Muscle mitochondrial uncoupling dismantles neuromuscular junction and triggers distal degeneration of motor neurons

PLoS ONE

Volumn 4, Issue 4, 2009, Pages

  Dupuis, Luc ^a,b   Gonzalez de Aguilar, Jose Luis ^a,b   Echaniz Laguna, Andoni ^a,b,c   Eschbach, Judith ^a,b   Rene, Frédérique ^a,b   Oudart, Hugues ^d   Halter, Benoit ^a,b   Huze, Caroline ^e   Schaeffer, Laurent ^e   Bouillaud, Frédéric ^f   Loeffler, Jean Philippe ^a,b  

^a INSERM   (France)

^b UNIVERSITÉ DE STRASBOURG   (France)

^c UNIVERSITY HOSPITAL OF STRASBOURG   (France)

^d IPHC   (France)

^e UNIVERSITÉ DE LYON   (France)

^f UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLINERGIC RECEPTOR; UNCOUPLING PROTEIN 1; ION CHANNEL; MITOCHONDRIAL PROTEIN; MITOCHONDRIAL UNCOUPLING PROTEIN;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GASTROCNEMIUS MUSCLE; GENE OVEREXPRESSION; MITOCHONDRIAL MEMBRANE POTENTIAL; MOTOR NEURON DISEASE; MOUSE; MUSCLE ATROPHY; MUSCLE DENERVATION; MUSCLE METABOLISM; MUSCLE MITOCHONDRION; NERVE CELL DEGENERATION; NERVE FIBER DEGENERATION; NEUROMUSCULAR JUNCTION DISORDER; NEUROMUSCULAR SYNAPSE; NONHUMAN; OXIDATIVE PHOSPHORYLATION UNCOUPLING; PHENOTYPE; SCIATIC NERVE; TRANSGENIC MOUSE; ANIMAL; ENERGY METABOLISM; GENETICS; METABOLISM; MOTONEURON; NERVE DEGENERATION; PATHOLOGY; SKELETAL MUSCLE;

ANIMALIA; MUS MUSCULUS;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; ENERGY METABOLISM; ION CHANNELS; MICE; MICE, TRANSGENIC; MITOCHONDRIA, MUSCLE; MITOCHONDRIAL PROTEINS; MOTOR NEURONS; MUSCLE, SKELETAL; NERVE DEGENERATION; NEUROMUSCULAR JUNCTION;

EID: 65549128133     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0005390     Document Type: Article

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