메뉴 건너뛰기




Volumn 69, Issue 4, 1997, Pages 1484-1490

A temporary local energy pool coupled to neuronal activity: Fluctuations of extracellular lactate levels in rat brain monitored with rapid-response enzyme-based sensor

Author keywords

Blood brain barrier; Brain extracellular fluid; Extracellular glucose and oxygen levels; Lactate sensor; Lactic acid; Neuronal activity; Rat brain; Regional blood flow

Indexed keywords

GLUCOSE; LACTIC ACID;

EID: 0030931102     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1997.69041484.x     Document Type: Article
Times cited : (279)

References (39)
  • 1
    • 0025044931 scopus 로고
    • Microdialysis - Theory and application
    • Benveniste H. and Huttemeier P. C. (1990) Microdialysis - theory and application. Prog. Neurobiol. 35, 195-215.
    • (1990) Prog. Neurobiol. , vol.35 , pp. 195-215
    • Benveniste, H.1    Huttemeier, P.C.2
  • 2
    • 0027438537 scopus 로고
    • Is brain a gluconeogenic organ? Mol
    • Bhattacharya S. B. and Datta A. G. (1993) Is brain a gluconeogenic organ? Mol. Cell. Biochem. 125, 51-57.
    • (1993) Cell. Biochem. , vol.125 , pp. 51-57
    • Bhattacharya, S.B.1    Datta, A.G.2
  • 3
    • 1842274662 scopus 로고
    • Selective distribution of lactate dehydrogenase (LDH) isoenzymes in neurons and astrocytes: Evidence for activity-dependent metabolic trafficking
    • Bittar P. G., Charnay Y., Kiraly M., Pellerin L., Bouras C., and Magistretti P. J. (1995) Selective distribution of lactate dehydrogenase (LDH) isoenzymes in neurons and astrocytes: evidence for activity-dependent metabolic trafficking. Soc. Neurosci. Abstr. 21, 1668.
    • (1995) Soc. Neurosci. Abstr. , vol.21 , pp. 1668
    • Bittar, P.G.1    Charnay, Y.2    Kiraly, M.3    Pellerin, L.4    Bouras, C.5    Magistretti, P.J.6
  • 4
    • 0020509440 scopus 로고
    • Relationships between extraction and metabolism of glucose, blood flow, and tissue blood volume in regions of rat brain
    • Cremer J. E., Cunningham V. J., and Seville M. P. (1983) Relationships between extraction and metabolism of glucose, blood flow, and tissue blood volume in regions of rat brain. J. Cereb. Blood Flow Metab. 3, 291-302.
    • (1983) J. Cereb. Blood Flow Metab. , vol.3 , pp. 291-302
    • Cremer, J.E.1    Cunningham, V.J.2    Seville, M.P.3
  • 5
    • 0025152141 scopus 로고
    • Effects of stress and exercise on rat hippocampus and striatum extracellular lactate
    • De Bruin L. A., Schasfoort E. M. C., Steffens A. B., and Korf J. (1990) Effects of stress and exercise on rat hippocampus and striatum extracellular lactate. Am. J. Physiol. 259, R773-R779.
    • (1990) Am. J. Physiol. , vol.259
    • De Bruin, L.A.1    Schasfoort, E.M.C.2    Steffens, A.B.3    Korf, J.4
  • 6
    • 0027216810 scopus 로고
    • Glycogen in astrocytes: Possible function as lactate supply for neighboring cells
    • Dringen R., Gebhardt R., and Hamprecht B. (1993) Glycogen in astrocytes: possible function as lactate supply for neighboring cells. Brain Res. 623, 208-214.
    • (1993) Brain Res. , vol.623 , pp. 208-214
    • Dringen, R.1    Gebhardt, R.2    Hamprecht, B.3
  • 7
    • 0015107695 scopus 로고
    • Alterations in intracranial pressure, blood-brain barrier, and brain edema after sub-chronic implantation of a cannula into the brain of conscious animals
    • Edvinsson L., Nielsen K. C., Owman C., and West K. A. (1971) Alterations in intracranial pressure, blood-brain barrier, and brain edema after sub-chronic implantation of a cannula into the brain of conscious animals. Acta Phvsiol. Scand. 82, 527-531.
    • (1971) Acta Phvsiol. Scand. , vol.82 , pp. 527-531
    • Edvinsson, L.1    Nielsen, K.C.2    Owman, C.3    West, K.A.4
  • 8
    • 0027477404 scopus 로고
    • Rapid changes in extracellular glucose levels and blood flow in the striatum of the freely moving rat
