Altered expression of metabolic proteins and adipokines in patients with amyotrophic lateral sclerosis

Journal of the Neurological Sciences

Volumn 357, Issue 1-2, 2015, Pages 22-27

  Ngo, S T ^a,b,c   Steyn, F J ^a,b   Huang, L ^a   Mantovani, S ^a,d   Pfluger, C M M ^b   Woodruff, T M ^a   O'Sullivan, J D ^a,c   Henderson, R D ^c   McCombe, P A ^a,b,c  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

^d Wesley Research Institute   (Australia)

Author keywords

Adipokines; Adipose; Amyotrophic lateral sclerosis; Body mass index; Metabolism; Neurodegeneration

Indexed keywords

ADIPOCYTOKINE; ADIPONECTIN; AMYLIN; C PEPTIDE; GASTRIC INHIBITORY POLYPEPTIDE; GHRELIN; GLUCAGON; INSULIN; INTERLEUKIN 6; INTERLEUKIN 8; LEPTIN; MONOCYTE CHEMOTACTIC PROTEIN 1; NERVE GROWTH FACTOR; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; PANCREAS POLYPEPTIDE; PEPTIDE YY; PLASMINOGEN ACTIVATOR INHIBITOR 1; RESISTIN; RILUZOLE; SCATTER FACTOR; TUMOR NECROSIS FACTOR ALPHA; ACUTE PHASE PROTEIN; LCN2 PROTEIN, HUMAN; LIPOCALIN; ONCOPROTEIN; PLASMA PROTEIN; TUMOR NECROSIS FACTOR;

ADULT; ALS FUNCTIONAL RATING SCALE; AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; BODY MASS; CLINICAL FEATURE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE DURATION; FEMALE; GLUCAGON BLOOD LEVEL; GLUCOSE HOMEOSTASIS; HUMAN; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; NEUROLOGIC DISEASE ASSESSMENT; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RATING SCALE; SEX DIFFERENCE; BLOOD; CASE CONTROL STUDY; GENE EXPRESSION PROFILING; METABOLISM; SEVERITY OF ILLNESS INDEX;

ACUTE-PHASE PROTEINS; ADIPOKINES; AMYOTROPHIC LATERAL SCLEROSIS; BLOOD PROTEINS; BODY MASS INDEX; CASE-CONTROL STUDIES; FEMALE; GASTRIC INHIBITORY POLYPEPTIDE; GENE EXPRESSION PROFILING; GHRELIN; GLUCAGON; HUMANS; INTERLEUKIN-6; INTERLEUKIN-8; LIPOCALINS; MALE; METABOLISM; MIDDLE AGED; NERVE GROWTH FACTOR; PANCREATIC POLYPEPTIDE; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTO-ONCOGENE PROTEINS; SEVERITY OF ILLNESS INDEX; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84956579128     PISSN: 0022510X     EISSN: 18785883     Source Type: Journal    
DOI: 10.1016/j.jns.2015.06.053     Document Type: Article

References (56)

