morbelli, Silvia ^f   De Carli, Fabrizio ^g   Fania, Piercarlo ^h   Cistaro, Angelina ^a,h  

^a INSTITUTE OF COGNITIVE SCIENCES AND TECHNOLOGIES   (Italy)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c UNIVERSITY OF TURIN   (Italy)

^d CTO HOSPITAL   (Italy)

^e CTO Hospital ^*  (United States)

^f UNIVERSITY OF GENOA   (Italy)

^g CNR   (Italy)

^h Euromedic Inc   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

FLUORODEOXYGLUCOSE F 18; RADIOPHARMACEUTICAL AGENT;

ADULT; AGED; AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; BRAIN FUNCTION; BRAIN SIZE; CEREBELLUM; COMPARATIVE STUDY; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG UPTAKE; FEMALE; FOLLOW UP; FRONTAL CORTEX; HIPPOCAMPUS; HUMAN; HYPERMETABOLISM; MAJOR CLINICAL STUDY; MALE; MESENCEPHALON; MOTOR CORTEX; OCCIPITAL CORTEX; PET-CT SCANNER; POSITRON EMISSION TOMOGRAPHY; PREFRONTAL CORTEX; PREMOTOR CORTEX; PRIORITY JOURNAL; PYRAMIDAL TRACT; SENSITIVITY AND SPECIFICITY; SUPERIOR TEMPORAL GYRUS; VERY ELDERLY; VISUAL CORTEX; WHITE MATTER; BRAIN; CASE CONTROL STUDY; DIAGNOSTIC USE; DISCRIMINANT ANALYSIS; MIDDLE AGED; NERVE TRACT; SCINTISCANNING; YOUNG ADULT;

ADULT; AGED; AGED, 80 AND OVER; AMYOTROPHIC LATERAL SCLEROSIS; BRAIN; CASE-CONTROL STUDIES; DISCRIMINANT ANALYSIS; FEMALE; FLUORODEOXYGLUCOSE F18; HUMANS; MALE; MIDDLE AGED; NEURAL PATHWAYS; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; SENSITIVITY AND SPECIFICITY; YOUNG ADULT;

EID: 84919396244     PISSN: 00283878     EISSN: 1526632X     Source Type: Journal    
DOI: 10.1212/WNL.0000000000000792     Document Type: Article

References (39)