    • Fellows L. K. and Boutelle M. G. (1993) Rapid changes in extracellular glucose levels and blood flow in the striatum of the freely moving rat. Brain Res. 604, 225-231.
    • (1993) Brain Res. , vol.604 , pp. 225-231
    • Fellows, L.K.1    Boutelle, M.G.2
  • 9
    • 0027512740 scopus 로고
    • Physiological stimulation increases nonoxidative glucose metabolism in the brain of the freely moving rat
    • Fellows L. K., Boutelle M. G., and Fillenz M. (1993) Physiological stimulation increases nonoxidative glucose metabolism in the brain of the freely moving rat. J. Neurochem. 60, 1258-1263.
    • (1993) J. Neurochem. , vol.60 , pp. 1258-1263
    • Fellows, L.K.1    Boutelle, M.G.2    Fillenz, M.3
  • 10
    • 0030061041 scopus 로고    scopus 로고
    • Dephosphorylation of 2-deoxyglucose 6-phosphate and 2-deoxyglucose export from cultured astrocytes
    • Forsyth R. J., Bartlett K., and Eyre J. (1996) Dephosphorylation of 2-deoxyglucose 6-phosphate and 2-deoxyglucose export from cultured astrocytes. Neurochem. Int. 28, 243-250.
    • (1996) Neurochem. Int. , vol.28 , pp. 243-250
    • Forsyth, R.J.1    Bartlett, K.2    Eyre, J.3
  • 11
    • 0023780085 scopus 로고
    • Non-oxidative glucose consumption during focal physiologic neural activity
    • Fox P. T., Raichle M. E., Mintun M. A., and Dence C. (1988) Non-oxidative glucose consumption during focal physiologic neural activity. Science 241, 462-464.
    • (1988) Science , vol.241 , pp. 462-464
    • Fox, P.T.1    Raichle, M.E.2    Mintun, M.A.3    Dence, C.4
  • 12
    • 0029857160 scopus 로고    scopus 로고
    • The mechanisms controlling physiologically stimulated changes in rat brain glucose and lactate: A microdialysis study
    • Fray A. E., Forsyth R. J., Boutelle M. G., and Fillenz M. (1996) The mechanisms controlling physiologically stimulated changes in rat brain glucose and lactate: a microdialysis study. J. Physiol. (Lond.) 496, 49-57.
    • (1996) J. Physiol. (Lond.) , vol.496 , pp. 49-57
    • Fray, A.E.1    Forsyth, R.J.2    Boutelle, M.G.3    Fillenz, M.4
  • 13
    • 0030894684 scopus 로고    scopus 로고
    • Rapid changes in local extracellular rat brain glucose observed with an in vivo glucose sensor
    • Hu Y. and Wilson G. S. (1997) Rapid changes in local extracellular rat brain glucose observed with an in vivo glucose sensor. J. Neurochem. 68, 1745-1752.
    • (1997) J. Neurochem. , vol.68 , pp. 1745-1752
    • Hu, Y.1    Wilson, G.S.2
  • 14
    • 0028070195 scopus 로고
    • Direct measurement of glutamate release in the brain using a dual enzyme-based electrochemical sensor
    • Hu Y., Mitchell K. M., Albahadily F. N., Michaelis E. K., and Wilson G. S. (1994) Direct measurement of glutamate release in the brain using a dual enzyme-based electrochemical sensor. Brain Res. 659, 117-125.
    • (1994) Brain Res. , vol.659 , pp. 117-125
    • Hu, Y.1    Mitchell, K.M.2    Albahadily, F.N.3    Michaelis, E.K.4    Wilson, G.S.5
  • 15
    • 0023860344 scopus 로고
    • Extracellular lactic acid as an indicator of brain metabolism: Continuous on-line measurement in conscious, freely moving rats with intrastriatal dialysis
    • Kuhr W. G. and Korf J. (1988) Extracellular lactic acid as an indicator of brain metabolism: continuous on-line measurement in conscious, freely moving rats with intrastriatal dialysis. J. Cereb. Blood Flow Metab. 8, 130-137.
    • (1988) J. Cereb. Blood Flow Metab. , vol.8 , pp. 130-137
    • Kuhr, W.G.1    Korf, J.2
  • 16
    • 0024263595 scopus 로고
    • In vivo identification and quantitative evaluation of carrier-mediated transport of lactate at the cellular level in the striatum of conscious, freely moving rats