1. J.D. Rothstein Current hypotheses for the underlying biology of amyotrophic lateral sclerosis Ann. Neurol. 65 Suppl. 1 2009 S3 S9
2. I.P. Blair, K.L. Williams, S.T. Warraich, J.C. Durnall, A.D. Thoeng, J. Manavis, P.C. Blumbergs, S. Vucic, M.C. Kiernan, G.A. Nicholson FUS mutations in amyotrophic lateral sclerosis: clinical, pathological, neurophysiological and genetic analysis J. Neurol. Neurosurg. Psychiatry 81 2009 639 645
3. M. DeJesus-Hernandez, I.R. Mackenzie, B.F. Boeve, A.L. Boxer, M. Baker, N.J. Rutherford, A.M. Nicholson, N.A. Finch, H. Flynn, J. Adamson, N. Kouri, A. Wojtas, P. Sengdy, G.Y. Hsiung, A. Karydas, W.W. Seeley, K.A. Josephs, G. Coppola, D.H. Geschwind, Z.K. Wszolek, H. Feldman, D.S. Knopman, R.C. Petersen, B.L. Miller, D.W. Dickson, K.B. Boylan, N.R. Graff-Radford, R. Rademakers Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS Neuron 72 2011 245 256
4. E. Kabashi, P.N. Valdmanis, P. Dion, D. Spiegelman, B.J. McConkey, C. Vande Velde, J.P. Bouchard, L. Lacomblez, K. Pochigaeva, F. Salachas, P.F. Pradat, W. Camu, V. Meininger, N. Dupre, G.A. Rouleau TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis Nat. Genet. 40 2008 572 574
5. H. Maruyama, H. Morino, H. Ito, Y. Izumi, H. Kato, Y. Watanabe, Y. Kinoshita, M. Kamada, H. Nodera, H. Suzuki, O. Komure, S. Matsuura, K. Kobatake, N. Morimoto, K. Abe, N. Suzuki, M. Aoki, A. Kawata, T. Hirai, T. Kato, K. Ogasawara, A. Hirano, T. Takumi, H. Kusaka, K. Hagiwara, R. Kaji, H. Kawakami Mutations of optineurin in amyotrophic lateral sclerosis Nature 465 2010 223 226
6. V.K. Mulligan, A. Chakrabartty Protein misfolding in the late-onset neurodegenerative diseases: common themes and the unique case of amyotrophic lateral sclerosis Proteins 81 2013 1285 1303
7. P.J. Shaw, P.G. Ince Glutamate, excitotoxicity and amyotrophic lateral sclerosis J. Neurol. 244 Suppl. 2 1997 S3 S14
8. V. Crugnola, C. Lamperti, V. Lucchini, D. Ronchi, L. Peverelli, A. Prelle, M. Sciacco, A. Bordoni, E. Fassone, F. Fortunato, S. Corti, V. Silani, N. Bresolin, S. Di Mauro, G.P. Comi, M. Moggio Mitochondrial respiratory chain dysfunction in muscle from patients with amyotrophic lateral sclerosis Arch. Neurol. 67 2010 849 854
9. A.M. Haidet-Phillips, M.E. Hester, C.J. Miranda, K. Meyer, L. Braun, A. Frakes, S. Song, S. Likhite, M.J. Murtha, K.D. Foust, M. Rao, A. Eagle, A. Kammesheidt, A. Christensen, J.R. Mendell, A.H. Burghes, B.K. Kaspar Astrocytes from familial and sporadic ALS patients are toxic to motor neurons Nat. Biotechnol. 29 2011 824 828
10. K. Yamanaka, S.J. Chun, S. Boillee, N. Fujimori-Tonou, H. Yamashita, D.H. Gutmann, R. Takahashi, H. Misawa, D.W. Cleveland Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis Nat. Neurosci. 11 2008 251 253
11. A.E. Renton, A. Chio, B.J. Traynor State of play in amyotrophic lateral sclerosis genetics Nat. Neurosci. 17 2014 17 23
12. J.C. Desport, F. Torny, M. Lacoste, P.M. Preux, P. Couratier Hypermetabolism in ALS: correlations with clinical and paraclinical parameters Neurodegener. Dis. 2 2005 202 207
13. B. Funalot, J.C. Desport, F. Sturtz, W. Camu, P. Couratier High metabolic level in patients with familial amyotrophic lateral sclerosis Amyotroph. Lateral Scler. 10 2009 113 117
