메뉴 건너뛰기




Volumn 8, Issue 11, 2016, Pages

Anticancer effects of rosemary (Rosmarinus officinalis L.) extract and rosemary extract polyphenols

Author keywords

Cancer; Carnosic acid; Cell signaling; Proliferation; Rosemary extract; Rosmarinic acid; Survival

Indexed keywords

CARCINOEMBRYONIC ANTIGEN; CARNOSIC ACID; CASPASE; CYTOCHROME C; DIETHYLNITROSAMINE; DIMETHYLBENZ[A]ANTHRACENE; EPIDERMAL GROWTH FACTOR RECEPTOR 2; FLUOROURACIL; GLUTATHIONE; GLUTATHIONE TRANSFERASE; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; HEME OXYGENASE 1; HYDROGEN PEROXIDE; LIPID PEROXIDASE; MICRORNA; MICRORNA 15B; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NICOTINAMIDE NUCLEOTIDE ADENYLYLTRANSFERASE; POLYPHENOL; PROSTATE SPECIFIC ANTIGEN; PROTEIN BCL 2; PUMA PROTEIN; REACTIVE OXYGEN METABOLITE; ROSMARINIC ACID; ROSMARINUS OFFICINALIS EXTRACT; THYMIDINE KINASE 1; THYMIDYLATE SYNTHASE; TRANSCRIPTION FACTOR NRF2; UNINDEXED DRUG; VITAMIN D; ANTINEOPLASTIC AGENT; CINNAMIC ACID DERIVATIVE; DEPSIDE; PLANT EXTRACT;

EID: 84996483426     PISSN: None     EISSN: 20726643     Source Type: Journal    
DOI: 10.3390/nu8110731     Document Type: Review
Times cited : (225)

References (121)
  • 1
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of Cancer: The Next Generation
    • [CrossRef] [PubMed]
    • Hanahan,D.; Weinberg,R.A. Hallmarks of Cancer: The Next Generation. Cell 2011,144,646-674. [CrossRef] [PubMed]
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 2
    • 9244227134 scopus 로고    scopus 로고
    • Stromal fibroblasts in cancer initiation and progression
    • [CrossRef] [PubMed]
    • Bhowmick,N.A.; Neilson,E.G.; Moses,H.L. Stromal fibroblasts in cancer initiation and progression. Nature 2004,432,332-337. [CrossRef] [PubMed]
    • (2004) Nature , vol.432 , pp. 332-337
    • Bhowmick, N.A.1    Neilson, E.G.2    Moses, H.L.3
  • 3
    • 54249093237 scopus 로고    scopus 로고
    • Transforming Growth Factor-β Signaling-Deficient Fibroblasts Enhance Hepatocyte Growth Factor Signaling in Mammary Carcinoma Cells to Promote Scattering and Invasion
    • [CrossRef] [PubMed]
    • Cheng,N.; Chytil,A.; Shyr,Y.; Joly,A.; Moses,H.L. Transforming Growth Factor-β Signaling-Deficient Fibroblasts Enhance Hepatocyte Growth Factor Signaling in Mammary Carcinoma Cells to Promote Scattering and Invasion. Mol. Cancer Res. 2008,6,1521-1533. [CrossRef] [PubMed]
    • (2008) Mol. Cancer Res. , vol.6 , pp. 1521-1533
    • Cheng, N.1    Chytil, A.2    Shyr, Y.3    Joly, A.4    Moses, H.L.5
  • 5
  • 6
    • 75649091175 scopus 로고    scopus 로고
    • Resveratrol induces apoptosis and cell cycle arrest of human T24 bladder cancer cells in vitro and inhibits tumor growth in vivo
    • [CrossRef] [PubMed]
    • Bai,Y.; Mao,Q.-Q.; Qin,J.; Zheng,X.-Y.; Wang,Y.-B.; Yang,K.; Shen,H.-F.; Xie,L.-P. Resveratrol induces apoptosis and cell cycle arrest of human T24 bladder cancer cells in vitro and inhibits tumor growth in vivo. Cancer Sci. 2010,101,488-493. [CrossRef] [PubMed]
    • (2010) Cancer Sci. , vol.101 , pp. 488-493
    • Bai, Y.1    Mao, Q.-Q.2    Qin, J.3    Zheng, X.-Y.4    Wang, Y.-B.5    Yang, K.6    Shen, H.-F.7    Xie, L.-P.8
  • 7
    • 81255144018 scopus 로고    scopus 로고
    • Resveratrol enhances prostate cancer cell response to ionizing radiation. Modulation of the AMPK,Akt and mTOR pathways
    • [CrossRef] [PubMed]
    • Rashid,A.; Liu,C.; Sanli,T.; Tsiani,E.; Singh,G.; Bristow,R.G.; Dayes,I.; Lukka,H.; Wright,J.; Tsakiridis,T. Resveratrol enhances prostate cancer cell response to ionizing radiation. Modulation of the AMPK,Akt and mTOR pathways. Radiat. Oncol. 2011,6,144. [CrossRef] [PubMed]
    • (2011) Radiat. Oncol. , vol.6 , pp. 144
    • Rashid, A.1    Liu, C.2    Sanli, T.3    Tsiani, E.4    Singh, G.5    Bristow, R.G.6    Dayes, I.7    Lukka, H.8    Wright, J.9    Tsakiridis, T.10
  • 9
    • 6944250259 scopus 로고    scopus 로고
    • Role of Resveratrol in Prevention and Therapy of Cancer: Preclinical and Clinical Studies
    • [PubMed]
    • Aggarwal,B.B.; Bhardwaj,A.; Aggarwal,R.S.; Seeram,N.P.; Shishodia,S.; Takada,Y. Role of Resveratrol in Prevention and Therapy of Cancer: Preclinical and Clinical Studies. Anticancer Res. 2004,24,2783-2840. [PubMed]
    • (2004) Anticancer Res. , vol.24 , pp. 2783-2840
    • Aggarwal, B.B.1    Bhardwaj, A.2    Aggarwal, R.S.3    Seeram, N.P.4    Shishodia, S.5    Takada, Y.6
  • 10
    • 84896736367 scopus 로고    scopus 로고
    • Inhibition of human lung cancer cell proliferation and survival by wine
    • [CrossRef] [PubMed]
    • Barron,C.C.; Moore,J.; Tsakiridis,T.; Pickering,G.; Tsiani,E. Inhibition of human lung cancer cell proliferation and survival by wine. Cancer Cell Int. 2014,14,6. [CrossRef] [PubMed]
    • (2014) Cancer Cell Int. , vol.14 , pp. 6
    • Barron, C.C.1    Moore, J.2    Tsakiridis, T.3    Pickering, G.4    Tsiani, E.5
  • 11
    • 0001214714 scopus 로고
    • Antioxidant Constituents in Sage (Salvia officinalis)
    • [CrossRef]
    • Cuvelier,M.E.; Berset,C.; Richard,H. Antioxidant Constituents in Sage (Salvia officinalis). J. Agric. Food Chem. 1994,42,665-669. [CrossRef]
    • (1994) J. Agric. Food Chem. , vol.42 , pp. 665-669
    • Cuvelier, M.E.1    Berset, C.2    Richard, H.3
  • 12
    • 84948699907 scopus 로고    scopus 로고
    • Rosemary (Rosmarinus officinalis L.) Extract as a Potential Complementary Agent in Anticancer Therapy
    • [CrossRef] [PubMed]
    • González-Vallinas,M.; Reglero,G.; Ramírez de Molina,A. Rosemary (Rosmarinus officinalis L.) Extract as a Potential Complementary Agent in Anticancer Therapy. Nutr. Cancer 2015,67,1221-1229. [CrossRef] [PubMed]
    • (2015) Nutr. Cancer , vol.67 , pp. 1221-1229
    • González-Vallinas, M.1    Reglero, G.2    Ramírez de Molina, A.3
  • 13
    • 84881517986 scopus 로고    scopus 로고
    • Polyphenols from the Mediterranean herb rosemary (Rosmarinus officinalis) for prostate cancer
    • [CrossRef] [PubMed]
    • Petiwala,S.M.; Puthenveetil,A.G.; Johnson,J.J. Polyphenols from the Mediterranean herb rosemary (Rosmarinus officinalis) for prostate cancer. Front. Pharmacol. 2013,4,e1-e4. [CrossRef] [PubMed]
    • (2013) Front. Pharmacol. , vol.4 , pp. e1-e4
    • Petiwala, S.M.1    Puthenveetil, A.G.2    Johnson, J.J.3
  • 14
    • 84939271452 scopus 로고    scopus 로고
    • Diterpenes from rosemary (Rosmarinus officinalis): Defining their potential for anti-cancer activity
    • [CrossRef] [PubMed]
    • Petiwala,S.M.; Johnson,J.J. Diterpenes from rosemary (Rosmarinus officinalis): Defining their potential for anti-cancer activity. Cancer Lett. 2015,367,93-102. [CrossRef] [PubMed]
    • (2015) Cancer Lett. , vol.367 , pp. 93-102
    • Petiwala, S.M.1    Johnson, J.J.2
  • 15
    • 0037187451 scopus 로고    scopus 로고
    • Rosemary-stimulated reduction of DNA strand breaks and FPG-sensitive sites in mammalian cells treated with H2O2 or visible light-excited Methylene Blue
    • [CrossRef]