1. Brooks BR, Miller RG, Swash M, et al. El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis. Amyotroph Lateral Scler Other Motor Neuron Disord 2000;1:293-299.
2. Pasinetti GM, Ungar LH, Lange DJ, et al. Identification of potential CSF biomarkers in ALS. Neurology 2006;66: 1218-1222.
3. Filippini N, Douaud G,Mackay CE, et al. Corpus callosum involvement is a consistent feature of amyotrophic lateral sclerosis. Neurology 2010;75:1645-1652.
4. Magistretti PJ. Cellular bases of functional brain imaging: insights from neuron-glia metabolic coupling. Brain Res 2000;886:108-112.
5. Schroeter M, Dennin MA, WalbererM, et al. Neuroinflammation extends brain tissue at risk to vital peri-infarct tissue: a double tracer [11C]PK11195-and [18F]FDG-PET study. J Cereb Blood Flow Metab 2009;29:1216-1225.
6. Claassen DO, Josephs KA, Peller PJ. The stripe of primary lateral sclerosis: focal primary motor cortex hypometabolism seen on fluorodeoxyglucose F18 positron emission tomography. Arch Neurol 2010;67:122-125.
7. Dalakas MC, Hatazawa J, Brooks RA, et al. Lowered cerebral glucose utilization in amyotrophic lateral sclerosis. Ann Neurol 1987;22:580-586.
8. Peavy GM, Herzog AG, Rubin NP, et al. Neuropsychological aspects of dementia of motor neuron disease: a report of two cases. Neurology 1992;42:1004-1008.
9. Ludolph AC, Langen KJ, Regard M, et al. Frontal lobe function in amyotrophic lateral sclerosis: a neuropsychologic and positron emission tomography study. Acta Neurol Scand 1992;85:81-89.
10. Cistaro A, Valentini MC, Chiò A, et al. Brain hypermetabolism in amyotrophic lateral sclerosis: a FDG PET study in ALS of spinal and bulbar onset. Eur J Nucl Med Mol Imaging 2012;39:251-259.
11. Varrone A, Asenbaum S, Vander Borght T, et al. EANM procedure guidelines for PET brain imaging using [18F]FDG, version 2. Eur J Nucl Med Mol Imaging 2009;36:2103-2110.
12. Morbelli S, Rodriguez G, Mignone A, et al. The need of appropriate brain SPECT templates for SPM comparisons. Q J Nucl Med Mol Imaging 2008;52:89-98.
13. Morbelli S, Drzezga A, Perneczky R, et al. Resting metabolic connectivity in prodromal Alzheimer's disease. A European Alzheimer Disease Consortium (EADC) project. Neurobiol Aging 2012;33:2533-2550.
14. Cistaro A, Pagani M, Montuschi A, et al. The metabolic signature of C9ORF72-related ALS: FDG PET comparison with non-mutated patients. Eur J Nucl Med Mol Imaging 2014;41:844-852.
15. Phukan J, Elamin M, Bede P, et al. The syndrome of cognitive impairment in amyotrophic lateral sclerosis: a population-based study. J Neurol Neurosurg Psychiatry 2012;83:102-108.
16. Bede P, Bokde A, Elamin M, et al. Grey matter correlates of clinical variables in amyotrophic lateral sclerosis (ALS): a neuroimaging study of ALS motor phenotype heterogeneity and cortical focality. J Neurol Neurosurg Psychiatry 2013;84:766-773.
17. Bede P, Bokde AL, Byrne S, et al. Multiparametric MRI study of ALS stratified for the C9orf72 genotype. Neurology 2013;81:361-369.
18. Verstraete E, Veldink JH, Hendrikse J, Schelhaas HJ, van den Heuvel MP, van den Berg LH. Structural MRI reveals cortical thinning in amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry 2012;83:383-388.
19. Lloyd CM, Richardson MP, Brooks DJ, et al. Extramotor involvement in ALS: PET studies with the GABA(A) ligand [(11)C]flumazenil. Brain 2000;123:2289-2296.
20. Yamanaka K, Chun SJ, Boillee S, et al. Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis. Nat Neurosci 2008;11:251-253.
21. Turner MR, Cagnin A, Turkheimer FE, et al. Evidence of widespread cerebral microglial activation in amyotrophic lateral sclerosis: an [11C](R)-PK11195 positron emission tomography study. Neurobiol Dis 2004;15:601-609.
22. Marik J, Ogasawara A, Martin-McNulty B, et al. PET of glial metabolism using 2-18F-fluoroacetate. J Nucl Med 2009;50:982-990.
23. Kushner PD, Stephenson DT, Wright S. Reactive astrogliosis is widespread in the subcortical white matter of amyotrophic lateral sclerosis brain. J Neuropathol Exp Neurol 1991;50:263-277.
24. Barbeito LH, Pehar M, Cassina P, et al. A role for astrocytes in motor neuron loss in amyotrophic lateral sclerosis. Brain Res Brain Res Rev 2004;47:263-274.
25. Philips T, Robberecht W. Neuroinflammation in amyotrophic lateral sclerosis: role of glial activation in motor neuron disease. Lancet Neurol 2011;10:253-263.
26. Johansson A, Engler H, Blomqvist G, et al. Evidence for astrocytosis in ALS demonstrated by [11C](L)-deprenyl-D2 PET. J Neurol Sci 2007;255:17-22.
27. Corcia P, Tauber C, Vercoullie J, et al. Molecular imaging of microglial activation in amyotrophic lateral sclerosis. PLoS One 2012;7:e52941.
28. Nehlig A, Coles J. Cellular pathways of energy metabolism in the brain: is glucose used by neurons or astrocytes? Glia 2007;55:1238-1250.
29. Pellerin L, Magistretti PJ. Sweet sixteen for ANLS. J Cereb Blood Flow Metab 2012;32:1152-1166.
30. Pioro EP, Majors AW, Mitsumoto H, et al. 1H-MRS evidence of neurodegeneration and excess glutamate 1 glutamine in ALS medulla. Neurology 1999;53:71-79.
31. Sage CA, Peeters RR, Görner A, et al. Quantitative diffusion tensor imaging in amyotrophic lateral sclerosis. Neuroimage 2007;34:486-499.
32. Traynor BJ, Codd MB, Corr B, Forde C, Frost E, Hardiman O. Amyotrophic lateral sclerosis mimic syndromes: a population-based study. Arch Neurol 2000; 57:109-113.
33. Shao J, Myers N, Yang Q, et al. Prediction of Alzheimer's disease using individual structural connectivity networks. Neurobiol Aging 2012;33:2756-2765.
34. Kakimoto A, Kamekawa Y, Ito S, et al. New computeraided diagnosis of dementia using positron emission tomography: brain regional sensitivity-mapping method. PLoS One 2011;6:e25033.
35. Mitchell RM, Freeman WM, Randazzo WT, et al. A CSF biomarker panel for identification of patients with amyotrophic lateral sclerosis. Neurology 2009;72:14-19.
36. Schuster C, Kasper E, Dyrba M, et al. Cortical thinning and its relation to cognition in amyotrophic lateral sclerosis. Neurobiol Aging 2014;35:240-246.
37. Pettit LD, Bastin ME, Smith C, Bak TH, Gillingwater TH, Abrahams S. Executive deficits, not processing speed relates to abnormalities in distinct prefrontal tracts in amyotrophic lateral sclerosis. Brain 2013;136: 3290-3304.
38. Sarro L, Agosta F, Canu E, et al. Cognitive functions and white matter tract damage in amyotrophic lateral sclerosis: a diffusion tensor tractography study. AJNR Am J Neuroradiol 2011;32:1866-1872.
39. Turner MR, Kiernan MC, Leigh PN, et al. Biomarkers in amyotrophic lateral sclerosis. Lancet Neurol 2009;8: 94-109.