14. E.J. Kasarskis, S. Berryman, J.G. Vanderleest, A.R. Schneider, C.J. McClain Nutritional status of patients with amyotrophic lateral sclerosis: relation to the proximity of death Am. J. Clin. Nutr. 63 1996 130 137
15. T. Shimizu, U. Nagaoka, Y. Nakayama, A. Kawata, C. Kugimoto, Y. Kuroiwa, M. Kawai, T. Shimohata, M. Nishizawa, B. Mihara, H. Arahata, N. Fujii, R. Namba, H. Ito, T. Imai, K. Nobukuni, K. Kondo, M. Ogino, T. Nakajima, T. Komori Reduction rate of body mass index predicts prognosis for survival in amyotrophic lateral sclerosis: a multicenter study in Japan Amyotroph. Lateral Scler. 13 2012 363 366
16. L. Dupuis, H. Oudart, F. Rene, J.L. Gonzalez de Aguilar, J.P. Loeffler Evidence for defective energy homeostasis in amyotrophic lateral sclerosis: benefit of a high-energy diet in a transgenic mouse model Proc. Natl. Acad. Sci. U. S. A. 101 2004 11159 11164
17. A.M. Wills, J. Hubbard, E.A. Macklin, J. Glass, R. Tandan, E.P. Simpson, B. Brooks, D. Gelinas, H. Mitsumoto, T. Mozaffar, G.P. Hanes, S.S. Ladha, T. Heiman-Patterson, J. Katz, J.S. Lou, K. Mahoney, D. Grasso, R. Lawson, H. Yu, M. Cudkowicz, M.D.A.C.R. Network Hypercaloric enteral nutrition in patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled phase 2 trial Lancet 383 2014 2065 2072
18. S. Paganoni, J. Deng, M. Jaffa, M.E. Cudkowicz, A.M. Wills Body mass index, not dyslipidemia, is an independent predictor of survival in amyotrophic lateral sclerosis Muscle Nerve 44 2011 20 24
19. J.M. Cedarbaum, N. Stambler, E. Malta, C. Fuller, D. Hilt, B. Thurmond, A. Nakanishi The ALSFRS-R: a revised ALS functional rating scale that incorporates assessments of respiratory function. BDNF ALS study group (Phase III) J. Neurol. Sci. 169 1999 13 21
20. B.R. Brooks, R.G. Miller, M. Swash, T.L. Munsat World Federation of Neurology Research Group on Motor Neuron D. El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis Amyotroph. Lateral Scler. Other Motor Neuron Disord. 1 2000 293 299
21. M. Kojima, K. Kangawa Ghrelin, an orexigenic signaling molecule from the gastrointestinal tract Curr. Opin. Pharmacol. 2 2002 665 668
22. N. Limousin, H. Blasco, P. Corcia, P.H. Gordon, B. De Toffol, C. Andres, J. Praline Malnutrition at the time of diagnosis is associated with a shorter disease duration in ALS J. Neurol. Sci. 297 2010 36 39
23. T. Matsuo, N. Murayama, R. Ogino, N. Inomata, T. Inoue, M. Furuya Ghrelin attenuates disease progression in a mouse model of amyotrophic lateral sclerosis International Symposium on Amyotrophic Lateral Sclerosis and Motor Neurone Disease 2013 2013 (Milan, Italy)
24. R.M. Elliott, L.M. Morgan, J.A. Tredger, S. Deacon, J. Wright, V. Marks Glucagon-like peptide-1 (7-36)amide and glucose-dependent insulinotropic polypeptide secretion in response to nutrient ingestion in man: acute post-prandial and 24-h secretion patterns J. Endocrinol. 138 1993 159 166
25. L.A. Slezak, D.K. Andersen Pancreatic resection: effects on glucose metabolism World J. Surg. 25 2001 452 460
26. P.F. Pradat, G. Bruneteau, P.H. Gordon, L. Dupuis, D. Bonnefont-Rousselot, D. Simon, F. Salachas, P. Corcia, V. Frochot, J.M. Lacorte, C. Jardel, C. Coussieu, N.L. Forestier, L. Lacomblez, J.P. Loeffler, V. Meininger Impaired glucose tolerance in patients with amyotrophic lateral sclerosis Amyotroph. Lateral Scler. 11 2010 166 171