    • Slamenova,D.; Kuboskova,K.; Horvathova,E.; Robichova,S. Rosemary-stimulated reduction of DNA strand breaks and FPG-sensitive sites in mammalian cells treated with H2O2 or visible light-excited Methylene Blue. Cancer Lett. 2002,177,145-153. [CrossRef]
    • (2002) Cancer Lett. , vol.177 , pp. 145-153
    • Slamenova, D.1    Kuboskova, K.2    Horvathova, E.3    Robichova, S.4
  • 16
    • 79959247736 scopus 로고    scopus 로고
    • Anti-tumorigenic activity of five culinary and medicinal herbs grown under greenhouse conditions and their combination effects
    • [CrossRef] [PubMed]
    • Yi,W.; Wetzstein,H.Y. Anti-tumorigenic activity of five culinary and medicinal herbs grown under greenhouse conditions and their combination effects. J. Sci. Food Agric. 2011,91,1849-1854. [CrossRef] [PubMed]
    • (2011) J. Sci. Food Agric. , vol.91 , pp. 1849-1854
    • Yi, W.1    Wetzstein, H.Y.2
  • 17
    • 84864935209 scopus 로고    scopus 로고
    • CE/LC-MS multiplatform for broad metabolomic analysis of dietary polyphenols effect on colon cancer cells proliferation
    • [CrossRef] [PubMed]
    • Ibáñez,C.; Simó,C.; García-Cañas,V.; Gómez-Martínez,Á.; Ferragut,J.A.; Cifuentes,A. CE/LC-MS multiplatform for broad metabolomic analysis of dietary polyphenols effect on colon cancer cells proliferation. Electrophoresis 2012,33,2328-2336. [CrossRef] [PubMed]
    • (2012) Electrophoresis , vol.33 , pp. 2328-2336
    • Ibáñez, C.1    Simó, C.2    García-Cañas, V.3    Gómez-Martínez, Á.4    Ferragut, J.A.5    Cifuentes, A.6
  • 19
    • 84872383022 scopus 로고    scopus 로고
    • Effect of rosemary polyphenols on human colon cancer cells: Transcriptomic profiling and functional enrichment analysis
    • [CrossRef] [PubMed]
    • Valdés,A.; Garcia-Canas,V.; Rocamora-Reverte,L.; Gomez-Martinez,A.; Ferragut,J.A.; Cifuentes,A. Effect of rosemary polyphenols on human colon cancer cells: Transcriptomic profiling and functional enrichment analysis. Genes Nutr. 2013,8,43-60. [CrossRef] [PubMed]
    • (2013) Genes Nutr. , vol.8 , pp. 43-60
    • Valdés, A.1    Garcia-Canas, V.2    Rocamora-Reverte, L.3    Gomez-Martinez, A.4    Ferragut, J.A.5    Cifuentes, A.6
  • 21
    • 84902436922 scopus 로고    scopus 로고
    • Expression of MicroRNA-15b and the Glycosyltransferase GCNT3 Correlates with Antitumor Efficacy of Rosemary Diterpenes in Colon and Pancreatic Cancer
    • [CrossRef] [PubMed]
    • González-Vallinas,M.; Molina,S.; Vicente,G.; Zarza,V.; Martín-Hernández,R.; García-Risco,M.R.; Fornari,T.; Reglero,G.; de Molina,A.R. Expression of MicroRNA-15b and the Glycosyltransferase GCNT3 Correlates with Antitumor Efficacy of Rosemary Diterpenes in Colon and Pancreatic Cancer. PLoS ONE 2014,9,e98556. [CrossRef] [PubMed]
    • (2014) PLoS ONE , vol.9 , pp. e98556
    • González-Vallinas, M.1    Molina, S.2    Vicente, G.3    Zarza, V.4    Martín-Hernández, R.5    García-Risco, M.R.6    Fornari, T.7    Reglero, G.8    de Molina, A.R.9
  • 23
    • 84922577700 scopus 로고    scopus 로고
    • Standardized rosemary (Rosmarinus officinalis) extract induces Nrf2/sestrin-2 pathway in colon cancer cells
    • [CrossRef]
    • Yan,M.; Li,G.; Petiwala,S.M.; Householter,E.; Johnson,J.J. Standardized rosemary (Rosmarinus officinalis) extract induces Nrf2/sestrin-2 pathway in colon cancer cells. J. Funct. Foods 2015,13,137-147. [CrossRef]
    • (2015) J. Funct. Foods , vol.13 , pp. 137-147
    • Yan, M.1    Li, G.2    Petiwala, S.M.3    Householter, E.4    Johnson, J.J.5
  • 24
    • 84929236723 scopus 로고    scopus 로고
    • Rosemary polyphenols induce unfolded protein response and changes in cholesterol metabolism in colon cancer cells
    • [CrossRef]
    • Valdés,A.; Sullini,G.; Ibáñez,E.; Cifuentes,A.; García-Cañas,V. Rosemary polyphenols induce unfolded protein response and changes in cholesterol metabolism in colon cancer cells. J. Funct. Foods 2015,15,429-439. [CrossRef]
    • (2015) J. Funct. Foods , vol.15 , pp. 429-439
    • Valdés, A.1    Sullini, G.2    Ibáñez, E.3    Cifuentes, A.4    García-Cañas, V.5
  • 25
    • 84959261579 scopus 로고    scopus 로고
    • Foodomics study on the effects of extracellular production of hydrogen peroxide by rosemary polyphenols on the anti-proliferative activity of rosemary polyphenols against HT-29 cells
    • [CrossRef] [PubMed]
    • Valdés,A.; García-Cañas,V.; Koçak,E.; Simó,C.; Cifuentes,A. Foodomics study on the effects of extracellular production of hydrogen peroxide by rosemary polyphenols on the anti-proliferative activity of rosemary polyphenols against HT-29 cells. Electrophoresis 2016,37,1795-1804. [CrossRef] [PubMed]
    • (2016) Electrophoresis , vol.37 , pp. 1795-1804
    • Valdés, A.1    García-Cañas, V.2    Koçak, E.3    Simó, C.4    Cifuentes, A.5
  • 26
    • 84973567132 scopus 로고    scopus 로고
    • Comprehensive Proteomic Study of the Antiproliferative Activity of a Polyphenol-Enriched Rosemary Extract on Colon Cancer Cells Using Nanoliquid Chromatography-Orbitrap MS/MS
    • [CrossRef] [PubMed]
    • Valdés,A.; Artemenko,K.A.; Bergquist,J.; García-Cañas,V.; Cifuentes,A. Comprehensive Proteomic Study of the Antiproliferative Activity of a Polyphenol-Enriched Rosemary Extract on Colon Cancer Cells Using Nanoliquid Chromatography-Orbitrap MS/MS. J. Proteome Res. 2016,15,1971-1985. [CrossRef] [PubMed]
    • (2016) J. Proteome Res. , vol.15 , pp. 1971-1985
    • Valdés, A.1    Artemenko, K.A.2    Bergquist, J.3    García-Cañas, V.4    Cifuentes, A.5
  • 27
    • 84865339937 scopus 로고    scopus 로고
    • Phytochemical profile of Rosmarinus officinalis and Salvia officinalis extracts and correlation to their antioxidant and anti-proliferative activity
    • [CrossRef] [PubMed]
    • Kontogianni,V.G.; Tomic,G.; Nikolic,I.; Nerantzaki,A.A.; Sayyad,N.; Stosic-Grujicic,S.; Stojanovic,I.; Gerothanassis,I.P.; Tzakos,A.G. Phytochemical profile of Rosmarinus officinalis and Salvia officinalis extracts and correlation to their antioxidant and anti-proliferative activity. Food Chem. 2013,136,120-129. [CrossRef] [PubMed]
    • (2013) Food Chem. , vol.136 , pp. 120-129
    • Kontogianni, V.G.1    Tomic, G.2    Nikolic, I.3    Nerantzaki, A.A.4    Sayyad, N.5    Stosic-Grujicic, S.6    Stojanovic, I.7    Gerothanassis, I.P.8    Tzakos, A.G.9
  • 28
    • 33846240854 scopus 로고    scopus 로고
    • DNA damage by benzo(a)pyrene in human cells is increased by cigarette smoke and decreased by a filter containing rosemary extract,which lowers free radicals
    • [CrossRef] [PubMed]
    • Alexandrov,K.; Rojas,M.; Rolando,C. DNA damage by benzo(a)pyrene in human cells is increased by cigarette smoke and decreased by a filter containing rosemary extract,which lowers free radicals. Cancer Res. 2006,66,11938-11945. [CrossRef] [PubMed]
    • (2006) Cancer Res. , vol.66 , pp. 11938-11945
    • Alexandrov, K.1    Rojas, M.2    Rolando, C.3
  • 29
    • 34548049537 scopus 로고    scopus 로고
    • Anti-proliferative and antioxidant properties of rosemary Rosmarinus officinalis
    • [CrossRef] [PubMed]
    • Cheung,S.; Tai,J. Anti-proliferative and antioxidant properties of rosemary Rosmarinus officinalis. Oncol. Rep. 2007,17,1525-1531. [CrossRef] [PubMed]