    • Kuhr W. G., van den Berg C. J., and Korf J. (1988) In vivo identification and quantitative evaluation of carrier-mediated transport of lactate at the cellular level in the striatum of conscious, freely moving rats. J. Cereb. Blood Flow Metab. 8, 848-856.
    • (1988) J. Cereb. Blood Flow Metab. , vol.8 , pp. 848-856
    • Kuhr, W.G.1    Van Den Berg, C.J.2    Korf, J.3
  • 17
    • 0020582922 scopus 로고
    • Lactate uptake and release in the presence of glucose by sympathetic ganglia of chicken embryos and by neuronal and nonneuronal cultures prepared from these ganglia
    • Larrabee M. G. (1983) Lactate uptake and release in the presence of glucose by sympathetic ganglia of chicken embryos and by neuronal and nonneuronal cultures prepared from these ganglia. J. Neurochem. 40, 1237-1250.
    • (1983) J. Neurochem. , vol.40 , pp. 1237-1250
    • Larrabee, M.G.1
  • 18
    • 0026701548 scopus 로고
    • Extracellular intermediates of glucose metabolism: Fluxes of endogenous lactate and alanine through extracellular pools in embryonic sympathetic ganglia
    • Larrabee M. G. (1992) Extracellular intermediates of glucose metabolism: fluxes of endogenous lactate and alanine through extracellular pools in embryonic sympathetic ganglia. J. Neurochem. 59, 1041-1052.
    • (1992) J. Neurochem. , vol.59 , pp. 1041-1052
    • Larrabee, M.G.1
  • 19
    • 0028906312 scopus 로고
    • Lactate metabolism and its effects on glucose metabolism in an excised neural tissue
    • Larrabee M. G. (1995) Lactate metabolism and its effects on glucose metabolism in an excised neural tissue. J. Neurochem. 64, 1734-1741.
    • (1995) J. Neurochem. , vol.64 , pp. 1734-1741
    • Larrabee, M.G.1
  • 20
    • 0001316349 scopus 로고
    • Substances which support respiration and metabolic response to electrical impulses in human cerebral tissues
    • McIlwain H. (1953) Substances which support respiration and metabolic response to electrical impulses in human cerebral tissues. J. Neurol. Neurosurg. Psychiatry 16, 257-266.
    • (1953) J. Neurol. Neurosurg. Psychiatry , vol.16 , pp. 257-266
    • McIlwain, H.1
  • 22
    • 0023200840 scopus 로고
    • Functional receptors for neurotransmitters on astroglial cells
    • Murphy S. and Pearce P. (1987) Functional receptors for neurotransmitters on astroglial cells. Neuroscience 22, 381-394.
    • (1987) Neuroscience , vol.22 , pp. 381-394
    • Murphy, S.1    Pearce, P.2
  • 23
    • 0015788448 scopus 로고
    • Carrier-mediated blood-brain transport of short-chain monocarboxylic organic acids
    • Oldendorf W. H. (1972) Carrier-mediated blood-brain transport of short-chain monocarboxylic organic acids. Am. J. Physiol. 224, 1450-1454.
    • (1972) Am. J. Physiol. , vol.224 , pp. 1450-1454
    • Oldendorf, W.H.1
  • 24
    • 0021020420 scopus 로고
    • Brain metabolism: A perspective from the blood-brain barrier
    • Pardridge W. M. (1983) Brain metabolism: a perspective from the blood-brain barrier. Physiol. Rev. 63, 1481-1535.
    • (1983) Physiol. Rev. , vol.63 , pp. 1481-1535
    • Pardridge, W.M.1
  • 26
    • 0028080101 scopus 로고
    • Glutamate uptake into astrocytes stimulates aerobic glycolysis: A mechanism coupling neuronal activity to glucose utilization
    • Pellerin L. and Magistretti P. J. (1994) Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization. Proc. Natl. Acad. Sci. USA 91, 10625-10629.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 10625-10629
    • Pellerin, L.1    Magistretti, P.J.2
  • 27
    • 1842380480 scopus 로고
    • Deoxyglucose uptake and c-fos expression, two markers of neural activation, are differentially stimulated by glutamate in astrocytes and neurons in vitro
    • Pellerin L., Martin J. L., and Magistretti P. J. (1995) Deoxyglucose uptake and c-fos expression, two markers of neural activation, are differentially stimulated by glutamate in astrocytes and neurons in vitro. Soc. Neurosci. Abstr. 21, 580.