27. C.M. Rondinone Adipocyte-derived hormones, cytokines, and mediators Endocrine 29 2006 81 90
28. P.J. Klover, A.H. Clementi, R.A. Mooney Interleukin-6 depletion selectively improves hepatic insulin action in obesity Endocrinology 146 2005 3417 3427
29. M.A. Febbraio, N. Hiscock, M. Sacchetti, C.P. Fischer, B.K. Pedersen Interleukin-6 is a novel factor mediating glucose homeostasis during skeletal muscle contraction Diabetes 53 2004 1643 1648
30. J.M. Bruun, C. Verdich, S. Toubro, A. Astrup, B. Richelsen Association between measures of insulin sensitivity and circulating levels of interleukin-8, interleukin-6 and tumor necrosis factor-alpha. Effect of weight loss in obese men Eur. J. Endocrinol. 148 2003 535 542
31. C.S. Kim, H.S. Park, T. Kawada, J.H. Kim, D. Lim, N.E. Hubbard, B.S. Kwon, K.L. Erickson, R. Yu Circulating levels of MCP-1 and IL-8 are elevated in human obese subjects and associated with obesity-related parameters Int. J. Obes. (Lond.) 30 2006 1347 1355
32. E.J. Giltay, J.M. Elbers, L.J. Gooren, J.J. Emeis, T. Kooistra, H. Asscheman, C.D. Stehouwer Visceral fat accumulation is an important determinant of PAI-1 levels in young, nonobese men and women: modulation by cross-sex hormone administration Arterioscler. Thromb. Vasc. Biol. 18 1998 1716 1722
33. T. Nakamura, H. Adachi, Y. Hirai, A. Satoh, M. Ohuchida, T. Imaizumi Association of plasminogen activator inhibitor-1 with insulin resistance in Japan where obesity is rare Metabolism 52 2003 226 229
34. C.M. Paton, M.P. Rogowski, A.L. Kozimor, J.L. Stevenson, H. Chang, J.A. Cooper Lipocalin-2 increases fat oxidation in vitro and is correlated with energy expenditure in normal weight but not obese women Obesity (Silver Spring) 21 2013 E640 E648
35. E.T. Reyes, O.H. Perurena, B.W. Festoff, R. Jorgensen, W.V. Moore Insulin resistance in amyotrophic lateral sclerosis J. Neurol. Sci. 63 1984 317 324
36. J.D. Lee, J.Y. Lee, S.M. Taylor, P.G. Noakes, T.M. Woodruff Innate immunity in ALS M. Maurer Amyotrophic Lateral Sclerosis 2012
37. J.L. Elliott Cytokine upregulation in a murine model of familial amyotrophic lateral sclerosis Brain Res. Mol. Brain Res. 95 2001 172 178
38. F. Bi, C. Huang, J. Tong, G. Qiu, B. Huang, Q. Wu, F. Li, Z. Xu, R. Bowser, X.G. Xia, H. Zhou Reactive astrocytes secrete lcn2 to promote neuron death Proc. Natl. Acad. Sci. U. S. A. 110 2013 4069 4074
39. R.V. Considine, M.K. Sinha, M.L. Heiman, A. Kriauciunas, T.W. Stephens, M.R. Nyce, J.P. Ohannesian, C.C. Marco, L.J. McKee, T.L. Bauer et al. Serum immunoreactive-leptin concentrations in normal-weight and obese humans N. Engl. J. Med. 334 1996 292 295
40. A.A.M. Hassanin, A.K.A. Elhusien, A.M. Osman Does obesity affect the plasma level of plasminogen activator inhibitor-1? And does CO2 pneumoperitoneum affect it? Egypt. J. Anaesth. 29 2013 203 206
41. M. Troseid, K.T. Lappegard, T. Claudi, J.K. Damas, L. Morkrid, R. Brendberg, T.E. Mollnes Exercise reduces plasma levels of the chemokines MCP-1 and IL-8 in subjects with the metabolic syndrome Eur. Heart J. 25 2004 349 355