    • (2007) Oncol. Rep. , vol.17 , pp. 1525-1531
    • Cheung, S.1    Tai, J.2
  • 30
    • 77953323951 scopus 로고    scopus 로고
    • Inhibitory Effects of Rosemary Extracts,Carnosic Acid and Rosmarinic Acid on the Growth of Various Human Cancer Cell Lines
    • [CrossRef] [PubMed]
    • Yesil-Celiktas,O.; Sevimli,C.; Bedir,E.; Vardar-Sukan,F. Inhibitory Effects of Rosemary Extracts,Carnosic Acid and Rosmarinic Acid on the Growth of Various Human Cancer Cell Lines. Plant Foods Hum. Nutr. 2010,65,158-163. [CrossRef] [PubMed]
    • (2010) Plant Foods Hum. Nutr. , vol.65 , pp. 158-163
    • Yesil-Celiktas, O.1    Sevimli, C.2    Bedir, E.3    Vardar-Sukan, F.4
  • 31
    • 79251631003 scopus 로고    scopus 로고
    • Assessment of selected Yemeni medicinal plants for their in vitro antimicrobial,anticancer,and antioxidant activities
    • [CrossRef] [PubMed]
    • Mothana,R.A.A.; Kriegisch,S.; Harms,M.; Wende,K.; Lindequist,U. Assessment of selected Yemeni medicinal plants for their in vitro antimicrobial,anticancer,and antioxidant activities. Pharm. Biol. 2011,49,200-210. [CrossRef] [PubMed]
    • (2011) Pharm. Biol. , vol.49 , pp. 200-210
    • Mothana, R.A.A.1    Kriegisch, S.2    Harms, M.3    Wende, K.4    Lindequist, U.5
  • 33
    • 84897146362 scopus 로고    scopus 로고
    • Rosemary (Rosmarinus officinalis) Extract Modulates CHOP/GADD153 to Promote Androgen Receptor Degradation and Decreases Xenograft Tumor Growth
    • [CrossRef] [PubMed]
    • Petiwala,S.M.; Berhe,S.; Li,G.; Puthenveetil,A.G.; Rahman,O.; Nonn,L.; Johnson,J.J. Rosemary (Rosmarinus officinalis) Extract Modulates CHOP/GADD153 to Promote Androgen Receptor Degradation and Decreases Xenograft Tumor Growth. PLoS ONE 2014,9,e89772. [CrossRef] [PubMed]
    • (2014) PLoS ONE , vol.9 , pp. e89772
    • Petiwala, S.M.1    Berhe, S.2    Li, G.3    Puthenveetil, A.G.4    Rahman, O.5    Nonn, L.6    Johnson, J.J.7
  • 34
    • 84858070539 scopus 로고    scopus 로고
    • Antiproliferation effect of Rosemary (Rosmarinus officinalis) on human ovarian cancer cells in vitro
    • [CrossRef] [PubMed]
    • Tai,J.; Cheung,S.;Wu,M.; Hasman,D. Antiproliferation effect of Rosemary (Rosmarinus officinalis) on human ovarian cancer cells in vitro. Phytomedicine 2012,19,436-443. [CrossRef] [PubMed]
    • (2012) Phytomedicine , vol.19 , pp. 436-443
    • Tai, J.1    Cheung, S.2    Wu, M.3    Hasman, D.4
  • 35
    • 84862297379 scopus 로고    scopus 로고
    • Anticancer Activity of Certain Herbs and Spices on the Cervical Epithelial Carcinoma (HeLa) Cell Line
    • [CrossRef] [PubMed]
    • Berrington,D.; Lall,N. Anticancer Activity of Certain Herbs and Spices on the Cervical Epithelial Carcinoma (HeLa) Cell Line. Evid. Based Complement. Alternat. Med. 2012,2012,e564927. [CrossRef] [PubMed]
    • (2012) Evid. Based Complement. Alternat. Med. , vol.2012 , pp. e564927
    • Berrington, D.1    Lall, N.2
  • 36
    • 84858975802 scopus 로고    scopus 로고
    • Antibacterial Activity and Anticancer Activity of Rosmarinus officinalis L. Essential Oil Compared to That of Its Main Components
    • [CrossRef] [PubMed]
    • Wang,W.; Li,N.; Luo,M.; Zu,Y.; Efferth,T. Antibacterial Activity and Anticancer Activity of Rosmarinus officinalis L. Essential Oil Compared to That of Its Main Components. Molecules 2012,17,2704-2713. [CrossRef] [PubMed]
    • (2012) Molecules , vol.17 , pp. 2704-2713
    • Wang, W.1    Li, N.2    Luo, M.3    Zu, Y.4    Efferth, T.5
  • 37
    • 36148988024 scopus 로고    scopus 로고
    • Supercritical Fluid Extracts of Rosemary Leaves Exhibit Potent Anti-Inflammation and Anti-Tumor Effects
    • [CrossRef] [PubMed]
    • Peng,C.-H.; Su,J.-D.; Chyau,C.-C.; Sung,T.-Y.; Ho,S.-S.; Peng,C.-C.; Peng,R.Y. Supercritical Fluid Extracts of Rosemary Leaves Exhibit Potent Anti-Inflammation and Anti-Tumor Effects. Biosci. Biotechnol. Biochem. 2007,71,2223-2232. [CrossRef] [PubMed]
    • (2007) Biosci. Biotechnol. Biochem. , vol.71 , pp. 2223-2232
    • Peng, C.-H.1    Su, J.-D.2    Chyau, C.-C.3    Sung, T.-Y.4    Ho, S.-S.5    Peng, C.-C.6    Peng, R.Y.7
  • 39
    • 84979516631 scopus 로고    scopus 로고
    • Rosemary extract reduces Akt/mTOR/p70S6K activation and inhibits proliferation and survival of A549 human lung cancer cells
    • [CrossRef] [PubMed]
    • Moore,J.; Megaly,M.; MacNeil,A.J.; Klentrou,P.; Tsiani,E. Rosemary extract reduces Akt/mTOR/p70S6K activation and inhibits proliferation and survival of A549 human lung cancer cells. Biomed. Pharmacother. 2016,83,725-732. [CrossRef] [PubMed]
    • (2016) Biomed. Pharmacother. , vol.83 , pp. 725-732
    • Moore, J.1    Megaly, M.2    MacNeil, A.J.3    Klentrou, P.4    Tsiani, E.5
  • 40
    • 53549116450 scopus 로고    scopus 로고
    • Synergistic Antileukemic Activity of Carnosic Acid-Rich Rosemary Extract and the 19-nor Gemini Vitamin D Analogue in a Mouse Model of Systemic Acute Myeloid Leukemia
    • [CrossRef] [PubMed]
    • Shabtay,A.; Sharabani,H.; Barvish,Z.; Kafka,M.; Amichay,D.; Levy,J.; Sharoni,Y.; Uskokovic,M.R.; Studzinski,G.P.; Danilenko,M. Synergistic Antileukemic Activity of Carnosic Acid-Rich Rosemary Extract and the 19-nor Gemini Vitamin D Analogue in a Mouse Model of Systemic Acute Myeloid Leukemia. Oncology 2008,75,203-214. [CrossRef] [PubMed]
    • (2008) Oncology , vol.75 , pp. 203-214
    • Shabtay, A.1    Sharabani, H.2    Barvish, Z.3    Kafka, M.4    Amichay, D.5    Levy, J.6    Sharoni, Y.7    Uskokovic, M.R.8    Studzinski, G.P.9    Danilenko, M.10
  • 41
    • 33646421969 scopus 로고    scopus 로고
    • Cooperative antitumor effects of vitamin D3 derivatives and rosemary preparations in a mouse model of myeloid leukemia
    • [CrossRef] [PubMed]
    • Sharabani,H.; Izumchenko,E.; Wang,Q.; Kreinin,R.; Steiner,M.; Barvish,Z.; Kafka,M.; Sharoni,Y.; Levy,J.; Uskokovic,M.; et al. Cooperative antitumor effects of vitamin D3 derivatives and rosemary preparations in a mouse model of myeloid leukemia. Int. J. Cancer 2006,118,3012-3021. [CrossRef] [PubMed]
    • (2006) Int. J. Cancer , vol.118 , pp. 3012-3021
    • Sharabani, H.1    Izumchenko, E.2    Wang, Q.3    Kreinin, R.4    Steiner, M.5    Barvish, Z.6    Kafka, M.7    Sharoni, Y.8    Levy, J.9    Uskokovic, M.10
  • 42
    • 84855220716 scopus 로고    scopus 로고
    • Terpinolene,a component of herbal sage,downregulates AKT1 expression in K562 cells
    • [PubMed]
    • Okumura,N.; Yoshida,H.; Nishimura,Y.; Kitagishi,Y.; Matsuda,S. Terpinolene,a component of herbal sage,downregulates AKT1 expression in K562 cells. Oncol. Lett. 2012,3,321-324. [PubMed]
    • (2012) Oncol. Lett. , vol.3 , pp. 321-324
    • Okumura, N.1    Yoshida, H.2    Nishimura, Y.3    Kitagishi, Y.4    Matsuda, S.5
  • 43
    • 84885339142 scopus 로고    scopus 로고
    • Promising therapeutic role of Rosmarinus officinalis successive methanolic fraction against colorectal cancer
    • Ahmad,H.H.; Hamza,A.H.; Hassan,A.Z.; Sayed,A.H. Promising therapeutic role of Rosmarinus officinalis successive methanolic fraction against colorectal cancer. Int. J. Pharm. Pharm. Sci. 2013,5,164-170.