    • (1995) Soc. Neurosci. Abstr. , vol.21 , pp. 580
    • Pellerin, L.1    Martin, J.L.2    Magistretti, P.J.3
  • 29
    • 0029009496 scopus 로고
    • Lactate released by Müller glial cells is metabolized by photoreceptors from mammalian retina
    • Poitry-Yamate C. L., Poitry S., and Tsacopoulos M. (1995) Lactate released by Müller glial cells is metabolized by photoreceptors from mammalian retina. J. Neurosci. 15, 5179-5191.
    • (1995) J. Neurosci. , vol.15 , pp. 5179-5191
    • Poitry-Yamate, C.L.1    Poitry, S.2    Tsacopoulos, M.3
  • 32
    • 0026604694 scopus 로고
    • Lactate and pH change in close correlation in the extracellular space of the rat brain during cortical spreading depression
    • Scheller D., Kolb J., and Tegtmeier F. (1992) Lactate and pH change in close correlation in the extracellular space of the rat brain during cortical spreading depression. Neurosci. Lett. 135, 83-86.
    • (1992) Neurosci. Lett. , vol.135 , pp. 83-86
    • Scheller, D.1    Kolb, J.2    Tegtmeier, F.3
  • 33
    • 0023890868 scopus 로고
    • Lactate-supported synaptic function in the rat hippocampal slice preparation
    • Schurr A., West C. A., and Rigor B. M. (1988) Lactate-supported synaptic function in the rat hippocampal slice preparation. Science 240, 1326-1328.
    • (1988) Science , vol.240 , pp. 1326-1328
    • Schurr, A.1    West, C.A.2    Rigor, B.M.3
  • 34
    • 0031034305 scopus 로고    scopus 로고
    • Brain lactate, not glucose, fuels the recovery of synaptic function from hypoxia upon reoxygeneration; an in vitro study
    • Schurr A., Payne R. S., Miller J., and Rigor B. M. (1997) Brain lactate, not glucose, fuels the recovery of synaptic function from hypoxia upon reoxygeneration; an in vitro study. Brain Res. 744, 105-111.
    • (1997) Brain Res. , vol.744 , pp. 105-111
    • Schurr, A.1    Payne, R.S.2    Miller, J.3    Rigor, B.M.4
  • 35
    • 0020955862 scopus 로고
    • "Epileptic" brain damage in rats induced by sustained electrical stimulation of the perfect path. I. Acute electrophysiological and light microscopic studies
    • Sloviter R. S. (1983) "Epileptic" brain damage in rats induced by sustained electrical stimulation of the perfect path. I. Acute electrophysiological and light microscopic studies. Brain Res. Bull. 10, 675-697.
    • (1983) Brain Res. Bull. , vol.10 , pp. 675-697
    • Sloviter, R.S.1
  • 36
    • 0019829662 scopus 로고
    • Relationship among local functional activity, energy metabolism, and blood flow in the central nervous system
    • Sokoloff L. (1981) Relationship among local functional activity, energy metabolism, and blood flow in the central nervous system. FASEB J. 40, 2311-2316.
    • (1981) FASEB J. , vol.40 , pp. 2311-2316
    • Sokoloff, L.1
  • 37
    • 0017083935 scopus 로고
    • Topographic organization of the projections from the entorhinal area to the hippocampal formation of the rat
    • Steward O. (1976) Topographic organization of the projections from the entorhinal area to the hippocampal formation of the rat. J. Camp. Neurol. 167, 285-314.
    • (1976) J. Camp. Neurol. , vol.167 , pp. 285-314
    • Steward, O.1
  • 38
    • 0029927343 scopus 로고    scopus 로고
    • Metabolic coupling between glia and neurons
    • Tsacopoulos M. and Magistretti P. J. (1996) Metabolic coupling between glia and neurons. J. Neurosci. 16, 877-885.
    • (1996) J. Neurosci. , vol.16 , pp. 877-885
    • Tsacopoulos, M.1    Magistretti, P.J.2
  • 39
    • 0024260649 scopus 로고
    • Lactate release from cultured astrocytes and neurons: A comparison
    • Walz W. and Mukerji S. (1988) Lactate release from cultured astrocytes and neurons: a comparison. Glia 1, 366-370.
    • (1988) Glia , vol.1 , pp. 366-370
    • Walz, W.1    Mukerji, S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.