42. E. Lindauer, L. Dupuis, H.P. Muller, H. Neumann, A.C. Ludolph, J. Kassubek Adipose tissue distribution predicts survival in amyotrophic lateral sclerosis PLoS One 8 2013 e67783
43. N. Stefan, B. Vozarova, T. Funahashi, Y. Matsuzawa, C. Weyer, R.S. Lindsay, J.F. Youngren, P.J. Havel, R.E. Pratley, C. Bogardus, P.A. Tataranni Plasma adiponectin concentration is associated with skeletal muscle insulin receptor tyrosine phosphorylation, and low plasma concentration precedes a decrease in whole-body insulin sensitivity in humans Diabetes 51 2002 1884 1888
44. S.M. Kuo, M.M. Halpern Lack of association between body mass index and plasma adiponectin levels in healthy adults Int. J. Obes. (Lond.) 35 2011 1487 1494
45. M. Ryo, T. Nakamura, S. Kihara, M. Kumada, S. Shibazaki, M. Takahashi, M. Nagai, Y. Matsuzawa, T. Funahashi Adiponectin as a biomarker of the metabolic syndrome Circ. J. 68 2004 975 981
46. R.W. Hubbard, A.D. Will, G.W. Peterson, A. Sanchez, W.W. Gillan, S.A. Tan Elevated plasma glucagon in amyotrophic lateral sclerosis Neurology 42 1992 1532 1534
47. M.D. Harris, M.B. Davidson, C.S. Rosenberg Insulin antagonism is not a primary abnormality of amyotrophic lateral sclerosis but is related to disease severity J. Clin. Endocrinol. Metab. 63 1986 41 46
48. M. Bullo, M.R. Peeraully, P. Trayhurn, J. Folch, J. Salas-Salvado Circulating nerve growth factor levels in relation to obesity and the metabolic syndrome in women Eur. J. Endocrinol. 157 2007 303 310
49. S. Yanev, L. Aloe, M. Fiore, G. Chaldakov Neurotrophic and metabotrophic potential of nerve growth factor and brain-derived neurotrophic factor: linking cardiometabolic and neuropsychiatric diseases World J. Pharmacol. 2 2013 92 99
50. H.J. Stuerenburg, K. Kunze Tissue nerve growth factor concentrations in neuromuscular diseases Eur. J. Neurol. 5 1998 487 490
51. L. Ferraiuolo, A. Higginbottom, P.R. Heath, S. Barber, D. Greenald, J. Kirby, P.J. Shaw Dysregulation of astrocyte-motoneuron cross-talk in mutant superoxide dismutase 1-related amyotrophic lateral sclerosis Brain 134 2011 2627 2641
52. P.A. McCombe, R.D. Henderson Effects of gender in amyotrophic lateral sclerosis Gend. Med. 7 2010 557 570
53. A. Hiratsuka, H. Adachi, Y. Fujiura, S. Yamagishi, Y. Hirai, M. Enomoto, A. Satoh, A. Hino, K. Furuki, T. Imaizumi Strong association between serum hepatocyte growth factor and metabolic syndrome J. Clin. Endocrinol. Metab. 90 2005 2927 2931
54. X. Hou, L. Sun, Z. Li, H. Mou, Z. Yu, H. Li, P. Jiang, D. Yu, H. Wu, X. Ye, X. Lin, Y. Le Associations of amylin with inflammatory markers and metabolic syndrome in apparently healthy Chinese PLoS One 6 2011 e24815
55. S.M. Boekholdt, R.J. Peters, C.E. Hack, N.E. Day, R. Luben, S.A. Bingham, N.J. Wareham, P.H. Reitsma, K.T. Khaw IL-8 plasma concentrations and the risk of future coronary artery disease in apparently healthy men and women: the EPIC-Norfolk prospective population study Arterioscler. Thromb. Vasc. Biol. 24 2004 1503 1508
56. J. Makovey, V. Naganathan, M. Seibel, P. Sambrook Gender differences in plasma ghrelin and its relations to body composition and bone - an opposite-sex twin study Clin. Endocrinol. (Oxf) 66 2007 530 537