    • (2013) Int. J. Pharm. Pharm. Sci. , vol.5 , pp. 164-170
    • Ahmad, H.H.1    Hamza, A.H.2    Hassan, A.Z.3    Sayed, A.H.4
  • 44
    • 0033855689 scopus 로고    scopus 로고
    • Chemopreventive effects of coumaperine from pepper on the initiation stage of chemical hepatocarcinogenesis in the rat
    • [CrossRef] [PubMed]
    • Kitano,M.; Wanibuchi,H.; Kikuzaki,H.; Nakatani,N.; Imaoka,S.; Funae,Y.; Hayashi,S.; Fukushima,S. Chemopreventive effects of coumaperine from pepper on the initiation stage of chemical hepatocarcinogenesis in the rat. Jpn. J. Cancer Res. Gann 2000,91,674-680. [CrossRef] [PubMed]
    • (2000) Jpn. J. Cancer Res. Gann , vol.91 , pp. 674-680
    • Kitano, M.1    Wanibuchi, H.2    Kikuzaki, H.3    Nakatani, N.4    Imaoka, S.5    Funae, Y.6    Hayashi, S.7    Fukushima, S.8
  • 45
    • 34548700117 scopus 로고    scopus 로고
    • Modulation of radiation-induced biochemical alterations in mice by rosemary (Rosemarinus officinalis) extract
    • [CrossRef] [PubMed]
    • Soyal,D.; Jindal,A.; Singh,I.; Goyal,P.K. Modulation of radiation-induced biochemical alterations in mice by rosemary (Rosemarinus officinalis) extract. Phytomed. Int. J. Phytother. Phytopharm. 2007,14,701-705. [CrossRef] [PubMed]
    • (2007) Phytomed. Int. J. Phytother. Phytopharm. , vol.14 , pp. 701-705
    • Soyal, D.1    Jindal, A.2    Singh, I.3    Goyal, P.K.4
  • 46
    • 33748442703 scopus 로고    scopus 로고
    • Modulatory influence of Rosemarinus officinalis on DMBA-induced mouse skin tumorigenesis
    • [PubMed]
    • Sancheti,G.; Goyal,P. Modulatory influence of Rosemarinus officinalis on DMBA-induced mouse skin tumorigenesis. Asian Pac. J. Cancer Prev. 2006,7,331-335. [PubMed]
    • (2006) Asian Pac. J. Cancer Prev. , vol.7 , pp. 331-335
    • Sancheti, G.1    Goyal, P.2
  • 47
    • 33751096153 scopus 로고    scopus 로고
    • Effect of Rosmarinus officinalis in modulating 7,12-dimethylbenz(a)anthracene induced skin tumorigenesis in mice
    • [CrossRef] [PubMed]
    • Sancheti,G.; Goyal,P.K. Effect of Rosmarinus officinalis in modulating 7,12-dimethylbenz(a)anthracene induced skin tumorigenesis in mice. Phytother. Res. 2006,20,981-986. [CrossRef] [PubMed]
    • (2006) Phytother. Res. , vol.20 , pp. 981-986
    • Sancheti, G.1    Goyal, P.K.2
  • 48
    • 33746300065 scopus 로고    scopus 로고
    • Induction of G2/M phase cell cycle arrest by carnosol and carnosic acid is associated with alteration of cyclin A and cyclin B1 levels
    • [CrossRef] [PubMed]
    • Visanji,J.M.; Thompson,D.G.; Padfield,P.J. Induction of G2/M phase cell cycle arrest by carnosol and carnosic acid is associated with alteration of cyclin A and cyclin B1 levels. Cancer Lett. 2006,237,130-136. [CrossRef] [PubMed]
    • (2006) Cancer Lett. , vol.237 , pp. 130-136
    • Visanji, J.M.1    Thompson, D.G.2    Padfield, P.J.3
  • 49
    • 84856582005 scopus 로고    scopus 로고
    • Carnosic acid inhibits the proliferation and migration capacity of human colorectal cancer cells
    • [PubMed]
    • Barni,M.V.; Carlini,M.J.; Cafferata,E.G.; Puricelli,L.; Moreno,S. Carnosic acid inhibits the proliferation and migration capacity of human colorectal cancer cells. Oncol. Rep. 2012,27,1041-1048. [PubMed]
    • (2012) Oncol. Rep. , vol.27 , pp. 1041-1048
    • Barni, M.V.1    Carlini, M.J.2    Cafferata, E.G.3    Puricelli, L.4    Moreno, S.5
  • 50
    • 84857724447 scopus 로고    scopus 로고
    • An intrinsically labile α-helix abutting the BCL9-binding site of β-catenin is required for its inhibition by carnosic acid
    • [CrossRef] [PubMed]
    • De la Roche,M.; Rutherford,T.J.; Gupta,D.; Veprintsev,D.B.; Saxty,B.; Freund,S.M.; Bienz,M. An intrinsically labile α-helix abutting the BCL9-binding site of β-catenin is required for its inhibition by carnosic acid. Nat. Commun. 2012,3,680. [CrossRef] [PubMed]
    • (2012) Nat. Commun. , vol.3 , pp. 680
    • De la Roche, M.1    Rutherford, T.J.2    Gupta, D.3    Veprintsev, D.B.4    Saxty, B.5    Freund, S.M.6    Bienz, M.7
  • 51
    • 84907929449 scopus 로고    scopus 로고
    • Comprehensive Foodomics Study on the Mechanisms Operating at Various Molecular Levels in Cancer Cells in Response to Individual Rosemary Polyphenols
    • [CrossRef] [PubMed]
    • Valdés,A.; García-Cañas,V.; Simó,C.; Ibáñez,C.; Micol,V.; Ferragut,J.A.; Cifuentes,A. Comprehensive Foodomics Study on the Mechanisms Operating at Various Molecular Levels in Cancer Cells in Response to Individual Rosemary Polyphenols. Anal. Chem. 2014,86,9807-9815. [CrossRef] [PubMed]
    • (2014) Anal. Chem. , vol.86 , pp. 9807-9815
    • Valdés, A.1    García-Cañas, V.2    Simó, C.3    Ibáñez, C.4    Micol, V.5    Ferragut, J.A.6    Cifuentes, A.7
  • 52
    • 84912121809 scopus 로고    scopus 로고
    • Carnosic acid suppresses colon tumor formation in association with anti-adipogenic activity
    • [CrossRef] [PubMed]
    • Kim,Y.-J.; Kim,J.-S.; Seo,Y.-R.; Park,J.-H.Y.; Choi,M.-S.; Sung,M.-K. Carnosic acid suppresses colon tumor formation in association with anti-adipogenic activity. Mol. Nutr. Food Res. 2014,58,2274-2285. [CrossRef] [PubMed]
    • (2014) Mol. Nutr. Food Res. , vol.58 , pp. 2274-2285
    • Kim, Y.-J.1    Kim, J.-S.2    Seo, Y.-R.3    Park, J.-H.Y.4    Choi, M.-S.5    Sung, M.-K.6
  • 53
    • 84936805532 scopus 로고    scopus 로고
    • Carnosic acid inhibits STAT3 signaling and induces apoptosis through generation of ROS in human colon cancer HCT116 cells
    • [CrossRef] [PubMed]
    • Kim,D.-H.; Park,K.-W.; Chae,I.G.; Kundu,J.; Kim,E.-H.; Kundu,J.K.; Chun,K.-S. Carnosic acid inhibits STAT3 signaling and induces apoptosis through generation of ROS in human colon cancer HCT116 cells. Mol. Carcinog. 2016,55,1096-1110. [CrossRef] [PubMed]
    • (2016) Mol. Carcinog. , vol.55 , pp. 1096-1110
    • Kim, D.-H.1    Park, K.-W.2    Chae, I.G.3    Kundu, J.4    Kim, E.-H.5    Kundu, J.K.6    Chun, K.-S.7
  • 54
    • 84865460101 scopus 로고    scopus 로고
    • Carnosic acid inhibits the growth of ER-negative human breast cancer cells and synergizes with curcumin
    • [CrossRef] [PubMed]
    • Einbond,L.S.; Wu,H.; Kashiwazaki,R.; He,K.; Roller,M.; Su,T.; Wang,X.; Goldsberry,S. Carnosic acid inhibits the growth of ER-negative human breast cancer cells and synergizes with curcumin. Fitoterapia 2012,83,1160-1168. [CrossRef] [PubMed]
    • (2012) Fitoterapia , vol.83 , pp. 1160-1168
    • Einbond, L.S.1    Wu, H.2    Kashiwazaki, R.3    He, K.4    Roller, M.5    Su, T.6    Wang, X.7    Goldsberry, S.8
  • 55
    • 84919352814 scopus 로고    scopus 로고
    • Carnosic Acid Induces Apoptosis Through Reactive Oxygen Species-mediated Endoplasmic Reticulum Stress Induction in Human Renal Carcinoma Caki Cells
    • [CrossRef] [PubMed]
    • Min,K.-J.; Jung,K.-J.; Kwon,T.K. Carnosic Acid Induces Apoptosis Through Reactive Oxygen Species-mediated Endoplasmic Reticulum Stress Induction in Human Renal Carcinoma Caki Cells. J. Cancer Prev. 2014,19,170-178. [CrossRef] [PubMed]
    • (2014) J. Cancer Prev. , vol.19 , pp. 170-178
    • Min, K.-J.1    Jung, K.-J.2    Kwon, T.K.3
  • 56
    • 84922704889 scopus 로고    scopus 로고
    • Carnosic acid sensitized TRAIL-mediated apoptosis through down-regulation of c-FLIP and Bcl-2 expression at the post translational levels and CHOP-dependent up-regulation of DR5,Bim,and PUMA expression in human carcinoma caki cells
    • [CrossRef] [PubMed]
    • Jung,K.-J.; Min,K.; Bae,J.H.; Kwon,T.K. Carnosic acid sensitized TRAIL-mediated apoptosis through down-regulation of c-FLIP and Bcl-2 expression at the post translational levels and CHOP-dependent up-regulation of DR5,Bim,and PUMA expression in human carcinoma caki cells. Oncotarget 2015,6,1556-1568. [CrossRef] [PubMed]
    • (2015) Oncotarget , vol.6 , pp. 1556-1568
    • Jung, K.-J.1    Min, K.2    Bae, J.H.3    Kwon, T.K.4
  • 57
  • 58
    • 84862501584 scopus 로고    scopus 로고
    • Carnosic acid modulates Akt/IKK/NF-κB signaling by PP2A and induces intrinsic and extrinsic pathway mediated apoptosis in human prostate carcinoma PC-3 cells
    • [CrossRef] [PubMed]
    • Kar,S.; Palit,S.; Ball,W.B.; Das,P.K. Carnosic acid modulates Akt/IKK/NF-κB signaling by PP2A and induces intrinsic and extrinsic pathway mediated apoptosis in human prostate carcinoma PC-3 cells. Apoptosis Int. J. Program. Cell Death 2012,17,735-747. [CrossRef] [PubMed]
    • (2012) Apoptosis Int. J. Program. Cell Death , vol.17 , pp. 735-747
    • Kar, S.1    Palit, S.2    Ball, W.B.3    Das, P.K.4
  • 59
    • 85028223515 scopus 로고    scopus 로고
    • Carnosic acid induces autophagic cell death through inhibition of the Akt/mTOR pathway in human hepatoma cells
    • [CrossRef] [PubMed]
    • Gao,Q.; Liu,H.; Yao,Y.; Geng,L.; Zhang,X.; Jiang,L.; Shi,B.; Yang,F. Carnosic acid induces autophagic cell death through inhibition of the Akt/mTOR pathway in human hepatoma cells. J. Appl. Toxicol. 2014,485-492. [CrossRef] [PubMed]
    • (2014) J. Appl. Toxicol. , pp. 485-492
    • Gao, Q.1    Liu, H.2    Yao, Y.3    Geng, L.4    Zhang, X.5    Jiang, L.6    Shi, B.7    Yang, F.8
  • 60
    • 84931030254 scopus 로고    scopus 로고
    • Induction of the pi class of glutathione S-transferase by carnosic acid in rat Clone 9 cells via the p38/Nrf2 pathway
    • [CrossRef] [PubMed]
    • Lin,C.-Y.; Wu,C.-R.; Chang,S.-W.; Wang,Y.-J.; Wu,J.-J.; Tsai,C.-W. Induction of the pi class of glutathione S-transferase by carnosic acid in rat Clone 9 cells via the p38/Nrf2 pathway. Food Funct. 2015,6,1936-1943. [CrossRef] [PubMed]
    • (2015) Food Funct. , vol.6 , pp. 1936-1943
    • Lin, C.-Y.1    Wu, C.-R.2    Chang, S.-W.3    Wang, Y.-J.4    Wu, J.-J.5    Tsai, C.-W.6
  • 61
    • 84862908099 scopus 로고    scopus 로고
    • Carnosic acid induces the NAD(P)H: Quinone oxidoreductase 1 expression in rat clone 9 cells through the p38/nuclear factor erythroid-2 related factor 2 pathway
    • [CrossRef] [PubMed]
    • Tsai,C.-W.; Lin,C.-Y.;Wang,Y.-J. Carnosic acid induces the NAD(P)H: Quinone oxidoreductase 1 expression in rat clone 9 cells through the p38/nuclear factor erythroid-2 related factor 2 pathway. J. Nutr. 2011,141,2119-2125. [CrossRef] [PubMed]
    • (2011) J. Nutr. , vol.141 , pp. 2119-2125
    • Tsai, C.-W.1    Lin, C.-Y.2    Wang, Y.-J.3
  • 62
    • 84872674746 scopus 로고    scopus 로고
    • Anti-angiogenic properties of carnosol and carnosic acid,two major dietary compounds from rosemary
    • [CrossRef] [PubMed]
    • López-Jiménez,A.; García-Caballero,M.; Medina,M.Á.; Quesada,A.R. Anti-angiogenic properties of carnosol and carnosic acid,two major dietary compounds from rosemary. Eur. J. Nutr. 2013,52,85-95. [CrossRef] [PubMed]
    • (2013) Eur. J. Nutr. , vol.52 , pp. 85-95
    • López-Jiménez, A.1    García-Caballero, M.2    Medina, M.Á.3    Quesada, A.R.4
  • 63
    • 84904479758 scopus 로고    scopus 로고
    • Carnosic Acid Inhibits the Epithelial-Mesenchymal Transition in B16F10 Melanoma Cells: A Possible Mechanism for the Inhibition of Cell Migration
    • [CrossRef] [PubMed]
    • Park,S.Y.; Song,H.; Sung,M.-K.; Kang,Y.-H.; Lee,K.W.; Park,J.H.Y. Carnosic Acid Inhibits the Epithelial-Mesenchymal Transition in B16F10 Melanoma Cells: A Possible Mechanism for the Inhibition of Cell Migration. Int. J. Mol. Sci. 2014,15,12698-12713. [CrossRef] [PubMed]
    • (2014) Int. J. Mol. Sci. , vol.15 , pp. 12698-12713
    • Park, S.Y.1    Song, H.2    Sung, M.-K.3    Kang, Y.-H.4    Lee, K.W.5    Park, J.H.Y.6
  • 64
    • 12744274953 scopus 로고    scopus 로고
    • Carnosic acid,a component of rosemary (Rosmarinus officinalis L.),promotes synthesis of nerve growth factor in T98G human glioblastoma cells
    • [CrossRef] [PubMed]
    • Kosaka,K.; Yokoi,T. Carnosic acid,a component of rosemary (Rosmarinus officinalis L.),promotes synthesis of nerve growth factor in T98G human glioblastoma cells. Biol. Pharm. Bull. 2003,26,1620-1622. [CrossRef] [PubMed]
    • (2003) Biol. Pharm. Bull. , vol.26 , pp. 1620-1622
    • Kosaka, K.1    Yokoi, T.2
  • 65
    • 79961064830 scopus 로고    scopus 로고
    • Nrf2 regulates NGF mRNA induction by carnosic acid in T98G glioblastoma cells and normal human astrocytes
    • [CrossRef] [PubMed]
    • Mimura,J.; Kosaka,K.; Maruyama,A.; Satoh,T.; Harada,N.; Yoshida,H.; Satoh,K.; Yamamoto,M.; Itoh,K. Nrf2 regulates NGF mRNA induction by carnosic acid in T98G glioblastoma cells and normal human astrocytes. J. Biochem. 2011,150,209-217. [CrossRef] [PubMed]
    • (2011) J. Biochem. , vol.150 , pp. 209-217
    • Mimura, J.1    Kosaka, K.2    Maruyama, A.3    Satoh, T.4    Harada, N.5    Yoshida, H.6    Satoh, K.7    Yamamoto, M.8    Itoh, K.9
  • 66
    • 80755187949 scopus 로고    scopus 로고
    • Carnosic acid,a rosemary phenolic compound,induces apoptosis through reactive oxygen species-mediated p38 activation in human neuroblastoma IMR-32 cells
    • [CrossRef] [PubMed]
    • Tsai,C.-W.; Lin,C.-Y.; Lin,H.-H.; Chen,J.-H. Carnosic acid,a rosemary phenolic compound,induces apoptosis through reactive oxygen species-mediated p38 activation in human neuroblastoma IMR-32 cells. Neurochem. Res. 2011,36,2442-2451. [CrossRef] [PubMed]
    • (2011) Neurochem. Res. , vol.36 , pp. 2442-2451
    • Tsai, C.-W.1    Lin, C.-Y.2    Lin, H.-H.3    Chen, J.-H.4
  • 67
    • 84947808361 scopus 로고    scopus 로고
    • Role for the PI3K/Akt/Nrf2 signaling pathway in the protective effects of carnosic acid against methylglyoxal-induced neurotoxicity in SH-SY5Y neuroblastoma cells
    • [CrossRef] [PubMed]
    • De Oliveira,M.R.; Ferreira,G.C.; Schuck,P.F.; dal Bosco,S.M. Role for the PI3K/Akt/Nrf2 signaling pathway in the protective effects of carnosic acid against methylglyoxal-induced neurotoxicity in SH-SY5Y neuroblastoma cells. Chem. Biol. Interact. 2015,242,396-406. [CrossRef] [PubMed]
    • (2015) Chem. Biol. Interact. , vol.242 , pp. 396-406
    • De Oliveira, M.R.1    Ferreira, G.C.2    Schuck, P.F.3    dal Bosco, S.M.4
  • 69
    • 84896723048 scopus 로고    scopus 로고
    • Carnosic acid suppresses the production of amyloid-β 1-42 and 1-43 by inducing an α-secretase TACE/ADAM17 in U373MG human astrocytoma cells
    • [CrossRef] [PubMed]
    • Yoshida,H.; Meng,P.; Matsumiya,T.; Tanji,K.; Hayakari,R.; Xing,F.; Wang,L.; Tsuruga,K.; Tanaka,H.; Mimura,J.; et al. Carnosic acid suppresses the production of amyloid-β 1-42 and 1-43 by inducing an α-secretase TACE/ADAM17 in U373MG human astrocytoma cells. Neurosci. Res. 2014,79,83-93. [CrossRef] [PubMed]
    • (2014) Neurosci. Res. , vol.79 , pp. 83-93
    • Yoshida, H.1    Meng, P.2    Matsumiya, T.3    Tanji, K.4    Hayakari, R.5    Xing, F.6    Wang, L.7    Tsuruga, K.8    Tanaka, H.9    Mimura, J.10
  • 71
    • 0035881060 scopus 로고    scopus 로고
    • Carnosic acid and promotion of monocytic differentiation of HL60-G cells initiated by other agents
    • [CrossRef] [PubMed]
    • Danilenko,M.; Wang,X.; Studzinski,G.P. Carnosic acid and promotion of monocytic differentiation of HL60-G cells initiated by other agents. J. Natl. Cancer Inst. 2001,93,1224-1233. [CrossRef] [PubMed]
    • (2001) J. Natl. Cancer Inst. , vol.93 , pp. 1224-1233
    • Danilenko, M.1    Wang, X.2    Studzinski, G.P.3
  • 72
    • 0035527494 scopus 로고    scopus 로고
    • Carnosic Acid Inhibits Proliferation and Augments Differentiation of Human Leukemic Cells Induced by 1,25-Dihydroxyvitamin Dsub3 and Retinoic Acid
    • [CrossRef] [PubMed]
    • Steiner,M. Carnosic Acid Inhibits Proliferation and Augments Differentiation of Human Leukemic Cells Induced by 1,25-Dihydroxyvitamin Dsub3 and Retinoic Acid. Nutr. Cancer 2001,41,135-144. [CrossRef] [PubMed]
    • (2001) Nutr. Cancer , vol.41 , pp. 135-144
    • Steiner, M.1
  • 73
    • 0037444401 scopus 로고    scopus 로고
    • Carnosic acid potentiates the antioxidant and prodifferentiation effects of 1alpha,25-dihydroxyvitamin D3 in leukemia cells but does not promote elevation of basal levels of intracellular calcium
    • [PubMed]
    • Danilenko,M.; Wang,Q.; Wang,X.; Levy,J.; Sharoni,Y.; Studzinski,G.P. Carnosic acid potentiates the antioxidant and prodifferentiation effects of 1alpha,25-dihydroxyvitamin D3 in leukemia cells but does not promote elevation of basal levels of intracellular calcium. Cancer Res. 2003,63,1325-1332. [PubMed]
    • (2003) Cancer Res. , vol.63 , pp. 1325-1332
    • Danilenko, M.1    Wang, Q.2    Wang, X.3    Levy, J.4    Sharoni, Y.5    Studzinski, G.P.6
  • 74
    • 27144560218 scopus 로고    scopus 로고
    • Translational study of vitamin D differentiation therapy of myeloid leukemia: Effects of the combination with a p38 MAPK inhibitor and an antioxidant
    • [CrossRef] [PubMed]
    • Wang,Q.; Harrison,J.S.; Uskokovic,M.; Kutner,A.; Studzinski,G.P. Translational study of vitamin D differentiation therapy of myeloid leukemia: Effects of the combination with a p38 MAPK inhibitor and an antioxidant. Leukemia 2005,19,1812-1817. [CrossRef] [PubMed]
    • (2005) Leukemia , vol.19 , pp. 1812-1817
    • Wang, Q.1    Harrison, J.S.2    Uskokovic, M.3    Kutner, A.4    Studzinski, G.P.5
  • 75
    • 67649373338 scopus 로고    scopus 로고
    • c-Jun N-terminal kinase 2 (JNK2) antagonizes the signaling of differentiation by JNK1 in human myeloid leukemia cells resistant to vitamin D
    • [CrossRef] [PubMed]
    • Chen-Deutsch,X.; Garay,E.; Zhang,J.; Harrison,J.S.; Studzinski,G.P. c-Jun N-terminal kinase 2 (JNK2) antagonizes the signaling of differentiation by JNK1 in human myeloid leukemia cells resistant to vitamin D. Leuk. Res. 2009,33,1372-1378. [CrossRef] [PubMed]
    • (2009) Leuk. Res. , vol.33 , pp. 1372-1378
    • Chen-Deutsch, X.1    Garay, E.2    Zhang, J.3    Harrison, J.S.4    Studzinski, G.P.5
  • 76
    • 84860322664 scopus 로고    scopus 로고
    • Dual role of hematopoietic progenitor kinase 1 (HPK1) as a positive regulator of 1α,25-dihydroxyvitamin D-induced differentiation and cell cycle arrest of AML cells and as a mediator of vitamin D resistance
    • [CrossRef] [PubMed]
    • Chen-Deutsch,X.; Studzinski,G.P. Dual role of hematopoietic progenitor kinase 1 (HPK1) as a positive regulator of 1α,25-dihydroxyvitamin D-induced differentiation and cell cycle arrest of AML cells and as a mediator of vitamin D resistance. Cell. Cycle Georget. Tex 2012,11,1364-1373. [CrossRef] [PubMed]
    • (2012) Cell. Cycle Georget. Tex , vol.11 , pp. 1364-1373
    • Chen-Deutsch, X.1    Studzinski, G.P.2
  • 77
    • 79951527854 scopus 로고    scopus 로고
    • The Nrf2 transcription factor is a positive regulator of myeloid differentiation of acute myeloid leukemia cells
    • [CrossRef] [PubMed]
    • Bobilev,I.; Novik,V.; Levi,I.; Shpilberg,O.; Levy,J.; Sharoni,Y.; Studzinski,G.P.; Danilenko,M. The Nrf2 transcription factor is a positive regulator of myeloid differentiation of acute myeloid leukemia cells. Cancer Biol. Ther. 2011,11,317-329. [CrossRef] [PubMed]
    • (2011) Cancer Biol. Ther. , vol.11 , pp. 317-329
    • Bobilev, I.1    Novik, V.2    Levi, I.3    Shpilberg, O.4    Levy, J.5    Sharoni, Y.6    Studzinski, G.P.7    Danilenko, M.8
  • 78
    • 84942042819 scopus 로고    scopus 로고
    • Novel analogs of 1,25-dihydroxyvitamin D2 combined with a plant polyphenol as highly efficient inducers of differentiation in human acute myeloid leukemia cells
    • [CrossRef] [PubMed]
    • Nachliely,M.; Sharony,E.; Kutner,A.; Danilenko,M. Novel analogs of 1,25-dihydroxyvitamin D2 combined with a plant polyphenol as highly efficient inducers of differentiation in human acute myeloid leukemia cells. J. Steroid Biochem. Mol. Biol. 2016,164,59-65. [CrossRef] [PubMed]
    • (2016) J. Steroid Biochem. Mol. Biol. , vol.164 , pp. 59-65
    • Nachliely, M.1    Sharony, E.2    Kutner, A.3    Danilenko, M.4
  • 79
    • 84974670889 scopus 로고    scopus 로고
    • Nrf2 activation ameliorates cytotoxic effects of arsenic trioxide in acute promyelocytic leukemia cells through increased glutathione levels and arsenic efflux from cells
    • [CrossRef] [PubMed]
    • Nishimoto,S.; Suzuki,T.; Koike,S.; Yuan,B.; Takagi,N.; Ogasawara,Y. Nrf2 activation ameliorates cytotoxic effects of arsenic trioxide in acute promyelocytic leukemia cells through increased glutathione levels and arsenic efflux from cells. Toxicol. Appl. Pharmacol. 2016,305,161-168. [CrossRef] [PubMed]
    • (2016) Toxicol. Appl. Pharmacol. , vol.305 , pp. 161-168
    • Nishimoto, S.1    Suzuki, T.2    Koike, S.3    Yuan, B.4    Takagi, N.5    Ogasawara, Y.6
  • 80
    • 84867262813 scopus 로고    scopus 로고
    • Reversion of P-glycoprotein-mediated multidrug resistance in human leukemic cell line by carnosic acid
    • [PubMed]
    • Yu,X.-N.; Chen,X.-L.; Li,H.; Li,X.-X.; Li,H.-Q.; Jin,W.-R. Reversion of P-glycoprotein-mediated multidrug resistance in human leukemic cell line by carnosic acid. Chin. J. Physiol. 2008,51,348-356. [PubMed]
    • (2008) Chin. J. Physiol. , vol.51 , pp. 348-356
    • Yu, X.-N.1    Chen, X.-L.2    Li, H.3    Li, X.-X.4    Li, H.-Q.5    Jin, W.-R.6
  • 81
    • 84885877226 scopus 로고    scopus 로고
    • Involvement of microRNA181a in differentiation and cell cycle arrest induced by a plant-derived antioxidant carnosic acid and vitamin D analog doxercalciferol in human leukemia cells
    • [CrossRef]
    • Duggal,J.; Harrison,J.S.; Studzinski,G.P.;Wang,X. Involvement of microRNA181a in differentiation and cell cycle arrest induced by a plant-derived antioxidant carnosic acid and vitamin D analog doxercalciferol in human leukemia cells. MicroRNA Shāriqah. United Arab Emir. 2012,1,26-33. [CrossRef]
    • (2012) MicroRNA Shāriqah. United Arab Emir. , vol.1 , pp. 26-33
    • Duggal, J.1    Harrison, J.S.2    Studzinski, G.P.3    Wang, X.4
  • 82
    • 84874485141 scopus 로고    scopus 로고
    • Synergism between carnosic acid and arsenic trioxide on induction of acute myeloid leukemia cell apoptosis is associated with modulation of PTEN/Akt signaling pathway
    • [CrossRef] [PubMed]
    • Wang,R.; Cong,W.; Guo,G.; Li,X.; Chen,X.; Yu,X.; Li,H. Synergism between carnosic acid and arsenic trioxide on induction of acute myeloid leukemia cell apoptosis is associated with modulation of PTEN/Akt signaling pathway. Chin. J. Integr. Med. 2012,18,934-941. [CrossRef] [PubMed]
    • (2012) Chin. J. Integr. Med. , vol.18 , pp. 934-941
    • Wang, R.1    Cong, W.2    Guo, G.3    Li, X.4    Chen, X.5    Yu, X.6    Li, H.7
  • 84
    • 84897920926 scopus 로고    scopus 로고
    • Proapoptotic,anti-cell proliferative,anti-inflammatory and anti-angiogenic potential of carnosic acid during 7,12 dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis
    • Rajasekaran,D.; Manoharan,S.; Silvan,S.; Vasudevan,K.; Baskaran,N.; Palanimuthu,D. Proapoptotic,anti-cell proliferative,anti-inflammatory and anti-angiogenic potential of carnosic acid during 7,12 dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis. Afr. J. Tradit. Complement. Altern. Med. AJTCAM Afr. Netw. Ethnomed. 2012,10,102-112.
    • (2012) Afr. J. Tradit. Complement. Altern. Med. AJTCAM Afr. Netw. Ethnomed. , vol.10 , pp. 102-112
    • Rajasekaran, D.1    Manoharan, S.2    Silvan, S.3    Vasudevan, K.4    Baskaran, N.5    Palanimuthu, D.6
  • 86
    • 84982913931 scopus 로고    scopus 로고
    • Carnosic acid promotes degradation of the androgen receptor and is regulated by the unfolded protein response pathway in vitro and in vivo
    • [CrossRef] [PubMed]
    • Petiwala,S.M.; Li,G.; Bosland,M.C.; Lantvit,D.D.; Petukhov,P.A.; Johnson,J.J. Carnosic acid promotes degradation of the androgen receptor and is regulated by the unfolded protein response pathway in vitro and in vivo. Carcinogenesis 2016,37,827-838. [CrossRef] [PubMed]
    • (2016) Carcinogenesis , vol.37 , pp. 827-838
    • Petiwala, S.M.1    Li, G.2    Bosland, M.C.3    Lantvit, D.D.4    Petukhov, P.A.5    Johnson, J.J.6
  • 87
    • 84940705666 scopus 로고    scopus 로고
    • The anti-leukemic effect of carnosic acid combined with Adriamycin in a K562/A02/SCID leukemia mouse model
    • [PubMed]
    • Wang,L.-Q.; Wang,R.; Li,X.-X.; Yu,X.-N.; Chen,X.-L.; Li,H. The anti-leukemic effect of carnosic acid combined with Adriamycin in a K562/A02/SCID leukemia mouse model. Int. J. Clin. Exp. Med. 2015,8,11708-11717. [PubMed]
    • (2015) Int. J. Clin. Exp. Med. , vol.8 , pp. 11708-11717
    • Wang, L.-Q.1    Wang, R.2    Li, X.-X.3    Yu, X.-N.4    Chen, X.-L.5    Li, H.6
  • 88
    • 55949110359 scopus 로고    scopus 로고
    • Rosmarinic acid antagonizes activator protein-1-dependent activation of cyclooxygenase-2 expression in human cancer and nonmalignant cell lines
    • [CrossRef] [PubMed]
    • Scheckel,K.A.; Degner,S.C.; Romagnolo,D.F. Rosmarinic acid antagonizes activator protein-1-dependent activation of cyclooxygenase-2 expression in human cancer and nonmalignant cell lines. J. Nutr. 2008,138,2098-2105. [CrossRef] [PubMed]
    • (2008) J. Nutr. , vol.138 , pp. 2098-2105
    • Scheckel, K.A.1    Degner, S.C.2    Romagnolo, D.F.3
  • 89
    • 70449627783 scopus 로고    scopus 로고
    • Salvia fruticosa,Salvia officinalis,and rosmarinic acid induce apoptosis and inhibit proliferation of human colorectal cell lines: The role in MAPK/ERK pathway
    • [CrossRef] [PubMed]
    • Xavier,C.P.R.; Lima,C.F.; Fernandes-Ferreira,M.; Pereira-Wilson,C. Salvia fruticosa,Salvia officinalis,and rosmarinic acid induce apoptosis and inhibit proliferation of human colorectal cell lines: The role in MAPK/ERK pathway. Nutr. Cancer 2009,61,564-571. [CrossRef] [PubMed]
    • (2009) Nutr. Cancer , vol.61 , pp. 564-571
    • Xavier, C.P.R.1    Lima, C.F.2    Fernandes-Ferreira, M.3    Pereira-Wilson, C.4
  • 90
    • 77957273633 scopus 로고    scopus 로고
    • Anti-invasion effect of rosmarinic acid via the extracellular signal-regulated kinase and oxidation-reduction pathway in Ls174-T cells
    • [CrossRef] [PubMed]
    • Xu,Y.; Xu,G.; Liu,L.; Xu,D.; Liu,J. Anti-invasion effect of rosmarinic acid via the extracellular signal-regulated kinase and oxidation-reduction pathway in Ls174-T cells. J. Cell. Biochem. 2010,111,370-379. [CrossRef] [PubMed]
    • (2010) J. Cell. Biochem. , vol.111 , pp. 370-379
    • Xu, Y.1    Xu, G.2    Liu, L.3    Xu, D.4    Liu, J.5
  • 91
    • 84864063441 scopus 로고    scopus 로고
    • Protection by Salvia extracts against oxidative and alkylation damage to DNA in human HCT15 and CO115 cells
    • [CrossRef] [PubMed]
    • Ramos,A.A.; Pedro,D.; Collins,A.R.; Pereira-Wilson,C. Protection by Salvia extracts against oxidative and alkylation damage to DNA in human HCT15 and CO115 cells. J. Toxicol. Environ. Health A 2012,75,765-775. [CrossRef] [PubMed]
    • (2012) J. Toxicol. Environ. Health A , vol.75 , pp. 765-775
    • Ramos, A.A.1    Pedro, D.2    Collins, A.R.3    Pereira-Wilson, C.4
  • 92
    • 74849083369 scopus 로고    scopus 로고
    • Rosmarinic acid sensitizes cell death through suppression of TNF-α-induced NF-κB activation and ROS generation in human leukemia U937 cells
    • [CrossRef] [PubMed]
    • Moon,D.-O.; Kim,M.-O.; Lee,J.-D.; Choi,Y.H.; Kim,G.-Y. Rosmarinic acid sensitizes cell death through suppression of TNF-α-induced NF-κB activation and ROS generation in human leukemia U937 cells. Cancer Lett. 2010,288,183-191. [CrossRef] [PubMed]
    • (2010) Cancer Lett. , vol.288 , pp. 183-191
    • Moon, D.-O.1    Kim, M.-O.2    Lee, J.-D.3    Choi, Y.H.4    Kim, G.-Y.5
  • 93
    • 73749085369 scopus 로고    scopus 로고
    • The effect of dietary polyphenols on the epigenetic regulation of gene expression in MCF7 breast cancer cells
    • [CrossRef] [PubMed]
    • Paluszczak,J.; Krajka-Kúzniak,V.; Baer-Dubowska,W. The effect of dietary polyphenols on the epigenetic regulation of gene expression in MCF7 breast cancer cells. Toxicol. Lett. 2010,192,119-125. [CrossRef] [PubMed]
    • (2010) Toxicol. Lett. , vol.192 , pp. 119-125
    • Paluszczak, J.1    Krajka-Kúzniak, V.2    Baer-Dubowska, W.3
  • 94
    • 84878395563 scopus 로고    scopus 로고
    • Cytotoxic impact of phenolics from Lamiaceae species on human breast cancer cells
    • [CrossRef] [PubMed]
    • Berdowska,I.; Zielínski,B.; Fecka,I.; Kulbacka,J.; Saczko,J.; Gamian,A. Cytotoxic impact of phenolics from Lamiaceae species on human breast cancer cells. Food Chem. 2013,141,1313-1321. [CrossRef] [PubMed]
    • (2013) Food Chem. , vol.141 , pp. 1313-1321
    • Berdowska, I.1    Zielínski, B.2    Fecka, I.3    Kulbacka, J.4    Saczko, J.5    Gamian, A.6
  • 97
    • 34548129609 scopus 로고    scopus 로고
    • Rosmarinic acid induces melanogenesis through protein kinase A activation signaling
    • [CrossRef] [PubMed]
    • Lee,J.; Kim,Y.S.; Park,D. Rosmarinic acid induces melanogenesis through protein kinase A activation signaling. Biochem. Pharmacol. 2007,74,960-968. [CrossRef] [PubMed]
    • (2007) Biochem. Pharmacol. , vol.74 , pp. 960-968
    • Lee, J.1    Kim, Y.S.2    Park, D.3
  • 98
    • 4444349616 scopus 로고    scopus 로고
    • Effects of rosmarinic acid against aflatoxin B1 and ochratoxin-A-induced cell damage in a human hepatoma cell line (HepG2)
    • [CrossRef] [PubMed]
    • Renzulli,C.; Galvano,F.; Pierdomenico,L.; Speroni,E.; Guerra,M.C. Effects of rosmarinic acid against aflatoxin B1 and ochratoxin-A-induced cell damage in a human hepatoma cell line (HepG2). J. Appl. Toxicol. 2004,24,289-296. [CrossRef] [PubMed]
    • (2004) J. Appl. Toxicol. , vol.24 , pp. 289-296
    • Renzulli, C.1    Galvano, F.2    Pierdomenico, L.3    Speroni, E.4    Guerra, M.C.5
  • 99
    • 34347327216 scopus 로고    scopus 로고
    • Growth inhibitory and apoptosis inducing effect of Perilla frutescens extract on human hepatoma HepG2 cells
    • [CrossRef] [PubMed]
    • Lin,C.-S.; Kuo,C.-L.;Wang,J.-P.; Cheng,J.-S.; Huang,Z.-W.; Chen,C.-F. Growth inhibitory and apoptosis inducing effect of Perilla frutescens extract on human hepatoma HepG2 cells. J. Ethnopharmacol. 2007,112,557-567. [CrossRef] [PubMed]
    • (2007) J. Ethnopharmacol. , vol.112 , pp. 557-567
    • Lin, C.-S.1    Kuo, C.-L.2    Wang, J.-P.3    Cheng, J.-S.4    Huang, Z.-W.5    Chen, C.-F.6
  • 100
    • 84982731656 scopus 로고    scopus 로고
    • Spica prunellae and its marker compound rosmarinic acid induced the expression of efflux transporters through activation of Nrf2-mediated signaling pathway in HepG2 cells
    • [CrossRef] [PubMed]
    • Wu,J.; Zhu,Y.; Li,F.; Zhang,G.; Shi,J.; Ou,R.; Tong,Y.; Liu,Y.; Liu,L.; Lu,L.; et al. Spica prunellae and its marker compound rosmarinic acid induced the expression of efflux transporters through activation of Nrf2-mediated signaling pathway in HepG2 cells. J. Ethnopharmacol. 2016,193,1-11. [CrossRef] [PubMed]
    • (2016) J. Ethnopharmacol. , vol.193 , pp. 1-11
    • Wu, J.1    Zhu, Y.2    Li, F.3    Zhang, G.4    Shi, J.5    Ou, R.6    Tong, Y.7    Liu, Y.8    Liu, L.9    Lu, L.10
  • 101
    • 84906939131 scopus 로고    scopus 로고
    • Phenolcarboxylic acids from medicinal herbs exert anticancer effects through disruption of COX-2 activity
    • [CrossRef] [PubMed]
    • Tao,L.; Wang,S.; Zhao,Y.; Sheng,X.; Wang,A.; Zheng,S.; Lu,Y. Phenolcarboxylic acids from medicinal herbs exert anticancer effects through disruption of COX-2 activity. Phytomed. Int. J. Phytother. Phytopharm. 2014,21,1473-1482. [CrossRef] [PubMed]
    • (2014) Phytomed. Int. J. Phytother. Phytopharm. , vol.21 , pp. 1473-1482
    • Tao, L.1    Wang, S.2    Zhao, Y.3    Sheng, X.4    Wang, A.5    Zheng, S.6    Lu, Y.7
  • 102
    • 33947500113 scopus 로고    scopus 로고
    • Reactive oxygen and nitrogen species are involved in sorbitol-induced apoptosis of human erithroleukaemia cells K562
    • [CrossRef] [PubMed]
    • Aquilano,K.; Filomeni,G.; Di Renzo,L.; Vito,M.D.; Stefano,C.D.; Salimei,P.S.; Ciriolo,M.R.; Marfè,G. Reactive oxygen and nitrogen species are involved in sorbitol-induced apoptosis of human erithroleukaemia cells K562. Free Radic. Res. 2007,41,452-460. [CrossRef] [PubMed]
    • (2007) Free Radic. Res. , vol.41 , pp. 452-460
    • Aquilano, K.1    Filomeni, G.2    Di Renzo, L.3    Vito, M.D.4    Stefano, C.D.5    Salimei, P.S.6    Ciriolo, M.R.7    Marfè, G.8
  • 103
    • 84919372319 scopus 로고    scopus 로고
    • Rosmarinic acid potentiates ATRA-induced macrophage differentiation in acute promyelocytic leukemia NB4 cells
    • [CrossRef] [PubMed]
    • Heo,S.-K.; Noh,E.-K.; Yoon,D.-J.; Jo,J.-C.; Koh,S.; Baek,J.H.; Park,J.-H.; Min,Y.J.; Kim,H. Rosmarinic acid potentiates ATRA-induced macrophage differentiation in acute promyelocytic leukemia NB4 cells. Eur. J. Pharmacol. 2015,747,36-44. [CrossRef] [PubMed]
    • (2015) Eur. J. Pharmacol. , vol.747 , pp. 36-44
    • Heo, S.-K.1    Noh, E.-K.2    Yoon, D.-J.3    Jo, J.-C.4    Koh, S.5    Baek, J.H.6    Park, J.-H.7    Min, Y.J.8    Kim, H.9
  • 104
    • 84920123096 scopus 로고    scopus 로고
    • Epigallocatechin gallate,ellagic acid,and rosmarinic acid perturb dNTP pools and inhibit de novo DNA synthesis and proliferation of human HL-60 promyelocytic leukemia cells: Synergism with arabinofuranosylcytosine
    • [CrossRef] [PubMed]
    • Saiko,P.; Steinmann,M.-T.; Schuster,H.; Graser,G.; Bressler,S.; Giessrigl,B.; Lackner,A.; Grusch,M.; Krupitza,G.; Bago-Horvath,Z.; et al. Epigallocatechin gallate,ellagic acid,and rosmarinic acid perturb dNTP pools and inhibit de novo DNA synthesis and proliferation of human HL-60 promyelocytic leukemia cells: Synergism with arabinofuranosylcytosine. Phytomedicine 2015,22,213-222. [CrossRef] [PubMed]
    • (2015) Phytomedicine , vol.22 , pp. 213-222
    • Saiko, P.1    Steinmann, M.-T.2    Schuster, H.3    Graser, G.4    Bressler, S.5    Giessrigl, B.6    Lackner, A.7    Grusch, M.8    Krupitza, G.9    Bago-Horvath, Z.10
  • 105
    • 84946041031 scopus 로고    scopus 로고
    • Molecular mechanisms of rosmarinic acid from Salvia miltiorrhiza in acute lymphoblastic leukemia cells
    • [CrossRef] [PubMed]
    • Wu,C.-F.; Hong,C.; Klauck,S.M.; Lin,Y.-L.; Efferth,T. Molecular mechanisms of rosmarinic acid from Salvia miltiorrhiza in acute lymphoblastic leukemia cells. J. Ethnopharmacol. 2015,176,55-68. [CrossRef] [PubMed]
    • (2015) J. Ethnopharmacol. , vol.176 , pp. 55-68
    • Wu, C.-F.1    Hong, C.2    Klauck, S.M.3    Lin, Y.-L.4    Efferth, T.5
  • 106
  • 107
    • 3042669507 scopus 로고    scopus 로고
    • Rosmarinic acid inhibits epidermal inflammatory responses: Anticarcinogenic effect of Perilla frutescens extract in the murine two-stage skin model
    • [CrossRef] [PubMed]
    • Osakabe,N.; Yasuda,A.; Natsume,M.; Yoshikawa,T. Rosmarinic acid inhibits epidermal inflammatory responses: Anticarcinogenic effect of Perilla frutescens extract in the murine two-stage skin model. Carcinogenesis 2004,25,549-557. [CrossRef] [PubMed]
    • (2004) Carcinogenesis , vol.25 , pp. 549-557
    • Osakabe, N.1    Yasuda, A.2    Natsume, M.3    Yoshikawa, T.4
  • 108
    • 82755186504 scopus 로고    scopus 로고
    • Antitumor initiating potential of rosmarinic acid in 7,12-dimethylbenz(a)anthracene-induced hamster buccal pouch carcinogenesis
    • [CrossRef]
    • Anusuya,C.; Manoharan,S. Antitumor initiating potential of rosmarinic acid in 7,12-dimethylbenz(a)anthracene-induced hamster buccal pouch carcinogenesis. J. Environ. Pathol. Toxicol. Oncol. Off. Organ Int. Soc. Environ. Toxicol. Cancer 2011,30,199-211. [CrossRef]
    • (2011) J. Environ. Pathol. Toxicol. Oncol. Off. Organ Int. Soc. Environ. Toxicol. Cancer , vol.30 , pp. 199-211
    • Anusuya, C.1    Manoharan, S.2
  • 109
    • 84861668022 scopus 로고    scopus 로고
    • Dietary intake of rosmarinic acid by Apc(Min) mice,a model of colorectal carcinogenesis: Levels of parent agent in the target tissue and effect on adenoma development
    • [CrossRef] [PubMed]
    • Karmokar,A.; Marczylo,T.H.; Cai,H.; Steward,W.P.; Gescher,A.J.; Brown,K. Dietary intake of rosmarinic acid by Apc(Min) mice,a model of colorectal carcinogenesis: Levels of parent agent in the target tissue and effect on adenoma development. Mol. Nutr. Food Res. 2012,56,775-783. [CrossRef] [PubMed]
    • (2012) Mol. Nutr. Food Res. , vol.56 , pp. 775-783
    • Karmokar, A.1    Marczylo, T.H.2    Cai, H.3    Steward, W.P.4    Gescher, A.J.5    Brown, K.6
  • 110
    • 84871738863 scopus 로고    scopus 로고
    • Modulatory efficacy of rosmarinic acid on premalignant lesions and antioxidant status in 1,2-dimethylhydrazine induced rat colon carcinogenesis
    • [CrossRef] [PubMed]
    • Karthikkumar,V.; Sivagami,G.; Vinothkumar,R.; Rajkumar,D.; Nalini,N. Modulatory efficacy of rosmarinic acid on premalignant lesions and antioxidant status in 1,2-dimethylhydrazine induced rat colon carcinogenesis. Environ. Toxicol. Pharmacol. 2012,34,949-958. [CrossRef] [PubMed]
    • (2012) Environ. Toxicol. Pharmacol. , vol.34 , pp. 949-958
    • Karthikkumar, V.1    Sivagami, G.2    Vinothkumar, R.3    Rajkumar, D.4    Nalini, N.5
  • 111
    • 84858600666 scopus 로고    scopus 로고
    • Anti-tumor activity of rosmarinic acid in 7,12-dimethylbenz(a)anthracene (DMBA) induced skin carcinogenesis in Swiss albino mice
    • [PubMed]
    • Sharmila,R.; Manoharan,S. Anti-tumor activity of rosmarinic acid in 7,12-dimethylbenz(a)anthracene (DMBA) induced skin carcinogenesis in Swiss albino mice. Indian J. Exp. Biol. 2012,50,187-194. [PubMed]
    • (2012) Indian J. Exp. Biol. , vol.50 , pp. 187-194
    • Sharmila, R.1    Manoharan, S.2
  • 112
    • 84875897578 scopus 로고    scopus 로고
    • The effect of rosmarinic acid on 1,2-dimethylhydrazine induced colon carcinogenesis
    • [CrossRef] [PubMed]
    • Venkatachalam,K.; Gunasekaran,S.; Jesudoss,V.A.S.; Namasivayam,N. The effect of rosmarinic acid on 1,2-dimethylhydrazine induced colon carcinogenesis. Exp. Toxicol. Pathol. 2013,65,409-418. [CrossRef] [PubMed]
    • (2013) Exp. Toxicol. Pathol. , vol.65 , pp. 409-418
    • Venkatachalam, K.1    Gunasekaran, S.2    Jesudoss, V.A.S.3    Namasivayam, N.4
  • 116
    • 79960198241 scopus 로고    scopus 로고
    • Absorption,Distribution and Elimination of Carnosic Acid,A Natural Antioxidant from Rosmarinus officinalis,in Rats
    • [CrossRef] [PubMed]
    • Doolaege,E.H.A.; Raes,K.; Vos,F.D.; Verhé,R.; Smet,S.D. Absorption,Distribution and Elimination of Carnosic Acid,A Natural Antioxidant from Rosmarinus officinalis,in Rats. Plant Foods Hum. Nutr. 2011,66,196-202. [CrossRef] [PubMed]
    • (2011) Plant Foods Hum. Nutr. , vol.66 , pp. 196-202
    • Doolaege, E.H.A.1    Raes, K.2    Vos, F.D.3    Verhé, R.4    Smet, S.D.5
  • 117
  • 118
    • 84898962581 scopus 로고    scopus 로고
    • A rosemary extract enriched in carnosic acid improves circulating adipocytokines and modulates key metabolic sensors in lean Zucker rats: Critical and contrasting differences in the obese genotype
    • [CrossRef] [PubMed]
    • Romo-Vaquero,M.; Larrosa,M.; Yáñez-Gascón,M.J.; Issaly,N.; Flanagan,J.; Roller,M.; Tomás-Barberán,F.A.; Espín,J.C.; García-Conesa,M.-T. A rosemary extract enriched in carnosic acid improves circulating adipocytokines and modulates key metabolic sensors in lean Zucker rats: Critical and contrasting differences in the obese genotype. Mol. Nutr. Food Res. 2014,58,942-953. [CrossRef] [PubMed]
    • (2014) Mol. Nutr. Food Res. , vol.58 , pp. 942-953
    • Romo-Vaquero, M.1    Larrosa, M.2    Yáñez-Gascón, M.J.3    Issaly, N.4    Flanagan, J.5    Roller, M.6    Tomás-Barberán, F.A.7    Espín, J.C.8    García-Conesa, M.-T.9
  • 119
    • 85078375635 scopus 로고    scopus 로고
    • Use of rosemary extracts as a food additive-Scientific Opinion of the Panel on Food Additives,Flavourings,Processing Aids and Materials in Contact with Food
    • European Food Safety Authority (EFSA). Use of rosemary extracts as a food additive-Scientific Opinion of the Panel on Food Additives,Flavourings,Processing Aids and Materials in Contact with Food. EFSA J. 2008,6,1-29.
    • (2008) EFSA J. , vol.6 , pp. 1-29
  • 121
    • 84899647673 scopus 로고    scopus 로고
    • A Rosemary Extract Rich in Carnosic Acid Selectively Modulates Caecum Microbiota and Inhibits β-Glucosidase Activity,Altering Fiber and Short Chain Fatty Acids Fecal Excretion in Lean and Obese Female Rats
    • [CrossRef] [PubMed]
    • Romo-Vaquero,M.; Selma,M.-V.; Larrosa,M.; Obiol,M.; García-Villalba,R.; González-Barrio,R.; Issaly,N.; Flanagan,J.; Roller,M.; Tomás-Barberán,F.A.; et al. A Rosemary Extract Rich in Carnosic Acid Selectively Modulates Caecum Microbiota and Inhibits β-Glucosidase Activity,Altering Fiber and Short Chain Fatty Acids Fecal Excretion in Lean and Obese Female Rats. PLoS ONE 2014,9,e94687. [CrossRef] [PubMed]
    • (2014) PLoS ONE , vol.9 , pp. e94687
    • Romo-Vaquero, M.1    Selma, M.-V.2    Larrosa, M.3    Obiol, M.4    García-Villalba, R.5    González-Barrio, R.6    Issaly, N.7    Flanagan, J.8    Roller, M.9    Tomás-Barberán, F.A.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.